scholarly journals Behavior Effect of Fluoxetine in Presence of Selenium Using Albino Mice

2017 ◽  
Vol 7 ◽  
pp. 1-8
Author(s):  
Suhera M. Aburawi ◽  
Sumaya A. Baayo
Keyword(s):  
Locomotor Activity ◽  
Motor Activity ◽  
Combined Treatment ◽  
Anxiolytic Effect ◽  
Tween 80 ◽  
Forced Swimming ◽  
Spontaneous Motor Activity ◽  
Antidepressant Effect ◽  
Plus Maze ◽  
Albino Mice

Depression is a major cause of morbidity worldwide. Fluoxetine is a selective serotonin reuptake inhibitor, and is effective antidepressant medication. Selenium is essential for good health but required only in small amounts.Aim of the study is to investigate the effects of fluxetine alone and in presence of selenium on anxiety, spontaneous motor activity and antidepressant behavior. Also, the study aims to investigate the effects of selenium on spontaneous motor activity, anxiety measure, and antidepressant behavior, using photoelectric cells, elevated plus maze and forced swimming maze.Mice were divided into 5 group (n=6). Group 1 (control), administered 1% tween 80 (5 ml/kg); group 2 administered selenium (200 µg/kg); group 3 received diazepam as a positive control (1 mg/kg); group 4 received fluoxetine (20 mg/kg); while group 5 received combined treatment of fluoxetine and selenium. All drugs injected sub acutely (three doses), mice were intraperitoneally administered at 24, 5, and 1.0 hrs before scoring. All drugs administered as suspension in 1% Tween 80 (T80). It was injected in volume 5ml/kg. Plus maze, photoelectric cells and forced swimming maze models were used.Fluoxetine has no effect on anxiety or locomotor activity; while selenium produced anxiolytic effect without changes on locomotor activity. Fluoxetine has antidepressant activity without any effect on duration of climbing. Selenium induced antidepressant effect with climbing action. Fluoxetine abolish the anxiolytic effect of selenium when administered together, but the combined treatment decreases the locomotor activity. Fluoxetine administration with selenium counteract the antidepressant effect of each other and climbing effect of selenium. Finally, selenium improves anxiety and depression behavior in albino mice, and might be used as an alternative therapy instead of fluoxetine (which treat antidepression only); but it must not be taken in combination with it.

Effects of single and combined gabapentin use in elevated plus maze and forced swimming tests

2014 ◽  
Vol 26 (5) ◽  
pp. 307-314 ◽  
Author(s):  
Fatma Sultan Kilic ◽  
Sule Ismailoglu ◽  
Bilgin Kaygisiz ◽  
Setenay Oner
Keyword(s):  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Experimental Models ◽  
Forced Swimming ◽  
Anxiety And Depression ◽  
Antidepressant Effect ◽  
Control Group ◽  
Psychiatric Illnesses ◽  
Plus Maze ◽  
Antidepressant Effects

BackgroundGabapentin, a third-generation antiepileptic drug, is a structural analogue of γ-aminobutyric acid, which is an important mediator of central nervous system. There is clinical data indicating its effectiveness in the treatment of psychiatric illnesses such as bipolar disorder and anxiety disorders.ObjectivesWe aimed to investigate the antidepressant and anxiolytic-like effects and mechanisms of gabapentin in rats.Material and MethodsFemale Spraque–Dawley rats weighing 250±20 g were used. A total of 13 groups were formed, each containing 8 rats: gabapentin (5, 10, 20, 40 mg/kg), amitriptyline (10 mg/kg), sertraline (5 mg/kg), diazepam (5 mg/kg), ketamine (10 mg/kg), gabapentin 20 mg/kg was also combined with amitriptyline (10 mg/kg), sertraline (5 mg/kg), diazepam (5 mg/kg) and ketamine (10 mg/kg). All the drugs were used intraperitoneally as single dose. Saline was administered to the control group. Elevated plus maze and forced swimming tests were used as experimental models of anxiety and depression, respectively.ResultsIt was observed that gabapentin showed an anxiolytic-like and antidepressant-like effect in all doses in rats. Its antidepressant effect was found to be the same as the antidepressant effects of amitriptyline and sertraline. There was no change in the antidepressant effect when gabapentin was combined with amitriptyline and ketamine, but there was an increase when combined with sertraline and diazepam. Gabapentin and amitriptyline showed similar anxiolytic effect, whereas ketamine and diazepam had more potent anxiolytic effect compared with them.ConclusionsThese data suggest that gabapentin may possess antidepressant- and anxiolytic-like effects.

scholarly journals First Evidence for an Anxiolytic Effect of a Diterpenoid from Salvia Cinnabarina

2009 ◽  
Vol 4 (4) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Francesco Maione ◽  
Maria Camela Bonito ◽  
Mariantonella Colucci ◽  
Virginia Cozzolino ◽  
Angela Bisio ◽  
...  
Keyword(s):  
Motor Activity ◽  
Forced Swimming Test ◽  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Spontaneous Motor Activity ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Sedative Activity ◽  
Swimming Test

The potential anxiolytic and anti-depressive activity of CMP1 was studied in the elevated plus-maze test and in the forced swimming test. Furthermore, CMP1 sedative activity was evaluated in pentobarbital treated animals; the effect of CMP1 on spontaneous motor activity (total locomotion) was also evaluated. Our data show that CMP1, at doses that did not affect locomotion, was able to induce anxiolytic and sedative, but not anti-depressive effects. In conclusion, our results represent first evidence for an anxiolytic activity of this diterpenoid from Salvia cinnabarina.

scholarly journals Effect of Caffeine at Different Concentrations on Behavior and Motor Activity in Mice

2020 ◽  
pp. 1-11
Author(s):  
Sakina S. Saadawi ◽  
Khairi A. Alennabi ◽  
Sumaya Baayo ◽  
Amera Fares ◽  
Najwa Alosta ◽  
...  
Keyword(s):  
Motor Activity ◽  
Spontaneous Motor Activity ◽  
Antidepressant Effect ◽  
Plus Maze ◽  
Dose Dependent Decrease ◽  
Post Hoc ◽  
Dose Dependent ◽  
Cns Depression ◽  
Higher Doses ◽  
Dose Dependent Effect

Aims: This article aimed to study the effect of different caffeine concentrations on behaviour and motor activity of mice. Place and Duration of Study: This study took place in Faculty of Pharmacy, University of Tripoli, and was conducted between 2017 to 2018. Methodology: The experiment was carried out using 24 male mice (25-30 gm). Plus maze was used for screening antianxiety effect of caffeine. While swimming maze was used to test the antidepressant effect. Descriptive statistics was performed using SPSS (version 22), followed by one sample Kolmogorov-Simirnov test. One-Way ANOVA was applied to compare between groups and Post Hoc test (LSD).  Results: At a dose of 100 mg/kg, caffeine produce significant decrease in the duration of immobility using forced swimming maze; while the lower (25 mg/kg) and the higher (200 mg/kg) doses did not produce any changes compared to the control. In plus maze, Caffeine decreases the anxiety measure at the dose used of 100 mg/kg; but did not change the anxiety measure when lower (25 mg/kg) or higher (200 mg/kg) doses used compared to the control. The spontaneous motor activity was decreased significantly after administration of the higher dose of 200 mg/kg; the lower dose (25 mg/kg) showed insignificant increase, while the dose of 100 mg/kg produce insignificant decrease in the spontaneous motor activity. Conclusion: Caffeine has dose dependent effect, in a dose 100 mg/kg it produce anxiolytic and antidepressant like action, while lower (25 mg/kg) and higher (200 mg/kg) doses did not show any changes. Caffeine also produce dose dependent decrease in the spontaneous motor activity, this indicate that caffeine produce CNS depression with higher doses.

scholarly journals Antidepressant effects of natural and micropropagated Bacopa monnieri (L.) plant extracts

2021 ◽  
Vol 8 (2) ◽  
pp. 141-145
Author(s):  
Firoj A Tamboli ◽  
Vinod D Rangari ◽  
Harinath N More ◽  
Vijay H Kutwade ◽  
Vivek M Patil
Keyword(s):  
Locomotor Activity ◽  
Motor Activity ◽  
Plant Extract ◽  
Antidepressant Activity ◽  
Spontaneous Motor Activity ◽  
P Value ◽  
Standard Drug ◽  
Antidepressant Effects ◽  
Different Doses ◽  
Micropropagated Plant

Linn. an important medicinal plant in Indian system of alternative medicine belonging to Scrophulariaceae family. It is distributed in the wet and marshy lands throughout India, Nepal and many other parts of world. This study was carried out to evaluate the natural and micropropagated plant extract for antidepressant activity. Antidepressant effects of natural and micropropagated plant extract was evaluated by spontaneous motor activity. All the extracts were administered 30 min prior to the test. The standard drug chlorpromazine (2mg/kg) was used. The locomotor activity was performed using an actophotometer after different doses of test drug. Result: The locomotor activity of control and treated mice were recorded and statistically correlated among the control, standard and the test drugs. The inhibition of spontaneous motor activity in case of BMN, BMS extract was found 291, 93.5 and 277, 93.66 count at interval of 30 and 60 min. respectively. But in case of BMM plant extract it was found 290, 87.33 and 146 count at 30, 60 and 120 min. interval respectively so results showed that a significant antidepressant-like effect at a dose of 100 mg/kg. It can be used as adjuvant therapy for depression. There was statistically highly significant (p value <0.001) association observed. Further evaluation on the different mechanisms of action of ethanolic extracts of natural and micropropagated plant needs to be studied in the future.

scholarly journals ANTIANXIETY EFFECT OF ETHANOLIC EXTRACT OF FRUITS OF LIMONIA ACIDISSIMA IN SWISS ALBINO MICE

2021 ◽  
Vol 6 (8) ◽  
pp. 104-117
Author(s):  
Chouhan Vaishali ◽  
Sujane Sandhya ◽  
Bapna Rajendra ◽  
Pyathi Asharani
Keyword(s):  
Elevated Plus Maze ◽  
Treatment Options ◽  
Ethanolic Extract ◽  
Anxiolytic Effect ◽  
Ethanol Extract ◽  
Active Constituent ◽  
Swiss Albino Mice ◽  
Plus Maze ◽  
Albino Mice ◽  
Limonia Acidissima

Anxiety disorder is one of the most common mental ailments exhibited by human. It is characterized by motor tension, sympathetic hyperactivity and apprehension and vigilance syndromes. A part from very few chemical remedies available like benzodiazepine and serotonin modulators, not much treatment options are at hand that safely and effectively alleviate anxiety. The ethanol extract of the fruits of plant Limonia acidissima was evaluated for its anti-anxiety activity in swiss albino mice at dose 200mg/kg and 400mg/kg body weight. Anti-anxiety was assessed by using elevated plus maze (EPM) and light and dark model methods. The ethanolic extract exhibit anxiolytic effect in experimental mice. So it is supports the use of Limonia acidissima as anxiolytic agents. Further investigation should be made to elucidate the active constituent of responsible for the activity.

scholarly journals Evaluation of the Anxiolytic Effect ofNepeta persicaBoiss. in Mice

2008 ◽  
Vol 5 (2) ◽  
pp. 181-186 ◽  
Author(s):  
M. Rabbani ◽  
S. E. Sajjadi ◽  
A. Mohammadi
Keyword(s):  
Locomotor Activity ◽  
Plant Extract ◽  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Optimal Dose ◽  
Hydroalcoholic Extract ◽  
Plus Maze ◽  
Specific Stimulation ◽  
Plant Produce ◽  
Higher Doses

The aim of the present study was to evaluate the anxiolytic effects of hydroalcoholic extract (HE) ofNepeta persicaBoiss. (Lamiaceae) on the elevated plus-maze (EPM) model of anxiety. The extract of arial parts of the plant was administered intraperitoneally to male NMRI mice, at various doses, 30 min before behavioural evaluation. The HE extract ofN. persicaat the dose of 50 mg kg−1significantly increased the percentage of time spent and percentage of arm entries in the open arms of the EPM. This dose of plant extract affected neither animal's locomotor activity nor ketamine-induced sleeping time. The 50 mg kg−1dose of the plant extract seemed to be the optimal dose in producing the anxiolytic effects, lower or higher doses of the plant produce either sedative or stimulant effects. At 100 mg kg−1, the plant extract increased the locomotor activity. These results suggested that the extract ofN. persicaat dose of 50 mg kg−1possess anxiolytic effect with less sedative and hypnotic effects than that of diazepam and causes a non-specific stimulation at 100 mg kg−1.

Increased antidepressant-like effect of desipramine combined with central stimulants (caffeine and amphetamine) in mice

2012 ◽  
Vol 7 (3) ◽  
pp. 391-396 ◽  
Author(s):  
Evelyn Robles-Molina ◽  
Daniel Millán ◽  
Enrique Hong ◽  
Fengyang Huang ◽  
Santiago Villafaña
Keyword(s):  
Motor Activity ◽  
Combined Treatment ◽  
Forced Swimming ◽  
Male Mice ◽  
Release Of Noradrenaline ◽  
Central Stimulants ◽  
Immobility Time ◽  
Antidepressive Agent ◽  
Different Doses

AbstractDesipramine is a widely used antidepressive agent that inhibits the reuptake of noradrenaline and serotonin, and central stimulants such as caffeine and amphetamine help to release noradrenaline and serotonin. This work aimed to evaluate whether the combination of these agents could produce a stronger antidepressant-like effect than either of the drugs alone. To this end, male mice were treated with different doses of desipramine, caffeine, amphetamine, desipramine-caffeine and desipramine-amphetamine. The results showed that all drugs produced decreased immobility time in the forced swimming model. The combined treatment of desipramine (0.31, 1.0 or 3.1 mg/kg i.p.) with caffeine or amphetamine (0.31 or 1 mg/kg i.p.) reduced immobility time greater than either of those drugs alone. The combined treatment of desipramine (0.31, 1 and 3.1 mg/kg i.p.) with amphetamine or caffeine (0.1 and 1 mg/kg i.p.) did not increase the motor activity significantly compared to the control. These results also suggested that drugs which promote the release of noradrenaline and serotonin could increase antidepressant-like effect of desipramine.

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