The Effect of Brotizolam Induced Appetite on Serum Ghrelin Levels in Mice

AbstractObjectiveThe aim of the present study was to investigate serum ghrelin and orexin levels in patients with varicocele and compare these levels with idiopathic infertile male and healthy control cases.MethodsThis study enrolled 24 men with varicocele, 24 males having idiopathic infertility, and 21 fertile men as the control group. Hormonal analyses, ghrelin and orexin levels were measured samples. Semen was analyzed after 3 and 5 days of sexual abstinence.ResultsSerum ghrelin levels were statistically different among the three groups (p=0.015), and it was due to a statistically lower level in group-1 than the level in the control cases (p=0.012). On the other hand, serum orexin levels were lower than healthy subjects in infertile groups with/without varicocele, but there was no difference (p=0.685) among three groups. Serum ghrelin level showed a negative and significant correlation only with sperm motility (r=−0.646, p=0.022), there was no correlation with other parameters. On the other hand, serum orexin levels did not show a significant correlation with seminal parameters.ConclusionBoth new investigated peptides ghrelin and orexin have regulatory effects on testicular function. However, ghrelin has a more obvious and complex effect on spermatogenesis. Impaired seminal parameters, especially motility was associated with increased serum ghrelin levels in infertile patients, especially with varicocele.

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Serum Ghrelin and Leptin Levels in Patients with Depression and the Effects of Treatment

Psychiatry Investigation ◽

10.4306/pi.2014.11.2.167 ◽

2014 ◽

Vol 11 (2) ◽

pp. 167 ◽

Cited By ~ 28

Author(s):

Saliha Ozsoy ◽

Aslı Besirli ◽

Ummuhan Abdulrezzak ◽

Mustafa Basturk

Keyword(s):

Serum Ghrelin

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Serum ghrelin and adiponectin levels are increased but serum leptin level is unchanged in low weight Chronic Obstructive Pulmonary Disease patients

European Journal of Internal Medicine ◽

10.1016/j.ejim.2013.02.012 ◽

2014 ◽

Vol 25 (4) ◽

pp. 364-369 ◽

Cited By ~ 16

Author(s):

Ayse Kubat Uzum ◽

Munevver Mertsoylu Aydin ◽

Yildiz Tutuncu ◽

Beyhan Omer ◽

Esen Kiyan ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Serum Leptin ◽

Low Weight ◽

Serum Ghrelin

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STUDY OF GHRELIN LEVELS IN HYPOTHYROID PATIENTS BEFORE AND AFTER TREATMENT

10.36106/ijsr/7325261 ◽

2021 ◽

pp. 52-54

Author(s):

Peeyush Yadav ◽

G. G. Kaushik

Keyword(s):

Treatment Group ◽

Thyroid Hormones ◽

Hdl Cholesterol ◽

Metabolic Disturbances ◽

Free T4 ◽

Before And After ◽

Group A ◽

Group B ◽

Serum Ghrelin ◽

Hypothyroid Patients

Objective: Aim of the present study was to evaluate the levels of ghrelin in hypothyroid patients before and after treatment with L-thyroxine and to nd a possible relationship between ghrelin and thyroid hormones. Material & Methods: The present study was conducted on 100 hypothyroid patients (44 Males & 56 Females) before treatment (Group A) and after treatment (Group B) attending the outpatient clinics or admitted in wards of J.L.N. Hospitals, Ajmer. 100 healthy control subjects (Group C) of same age group of either gender were selected for the study. Blood samples were drawn from patients and controls, after overnight fast of at least 8 hours. Estimation of Serum Ghrelin, free T3, free T4, and TSH was done by using Enzyme- Linked Immunosorbant Assay (ELISA) technique. Total Cholesterol, Triglyceride, HDL – Cholesterol were measured by automated analyser (Beckman & Coulter's AU680). VLDL – Cholesterol, LDL – Cholesterol were calculated by Friedwald's formula. Differences in the parameters among the groups were analyzed by ANOVA test followed by its Tukey HSD post hoc analysis. Correlations between variables were tested using the Pearson rho (r: Correlation coefcient) correlation test. Results: Findings of the present study shows that the levels of serum fT3 (1.79 ± 0.29 pg/mL) and serum fT4 (0.34 ± 0.11 ng/dL) were signicantly lower in Group A compared to Group B (fT3 = 3.00 ± 0.32 pg/mL & fT4 = 0.81 ± 0.15 ng/dL) and Group C (fT3 = 3.12 ± 0.31 pg/mL & fT4 = 0.85 ± 0.11ng/dL) whereas serum TSH levels were signicantly higher in Group A (40.59 ± 13.55 μIU/mL) compared to Group B (5.34 ± 1.47 μIU/mL) and Group C (3.23 ± 1.04 μIU/mL). Levels of serum Ghrelin were signicantly higher in Group A (918.19 ± 48.47 pg/mL) compared to Group B (700.34 ± 46.35 pg/mL) and Group C (681.49 ± 35.80 pg/mL). A non signicant correlation of Ghrelin with S.fT4 and TSH was found in both Group A and Group B whereas S.fT3 and BMI shows a non signicant correlation in Group A in comparison to a signicant correlation in Group B. Conclusion: There is a reversible increase in the levels of serum ghrelin which became normalized after L-thyroxine substitution in hypothyroid patients. Alteration in the levels of serum ghrelin in thyroid disorders indicates a compensatory role of ghrelin in metabolic disturbances and also suggests a possible association between thyroid hormones and serum ghrelin levels.

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Changes in serum ghrelin level in relation to meal‐time in patients with functional dyspepsia

United European Gastroenterology Journal ◽

10.1177/2050640614563373 ◽

2015 ◽

Vol 3 (1) ◽

pp. 11-16 ◽

Cited By ~ 10

Author(s):

MH Kazemi ◽

A Eshraghian ◽

L Hamidpour ◽

SA Taghavi

Keyword(s):

Functional Dyspepsia ◽

Ghrelin Level ◽

Meal Time ◽

Serum Ghrelin

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Serum ghrelin, but not obestatin, is a potential predictor of acute pancreatitis severity

Medicine ◽

10.1097/md.0000000000007963 ◽

2017 ◽

Vol 96 (35) ◽

pp. e7963 ◽

Cited By ~ 3

Author(s):

Huilin Wang ◽

Mengbin Qin ◽

Zhihai Liang ◽

Renjie Chang ◽

Hongzong Fu ◽

...

Keyword(s):

Acute Pancreatitis ◽

Potential Predictor ◽

Serum Ghrelin

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Ghrelin in Serum and Urine of Post-Partum Women with Gestational Diabetes Mellitus

International Journal of Molecular Sciences ◽

10.3390/ijms19103001 ◽

2018 ◽

Vol 19 (10) ◽

pp. 3001 ◽

Cited By ~ 4

Author(s):

Żaneta Kimber-Trojnar ◽

Jolanta Patro-Małysza ◽

Katarzyna Skórzyńska-Dziduszko ◽

Jan Oleszczuk ◽

Marcin Trojnar ◽

...

Keyword(s):

Diabetes Mellitus ◽

Body Composition ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Post Partum ◽

Enzyme Linked Immunosorbent Assay ◽

Hydration Status ◽

Increased Risk ◽

Serum Ghrelin ◽

Serum And Urine

Women with a previous history of gestational diabetes mellitus (GDM) have a significantly increased risk of developing type 2 diabetes, obesity, and cardiovascular diseases in the future. The aim of the study was to evaluate ghrelin concentrations in serum and urine in the GDM group in the early post-partum period, with reference to laboratory results, body composition, and hydration status. The study subjects were divided into two groups, that is, 28 healthy controls and 26 patients with diagnosed GDM. The maternal body composition and hydration status were evaluated by the bioelectrical impedance analysis (BIA) method. The concentrations of ghrelin in the maternal serum and urine were determined via enzyme-linked immunosorbent assay (ELISA). The laboratory and BIA results of the mothers with GDM were different from those without GDM. Urine ghrelin positively correlated with serum ghrelin and high-density lipoprotein cholesterol (HDL) levels in healthy mothers. There were direct correlations between urine ghrelin and HDL as well as triglycerides levels in the GDM group. Neither the lean tissue index nor body cell mass index were related to the serum ghrelin concentrations in this group. Only the urine ghrelin of healthy mothers correlated with the fat tissue index. Our results draw attention to urine as an easily available and appropriable biological material for further studies.

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Fasting Serum Ghrelin Level is Associated with Metabolic Syndrome in Peritoneal Dialysis Patients

Peritoneal Dialysis International ◽

10.1177/089686080802803s36 ◽

2008 ◽

Vol 28 (3_suppl) ◽

pp. 196-200

Author(s):

Chung-Jen Lee ◽

Yi-Maun Subeq ◽

Chih-Hsien Wang ◽

Ru-Ping Lee ◽

Te-Chao Fang ◽

...

Keyword(s):

Metabolic Syndrome ◽

Regression Analysis ◽

Peritoneal Dialysis ◽

Waist Circumference ◽

Linear Regression ◽

Diagnostic Criteria ◽

Linear Regression Analysis ◽

Enzyme Linked Immunosorbent Assay ◽

Fasting Serum ◽

Serum Ghrelin

⋄ Background Serum ghrelin levels are elevated in uremic patients. However, no data are available on the relationship between metabolic syndrome and serum ghrelin levels in peritoneal dialysis (PD) patients. ⋄ Methods Metabolic syndrome and its components were defined using diagnostic criteria recommended by the International Diabetes Federation. Fasting serum samples were taken from 30 PD patients. Serum ghrelin levels were measured by using a commercial enzyme-linked immunosorbent assay kit. ⋄ Results Of the 30 PD patients, 53.3% (16/30) had metabolic syndrome. Fasting serum ghrelin corrected inversely with metabolic syndrome among these PDs patients ( p = 0.002). By odds ratio (OR) analysis of metabolic syndrome and metabolic syndrome diagnostic criteria, the predictors for metabolic syndrome are fasting glucose [OR: 39.00; 95% confidence interval (CI): 3.80 to 399.85; p < 0.001], triglycerides (OR: 37.50; 95% CI: 3.64 to 386.51; p < 0.001), and waist circumference (OR: 4.20; 95% CI: 1.95 to 9.03; p < 0.001). Univariate linear regression analysis showed that body weight ( r = –0.461, p = 0.010), waist circumference ( r = –0.390, p = 0.033), and body mass index ( r = –0.438, p = 0.016) were negatively correlated with serum ghrelin, and serum high density lipoprotein [HDL ( r = 0.626, p < 0.001)] was positively correlated with serum ghrelin. Multivariate forward stepwise linear regression analysis of the significant variables showed that HDL ( R2 change = 0.392; p < 0.001) was the independent predictor of serum ghrelin in PD patients and explained 39.2% of the variance. ⋄ Conclusions These results indicate an inverse association between circulating fasting ghrelin and metabolic syndrome in PD patients. Serum HDL was associated with serum ghrelin among PD patients.

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