scholarly journals Smac/DIABLO can predict postoperative delirium in elderly patients after cardiac surgery : A prospective nested case-control study

2021 ◽  
Author(s):  
Xin Ding ◽  
Zeping Li ◽  
Lei Lei ◽  
Muhuo Ji ◽  
Jianjun Yang
Keyword(s):  
Oxidative Stress ◽  
Cardiac Surgery ◽  
Postoperative Delirium ◽  
Case Control Study ◽  
Critical Role ◽  
Case Control ◽  
Nervous System Diseases ◽  
Common Complication ◽  
Nested Case Control ◽  
Control Study

Background：Postoperative delirium (POD) is a common complication following cardiac surgery. Mitochondrial injury, demonstrated by excessively activated oxidative stress and regulating cell apoptosis, has been reported to contribute to POD. [Mitophagy](https://www.geenmedical.com/article?id=34752757&type=true), apoptosis, pyroptosis, ferroptosis had been known to play a critical role in degenerative nervous system diseases. However, the serum change of Smac/DIABLO in POD induced by cardiac surgery/anesthesia is still undetermined. We designed the study to determine the expression level of SMAC/DIABLO in POD patients. Methods：A nested case-control study was performed, including 21 POD patients and a matched group of 63 non-POD controls.

scholarly journals Risk factors for the development of significant postoperative bleeding after pediatric cardiac surgery with cardiopulmonary bypass: A nested case-control study

2017 ◽  
Vol 6 (3) ◽  
pp. 5
Author(s):  
JuanCarlos Núñez-Enríquez ◽  
IsabelZnaya Ramírez-Flores ◽  
Maribel Ibarra-Sarlat ◽  
Vivian Neme-Bechara ◽  
Alejandro Herrera-Landero ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Case Control Study ◽  
Postoperative Bleeding ◽  
Case Control ◽  
Pediatric Cardiac Surgery ◽  
Nested Case Control ◽  
Control Study

The association between allopurinol use and urologic malignancies: A nested case-control study.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 435-435
Author(s):  
Daniel Keizman ◽  
Ido Wolf ◽  
Hadas Dresler ◽  
David Sarid ◽  
Avivit Peer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Bladder Cancer ◽  
Uric Acid ◽  
Cancer Diagnosis ◽  
Case Control Study ◽  
Case Control ◽  
Urologic Malignancies ◽  
Nested Case Control ◽  
Control Study

435 Background: Oxidative stress may be involved in tumorigenesis processes. Uric acid is an important natural antioxidant that may reduce oxidative stress. Allopurinol is a commonly used uric acid lowering agent. There are conflicting data regarding the association between allopurinol use and cancer incidence. In the present nested case control study, we aimed to evaluated the association between allopurinol use and urologic malignancies in a large western population. Methods: conducted a nested case-control study within a population-representative database from the United Kingdom (THIN). Study cases were defined as individuals with any diagnostic code of prostate cancer, bladder cancer, or renal cell carcinoma. For every case, four eligible controls were matched on age, gender, practice site, time of diagnosis, and duration of follow-up. Exposure of interest was any allopurinol use prior to cancer diagnosis. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for urologic malignancies were estimated using conditional logistic regression. Adjustment was performed for factors including smoking, BMI, and diabetes. Results: The study population included: for bladder cancer 13440 and 52421 matched controls, prostate cancer 27212 cases and 105940 controls, RCC 1547 cases and 6066 controls. Allopurinol use was associated with a significantly increase of risk for bladder cancer (adjusted OR 1.2, 95%CI 1.09-1.32, p<0.001). prostate cancer (adjusted OR 1.1, 95%CI 1.03-1.,17, p=0.003), RCC (adjusted OR 1.32, 95%CI 1-1..75, p=0.05). In a sensitivity analyses we observed similar associations when alopurinol use was initiated more than two years prior to cancer diagnosis, for bladder cancer (adjusted OR 1.2, 95%CI 1.08-1.33, p=0.001), prostate cancer (adjusted OR 1.09, 95%CI 1.02-1.16, p=0.01), RCC (adjusted OR 1.09, 95%CI 0.78-1.53, p=0.62). Conclusions: Allopurinol use may be associated with an increased risk for urologic malignancies.

Biomarkers of Oxidative Stress and Risk of Colorectal Cancer: A Cohort-Nested Case-Control Study in the EPIC Database

2011 ◽  
Vol 140 (5) ◽  
pp. S-347-S-348
Author(s):  
Anke M. Leufkens ◽  
Fränzel J. van Duijnhoven ◽  
Sjoukje Woudt ◽  
Peter D. Siersema ◽  
Hendrik B. Bueno-de-Mesquita
Keyword(s):  
Oxidative Stress ◽  
Colorectal Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study ◽  
Biomarkers Of Oxidative Stress

scholarly journals The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Blood ◽  
2011 ◽  
Vol 117 (16) ◽  
pp. 4218-4225 ◽  
Author(s):  
Alexander P. J. Vlaar ◽  
Jorrit J. Hofstra ◽  
Rogier M. Determann ◽  
Denise P. Veelo ◽  
Frederique Paulus ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiac Surgery ◽  
Acute Lung Injury ◽  
Case Control Study ◽  
Case Control ◽  
Blood Products ◽  
Bioactive Lipids ◽  
Related Risk ◽  
Nested Case Control ◽  
Control Study

Abstract Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related morbidity and mortality. Both antibodies and bioactive lipids that have accumulated during storage of blood have been implicated in TRALI pathogenesis. In a single-center, nested, case-control study, patients were prospectively observed for onset of TRALI according to the consensus definition. Of 668 patients, 16 patients (2.4%) developed TRALI. Patient-related risk factors for onset of TRALI were age and time on the cardiopulmonary bypass. Transfusion-related risk factors were total amount of blood products (odds ratio [OR] = 1.2; 95% confidence interval [CI], 1.03-1.44), number of red blood cells stored more than 14 days (OR = 1.6; 95% CI, 1.04-2.37), total amount of plasma (OR = 1.2; 95% CI, 1.03-1.44), presence of antibodies in donor plasma (OR = 8.8; 95% CI, 1.8-44), and total amount of transfused bioactive lipids (OR = 1.0; 95% CI, 1.00-1.07). When adjusted for patient risk factors, only the presence of antibodies in the associated blood products remained a risk factor for TRALI (OR = 14.2; 95% CI, 1.5-132). In-hospital mortality of TRALI was 13% compared with 0% and 3% in transfused and nontransfused patients, respectively (P < .05). In conclusion, the incidence of TRALI is high in cardiac surgery patients and associated with adverse outcome. Our results suggest that cardiac surgery patients may benefit from exclusion of blood products containing HLA/HNA antibodies.

Oxidative Stress and Atrial Fibrillation After Cardiac Surgery: A Case-Control Study

2007 ◽  
Vol 84 (4) ◽  
pp. 1166-1173 ◽  
Author(s):  
Basel Ramlawi ◽  
Hasan Otu ◽  
Shigetoshi Mieno ◽  
Munir Boodhwani ◽  
Neel R. Sodha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atrial Fibrillation ◽  
Cardiac Surgery ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

MP217DIABETES MELLITUS DOES NOT INCREASE THE INCIDENCE OF ACUTE KIDNEY INJURY AFTER CARDIAC SURGERY IN PATIENTS WITH CHRONIC KIDNEY DISEASE; A NESTED CASE-CONTROL STUDY

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i412-i412
Author(s):  
Loutradis Charalampos ◽  
Maria Moschopoulou ◽  
Foteini Ampatzidou ◽  
Afroditi Mpoutou ◽  
Charilaos-Panagiotis Koutsogiannidis ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Kidney Disease ◽  
Case Control Study ◽  
Kidney Injury ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study
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