Clinical Study of Iodine-Glycerol Combined With Valvaguang in the Treatment of Acute Pharyngitis

2021 ◽  
Vol 7 (5) ◽  
pp. 1365-1372
Author(s):  
Guiling Zhang ◽  
Xuemei Zhang ◽  
Qianqian Xu ◽  
Guangsheng Li ◽  
Zi Tian ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Measurement Data ◽  
Inflammatory Factors ◽  
Control Group ◽  
Study Group ◽  
Necrosis Factor Alpha ◽  
Acute Pharyngitis ◽  
Significant Difference ◽  
Disappearance Time ◽  
The Difference

To explore the clinical effect of iodine-glycerol combined with Weivaguang in the treatment of acute pharyngitis. Methods: A total of 118 patients with acute pharyngitis treated in our hospital from July 2017 to December 2019 were selected as the research object, and they were randomly divided into 59 cases in the control group and the study group by random number table method. The group was given Weivaguang treatment on the basis of the control group, comparing the disappearance time, signs or symptoms score, inflammatory factors [tumor necrosis factor alpha (TNF-±), C-reactive protein (CRP), interleukin (IL-6)] Level and therapeutic effect. Results: The throat disappearance time, throat pain disappearance time, hoarseness disappearance time, and pharyngeal edema disappearance time of the study group were significantly shorter than those of the control group, and the differences were statistically significant (P <0.05). Repeated measurement data analysis of variance showed that the difference in the subject’s intra-subject effect was statistically significant (P <0.05), with the group factor as the source and the time factor and group interaction as the source within the subject There was no statistically significant difference in effect comparison (P > 0.05), which shows that the signs or symptoms scores have a tendency to change with time; the sign or symptom scores of the two groups are compared: after 5 days of treatment <2 days after treatment <before treatment, the differences are both Statistically significant (P <0.05); before the treatment, there were no statistically significant differences in the signs or symptoms scores between the two groups (P > 0.05). After 2 days of treatment and 5 days of treatment, the signs or symptoms of the study group were significantly lower than the control Group, the difference was statistically significant (P <0.05). Before treatment, the levels of TNF-±, CRP, and IL-6 were not statistically significant (P > 0.05); after treatment, the levels of TNF-±, CRP, and IL-6 decreased in both groups, and the study group and the control The group comparison was significantly lower, and the differences were statistically significant (P <0.05). The therapeutic effect of the study group was better than that of the control group (P <0.05), and the total effective rate of treatment in the study group was 96.61%, significantly higher than 81.36% of the control group, the difference was statistically significant (P <0.05). Conclusion: The application of iodine-glycerin combined with valvaguang in the treatment of acute pharyngitis can effectively shorten the disappearance time of patients’ clinically relevant indicators, relieve signs or symptoms, reduce the body’s inflammatory response, and improve the therapeutic effect.

Effect of Aerosol Inhalation of Budesonide Suspension on Clinical Efficacy, Remission Time of Asthma and Disappearance Time of Rales in Children with Mycoplasma Pneumoniae Pneumonia

2021 ◽  
Vol 7 (5) ◽  
pp. 3057-3062
Author(s):  
TingTing Zheng ◽  
XiNi Liu ◽  
Xuechun Chen
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Clinical Efficacy ◽  
Oral Treatment ◽  
Control Group ◽  
Study Group ◽  
Aerosol Inhalation ◽  
Significant Difference ◽  
Disappearance Time ◽  
And Control ◽  
Mycoplasma Pneumoniae Pneumonia

To investigate the effect of aerosol inhalation of budesonide suspension on clinical efficacy, remission time of asthma and disappearance time of rales in children with mycoplasma pneumoniae pneumonia. Methods: 100 cases of mycoplasma pneumoniae pneumonia in our hospital from February 2019 to February 2021 were randomly divided into study group (n = 50) and control group (n = 50). The control group was given azithromycin intravenous drip followed by oral treatment, and the study group was given aerosol inhalation of budesonide suspension on the basis of the control group. Results: Compared with the control group, disappearance time of rales in the study group, remission time of cough, remission time of asthma and time of hospitalization in the study group were relatively short (P<0.05), and the efficacy in the study group was relatively high (P<0.05). There was no significant difference in the incidence of nausea, vomiting, abdominal pain, diarrhea and hoarseness between the two groups (P>0.05). The improvement of FVCS FEV1 and PEF and other indexes was relatively high in the study group by comparing with the control group (P<0.05). Conclusion: Aerosol inhalation of budesonide suspension in children with mycoplasma pneumoniae pneumonia can effectively enhance the therapeutic effect, promote the improvement of lung function, and reduce the disappearance time of rales and remission time of asthma, so it can be popularized.

A Randomized Clinical Trial to Evaluate Attached Hamstring Anterior Cruciate Ligament Graft Maturity With Magnetic Resonance Imaging

2018 ◽  
Vol 46 (5) ◽  
pp. 1143-1149 ◽  
Author(s):  
Shaohua Liu ◽  
Hong Li ◽  
Hongyue Tao ◽  
Yaying Sun ◽  
Shiyi Chen ◽  
...  
Keyword(s):  
Acl Reconstruction ◽  
Signal Intensity ◽  
Cruciate Ligament ◽  
Hamstring Tendon ◽  
Control Group ◽  
Study Group ◽  
Tibial Insertion ◽  
Significant Difference ◽  
The Difference ◽  
Anterior Cruciate

Background: The hamstring tendons are commonly harvested for anterior cruciate ligament (ACL) reconstruction with detachment of the tibial insertion. Retaining the insertion may help to preserve vascularity and viability of the graft and bypass the stages of avascular necrosis and revascularization, which might be beneficial to graft maturity. Purpose: To investigate and compare graft maturity by magnetic resonance imaging (MRI) after ACL reconstruction with preservation or detachment of hamstring tendon tibial insertion at up to 2 years. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: Forty-five patients (age range, 18-45 years) undergoing isolated ACL reconstruction with hamstring tendon were enrolled and randomized to 2 groups. The tibial insertion of the hamstring tendon was preserved in the study group (n = 21) and detached in the control group (n = 24). Patients had follow-up at 3, 6, 12, and 24 months, which consisted of the following: (1) clinical examination and (2) MRI evaluation of graft signal intensity based on signal/noise quotient (SNQ) values. Finally, 18 patients in the study group and 19 in the control group received full follow-up evaluation (ie, at all 4 time points). Results: All knees acquired full range of motion at 24 months without significant laxity. At each time point, the KT-1000 arthrometer revealed no significant difference between groups; the clinical scores significantly improved in both groups, although the difference between groups was not significant. In the control group, the SNQ value increased from 3 months, peaked at 6 months, and then decreased (3 months, 21.4 ± 12.7; 6 months, 25.6 ± 12; 12 months, 18.3 ± 7.7; 24 months, 15.3 ± 6.3). However, the insertion-preserved graft in the study group maintained relatively lower and unchanged signal intensity throughout all time points (3 months, 15.0 ± 11.2; 6 months, 14.9 ± 6.3; 12 months, 12.6 ± 7.0; 24 months, 14.6 ± 7.0). Between groups, there was no significant difference at 3 or 24 months ( P = .11 and .75, respectively), while the SNQ values were significantly lower in the study group versus the control group at 6 and 12 months ( P = .002 and .02, respectively). Conclusion: The insertion-detached hamstring tendon grafts underwent a significantly increasing change in signal intensity during the first 2 years after ACL reconstruction, while the insertion-preserved grafts kept a relatively lower and unchanged signal intensity. The difference was most significant at 6 and 12 months postoperatively.

scholarly journals A Randomized Control Trial Study to Determine the Effect of Melatonin on Serum Levels of IL-1β and TNF-α in Patients with Multiple Sclerosis

2020 ◽  
Author(s):  
Masoomeh Yosefifard ◽  
Gholamhassan Vaezi ◽  
Ali Akbar Malekirad ◽  
Fardin Faraji ◽  
Vida Hojati
Keyword(s):  
Multiple Sclerosis ◽  
Interleukin 1 ◽  
Serum Levels ◽  
Inflammatory Factors ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Treatment Groups ◽  
Tnf Α ◽  
Significant Difference ◽  
The Central Nervous System

Multiple sclerosis (MS) is the most common neurological disease that happens at a young age. MS is an inflammatory disease; associated with the demyelination of the central nervous system. Therefore, some inflammatory factors are effective in the mechanism and progression of the disease. Melatonin, as a multi-effect substance including anti-inflammatory effects, can reduce symptoms of MS in patients with a change in their inflammatory factors level. In this study, 50 MS patients who were referred to the MS Society of Markazi Province were randomly selected. All patients were treated with routine MS treatment (interferon) and were divided into control (25 placebo recipients) and treatment (25 recipients of 3 mg melatonin per day for 24 weeks) groups. Anthropometric data of patients including height, weight, and age were determined. Blood samples were collected after fasting in order to determine serum levels of interleukin 1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α). Then, samples were immediately centrifuged for serum separation and sera were transferred to a freezer at -80°C and serum levels of these factors were determined; using ELISA kit. The results of this study showed that there was no significant difference between the control and treatment groups in terms of serum levels of TNF-α. However, the level of IL-1β was significantly reduced in the treatment group compared to the control group, indicating that melatonin decreases this inflammatory substance. Our findings suggest a valuable strategy in the treatment of patients who suffer from MS

scholarly journals Evaluation of P Dispersion and P Dispersion Recovery in Patients with Pseudoexfoliative Syndrome

2019 ◽  
Vol 4 (05) ◽  
Author(s):  
Cosgun Ayhan ◽  
Gunes Alper
Keyword(s):  
Outpatient Clinic ◽  
Stress Test ◽  
Wave Dispersion ◽  
P Wave ◽  
Control Group ◽  
Study Group ◽  
P Wave Dispersion ◽  
The Third ◽  
Significant Difference ◽  
The Difference

Background: Pseudoexfoliative syndrome (PEX) is an old-age disease characterized by the accumulation of fibril materials in both the eye and extraocular organs. PEX is associated with many morbid and mortal cardiovascular diseases. The aim of our study was to investigate the effects of the stress test on P Wave dispersion (PWD) in patients with PEX. Patients and Methods: Forty patients who presented to the ophthalmology outpatient clinic between February 2018 and September 2018 and diagnosed as PEX in the ophthalmologic examination were included in the study. As a control group, forty-four patients, age and gender-matched, who applied to the cardiology outpatient clinic, diagnosed in the outpatient clinic of ophthalmology non-PEX, were included in the study. The study and control group were subjected to treadmill exercise test (TET) according to Bruce protocol. Results: The recovery PWD value of the study group in the third minutes was 34.4 ±4.35 ms and rest PWD value of study group 32.925±5.17 ms. There was no statistically significant difference between the two values (t=1.37992, p=0.08). The basal PWD value of the control group was 31.79±3.9ms, the recovery PWD value of the control group in the second minute 32.65±3.48 ms. There was no statistically significant difference between the two values (t=1.09495, p=0.13). Conclusion: The most interesting result of the study was that the difference between the recovery PWD value and the resting PWD value in the study group was statistically insignificant in the third recovery minute, whereas in the control group it occurred in the second minute.

Clinical Effect Analysis of Acupuncture Combined with Cupping Exercise in The Treatment of Chronic Pelvic Inflammatory Disease

2021 ◽  
Vol 7 (6) ◽  
pp. 6460-6468
Author(s):  
Xijing Yu ◽  
Xiuwu Hu ◽  
Shuisheng Hua ◽  
Rong Guo ◽  
Xiaoyan Zhu
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Clinical Effect ◽  
Abdominal Distension ◽  
Plasma Viscosity ◽  
Inflammatory Factors ◽  
Control Group ◽  
Study Group ◽  
Clinical Effects ◽  
Significant Difference

Objective: To explore the clinical efficacy of acupuncture combined with cupping exercise in the treatment of chronic pelvic inflammation. Methods: The subjects of this study were all patients with chronic pelvic inflammation who visited our hospital from November 2018 to November 2019, a total of 90 cases. The patients were divided into control group and research group according to the single and double numbers of the beds, 45 cases in each group. The patients in the control group were treated with conventional Western medicine, while the patients in the study group were treated with acupuncture and cupping exercise, and the clinical effects of the two treatment methods were compared. Results: The total effective rate was 95.56% in the study group and 84.44% in the control group, which was significantly higher in the study group than in the control group. The data between the two groups were statistically significant (P<0.05). The scores of menstrual disorder, abdominal distension, abnormal leucorrhea and lumbosacral pain in the two groups were significantly lower than those before treatment (P<0.05), and the corresponding scores of syndromes in the study group after treatment were (1.05+0.40), (0.73+0.38), (0.74+0.24) and (0.53+0.16), which were significantly lower than those in the control group (P<0.05). The plasma viscosity and hematocrit in both groups were significantly lower than those before treatment (P<0.05). The plasma viscosity and hematocrit in the study group after treatment were (1.14+0.32) mPa * s and (0.41+0.06) %, respectively, which were significantly lower than those in the control group (P<0.05). There was no significant difference in the levels of inflammatory factors between the two groups before treatment (P>0.05). The level of inflammatory factors in the study group after treatment was (5.74 + 2.35) mg/L, which was significantly lower than that in the control group after treatment, and the difference between tne groups was statistically significant (P < 0.05). Conclusion: Acupuncture combined with cupping exercise has a very significant clinical effect in the treatment of chronic pelvic inflammatory disease, can effectively improve the TCM syndrome score of patients, and improve the hemorheology and inflammation level of patients, so it can be widely used in clinical practice.

The impact of genetic factors in the development of thrombosis in cancer patients

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22227-e22227
Author(s):  
M. Özkan ◽  
I. Koçyigit ◽  
M. Dikilitas ◽  
Y. Özkul ◽  
I. Sari ◽  
...  
Keyword(s):  
Genetic Factors ◽  
Factor V Leiden ◽  
Mthfr C677t ◽  
Control Group ◽  
Study Group ◽  
Factor V ◽  
Mthfr C677t Polymorphism ◽  
Significant Difference ◽  
The Difference ◽  
And Control

e22227 Background: Thromboembolism is frequent in patients with cancer. Although it is known that several acquired factors take place in this process, the role of the genetic factors is controversial. In this study we analysed the most common genetic polymorphisms which have a role in the development of thrombosis. Methods: Study population consists of 292 (158 with thrombosis and 134 without thrombosis) patients treated between 2004 and 2008. Thrombosis was diagnosed by clinically and radiological measures in any time during the course of disease. Factor V Leiden G1691A, Prothrombin G20210A, Methlene Tetra Hydrofolate Reductase (MTHFR) C677T and Plazminogen Activator Inhibitor (PAI-1) 4G/5G were analysed with PCR-RFLP (Polymerase Chain Reaction- Restriction Fragment Length Polymorphism). Results: In the study group 48 and 1 patient had heterozygot and homozygot polymorphism for Factor V Leiden G1691A respectively. In the control group 32 heterozygot and 1 homozygot polymorphism and there was no statistically significant differents between study and control group (p=0,462).For Protrombin G20210A 11 and 4 heterozygot polymorphism were observed in control and study group respectively. While there was 1 homozygot polymorphism in study group there was no in control group and the difference between two groups was not statistically significant (p=0,198). For MTHFR C677T, 48 and 24 heterozygot polymorphism, 15 and 12 homozygot polymorphism were observed in study and control group respectively. The difference between two groups were statistically significant (p=0,04). There was no statistically significant difference between two groups for PAI-1 4G/5G polymorphisms (p=0,362). In subgroup analyses, statistically significant difference was found only in MTHFR C677T polymorphism in patients with GI cancer and with and without thrombosis (p=0,028). Conclusions: The studies investigating the relationship between genetic factors and thrombosis revealed controversial results. However, we found no genetic factor relevant to thrombosis other than MTHFR C677T polymorphism. Further studies investigating genetic and acquired factors in the development of the thrombosis in detail are warranted for documenting clearly the role of genetic polymorphisms. No significant financial relationships to disclose.

scholarly journals Effect of arthroscopic surgery combined with platelet-rich plasma in the treatment of discoid meniscus injury of knee joint and its influence on serum inflammatory factors

2019 ◽  
Vol 17 ◽  
pp. 205873921881433
Author(s):  
Jia Liu
Keyword(s):  
Knee Joint ◽  
Platelet Rich Plasma ◽  
Arthroscopic Surgery ◽  
Inflammatory Factors ◽  
Control Group ◽  
Study Group ◽  
Discoid Meniscus ◽  
Meniscus Injury ◽  
Tnf Α ◽  
Significant Difference

This study was to observe the effect of arthroscopic surgery combined with platelet-rich plasma (PRP) in the treatment of discoid meniscus injury of knee joint and its influence on serum inflammatory factors. A total of 80 patients with discoid meniscus injury in our hospital from June 2014 to June 2016 were enrolled and divided into study group and control group randomly with 40 patients in each group. The control group was treated with arthroscopy alone, and the study group was treated with arthroscopy combined with PRP. The clinical efficacy of the two groups was observed, and the Lysholm scores, Knee injury and Osteoarthritis Outcome Score (KOOS scores), and serum inflammatory factors (IL-1, TNF-α, and IL-6) were compared between the two groups before and after treatment. Six months after the treatment, the improvement rate, defined as (Excellent + Good)/total*100, of the study group was 97.5%, significantly higher than that of the control group, which was 87.5% ( P < 0.05); before treatment, there was no significant difference in both Lysholm scores and KOOS scores between the two groups ( P > 0.05); and 6 months later, the Lysholm scores and KOOS scores in the two groups were both significantly higher than those before, and the scores in the study group increased more significantly compared with those of the control group ( P < 0.05); the values of serum IL-1, TNF-α, and IL-6 in the two groups were both significantly lower than those before, and the values in the study group decreased more significantly compared with those of the control group ( P < 0.05). In conclusion, arthroscopic surgery combined with PRP therapy can effectively improve the clinical symptoms and reduce the level of serum inflammatory factors in patients with discoid meniscus injury of the knee, which is worthy of promotion and application.

Effect of Resveratrol on NF-κB Activity in Rat Peritoneal Macrophages

2006 ◽  
Vol 34 (04) ◽  
pp. 623-630 ◽  
Author(s):  
Zhen-Hua Ma ◽  
Qing-Yong Ma ◽  
Lian-Cai Wang ◽  
Huan-Chen Sha ◽  
Sheng-Li Wu ◽  
...  
Keyword(s):  
Culture Medium ◽  
Interleukin 1 ◽  
Peritoneal Macrophages ◽  
Inflammatory Factors ◽  
Future Application ◽  
Control Group ◽  
Sprague Dawley ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Significant Difference

This study was to investigate the inhibitive effect of resveratrol (RESV) on nuclear factor kappa B (NF-κB) expression and activity induced by lipopolysaccharide (LPS) in rat peritoneal macrophages (PMA). Male Sprague-Dawley (SD) rats were randomly divided into 7 groups, including control group, LPS group and RESV I-V group. In the LPS group, PMA were incubated in DMEM containing LPS (10 μg/ml), whereas in control group, PMA were incubated in DMEM only. In the RESV I-V groups, PMA were incubated in DMEM containing LPS (10 μg/ml) and different concentrations of RESV. After 24 hours of incubation, NF-κB activity in PMA, and the levels of tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1) and nitric oxide (NO) in the culture medium were measured. In the concentrations of 1.25-5 μg/ml, RESV had a dose- dependent inhibitive effect on NF-κB activity in PMA as well as the expressions of TNF-α, IL-1 and NO in the culture medium contrasted with the LPS group. There was no significant difference in the levels of these pro-inflammatory factors between the groups of 5 μg/ml and 10 μg/ml RESV. In conclusion, RESV has the potential for the future application of preventing inflammatory diseases involving PMA.

scholarly journals Multidisciplinary cooperative first aid model for the treatment of patients with pelvic and multiple fractures

2022 ◽  
Vol 38 (3) ◽  
Author(s):  
Yun Han ◽  
Ganggang Peng ◽  
Lijun Liu ◽  
Xiaohua Xie
Keyword(s):  
First Aid ◽  
Fracture Reduction ◽  
Inflammatory Factors ◽  
Functional Score ◽  
Control Group ◽  
Study Group ◽  
Inflammatory Factor ◽  
Complication Rates ◽  
Multiple Fractures ◽  
The Difference

Objectives: To retrospectively evaluate a multidisciplinary cooperative first aid model for the treatment of patients with pelvic and multiple fractures in the emergency department. Methods: The records of patients with pelvic fractures complicated with multiple fractures treated in our hospital from February 2020 to April 2021 were selected, of which 34 patients received conventional trauma first aid mode (control group) and 34 patients received multidisciplinary joint first aid mode (study group). We compared pelvic function (Majeed functional score) and fracture reduction outcomes, as well as serum inflammatory factor levels and complication rates after treatment between the two groups. Results: The Majeed score in the study group (90.15 ± 6.83) was higher than that in the control group (75. 47 ± 5.35), and the differences were statistically significant (P<0.05). The value for combined excellent and good rates of fracture reduction in the study group (85.29%, 29/34) was significantly higher than that in the control group (58.82%, 20/34), and the difference was statistically significant(P<0.05). We found similar levels of TNF-a and IL-6 between the two groups at admission (P>0.05); however, the serum levels of TNF-a and IL-6 in the study group were lower than those in the control group on the fifth day after admission, and the difference was statistically significant (P<0.05 or P<0.01). The incidence of complications in the study group (17.64%, 6/34) was significantly lower than that in the control group (61.76%, 21/34), the difference was statistically significant (P<0.05). Conclusion: The multidisciplinary cooperative first aid model for the treatment of patients with pelvic and multiple fractures can effectively shorten the treatment time, increase the excellent functional rehabilitation rate, inhibit the release of inflammatory factors, and reduce the incidence of complications (such as infections), when compared to the conventional trauma emergency system. doi: https://doi.org/10.12669/pjms.38.3.5014 How to cite this:Han Y, Peng G, Liu L, Xie X. Multidisciplinary cooperative first aid model for the treatment of patients with pelvic and multiple fractures. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.5014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals TO FIND OUT THE TOXICITY PROFILE OF TWICE WEEKLY CISPLATIN OVER CONVENTIONAL ONCE WEEKLY CISPLATIN BASED CRT IN LOCALLY ADVANCED CERVICAL CANCER.

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Ranveer Vardhan ◽  
Amit Rana ◽  
Manoj Gupta ◽  
Rajeev Seam ◽  
Manish Gupta
Keyword(s):  
Locally Advanced ◽  
Control Group ◽  
Study Group ◽  
Cutaneous Toxicity ◽  
Carcinoma Of Cervix ◽  
Significant Difference ◽  
Prospective Comparative Study ◽  
The Difference ◽  
Total Burden ◽  
Weekly Cisplatin

Background: Carcinoma cervix ranks fourth most common malignancy (for both incidence & mortality) globally and third most common diagnosed malignancy in females (~16.5%) in India, (after breast & lip/oral cavity), with about 80% of the total burden occurring in developing countries  like India. Methods: This Prospective comparative study was conducted in the Department of Radiotherapy and Oncology TCC, IGMC, Shimla, in patients suffering from advanced carcinoma of cervix. Results: Hematological toxicities were seen mainly in the study group as compared to the control group (28 patients in the study group vs. 22 patients in control group). The difference was not statistically significant (p = 0.214). Grade III toxicities were seen in 5 patients in study group and 4 patients in control group. Cutaneous toxicity of different grades was seen in all the patients in the study arm and of the patients in the control arm. There was no statistically significant difference between the two arms (p=0.8121). Conclusion: Both (Study & control) groups are comparable in terms of toxicity and are equally well tolerated by the patients. Keywords: Chemoradiotherapy, RT, Partial response, toxicity.

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