scholarly journals Serum Proteomic Analysis in Esophagectomy Patients with Postoperative Delirium: A Case-Control Study

2020 ◽  
Vol 3 ◽  
Author(s):  
Walter Fitschen ◽  
Sikandar Khan ◽  
Heidi Lindroth ◽  
Sophia Wang ◽  
Sundus Imran ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Postoperative Delirium ◽  
Case Control Study ◽  
Coagulation Factor ◽  
Assessment Method ◽  
Case Control ◽  
Factor Ix ◽  
Protein Abundance ◽  
Elevated Protein ◽  
Control Study

Background: Delirium is a common post-operative complication for patients who undergo esophagectomy. The pathophysiology of delirium is poorly understood, limiting therapeutic options. To advance our pathophysiologic understanding, we conducted this study to evaluate the association of protein expression with postoperative delirium.  Methods: A case-control study was performed using blood samples from the PEPOD randomized clinical control trial (NCT02213900). 52 patients (26 cases with delirium, 26 control)  who were >18 years old, spoke English, and underwent esophagectomy were included, while those with schizophrenia, Parkinson’s, alcohol abuse, neuroleptic malignant syndrome, haloperidol allergy, and severe dementia were excluded. Samples were from pre-op and post-op day 1. Delirium was assessed for using the Confusion Assessment Method for the Intensive Care Unit and Richmond Agitation Sedation Scale, while the severity was assessed using DRS-R-68. Proteomic analysis was performed using TMT 10ples isobaric labels. Proteome Discoverer and STRING web-based tools were used for bioinformatic analyses, and the Wilcoxon-Mann-Whitney Odds (WMWodds) test was used to report between-group differences in protein abundance ratios.  Results: 52 samples (26 cases, 26 controls) were analyzed for this study. Elevated protein abundance ratios of Coagulation factor IX (Median (IQR): 1.18 (1.08-1.28) p=0.047) and Mannosyl-oligosaccharide 1,2-alpha-mannosidase (Median (IQR): 1.50 (1.35-1.60) p=0.049) were noted in patients that developed delirium. Elevated protein abundance ratios of angiotensinogen (Median (IQR): 1.19 (1.14-1.23) p=0.038), ceruloplasmin (Median (IQR): 1.02 (0.98-1.08) p=0.038), and Complement C2 (Median (IQR): 1.01 (0.96-1.08) p=0.016) were noted in control patients. Protein abundance ratios for Complement C2 (Spearman rs=0.31, 95%CI [-0.55, -0.02]) and Mannosyl-oligosaccharide 1,2-alpha-mannosidase (rs=0.61, 95%CI [0.29, 0.81]) were associated with the severity of delirium in case patients.   Conclusions: Changes in proteins associated with coagulation, inflammation, and protein handling were identified. These could be evaluated in future studies to develop tools for predicting onset and severity of post-operative delirium. 

scholarly journals Genetic polymorphisms of UGT1A1 and susceptibility to anti-tuberculosis drug-induced liver: A RUCAM-based case–control study

2018 ◽  
Vol 32 ◽  
pp. 205873841881628 ◽  
Author(s):  
Bilin Tao ◽  
Shixian Chen ◽  
Guancheng Lin ◽  
Miaomiao Yang ◽  
Lihuan Lu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Genetic Polymorphisms ◽  
Case Control Study ◽  
Causality Assessment ◽  
Conditional Logistic Regression ◽  
Assessment Method ◽  
Case Control ◽  
Bile Acid Metabolism ◽  
Drug Induced ◽  
Control Study

Uridine 5’-diphospho-glucuronosyl-transferase 1A1 (UGT1A1) plays an important role in the biliary excretion of bilirubin, suggesting genetic polymorphisms of UGT1A1 may have an impact on bile acid metabolism, which may be related to the development of anti-tuberculosis drug-induced liver injury (ATLI). This study explores the associations between genetic polymorphisms of UGT1A1 and ATLI in a Chinese anti-tuberculosis population. A 1:2 matched case–control study was conducted among 290 ATLI cases and 580 controls, of which causality assessment of ATLI cases was based on the updated Roussel Uclaf Causality Assessment Method (RUCAM). Conditional logistic regression was applied to calculate odds ratio (OR) and 95% confidence intervals (CIs), with weight and use of hepatoprotectant as covariates. The Bonferroni correction was used to adjust P values for multiple testing. Compared with those carrying rs6719561 TT genotype, patients with TC genotype had lower risk of ATLI (adjusted OR = 0.723, 95% CI: 0.531–0.985, P = 0.040). The haplotype TAG (rs3755319-rs2003569-rs4148323) could marginally significantly increase the risk of ATLI (adjusted OR = 5.071, 95% CI: 1.007–25.531, P = 0.049), while haplotype TC (rs4148329-rs6719561) could reduce the risk of ATLI (adjusted OR = 0.719, 95% CI: 0.527–0.982, P = 0.038). Patients with polymorphisms at rs4148328 or rs3755319 were at a reduced risk of moderate and severe liver injury under different genetic models. Based on this case–control study, genetic polymorphisms of UGT1A1 may be associated with susceptibility to ATLI in the Chinese anti-tuberculosis population.

scholarly journals KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Mark Terrelonge ◽  
Sara C. LaHue ◽  
Christopher Tang ◽  
Irina Movsesyan ◽  
Clive R. Pullinger ◽  
...  
Keyword(s):  
Older Adults ◽  
Postoperative Delirium ◽  
Case Control Study ◽  
Case Control ◽  
Surgical Patients ◽  
Primary Study ◽  
Diverse Populations ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Control Study

AbstractDespite the association between cognitive impairment and delirium, little is known about whether genetic differences that confer cognitive resilience also confer resistance to delirium. To investigate whether older adults without postoperative delirium, compared with those with postoperative delirium, are more likely to have specific single nucleotide polymorphisms (SNPs) in the FKBP5, KIBRA, KLOTHO, MTNR1B, and SIRT1 genes known to be associated with cognition or delirium. This prospective nested matched exploratory case–control study included 94 older adults who underwent orthopedic surgery and screened for postoperative delirium. Forty-seven subjects had incident delirium, and 47 age-matched controls were not delirious. The primary study outcome was genotype frequency for the five SNPs. Compared with participants with delirium, those without delirium had higher adjusted odds of KIBRA SNP rs17070145 CT/TT [vs. CC; adjusted odds ratio (aOR) 2.80, 95% confidence interval (CI) 1.03, 7.54; p = 0.04] and MTNR1B SNP rs10830963 CG/GG (vs. CC; aOR 4.14, 95% CI 1.36, 12.59; p = 0.01). FKBP5 SNP rs1360780 CT/TT (vs. CC) demonstrated borderline increased adjusted odds of not developing delirium (aOR 2.51, 95% CI 1.00, 7.34; p = 0.05). Our results highlight the relevance of KIBRA, MTNR1B, and FKBP5 in understanding the complex relationship between delirium, cognition, and sleep, which warrant further study in larger, more diverse populations.

scholarly journals Effects of hypertriglyceridaemia on blood coagulation factor VII: a case control study of 110 cases

1970 ◽  
Vol 22 (1) ◽  
pp. 32-34
Author(s):  
Rehana Aziz ◽  
ASM Towhidul Alam ◽  
Ajoy Deb ◽  
Mahmudul Haque
Keyword(s):  
Coronary Artery ◽  
Blood Coagulation ◽  
Case Control Study ◽  
Coagulation Factor ◽  
Case Control ◽  
Factor Vii ◽  
Plasma Coagulation ◽  
Coagulation Factor Vii ◽  
Control Study

Keywords: Hypertriglyceridaemia; plasma coagulation factor VII; hypercoagulability; coronary artery diseaseDOI: http://dx.doi.org/10.3329/jcmcta.v22i1.9110 JCMCTA 2011; 22(1): 32-34

scholarly journals Smac/DIABLO can predict postoperative delirium in elderly patients after cardiac surgery : A prospective nested case-control study

2021 ◽  
Author(s):  
Xin Ding ◽  
Zeping Li ◽  
Lei Lei ◽  
Muhuo Ji ◽  
Jianjun Yang
Keyword(s):  
Oxidative Stress ◽  
Cardiac Surgery ◽  
Postoperative Delirium ◽  
Case Control Study ◽  
Critical Role ◽  
Case Control ◽  
Nervous System Diseases ◽  
Common Complication ◽  
Nested Case Control ◽  
Control Study

Background：Postoperative delirium (POD) is a common complication following cardiac surgery. Mitochondrial injury, demonstrated by excessively activated oxidative stress and regulating cell apoptosis, has been reported to contribute to POD. [Mitophagy](https://www.geenmedical.com/article?id=34752757&type=true), apoptosis, pyroptosis, ferroptosis had been known to play a critical role in degenerative nervous system diseases. However, the serum change of Smac/DIABLO in POD induced by cardiac surgery/anesthesia is still undetermined. We designed the study to determine the expression level of SMAC/DIABLO in POD patients. Methods：A nested case-control study was performed, including 21 POD patients and a matched group of 63 non-POD controls.

scholarly journals Factors Involved in the Development of Inhibitory Antibodies in Patients with Hemophilia in Colombia: A Case-Control Study

2020 ◽  
Vol 13 ◽  
pp. 263485352096246
Author(s):  
Jorge E Machado-Alba ◽  
Laura A Chica-Quintero ◽  
Manuel E Machado-Duque ◽  
Andrés Gaviria-Mendoza ◽  
Juan David Wilches-Gutierrez ◽  
...  
Keyword(s):  
Case Control Study ◽  
Coagulation Factor ◽  
Care Program ◽  
Coagulation Factors ◽  
Case Control ◽  
Severe Hemophilia ◽  
Inhibitory Antibodies ◽  
Control Study ◽  
Lack Of Knowledge

Background: The appearance of inhibitory antibodies against antihemophilic factors is one of the most serious complications related to hemophilia. Objective: The objective of this study was to identify variables and factors related to the development of inhibitory antibodies in a group of patients undergoing antihemophilic therapy in Colombia. Methods: A case-control study in patients with hemophilia treated in Specialized Healthcare Provider Institutions (IPS-E) in 21 cities of Colombia of any age and with a diagnosis of inhibitory antibodies against factor VIII or IX during 2016. Four controls per case paired by age and type of hemophilia were used. Sociodemographic, clinical, and pharmacological variables were identified and analyzed. Results: Seventeen patients with inhibitory antibodies and 68 controls with hemophilia were identified. The mean age was 28.3 ± 17.8 years. A total of 94.1% had hemophilia A, and 88.2% of the cases and 50.0% of the controls had severe hemophilia; 47.1% of the cases and 54.4% of the controls were receiving prophylaxis with coagulation factors. Multivariate analysis showed that having severe hemophilia (OR:17.0, 95%CI:1.32–219.60) and lack of knowledge of the coagulation factor with which the patient was treated before entering the care program in the IPS-E (OR:8.9, 95%CI:1.82–43.75) were significantly associated with a higher probability of developing inhibitory antibodies. Conclusion and relevance: Coagulation factors associated with the development of inhibitory antibodies were severe hemophilia and lack of knowledge of the type of factor used prior to entering the follow-up cohort.

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