scholarly journals Being aware of the neurological manifestations of COVID-19 infection

2021 ◽  
Vol 40 (3) ◽  
pp. 187-189
Author(s):  
Basak Atalay
Keyword(s):  
Respiratory Tract ◽  
Sore Throat ◽  
Strong Evidence ◽  
Initial Presentation ◽  
The Novel ◽  
Neurologic Manifestations ◽  
Neurological Manifestations ◽  
Impaired Consciousness ◽  
Atypical Symptoms ◽  
Novel Coronavirus

The novel coronavirus disease- 2019 (COVID-19) is first reported from China, and unfortunately, no longer restricted, and spreads in all geographies.(1) The main symptoms of COVID-19 infection are respiratory tract related. Infected patients usually have symptoms such as fever, sore throat, and fatigue, and they may have atypical symptoms like headache, seizure, anosmia, stroke, and even impaired consciousness. Strong evidence of an association between COVID-19 infection and neurological manifestations has been reported. Besides, the neurologic manifestations may be the initial presentation of COVID-19 infection.

scholarly journals Nonepileptic Myoclonus in COVID-19: Case Report

2021 ◽  
pp. 194187442110043
Author(s):  
Henly Hewan ◽  
Annie Yang ◽  
Aparna Vaddiparti ◽  
Benison Keung
Keyword(s):  
Case Report ◽  
Critically Ill ◽  
Recovery Phase ◽  
Critically Ill Patient ◽  
High Dose ◽  
The Novel ◽  
Neurological Manifestations ◽  
Immune Mediated ◽  
Novel Coronavirus ◽  
Post Infectious

In late 2019, the novel coronavirus, SARS-CoV-2, and the disease it causes, COVID-19, was identified. Since then many different neurological manifestations of COVID-19 have been well reported. Movement abnormalities have been rarely described. We report here a critically ill patient with COVID-19 who developed generalized myoclonus during the recovery phase of the infection. Myoclonus was associated with cyclical fevers and decreased alertness. Movements were refractory to conventional anti-epileptic therapies. There was concern that myoclonus could be part of a post-infectious immune-mediated syndrome. The patient improved fully with a 4-day course of high-dose steroids. Our experience highlights a rare, generalized myoclonus syndrome associated with COVID-19 that may be immune-mediated and is responsive to treatment.

scholarly journals Research on the Neurobiology of COVID-19

2021 ◽  
Vol 245 ◽  
pp. 03045
Author(s):  
Yilun Tong
Keyword(s):  
Nervous System ◽  
Molecular Mechanism ◽  
The Novel ◽  
Neurologic Manifestations ◽  
Neurological Manifestations ◽  
Corona Virus ◽  
The World ◽  
Human Nervous System ◽  
Different Parts

More studies have shown the neurological manifestations of the novel corona virus (COVID-19) and have inferred the molecular mechanism by which it invades the nervous system. The neurological aspect of the COVID-19 pandemic has been differently interpreted and dealt with in different parts of the world. To review the neurological manifestations and the neurovirulent mechanism by which CoV attacks the human nervous system and to examine different perspectives on this very same topic, the research on PubMed and ScienceDirect is conducted. The mechanisms that CoV enter and attack the nervous system and the subsequent neurologic manifestations have been proposed and now seems quite clear. However, more studies have to be done directly on the effect of COVID-19 on the CNS as well as the PNS.

scholarly journals COVID-19 in Renal Transplant Patient Presenting With Active Typical Symptoms and Resolved Atypical Symptoms

2020 ◽  
Vol 8 ◽  
pp. 232470962094930 ◽  
Author(s):  
Sreedhar Adapa ◽  
Venu Madhav Konala ◽  
Srikanth Naramala ◽  
Subba Rao Daggubati ◽  
Narayana Murty Koduri ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Gastrointestinal Symptoms ◽  
Published Data ◽  
The Novel ◽  
Transplant Recipients ◽  
Atypical Symptoms ◽  
Rapid Transmission ◽  
Novel Coronavirus

The novel coronavirus disease has brought the world to standstill with high infectivity and rapid transmission. The disease caused by novel coronavirus is termed as coronavirus disease 2019 (COVID-19). We present the case of a renal transplant patient who was infected with COVID-19 through community spread and presented with fever and gastrointestinal symptoms. Transplant recipients are particularly vulnerable because of the immunosuppressed state. These patients can shed a virus for a prolonged period and can have a higher load of the virus. There have been no COVID-19 cases transmitted through organ donation. Preinfection immunological impairment can aggravate the severity of the infection. The transplant team plays a crucial role in donor and recipient evaluation and guiding the timing of the transplant. Although specific published data are lacking with regard to transplant recipients, they should follow the same precautions as the general population, like avoiding nonessential travel and practice social distancing.

scholarly journals Correlation between ginseng radix and the novel coronavirus about a possible future alternative treatment

2020 ◽  
Vol 9 (8) ◽  
pp. e712985720
Author(s):  
Anne Karynne da Silva Barbosa ◽  
Wenna Lúcia Lima
Keyword(s):  
Clinical Practice ◽  
Herbal Medicine ◽  
Respiratory Tract ◽  
Alternative Treatment ◽  
Herbal Medicines ◽  
The Novel ◽  
Wuhan City ◽  
Radix Ginseng ◽  
First Millennium ◽  
Novel Coronavirus

In 2019 in Wuhan city (China), is was outbreak about a novel coronavirus, causes an infections respirator, in children and adults, and is new condition was call for COVID-19. The present study being about herbal medicines and their correlation with diseases on respiratory tract basically COVID-19. To date, there are no studies showing how Ginseng Radix cooperated with the prevention or for to treat coronavirus diseases, so the aimed the present study was a to analyze in literature about this. The aim is to observe the correlation about the Ginseng Radix as a future treatment in novel coronavirus. The present study is a fruit of a review integrative of literature, where the keywords was search in databases Pubmed and Scielo.org, the keywords (Herbal medicines, Ginseng radix and Coronavirus infections) are presents in DeCS. The herbal medicines are famous alternative therapeutic for the treatment a most diseases, when used the herbal medicines for various diseases, being diseases cardiology, immunology, and too tract respiratory. The use for the herbal medicines is a secular practice, and we found a most popular, but is present study is about the ginseng radix. Ginseng is an herbal medicine derived from the root of the panax, and your use is described since the first millennium, your properties are preventing many diseases, including cancer, hypertension, and others, described in the literature. The Ginseng radix is an herbal medicine be used in the treatment for the children and adults, the problems for the tract respiratory, and exists a guideline specific for the herbal medicines and the use in clinical practice.

scholarly journals Molecular Mechanism of Coronaviruses (COVID-19) and Diagnostic Approaches

2020 ◽  
Author(s):  
Lalit Mohan Jeena ◽  
Nidhi Singh ◽  
Anjali Tempe
Keyword(s):  
Respiratory Tract ◽  
Molecular Mechanism ◽  
Viral Entry ◽  
Genomic Structure ◽  
The Novel ◽  
Angiotensin Converting Enzyme 2 ◽  
Diagnostic Approaches ◽  
Current Point ◽  
Novel Coronavirus ◽  
Bat Coronavirus

An acute respiratory disease is rampantly spreading in population worldwide caused by a novel coronavirus (SARS-CoV-2, also known as COVID-19). The COVID-19 is a major source of disaster in the 21thcentury. It has spread throughout China and is received as a pandemic worldwide. To date (18th May 2020), a total of 4,827,272patients are infected and more than 3,17,174confirmed deaths have been reported with 6.57% fatality rate. Several research investigations have identified that COVID-19 belongs to ?-coronavirus family and has a highly identical genomic structure to bat coronavirus. The novel coronavirus uses the same receptor, ACE-2 (angiotensin-converting enzyme 2) as that for SARS-CoV, and mainly spreads through the respiratory tract. As per WHO, symptoms include shortness of breath especially in the lower respiratory tract, sore, throat, cough, headaches, and fever. However, the specific drugs required to prevent/treat an attack is a major need at this current point of time. In this regard, we conducted a systematic review on coronavirus to cover the molecular mechanism of viral entry and replication, which provides the basis of future management of COVID-19.

scholarly journals Lessons from mainland China’s epidemic experience about the growth rules of infected and recovered cases of COVID-19 worldwide

2020 ◽  
Author(s):  
Chuanliang Han ◽  
Yimeng Liu ◽  
Jiting Tang ◽  
Yuyao Zhu ◽  
Carlo Jaeger ◽  
...  
Keyword(s):  
Growth Rate ◽  
Strong Evidence ◽  
Logistic Model ◽  
Mainland China ◽  
Linear Connection ◽  
Control Measures ◽  
Logistic Growth ◽  
Strong Positive Correlation ◽  
The Novel ◽  
Novel Coronavirus

AbstractThe novel coronavirus disease (COVID-19) that emerged at the end of 2019 has been controlled in mainland China so far, while it is still spreading globally. When the pandemic will end is a question of great concern. A logistic model depicting the growth rules of infected and recovered cases in mainland China may shed some light on this question. We extended this model to 31 countries outside China experiencing serious COVID-2019 outbreaks. The model well explained the data in our study (R2 ≥ 0.95). For infected cases, the semi-saturation period (SSP) ranges from 63 to 170 days (March 3 to June 18). The logistic growth rate of infected cases is positively correlated with that of recovered cases, and the same holds for the SSP. According to the linear connection between the growth rules for infected and recovered cases identified from the Chinese data, we predicted that the SSP of the recovered cases outside China ranges from 82 to 196 days (March 22 to July 8). More importantly, we found a strong positive correlation between the SSP of infected cases and the timing of government’s response, providing strong evidence for the effectiveness of rapid epidemic control measures in various countries.

scholarly journals Viral Shedding Time of SARS-CoV-2 and the Factors Involved: A Retrospective Observational Study

2021 ◽  
Author(s):  
Guixian Wu ◽  
Ling Lin ◽  
Susu He ◽  
Qian Chen ◽  
Xiaomai Wu ◽  
...  
Keyword(s):  
Observational Study ◽  
Respiratory Tract ◽  
Digestive Tract ◽  
Severe Disease ◽  
Advanced Age ◽  
Retrospective Observational Study ◽  
The Novel ◽  
Clearance Time ◽  
Viral Shedding ◽  
Novel Coronavirus

Abstract Background: In December 2019, the discovery of the novel coronavirus was first reported in Wuhan, China, which subsequently and rapidly spread throughout the country and worldwide, resulting in a pandemic.After a year of intense research, our knowledge of the new coronaviruses has gradually improved; however, knowledge regarding the time of their complete clearance from the body and the factors influencing clearance are currently inadequate. Results: We conducted a retrospective observational study comprising 135 patients above the age of 18 years with a confirmed diagnosis of COVID-19 pneumonia, who were admitted to the Public Health Center of Taizhou Hospital of Zhejiang Province, Zhejiang University from January 23, 2020, to March 11, 2020. The findings regarding the duration of the infection from the time of onset to the time of being asymptomatic (whichever was observed first) indicated that novel coronaviruses were cleared from the respiratory tract in a maximum of 84 days and a minimum of 1 day with a median clearance time (quartile) of 20 (13, 30) days. Moreover, viruses were cleared from the digestive tract in a maximum of 72 days and a minimum of 5 days with a median clearance time (quartile) of 25 (20.75, 31) days. The viral shedding time of SARS in the digestive tract was found to be longer than that in the respiratory tract (p = 0.03). Severe disease (P < 0.001), advanced age (P < 0.001), lymphopenia (P = 0.01) and elevated CRP (P = 0.036) were significantly associated with longer clearance time in the respiratory tract. Gender (P = 0.754), novel coronavirus antibodies (P = 0.75), and antibiotic use (P = 0.093) were not associated with the time span required for the novel coronavirus to be cleared from the respiratory tract. Conclusions: Independent risk factors for the longer clearance time of novel coronaviruses in the digestive tract versus that in the respiratory tract were compared. Severe disease, advanced age, lymphopenia, and elevated CRP were determined to be factors prolonging the clearance of novel coronaviruses.

Tropism of the Novel Coronavirus SARS-CoV-2 in Human Respiratory Tract: An Analysis in Ex Vivo and In Vitro Cultures

2020 ◽  
Author(s):  
Kenrie PY Hui ◽  
Man-Chun Cheung ◽  
Ranawaka APM Perera ◽  
Ka-Chun Ng ◽  
Christine BT Bui ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Ex Vivo ◽  
The Novel ◽  
Human Respiratory Tract ◽  
Novel Coronavirus

scholarly journals The potential application of probiotics and prebiotics for the prevention and treatment of COVID-19

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Amin N. Olaimat ◽  
Iman Aolymat ◽  
Murad Al-Holy ◽  
Mutamed Ayyash ◽  
Mahmoud Abu Ghoush ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Scientific Evidence ◽  
The Novel ◽  
Probiotic Supplementation ◽  
Prevention And Treatment ◽  
Human Immunity ◽  
Novel Coronavirus ◽  
Tract Infections

Abstract COVID-19 is a pandemic disease caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This new viral infection was first identified in China in December 2019, and it has subsequently spread globally. The lack of a vaccine or curative treatment for COVID-19 necessitates a focus on other strategies to prevent and treat the infection. Probiotics consist of single or mixed cultures of live microorganisms that can beneficially affect the host by maintaining the intestinal or lung microbiota that play a major role in human health. At present, good scientific evidence exists to support the ability of probiotics to boost human immunity, thereby preventing colonization by pathogens and reducing the incidence and severity of infections. Herein, we present clinical studies of the use of probiotic supplementation to prevent or treat respiratory tract infections. These data lead to promising benefits of probiotics in reducing the risk of COVID-19. Further studies should be conducted to assess the ability of probiotics to combat COVID-19.

scholarly journals Ischaemic stroke as an initial presentation in patients with COVID-19: evaluation of a case series in an emergency in Brazil

2021 ◽  
pp. 197140092098735
Author(s):  
Isabella B Oliveira ◽  
Mariana SL Pessoa ◽  
Carla FC Lima ◽  
Jorge LB Holanda ◽  
Pablo P de A Coimbra
Keyword(s):  
Respiratory Tract ◽  
Ischaemic Stroke ◽  
Laboratory Tests ◽  
Case Series ◽  
Neurological Symptoms ◽  
Initial Presentation ◽  
Cytokine Storm ◽  
Neurological Manifestations ◽  
Global Impact

The disease caused by the new coronavirus, initially described in China in December 2019, became known as coronavirus disease 2019 and quickly spread to countries on all continents, becoming a pandemic with an important global impact. Despite being a virus that typically affects the respiratory tract, some studies have already described neurological manifestations associated with this infection, including acute ischaemic vascular insult. We report a case series including 30 patients, who presented with neurological symptoms during admission to our service, being diagnosed with ischaemic stroke and, concomitantly, coronavirus disease 2019. In the subgroup of patients analysed, a state of hypercoagulability and pro thrombosis was observed through laboratory tests, probably related to the cytokine storm syndrome associated with infection by this virus. With that, we discussed the possibility of this finding being an aggravating factor in the occurrence of stroke in these patients.

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