ACUTE LYMPHOBLASTIC LEUKEMIA; CHROMOSOMAL ABNORMALITIES IN CHILDHOOD REPORTING AT A TERTIARY CARE HOSPITAL OF SINDH

Objective: Cytogenetic plays an inevitable role in predicting the diagnosis of acute leukemia. The recurrent chromosomal aberrations in acute leukemia have provided critical insights into the pathophysiological mechanism of leukemogenesis. Cytogenetics findings at diagnostics provide important information for decision-making in both childhood and adult acute lymphoblastic leukemia (ALL). The cure rate for ALL is >80% in children and 35% in adults. Despite the therapeutic advances in ALL, several important biological and pathophysiological questions remain to be answered to achieve an accurate diagnosis, timely prognosis, and maximum therapeutic benefit. Methods: The present study was carried out at tertiary care hospital, New Delhi, India. A total of 144 newly diagnosed ALL patients were analyzed for clinicohematological profile, immunophenotyping, conventional, and molecular cytogenetics. Results: The study population was found to have normal karyotypes in most of the cases; however, abnormalities also reported. Our study clearly indicates that the application of fluorescence in situ hybridization has increased sensitivity and accuracy for detecting various chromosomal abnormalities, more so with the cryptic rearrangements. Conclusion: We observed that the prevalence of the molecular subgroup of leukemia with a potential for a favorable clinical outcome (ETV6-RUNX1 and hyperdiploidy) in precursor B-ALL is higher in the North India.

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Physician Delay for Delayed Diagnosis of Acute Lymphoblastic Leukemia among Children in a Tertiary Care Hospital

Cytokines:Their Relation with Mineral Dust Induced Diseases ◽

10.24966/ppp-5649/100018 ◽

2020 ◽

Vol 4 (1) ◽

pp. 1-5

Author(s):

Yasmin T ◽

Keyword(s):

Developing Countries ◽

Tertiary Care Hospital ◽

Lymphoblastic Leukemia ◽

Tertiary Care ◽

Delayed Diagnosis ◽

Late Presentation ◽

Care Hospital ◽

Childhood Cancers ◽

Early Diagnosis Of Cancer ◽

Diagnosis Of Cancer

Early diagnosis of cancer gives an opportunity for early treatment which is very important. Unfortunately, late presentation and delayed diagnosis of childhood cancers remain a problem in developing countries including Bangladesh. Few studies on delayed diagnosis of childhood cancers have been conducted in Bangladesh.

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Acute Lymphoblastic Leukemia: Fourteen Years Experience of a Single Institution

Journal of Nepal Paediatric Society ◽

10.3126/jnps.v34i1.9056 ◽

2014 ◽

Vol 34 (1) ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

KP Sah ◽

PN Shrestha

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Acute Leukemia ◽

Remission Rate ◽

Lymphoblastic Leukemia ◽

Tertiary Care ◽

Malignant Neoplasm ◽

Bone Marrow Aspiration ◽

Care Hospital ◽

Female Ratio ◽

Oncology Unit

Introduction: Leukemia commonly known as blood cancer is the most common malignant neoplasm in childhood accounting for about 41 % of all malignancies that occur in children younger than 15 year of age. The objectives of this study were to find out the clinico-laboratory features and survival of children with acute lymphoblastic leukemia (ALL) during fourteen years in pediatric oncology unit of a tertiary care hospital. Materials and Methods: This was a retrospective study conducted at Kanti Children’s Hospital (KCH) from March 1998 to March 2012. Bone marrow aspiration showing ≥25 % blast cells was the criteria for diagnosis of ALL. Results: Out of 755 childhood cancers reported in this hospital during study period, total number of Acute leukemia patients were 375 (49.7%). Among acute leukemia, patients with ALL were 300, which was 80.0 % among all leukemias and 39.7% of all cases of cancers. Among cases of ALL, L1, L2 and L3 constituted 163 (54.3%), 131 (43.7%) and 6 (2%) respectively. The age of the children with acute leukemia ranged from six months to fourteen years, with a mean age of 7.3 years. The majority of children (61.7 %) with ALL fell into the age group of 2-9 years. Males: Female ratio was (M:F=1.3:1 ). The most common presenting features in ALL were fever (89.2 %), followed by splenomegaly (89.1%), hepatomegaly (69.2%) and lymphadenopathy (58.4 %). Among all patients, remission rate was 28.3% at ≥ 5 years, 17.7% were on maintenance, 30.3% abandoned treatment and 23.7 % died. Conclusion: This study showed that the patients on remission at ≥ 5 years in this centre were 28.3%. DOI: http://dx.doi.org/10.3126/jnps.v34i1.9056 J Nepal Paediatr Soc 2014;34(1):1-6

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