Increased antidepressant-like effect of desipramine combined with central stimulants (caffeine and amphetamine) in mice

2012 ◽  
Vol 7 (3) ◽  
pp. 391-396 ◽  
Author(s):  
Evelyn Robles-Molina ◽  
Daniel Millán ◽  
Enrique Hong ◽  
Fengyang Huang ◽  
Santiago Villafaña
Keyword(s):  
Motor Activity ◽  
Combined Treatment ◽  
Forced Swimming ◽  
Male Mice ◽  
Release Of Noradrenaline ◽  
Central Stimulants ◽  
Immobility Time ◽  
Antidepressive Agent ◽  
Different Doses

AbstractDesipramine is a widely used antidepressive agent that inhibits the reuptake of noradrenaline and serotonin, and central stimulants such as caffeine and amphetamine help to release noradrenaline and serotonin. This work aimed to evaluate whether the combination of these agents could produce a stronger antidepressant-like effect than either of the drugs alone. To this end, male mice were treated with different doses of desipramine, caffeine, amphetamine, desipramine-caffeine and desipramine-amphetamine. The results showed that all drugs produced decreased immobility time in the forced swimming model. The combined treatment of desipramine (0.31, 1.0 or 3.1 mg/kg i.p.) with caffeine or amphetamine (0.31 or 1 mg/kg i.p.) reduced immobility time greater than either of those drugs alone. The combined treatment of desipramine (0.31, 1 and 3.1 mg/kg i.p.) with amphetamine or caffeine (0.1 and 1 mg/kg i.p.) did not increase the motor activity significantly compared to the control. These results also suggested that drugs which promote the release of noradrenaline and serotonin could increase antidepressant-like effect of desipramine.

Activity of several GABAergic agents on the behavioral “despair” test in rats

1989 ◽  
Vol 4 (3) ◽  
pp. 167-173
Author(s):  
A. Fernandez-Teruel ◽  
F . Boix ◽  
R .M . Escorihuela ◽  
T . Guix ◽  
A . Tobeña
Keyword(s):  
Motor Activity ◽  
Open Field Test ◽  
The Other ◽  
Gabaergic Transmission ◽  
Gaba A ◽  
Behavioral Despair ◽  
Immobility Time ◽  
Swimming Test ◽  
Behavioral Despair Test ◽  
Different Doses

SummaryThe present study was conducted to investigate whether several GABAergic drugs could affect immobility in the behavioral “despair” test (swimming test). The subacute (3 injections) treatment with the GABA-B agonist baclofen 0.5 mg/kg (BC05) partially antagonised the antiimmobility action of imipramine (IMI), whereas muscimol 0.00125 mg/kg (MU ; GABA-A agonist) did not affect the imipramine effect on immobility. The highest doses of baclofen alone increased immobility time, and no effect of muscimol alone was observed on this measure. Other experiments indicated that different doses of δ-α-aminovaleric acid (a GABA-B antagonist and GABA-A agonist) or progabide (a GABA A/B agonist with clinical antidepressive properties) did not modify immobility time. On the other hand, sodium valproate (VPA), chronically administered, was effective in reducing the time of immobility of rats in the swimming test, at doses which did not alter motor activity in an open field test. Since there is evidence indicating that valproate can be considered as a GABA-mimetic agent, the present data is consistent with other results showing an antidepressant-like activity of agents which enhance GABAergic transmission.

scholarly journals Behavior Effect of Fluoxetine in Presence of Selenium Using Albino Mice

2017 ◽  
Vol 7 ◽  
pp. 1-8
Author(s):  
Suhera M. Aburawi ◽  
Sumaya A. Baayo
Keyword(s):  
Locomotor Activity ◽  
Motor Activity ◽  
Combined Treatment ◽  
Anxiolytic Effect ◽  
Tween 80 ◽  
Forced Swimming ◽  
Spontaneous Motor Activity ◽  
Antidepressant Effect ◽  
Plus Maze ◽  
Albino Mice

Depression is a major cause of morbidity worldwide. Fluoxetine is a selective serotonin reuptake inhibitor, and is effective antidepressant medication. Selenium is essential for good health but required only in small amounts.Aim of the study is to investigate the effects of fluxetine alone and in presence of selenium on anxiety, spontaneous motor activity and antidepressant behavior. Also, the study aims to investigate the effects of selenium on spontaneous motor activity, anxiety measure, and antidepressant behavior, using photoelectric cells, elevated plus maze and forced swimming maze.Mice were divided into 5 group (n=6). Group 1 (control), administered 1% tween 80 (5 ml/kg); group 2 administered selenium (200 µg/kg); group 3 received diazepam as a positive control (1 mg/kg); group 4 received fluoxetine (20 mg/kg); while group 5 received combined treatment of fluoxetine and selenium. All drugs injected sub acutely (three doses), mice were intraperitoneally administered at 24, 5, and 1.0 hrs before scoring. All drugs administered as suspension in 1% Tween 80 (T80). It was injected in volume 5ml/kg. Plus maze, photoelectric cells and forced swimming maze models were used.Fluoxetine has no effect on anxiety or locomotor activity; while selenium produced anxiolytic effect without changes on locomotor activity. Fluoxetine has antidepressant activity without any effect on duration of climbing. Selenium induced antidepressant effect with climbing action. Fluoxetine abolish the anxiolytic effect of selenium when administered together, but the combined treatment decreases the locomotor activity. Fluoxetine administration with selenium counteract the antidepressant effect of each other and climbing effect of selenium. Finally, selenium improves anxiety and depression behavior in albino mice, and might be used as an alternative therapy instead of fluoxetine (which treat antidepression only); but it must not be taken in combination with it.

Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster

2020 ◽  
Vol 17 (3) ◽  
Author(s):  
Emmanuel Tiyo Ayikobua ◽  
Josephine Kasolo ◽  
Keneth Iceland Kasozi ◽  
Ejike Daniel Eze ◽  
Abass Safiriyu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Drosophila Melanogaster ◽  
Side Effects ◽  
Motor Activity ◽  
Ethanolic Extract ◽  
Synergistic Action ◽  
Content Type ◽  
Treatment Groups ◽  
Ethanolic Extract Of Propolis ◽  
Different Doses

AbstractBackgroundThe Phosphatase and tensin-induced putative kinase 1 (PINK1B9) mutant for Drosophila melanogaster is a key tool that has been used in assessing the pathology of Parkinsonism and its possible remedy. This research was targeted toward determining the effects of ethanolic extract of propolis, with levodopa therapy in the management of Parkinsonism.MethodThe PINK1B9 flies were divided into groups and fed with the different treatment doses of ethanoic extract of propolis. The treatment groups were subjected to 21 days of administration of propolis and the levodopa at different doses after which percentage climbing index, antioxidant activity and lifespan studies were done.ResultsPropolis alone improved motor activity, antioxidant and lifespan in Drosophila melanogaster than in PINK1 flies. Propolis in combination with levodopa significantly (P<0.05) improved physiological parameters at higher than lower concentrations in Parkinsonism Drosophila melanogaster demonstrating its importance in managing side effects associated with levodopa.ConclusionPropolis is a novel candidate as an alternative and integrative medicinal option to use in the management of Parkinsonism in both animals and humans at higher concentrations.

Nitric oxide mediates the antidepressant-like effect of modafinil in mouse forced swimming and tail suspension tests

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Hossein Omidi-Ardali ◽  
Abolfazl Ghasemi Badi ◽  
Elham Saghaei ◽  
Hossein Amini-Khoei
Keyword(s):  
Nitric Oxide ◽  
Effective Dose ◽  
Animal Studies ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Immobility Time ◽  
Swimming Test ◽  
Underlying Mechanisms

AbstractObjectivesPrevious studies have suggested antidepressant properties for modafinil; however, the underlying mechanisms mediating the antidepressant effect of modafinil have not been well recognized in clinical and animal studies. Nitric oxide (NO) is involved in the pathophysiology of depression. We attempted to investigate the possible role of NO in the antidepressant-like effect of modafinil in mouse forced swimming test (FST) and tail suspension test (TST).MethodsThe antidepressant-like effect of modafinil (25, 50 and 75 mg/kg), alone and in combination with l-arginine, l-arg, (100 mg/kg) and NG-l-arginine methyl ester, l-NAME (5 mg/kg), was evaluated using FST and TST. Following behavioral tests, the hippocampi were dissected out to measure nitrite levels.ResultsFindings suggested that administration of modafinil at doses of 50 and 75 mg/kg significantly reduced immobility time in the FST and TST. Furthermore, administration of l-arg and l-NAME increased and decreased, respectively, the immobility time in the FST and TST. We showed that co-administration of a sub-effective dose of modafinil (25 mg/kg) plus l-NAME potentiated the antidepressant-like effect of the sub-effective dose of modafinil. In addition, co-treatment of an effective dose of modafinil (75 mg/kg) with l-arg attenuated the antidepressant-like effect of the effective dose of modafinil. We showed that the antidepressant-like effect of modafinil is associated with decreased nitrite levels in the hippocampus.ConclusionsOur findings for the first time support that the modulation of NO, partially at least, is involved in the antidepressant-like effect of modafinil in mouse FST and TST.

Preliminary Study on the Anti-radiation Effect of Jen-Sheng-Yang-Yung-Tang

1993 ◽  
Vol 21 (02) ◽  
pp. 187-195 ◽  
Author(s):  
Hsue-yin Hsu ◽  
Yau-hui Ho ◽  
Shi-Iong Lian ◽  
Chun-ching Lin
Keyword(s):  
Bone Marrow ◽  
Radiation Effect ◽  
Bone Marrow Cells ◽  
X Rays ◽  
Male Mice ◽  
X Ray ◽  
Colony Forming Units ◽  
Before And After ◽  
Preliminary Study ◽  
Different Doses

Six to seven week old male mice of ICR strain were exposed to different doses of x-rays to determine if Jen-Sheng-Yang-Yung-Tang could be a modifier in the elimination of radiation damage. Colony forming units of bone marrow cells in the spleen (CFUs) were measured before and after x-ray irradiation with intraperitoneal injection of 10 mg/20 g or 20 mg/20 g body weight of Jen-Sheng-Yang-Yung-Tang, once a day for seven consecutive days. The recovery of CFUs and hemocytes counts by 4 Gy irradiation with Jen-Sheng-Yang-Yung-Tang administration was faster for a concentration of 20 mg/20 g than 10 mg/20 g. The measurement of 10-day CFUs showed an increase of radiotolerance in the treatment of 20 mg/20 g administration before x-ray irradiation. The injection of Jen-Sheng-Yang-Yung-Tang accelerated the recovery of hemocyte counts in mice irradiated with 4 Gy x-ray; the effect was especially profound for leukocytes with 20 mg/20 g Jen-Sheng-Yang-Yung-Tang administration after irradiation.

The Antioxidant Effects of Germinating Tartary Buckwheat Vinegar

2014 ◽  
Vol 651-653 ◽  
pp. 305-312 ◽  
Author(s):  
Yun Long Li ◽  
Ting Jun Ma ◽  
Hong Mei Li ◽  
Jun Jun Hu ◽  
Jun Sheng Bian ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Dose Group ◽  
Low Dose ◽  
Positive Control ◽  
Control Model ◽  
Male Mice ◽  
Total Antioxidant ◽  
Antioxidant Effects ◽  
Different Doses

The present study was to evaluated the antioxidant capacity and the effect to the D - galactose senile mice of buckwheat vinegar which maked by sprouting buckwheat, divided healthy Kunming male mice into blank, positive control, model and three dose groups of vinega made by stirring buckwheat randomly. After 6 weeks, it was determined the activity of antioxidant enzyme and malondialdehyde in mice with different doses groups. The results showed that: the stirring buckwheat vinegar exhibited strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC50 was 0.58*10-2 ) and total antioxidant capacity (210.58 mmolFe2SO4•ml-1 ); the vinegar can droped the level of MDA and improved the activity of SOD in liver of D - galactose senile mice. The low-dose group can improved the activity of SOD in serum. However, for the aging mice, the buckwheat vinegar had no effect on behavior when they were in the new environment, the ability of reduced the activity of TChE in brain and the level of MDA in serum was not significant, at the same time, the activity of GSH-px in the serum couldn't be enhanced.

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