scholarly journals Cutaneous Manifestation of Disseminated Cryptococcosis Mimicking Herpes Zoster

2021 ◽  
pp. 77-81
Author(s):  
Hoon Choi ◽  
Dong Hyun Shim ◽  
Min Sung Kim ◽  
Bong Seok Shin ◽  
Chan Ho Na
Keyword(s):  
Herpes Zoster ◽  
Skin Lesions ◽  
Fungal Culture ◽  
Cutaneous Manifestations ◽  
Systemic Involvement ◽  
Early Markers ◽  
The Face ◽  
Intravenous Amphotericin ◽  
Systemic Symptoms ◽  
Cutaneous Cryptococcosis

Cutaneous cryptococcosis is classified either as localized cutaneous cryptococcosis, in which the lesions are confined to one area of the skin, or as disseminated cryptococcosis, in which cutaneous manifestations are more widespread. We report a case of fatal disseminated cryptococcosis with characteristic cutaneous manifestations. An 84-year-old woman with diabetes presented with crusted plaques and ulcers that were painful, diffuse, and erythematous to crusted and on only the left side of her face, neck, and upper chest. She was referred to our hospital from a local clinic, where herpes zoster had been suspected. She had no specific systemic symptoms. Histological examination of the skin lesion revealed granulomatous reactions and purple to reddish encapsulated spores. Cryptococcus neoformans was identified in fungal culture, and hospitalization was recommended. Oral fluconazole was prescribed, and she was admitted to another hospital. After 2 weeks, the patient's condition deteriorated, and she was transferred to our hospital. C. neoformans antigen was detected in the blood and urine during the evaluation for systemic involvement. The patient was treated with intravenous amphotericin B and fluconazole; however, she died 10 days after admission. Cutaneous manifestations of disseminated cryptococcosis can appear in various forms and mimic molluscum contagiosum, Kaposi's sarcoma, and cellulitis. In this case, the skin lesions occurred on only the left side of the face, neck, and chest, as in herpes zoster. Cutaneous cryptococcosis can occur before the onset of symptoms of systemic involvement; therefore, diagnosis is important. Systemic evaluation may reveal early markers of disseminated cryptococcosis.

Cutaneous Cryptococcosis Mimicking Basal Cell Carcinoma in a Patient with AIDS

1998 ◽  
Vol 3 (1) ◽  
pp. 43-45 ◽  
Author(s):  
Rosemarie Ingleton ◽  
Evelyn Koestenblatt ◽  
Philip Don ◽  
Howard Levy ◽  
Wojciech Szaniawski ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Systemic Disease ◽  
Immune Deficiency Syndrome ◽  
Skin Lesions ◽  
Deficiency Syndrome ◽  
Cutaneous Manifestations ◽  
Systemic Involvement ◽  
Cutaneous Cryptococcosis

Background: Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans. This ubiquitous organism has emerged as a frequent finding in immunosuppressed patients, especially those with underlying malignancies, organ transplants, and the acquired immune deficiency syndrome (AIDS). Cutaneous manifestations of cryptococcosis occur in 10 to 15% of patients having systemic involvement. These skin lesions may simulate a variety of different disease entities. Methods: A case of crytococcosis mimicking a basal cell carcinoma is the subject of a case report presentation. Results: A case of cutaneous cryptococcosis mimicking basal cell carcinoma occurred in a patient with AIDS, who did not appear to have dissemination, but was treated aggressively to stem possible occult systemic disease. Conclusion: Cutaneous crytococcosis may mimic other dermatologic disorders.

scholarly journals A rare case of Sweet syndrome secondary to melioidosis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Sahathevan Vithoosan ◽  
Balendran Thanushah ◽  
Paramarajan Piranavan ◽  
Dayal Gamlaksha ◽  
Harindra Karunatilake ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Burkholderia Pseudomallei ◽  
Skin Lesions ◽  
Upper Limbs ◽  
Cutaneous Manifestations ◽  
Sweet Syndrome ◽  
Emerging Infection ◽  
Oral Ulcers ◽  
First Case ◽  
The Face

Abstract Background Melioidosis is an emerging infection in South Asia caused by Burkholderia pseudomallei with various clinical presentations that include pneumonia, bacteraemia, arthritis, and deep-seated abscesses. Various cutaneous manifestations have been described in association with melioidosis. However Sweet Syndrome secondary to melioidosis has not been reported in the literature. Herein we describe the first case of Sweet syndrome secondary to melioidosis. Case presentation A 53-year-old previously healthy Sri Lankan female presented with high-grade fever, painful oral ulcers, odynophagia and multiple bilateral cervical lymphadenopathies for 1 month. She also had a loss of appetite and weight. She had oral ulcers and bilateral blepharitis. Dermatological examination revealed multiple tender papules with a mamillated appearance and targetoid lesions with a yellowish centre over the face, upper trunk and upper limbs. She also had multiple tender subcutaneous nodules over the extensor aspect of upper limbs. Her inflammatory markers were significantly elevated. Aspirate from a submental lymph node abscess revealed the growth of Burkholderia pseudomallei. Melioidosis antibody titer was > 10,240. The histology of the skin lesions of the face and left forearm showed a prominent neutrophilic infiltrate in the dermis and the morphological features were in favour of Sweet syndrome with panniculitis. She was started on intravenous meropenem 2 g daily and showed rapid clinical improvement with the disappearance of skin lesions as well as a reduction in inflammatory markers. Conclusion Sweet syndrome is an uncommon inflammatory disorder known to be associated with upper respiratory tract and gastrointestinal infections, malignancies and the use of certain drugs. Melioidosis is an emerging infection with various cutaneous manifestations. This is the first case of melioidosis causing the secondary sweet syndrome. It emphasizes the importance of considering melioidosis as a potential aetiology in patients with Sweet syndrome.

scholarly journals Dermatological Manifestations of COVID-19 in Children

2020 ◽  
Vol 7 (2) ◽  
Author(s):  
Vivek Athwani ◽  
Sunil Gothwal
Keyword(s):  
Toxic Shock Syndrome ◽  
Gastrointestinal Symptoms ◽  
Skin Lesions ◽  
Skin Involvement ◽  
Toxic Shock ◽  
Cutaneous Manifestations ◽  
Systemic Involvement ◽  
Atypical Kawasaki Disease ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome

: Coronavirus infection 2019 (COVID-19) primarily has a respiratory system and multi-systemic involvement. Respiratory and gastrointestinal symptoms are predominantly seen in children. In adults, few COVID-19 cases are reported with cutaneous manifestations. Although children are less severely affected by COVID-19, there is increasing evidence for skin involvement, which is in the form of chilblain (e.g., lesions, vesicular, and maculopapular) and erythema multiforme (e.g., rash). Also, few COVID-19 cases are presented with a clinical picture of atypical Kawasaki disease and toxic shock syndrome, later defined as pediatric multisystem inflammatory syndrome (PMIS). The present study aims to summarize various skin lesions with COVID-19.

scholarly journals Cutaneous Manifestations of COVID-19: A Case Series from Brazil

2020 ◽  
Vol 78 (4) ◽  
pp. 329-334
Author(s):  
David De Almeida Souza ◽  
Daniela Alves Pereira Antelo
Keyword(s):  
Case Series ◽  
Skin Lesions ◽  
Daily Routine ◽  
Skin Involvement ◽  
Cutaneous Manifestations ◽  
Infected People ◽  
Maculopapular Eruption ◽  
The World ◽  
Systemic Symptoms ◽  
Epidemiological Characteristics

Introduction: Brazil has presented alarming and growing data on infection and deaths from SARS-CoV-2. There are more than 4 500 000 confirmed cases and more than 137 000 deaths ranking second in the world ranking of infected people. In addition to the involvement of the respiratory, cardiovascular, renal and neurological systems, this virus also causes non-specific skin lesions in same patients. Little is known about the pathophysiology of cutaneous involvement. At this moment, we cannot predict a difference in prognosis based on skin lesions. Methods: We conducted an observational case study of 25 patients affected by SARS-CoV-2 who had dermatological lesions. We described the clinical and epidemiological characteristics of each case, demonstrating the polymorphism of the skin lesions and also making a correlation with the chronology of presented systemic symptoms. Results: Twenty five cases of COVID-19 with cutaneous manifestations (urticaria, erythematous rash, maculopapular eruption, pruritus, erythema multiforme-like lesions, dyshidrotic eczema) were observed during, after and before systemic symptoms. A few cases with skin involvement were also observed as isolated symptoms of the viral infection. These data demonstrate the clinical polymorphism related to skin involvement of patients infected with SARS-CoV-2, emphasizing the importance of clinical suspicion by dermatologists when handling suspected cases in the current epidemiological scenario. Conclusion: Although the number of cases in the world stage seems to be regressing, infection by SARS-CoV-2 will be part of the dermatologist's daily routine. As long as we do not have a widely available vaccine and the pandemic takes on an endemic profile, we need to be aware of these manifestations, not only for the proper diagnosis, indication of patient isolation, as well as all the necessary biosafety procedures in dermatology clinics.    

scholarly journals Clinical report of rare manifestation of Herpes Zoster in the mandibular nerve

2021 ◽  
Vol 10 (4) ◽  
pp. e46010414225
Author(s):  
Victor Teixeira Prest ◽  
Radamés Bezerra Melo ◽  
Carlos Diego Lopes Sá ◽  
Nayara Cristina Monteiro Carneiro ◽  
Ranelle de Souza Bernardino ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Skin Lesions ◽  
Codeine Phosphate ◽  
Clinical Report ◽  
Initial Exposure ◽  
Lower Lip ◽  
Varicella Zoster ◽  
The Face ◽  
Triggering Factor ◽  
Mandibular Region

Herpes zoster (HZ) – a viral infection commonly known as shingles – is caused by reactivation of the varicella-zoster virus (VZV), one of eight known herpes viruses that infect humans. It is ubiquitous and highly contagious, with initial exposure usually occurring during childhood, when it causes chickenpox. The mechanism responsible for reactivating the virus is still not fully understood. However, it appears to be associated with a weakened immune system, with stress also having been identified as a possible triggering factor. Vesicular-bullous lesions on the skin that follow the pathway of a particular nerve are typically the clinical basis for diagnosing HZ with no need for further laboratory testing. The objective of this study is to report a clinical case of a patient, 17 years old, diagnosed with HZ in the trigeminal nerve with involvement of the mandibular branch. There were vesicular-bullous skin lesions in the mesenteric region, the mandibular region and the lower lip, in addition to erythematous lesions on the tongue, with pain in all the affected regions. All lesions were located on the left side of the face and did not exceed the midline. The treatment was performed with acyclovir and pain medication (Paracetamol and Codeine Phosphate, Tylex® 30mg), with complete resolution occurring in 30 days. The patient is undergoing a 6 month outpatient follow-up and did not exhibit any functional sequelae.

scholarly journals Staphylococcal scalded skin syndrome caused by methicillin-resistant Staphylococcus aureus with superadded fungal infection in a neonate

2017 ◽  
Vol 5 (12) ◽  
pp. 5456
Author(s):  
Mayuri Gogoi ◽  
Nilakshi Borah ◽  
Ajanta Sharma
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Sensitivity ◽  
Skin Lesions ◽  
Staphylococcal Infection ◽  
Entire Body ◽  
Fungal Culture ◽  
Staphylococcal Scalded Skin Syndrome ◽  
Clinical Criteria ◽  
Sensitivity Pattern ◽  
The Face

Staphylococcal scalded skin syndrome (SSSS) or acute staphylococcal epidermolysis is an exfoliative skin disease and a toxin mediated staphylococcal infection affecting mostly neonates and adolescents. We describe here a case of 10-day old full term, vaginally delivered baby weighing 1530gms presenting with erythematous lesions first developing on the face and later spreading to the entire body for the last 6 days. The mucosal areas were spared. Blood culture of the patient revealed growth of Methicllin Resistant Staphylococcus aureus (MRSA). Culture from the skin lesions also revealed growth of MRSA with similar antibiotic sensitivity pattern. Fungal culture from the skin lesions revealed growth of Candida tropicalis. The diagnosis of SSSS was based on clinical criteria and microbiological findings. 

scholarly journals A Rare Case of Juvenile Xanthogranuloma in 8 Months Old Baby with Dyslipidemia

2021 ◽  
Vol 5 (4) ◽  
pp. 1212-1217
Author(s):  
Jessica Herlianez Saiful ◽  
Rina Gustia
Keyword(s):  
Lower Limb ◽  
Foam Cell ◽  
Laboratory Finding ◽  
Skin Lesions ◽  
Langerhans Cell ◽  
Juvenile Xanthogranuloma ◽  
Formula Milk ◽  
Systemic Involvement ◽  
The Face ◽  
Lipid Abnormalities

Background: Juvenile xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis disease of childhood. But due to rarity of non Langerhans cell hystiosis itself, the exact prevalence of juvenile xanthogranuloma remain unknown with only a few epidemiological journal ever published. Juvenile xanthogranuloma usually wihout lipid abnormality and systemic involvement. But association between JXG and lipid abnormalities is still not well understood. We describe a patient with multiple cutaneous JXG who also developed hyperlipidemia. Case: A case of a  8 months-old baby patient with juvenile xanthogranuloma is reported.  Patient parents noticed yellowish dots on child’s face since six months ago, and it was gradually increase in size and number, and spread to trunks, upper and lower limb since 2 months ago. Patients got formula milk since 7 months ago. Patients father has uncontrolled hypercholesterolemia, and grandparents  had controlled dyslipidemia. Dermatological state showed yellowish plaque and papule on the face, trunk, lower limb, and upper limb. Dermoscopy show yellowish papule with sun setting appearance and branched and linear vessel on orange yellow background. Laboratory finding showed  elevated lipid serum. Foam cell and Touton giant  cell is found on histopathology examination. Discussion: The presented case demonstrates that skin lesions in patients with diagnosed JXG may have a variable clinical presentation, ranging from single to diffuse skin lesions, also present from the birth to childhood. The diagnosis requires histopathological confirmation to avoid misdiagnosis of malignant disease. Association between JXG and lipid abnormalities remain unknown, with most of the patient show normal  lipid serum. Majority of patients presenting lesions limited to the skin requires only a strict dermatological observation.

scholarly journals Multiple Reticulohistiocytomas in an 88-year-old Man: a Case Report

2013 ◽  
Vol 5 (2) ◽  
pp. 87-93
Author(s):  
Branislava Gajić ◽  
Tatjana Roš ◽  
Andrijana Arapović ◽  
Nada Vučković ◽  
Aleksandra Fejsa Levakov
Keyword(s):  
Treatment Options ◽  
Skin Lesions ◽  
Systemic Involvement ◽  
Multicentric Reticulohistiocytosis ◽  
Mucosal Involvement ◽  
Multinuclear Cells ◽  
Systemic Symptoms ◽  
One Year ◽  
Foamy Cytoplasm

Abstract Solitary and multiple reticulohistiocytomas, often referred to as diffuse cutaneous reticulohistiocytosis, that are generally restricted to skin, must be differentiated from multicentric reticulohistiocytosis. Multicentric reticulohistiocytosis is a rare histiocytic proliferative disease affecting joints, skin and mucous membranes, while arthropathy usually precedes skin and mucosal involvement. Other organs may also be involved, and 20% of patients have an associated internal malignancy. Multicentric reticulohistiocytosis has been reported to be associated with autoimmune diseases and malignancies. We present an 88-year-old man, with a sudden eruption of asymptomatic, firm, skin to brown colored papules and nodules, 6 to 17 mm in diameter, localized on forehead, arms, legs, and buttocks. There were no symptoms of joint or other organ involvement. Clinical and dermoscopic characteristics pointed to reticulohystiocytomas. Multiple excision biopsies of different tumors were performed and histopathology reports confirmed the diagnosis. In the case presented, reticulohistiocytosis was limited to the skin, exhibiting multiple reticlohistiocytomas with typical clinical, dermoscopic and rather peculiar histopathology presentation. Apart from this, some histologic features were seen in early lesions of multicentric reticulohistiocytosis, such as multinuclear cells dissociating collagen fibers with pale eosinophilic and foamy cytoplasm. Besides surgical excisions, no other treatment options were done. Laboratory and other tests showed no presence of extracutaneous illness, and no autoimmune or paraneoplastic processes. At one year follow up, the remaining tumors were of the same size, but there were no recurrences at excision sites, no signs of disease progression or systemic involvement. Since diffuse cutaneous reticulohistiocytosis without arthropathy as well as isolated reticulohistiocytomas have been described, in some cases of multiple reticulohistiocytomas even without systemic symptoms and signs, multicentric reticulohistiocytosis should be considered with an appropriate follow up. In such cases, skin lesions have the same histological features as lesions in multicentric reticulohistiocytosis, but they are not associated with joint problems or neoplasms.

scholarly journals Cutaneous manifestations of COVID-19 in Mexican patients: A case series and review of literature

2021 ◽  
Vol 9 ◽  
pp. 2050313X2199719
Author(s):  
Juan Carlos Palomo-Pérez ◽  
Maria Elisa Vega-Memije ◽  
David Aguilar-Blancas ◽  
Erik González-Martínez ◽  
Lucia Rangel-Gamboa
Keyword(s):  
Respiratory Symptoms ◽  
Case Series ◽  
Signs And Symptoms ◽  
Skin Lesions ◽  
World Health ◽  
Medical Community ◽  
Atypical Pneumonia ◽  
Cutaneous Lesions ◽  
Cutaneous Manifestations ◽  
Mexican Patients

China officially recognized atypical pneumonia outbreak in December 2019; on 11 March 2020, the World Health Organization declared COVID-19 as a pandemic that is produced by a new coronavirus, named SARS-CoV-2, of rapid transmissibility, which can be asymptomatic, with mild to severe respiratory symptoms, and with cardiovascular, neurological, gastrointestinal, and cutaneous complications. Considering that the pandemic prolonged more than initially expected was prognostic, it is essential for the medical community to identify the signs and symptoms of COVID-19. Thus, this work’s objectives were to present cases of cutaneous lesions observed in COVID-19 Mexican patients. We register cutaneous lesions in COVID-19 patients referred from internal medicine and otorhinolaryngology services to dermatology. We presented four interesting cases with cutaneous lesions, including exanthema morbilliform, urticaria, chilblains, ecchymosis, and facial edema, and review the available literature. The most frequent cutaneous markers are rash, chilblains, and urticaria. Skin lesions may be the first manifestation of COVID-19, accompany initial respiratory symptoms, or appear during the disease course. Symptoms associated with vascular changes (livedo reticularis and vasculitis) are considered of poor prognosis.

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