scholarly journals Correlation between ginseng radix and the novel coronavirus about a possible future alternative treatment

2020 ◽  
Vol 9 (8) ◽  
pp. e712985720
Author(s):  
Anne Karynne da Silva Barbosa ◽  
Wenna Lúcia Lima
Keyword(s):  
Clinical Practice ◽  
Herbal Medicine ◽  
Respiratory Tract ◽  
Alternative Treatment ◽  
Herbal Medicines ◽  
The Novel ◽  
Wuhan City ◽  
Radix Ginseng ◽  
First Millennium ◽  
Novel Coronavirus

In 2019 in Wuhan city (China), is was outbreak about a novel coronavirus, causes an infections respirator, in children and adults, and is new condition was call for COVID-19. The present study being about herbal medicines and their correlation with diseases on respiratory tract basically COVID-19. To date, there are no studies showing how Ginseng Radix cooperated with the prevention or for to treat coronavirus diseases, so the aimed the present study was a to analyze in literature about this. The aim is to observe the correlation about the Ginseng Radix as a future treatment in novel coronavirus. The present study is a fruit of a review integrative of literature, where the keywords was search in databases Pubmed and Scielo.org, the keywords (Herbal medicines, Ginseng radix and Coronavirus infections) are presents in DeCS. The herbal medicines are famous alternative therapeutic for the treatment a most diseases, when used the herbal medicines for various diseases, being diseases cardiology, immunology, and too tract respiratory. The use for the herbal medicines is a secular practice, and we found a most popular, but is present study is about the ginseng radix. Ginseng is an herbal medicine derived from the root of the panax, and your use is described since the first millennium, your properties are preventing many diseases, including cancer, hypertension, and others, described in the literature. The Ginseng radix is an herbal medicine be used in the treatment for the children and adults, the problems for the tract respiratory, and exists a guideline specific for the herbal medicines and the use in clinical practice.

scholarly journals Early epidemiological assessment of the transmission potential and virulence of coronavirus disease 2019 (COVID-19) in Wuhan City: China, January-February, 2020

2020 ◽  
Author(s):  
Kenji Mizumoto ◽  
Katsushi Kagaya ◽  
Gerardo Chowell
Keyword(s):  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Public Health Intervention ◽  
Ecological Modelling ◽  
The Novel ◽  
Wuhan City ◽  
Transmission Potential ◽  
The World ◽  
Novel Coronavirus ◽  
Epidemiological Parameters

AbstractBackgroundSince the first cluster of cases was identified in Wuhan City, China, in December, 2019, coronavirus disease 2019 (COVID-19) rapidly spread around the world. Despite the scarcity of publicly available data, scientists around the world have made strides in estimating the magnitude of the epidemic, the basic reproduction number, and transmission patterns. Accumulating evidence suggests that a substantial fraction of the infected individuals with the novel coronavirus show little if any symptoms, which highlights the need to reassess the transmission potential of this emerging disease. In this study, we derive estimates of the transmissibility and virulence of COVID-19 in Wuhan City, China, by reconstructing the underlying transmission dynamics using multiple data sources.MethodsWe employ statistical methods and publicly available epidemiological datasets to jointly derive estimates of transmissibility and severity associated with the novel coronavirus. For this purpose, the daily series of laboratory–confirmed COVID-19 cases and deaths in Wuhan City together with epidemiological data of Japanese repatriated from Wuhan City on board government–chartered flights were integrated into our analysis.ResultsOur posterior estimates of basic reproduction number (R) in Wuhan City, China in 2019–2020 reached values at 3.49 (95%CrI: 3.39–3.62) with a mean serial interval of 6.0 days, and the enhanced public health intervention after January 23rd in 2020 was associated with a significantly reduced R at 0.84 (95%CrI: 0.81–0.88), with the total number of infections (i.e. cumulative infections) estimated at 1906634 (95%CrI: 1373500–2651124) in Wuhan City, elevating the overall proportion of infected individuals to 19.1% (95%CrI: 13.5–26.6%). We also estimated the most recent crude infection fatality ratio (IFR) and time–delay adjusted IFR at 0.04% (95% CrI: 0.03%–0.06%) and 0.12% (95%CrI: 0.08–0.17%), respectively, estimates that are several orders of magnitude smaller than the crude CFR estimated at 4.06%ConclusionsWe have estimated key epidemiological parameters of the transmissibility and virulence of COVID-19 in Wuhan, China during January-February, 2020 using an ecological modelling approach. The power of this approach lies in the ability to infer epidemiological parameters with quantified uncertainty from partial observations collected by surveillance systems.

scholarly journals Consideration of the Management of Pediatric Fever Clinics During the Novel Coronavirus Pneumonia Outbreak

2020 ◽  
pp. 1-7
Author(s):  
Hui Ding ◽  
Zhaoling Shi ◽  
Zhen Ruan ◽  
Xiaoning Cheng ◽  
Ruying Li ◽  
...  
Keyword(s):  
Medical Staff ◽  
Prevention And Control ◽  
Cross Infection ◽  
The Novel ◽  
Wuhan City ◽  
Control Programs ◽  
Treatment And Prevention ◽  
Epidemic Period ◽  
Novel Coronavirus ◽  
And Control

ABSTRACT Since the outbreak of 2019 novel coronavirus (2019-nCoV) infection in Wuhan City, China, pediatric cases have gradually increased. It is very important to prevent cross-infection in pediatric fever clinics, to identify children with fever in pediatric fever clinics, and to strengthen the management of pediatric fever clinics. According to prevention and control programs, we propose the guidance on the management of pediatric fever clinics during the nCoV pneumonia epidemic period, which outlines in detail how to optimize processes, prevent cross-infection, provide health protection, and prevent disinfection of medical staff. The present consideration statement summarizes current strategies on the pre-diagnosis, triage, diagnosis, treatment, and prevention of 2019-nCoV infection, which provides practical suggestions on strengthening the management of pediatric fever clinics during the nCoV pneumonia epidemic period.

scholarly journals How to Face COVID-19 in Ophthalmology Practice

2020 ◽  
Vol 9 (3) ◽  
pp. 164-171 ◽  
Author(s):  
Xiaoting Pei ◽  
Xinwei Jiao ◽  
Dingli Lu ◽  
Di Qi ◽  
Shenzhen Huang ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Severe Acute Respiratory Syndrome ◽  
Search Strategy ◽  
International Community ◽  
The Novel ◽  
The World ◽  
Novel Coronavirus

Background: The novel coronavirus pneumonia has attracted considerable attention from the international community. With the spread of outbreaks around the world, the WHO characterized COVID-19 as a pandemic. Methods: Relevant studies in PubMed were searched from January 1, 2020 to April 12, 2020, using the following search strategy: (“novel coronavirus pneumonia” OR “severe acute respiratory syndrome coronavirus 2” OR “coronavirus disease 2019” OR “COVID-19” OR “novel coronavirus pneumonia”) AND (“ophthalmology” OR “ophthalmologist” OR “eye” OR “conjunctiva” OR “conjunctivitis” OR “corneal” OR “keratitis”). Results: SARS-CoV-2 can spread through aerosol and is detected in tears of patients with COVID-19 infection. Notably, some infected patients had conjunctivitis, and conjunctivitis was the first symptom in some patients later diagnosed to have COVID-19 infection. This would increase the risk for ophthalmologists through inpatient consultations or regular clinical practice. When dealing with seemingly regular ophthalmic patients, the vigilance of ophthalmologists and associated staff tends to be reduced. Conclusion: Ophthalmologists must continuously update their knowledge regarding COVID-19 and take effective measures to prevent COVID-19 transmission.

scholarly journals The effects of the clinical symptoms pneumonia-confirmation strategy of the COVID-19 epidemic in Wuhan, China

2020 ◽  
Author(s):  
Yanjin Wang ◽  
Pei Wang ◽  
Shudao Zhang ◽  
Hao Pan
Keyword(s):  
Turning Point ◽  
Clinical Symptoms ◽  
Transmission Rate ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
The Novel ◽  
Wuhan City ◽  
Start Date ◽  
Rapid Spread ◽  
Novel Coronavirus

Abstract Motivated by the quick control in Wuhan, China, and the rapid spread in other countries of COVID-19, we investigate the questions that what is the turning point in Wuhan by quantifying the variety of basic reproductive number after the lockdown city. The answer may help the world to control the COVID-19 epidemic. A modified SEIR model is used to study the COVID-19 epidemic in Wuhan city. Our model is calibrated by the hospitalized cases. The modeling result gives out that the means of basic reproductive numbers are 1.5517 (95% CI 1.1716-4.4283) for the period from Jan 25 to Feb 11, 2020, and 0.4738(95% CI 0.0997-0.8370) for the period from Feb 12 to Mar 10. The transmission rate fell after Feb 12, 2020 as a result of China’s COVID-19 strategy of keeping society distance and the medical support from all China, but principally because of the clinical symptoms to be used for the novel coronavirus pneumonia (NCP) confirmation in Wuhan since Feb 12, 2020. Clinical diagnosis can quicken up NCP-confirmation such that the COVID-19 patients can be isolated without delay. So the clinical symptoms pneumonia-confirmation is the turning point of the COVID-19 battle of Wuhan. The measure of clinical symptoms pneumonia-confirmation in Wuhan has delayed the growth and reduced size of the COVID-19 epidemic, decreased the peak number of the hospitalized cases by 96% in Wuhan. Our modeling also indicates that the earliest start date of COVID-19 in Wuhan may be Nov 2, 2019.

scholarly journals COVID-19: Diagnosis, Management and Response

2021 ◽  
pp. 161-170
Author(s):  
Ashwini Shalikrao Mhaske ◽  
Swaroopa Chakole
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Hubei Province ◽  
Positive Patient ◽  
The Novel ◽  
Wuhan City ◽  
Corona Virus ◽  
Early Reaction ◽  
Novel Coronavirus ◽  
Predetermined Number

Background: COVID infection 2019 (COVID-19) is identified as a disease caused by Corona virus formally known as severe acute respiratory syndrome (SARS-CoV-2), which was first detected in Wuhan City, Hubei Province, China, amidst of an outbreak of respiratory sickness cases. Summary: As there is no affirmed total course of treatment for the Novel Coronavirus, the best way to handle it is by playing it safe, its administration and early reaction. Segregation and disinfection go inseparably with regards to dealing with a COVID positive patient. In any case, the predetermined number of clinical office accessible is blocking the cycle of control and anticipation for a particularly number of infected patients. Conclusion: As the pandemic is advancing, more examinations and exploration is needed to effectively deal with the spread of the novel Corona virus. Foundation improvement and arrangement of clinical office and gear is the preeminent prerequisite for early reaction and treatment.

scholarly journals Being aware of the neurological manifestations of COVID-19 infection

2021 ◽  
Vol 40 (3) ◽  
pp. 187-189
Author(s):  
Basak Atalay
Keyword(s):  
Respiratory Tract ◽  
Sore Throat ◽  
Strong Evidence ◽  
Initial Presentation ◽  
The Novel ◽  
Neurologic Manifestations ◽  
Neurological Manifestations ◽  
Impaired Consciousness ◽  
Atypical Symptoms ◽  
Novel Coronavirus

The novel coronavirus disease- 2019 (COVID-19) is first reported from China, and unfortunately, no longer restricted, and spreads in all geographies.(1) The main symptoms of COVID-19 infection are respiratory tract related. Infected patients usually have symptoms such as fever, sore throat, and fatigue, and they may have atypical symptoms like headache, seizure, anosmia, stroke, and even impaired consciousness. Strong evidence of an association between COVID-19 infection and neurological manifestations has been reported. Besides, the neurologic manifestations may be the initial presentation of COVID-19 infection.

scholarly journals Update on recommendations for the diagnosis and treatment of SARS-CoV-2 infection in children

2020 ◽  
Vol 39 (12) ◽  
pp. 2211-2223 ◽  
Author(s):  
Hongjun Miao ◽  
Han Li ◽  
Yinying Yao ◽  
Mingfu Wu ◽  
Chao Lu ◽  
...  
Keyword(s):  
Treatment Strategies ◽  
Diagnosis And Treatment ◽  
The Novel ◽  
Treatment Standards ◽  
Wuhan City ◽  
Health Committee ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
The Impact ◽  
Pneumonia Diagnosis

AbstractSince the outbreak of novel coronavirus infection pneumonia in Wuhan City, China, in late 2019, such cases have been gradually reported in other parts of China and abroad. Children have become susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because of their immature immune function. As the outbreak has progressed, more cases of novel coronavirus infection/pneumonia in children have been reported. Compared with adults, the impact of SARS-CoV-2 infection in children is less severe, with a lower incidence and susceptibility in children, which results in fewer children being tested, thereby underestimating the actual number of infections. Therefore, strengthening the diagnosis of the disease is particularly important for children, and early and clear diagnosis can determine treatment strategies and reduce the harm caused by the disease to children. According to the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (trial version 7) issued by National Health Committee and the latest diagnosis and treatment strategies for novel coronavirus infection pneumonia in children, this review summarizes current strategies on diagnosis and treatment of SARS-CoV-2 infection in children.

scholarly journals Sterols and Triterpenes: Antiviral     Potential Supported by In-Silico Analysis

Plants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 41
Author(s):  
Nourhan Hisham Shady ◽  
Khayrya A. Youssif ◽  
Ahmed M. Sayed ◽  
Lassaad Belbahri ◽  
Tomasz Oszako ◽  
...  
Keyword(s):  
Active Sites ◽  
Herbal Medicines ◽  
Specific Treatment ◽  
In Silico Analysis ◽  
The Novel ◽  
Protein Targets ◽  
Drug Candidates ◽  
Novel Coronavirus ◽  
Silico Analysis

The acute respiratory syndrome caused by the novel coronavirus (SARS-CoV-2) caused severe panic all over the world. The coronavirus (COVID-19) outbreak has already brought massive human suffering and major economic disruption and unfortunately, there is no specific treatment for COVID-19 so far. Herbal medicines and purified natural products can provide a rich resource for novel antiviral drugs. Therefore, in this review, we focused on the sterols and triterpenes as potential candidates derived from natural sources with well-reported in vitro efficacy against numerous types of viruses. Moreover, we compiled from these reviewed compounds a library of 162 sterols and triterpenes that was subjected to a computer-aided virtual screening against the active sites of the recently reported SARS-CoV-2 protein targets. Interestingly, the results suggested some compounds as potential drug candidates for the development of anti-SARS-CoV-2 therapeutics.

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