Ischemic Heart Disease in Subjects of Young Age: Current State of the Problem. Features of Etiology, Clinical Manifestation and Prognosis

Kardiologiia ◽  
2018 ◽  
Vol 58 (11) ◽  
pp. 24-34 ◽  
Author(s):  
E. Yu. Andreenko ◽  
I. S. Yavelov ◽  
М. М. Loukianov ◽  
A. N. Vernohaeva ◽  
O. M. Drapkina ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Molecular Genetic ◽  
Young Patients ◽  
Ischemic Heart ◽  
Coronary Syndrome ◽  
Current State ◽  
Monogenic Diseases ◽  
Conventional Risk Factors

In addition to conventional risk factors in young patients with ischemic heart disease (IHD) numerous other risk factors including genetics play an important role in its causation. Molecular genetic testing is recommended for the detection of monogenic diseases with a high risk of developing IHD, such as familial hypercholesterolemia. In majority ofyoung patients, the first manifestation of IHD is an acute coronary syndrome. Young patients with IHD more often have normal coronary arteries or single-vessel coronary disease, and in up to 20% of them cause of myocardial ischemia is not related to atherosclerosis. In general, young patients with IHD have better prognosis. However, there are sex differences in IHD outcomes the prognosis of patients with premature IHD and reason for this is still unclear.

IMPACT OF RISK FACTORS OF ISCHEMIC HEART DISEASE ON THE DEVELOPMENT OF ACUTE CORONARY SYNDROME, PLATELET ULTRASTRUCTURE, AND ASPIRIN RESISTANCE

2019 ◽  
Vol 72 (11) ◽  
Author(s):  
Yulian H. Kyyak ◽  
Olga Yu. Barnett ◽  
Marta P. Halkevych ◽  
Olha Ye. Labinska ◽  
Hryhoriy Yu. Kyyak ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Aspirin Resistance ◽  
Ischemic Heart ◽  
Coronary Syndrome

IMPACT OF RISK FACTORS OF ISCHEMIC HEART DISEASE ON THE DEVELOPMENT OF ACUTE CORONARY SYNDROME, PLATELET ULTRASTRUCTURE, AND ASPIRIN RESISTANCE

2019 ◽  
Vol 72 (11) ◽  
Author(s):  
Yulian H. Kyyak ◽  
Olga Yu. Barnett ◽  
Marta P. Halkevych ◽  
Olha Ye. Labinska ◽  
Hryhoriy Yu. Kyyak ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Aspirin Resistance ◽  
Ischemic Heart ◽  
Coronary Syndrome

scholarly journals Hemodialysis patients with better coronary flow reserve and nutrition status have surprising prognosis

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
T Imaoka ◽  
N Umemoto ◽  
S Oshima
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Ischemic Heart ◽  
Nutrition Status ◽  
Flow Reserve ◽  
All Cause Mortality ◽  
Conventional Risk Factors

Abstract Background In clinical setting, ischemic heart disease is a challenging problem in hemodialysis (HD) population. Coronary flow reserve (CFR) measured by 13 ammonia positron emitting tomography (13NH3PET) is an established and reliable modality for detecting coronary artery disease. Furthermore, some prior studies show CFR is an important and independent predictor for cardiovascular event and mortality. On the other hand, HD patients with malnutrition status have poor prognosis. We have reported about the relationship between cardiovascular events and geriatric nutrition risk index (GNRI). Now, we wonder the predictability of combination of CFR and GNRI. Methods and result We collected 438 consecutive HD patients who received 13NH3PET in our hospital suspected for ischemic heart disease. 29 patients were excluded due to undergoing coronary revascularization within 60 days, 103 patients were excluded due to incomplete database. In total, 306 HD patients were classified into 4 group according the median value of CFR (1.99) and GNRI (97.73); Low CFR Low GNRI group (n=77), High CFR and Low GNRI group (n=76), Low CFR High GNRI group (n=78) and High CFR High GNRI group (n=75). We collected their follow up data up to 1544 days (median 833 days) about all-cause mortality and cardiovascular (CV) mortality. Surprisingly, there is no mortality event in High CFR High GNRI group. We analyzed about all-cause mortality, CV mortality. Kaplan-Meyer analysis shows there are statistically intergroup differences in each (all-cause mortality; log rank p<0.01, CV mortality; log rank p=0.02). Furthermore, we calculated area under the curve (AUC) analysis, net reclassification improvement (NRI) and integrated discrimination improvement (IDI)m adding GNRI and CFR on conventional risk factors. There are intergroup differences for all-cause mortality in AUC [conventional risk factors, +GNRI, +GNRI+CFR; 0.70, 0.72 (p=0.29), 0.79 (p<0.01)], NRI [+GNRI; 0.32 (p=0.04), +GNRI+CFR 0.82 (p<0.01)] and IDI [+GNRI; 0.01 (p=0.05), +GNRI+CFR 0.09 (p<0.01)]. Conclusion HD patients with low CFR and malnutrition status has statistically significant poorer prognosis comparing HD patients with high CFR and without malnutrition status. Adding combination of GNRI and CFR on conventional risk factors improves the predictability of HD population's prognosis. Funding Acknowledgement Type of funding source: None

scholarly journals Prevalence of ischemic heart disease depending on factors of psychoemotional stress among men of mature age (epidemiological study)

2021 ◽  
Vol 93 (1) ◽  
pp. 25-29
Author(s):  
Ekaterina V. Akimova ◽  
Mikhail Y. Akimov ◽  
Marina M. Kayumova ◽  
Valery V. Gafarov
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Epidemiological Study ◽  
Emotional Stress ◽  
Stress Factors ◽  
Ischemic Heart ◽  
Psychoemotional Stress ◽  
Open Population ◽  
Conventional Risk Factors

Aim. To establish associations of the prevalence of ischemic heart disease (IHD) and factors of psychoemotional stress in men of the open urban population in the age group 4564 years after two decades of life. Materials and methods. A cross-sectional epidemiological study using a model of the city of Tyumen was conducted on a representative sample of the population among males of mature age (4564 years). Based on standard epidemiological methods, IHD was established according to strict epidemiological criteria definite IHD. The study of the factors of psycho-emotional stress (depression, hostility, life exhaustion) was carried out according to the algorithms of the World Health Organization program MONICA-psychosocial. When calculating the odds ratio for the development of IHD, a low level of psycho-emotional stress factors was regarded as the absence of a sign, a combination of medium and high levels as a presence. Results. The prevalence of ischemic heart disease in the open population (on the model of Tyumen) according to strict epidemiological criteria in men aged 4554 years was 8.2%, at the age of 5564 years 19.2%, a predominance of painless form of ischemic heart disease was revealed. According to the levels of factors of psychoemotional stress in mature men, mainly the average level of depression and life exhaustion, a high level of hostility were established. In men of an open population (on the model of Tyumen), depending on the psychoemotional stress, a high risk of developing a certain coronary heart disease was established in the age categories 4554 and 5564 years old in the presence of depression, at the age of 5564 years in the presence of hostility or life exhaustion. Conclusion. Consequently, the data obtained indicate the importance of further studying the factors of psychoemotional stress in men of mature age in Siberian populations, their relationships with conventional risk factors for coronary artery disease, as well as the advisability of preventive measures aimed at weakening the influence of not only conventional risk factors, but also factors of psycho-emotional stress. among the Russian population.

scholarly journals Evaluation of Ischemic Heart Disease in the Young Population of Georgia

2021 ◽  
Vol 17 (18) ◽  
Author(s):  
Gogishvili Giorgi
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Young People ◽  
Ischemic Heart Disease ◽  
Night Shift ◽  
Young Patients ◽  
Female Gender ◽  
Ischemic Heart ◽  
Control Group ◽  
Ischemic Disease

Objective: Study of risk factors (RF) for ischemic heart disease (IHD) in young people is a significant problem in cardiology. Aims: Study and prognosis of ischemic heart disease in Georgian population under 45 years of age. Methods: The study included 107 young patients with coronary heart disease (from 18 to 44 years old), who were treated in the cardiology department of the St. John the Merciful Private Clinic. The average age was (34.68 ± 6.2) years. The control group consisted of 199 healthy volunteers without cardiovascular diseases at the age from 18 to 44 years, the average age was (35.9 ± 5.2) years. In all patients, traditional risk factors were assessed. Results: Regression analysis has shown that it increases the risk of ischemic heart disease: living in the city - OR=6.90(95%CI:1.28-37.18); sleep disturbance - OR=45.62(95%CI:3.52-590.64); obesity -OR=24.56(95%CI:4.14-145.66); hypertension - OR=40.76(95%CI:8.07-205.92); excess intake of saturated fats - OR=79.94(95%CI:10.93-584.43); night shift - OR=39.01(95%CI:3.75-405.75); early detection of ischemic disease in grade I-II relatives - OR=44.22(95%CI:8.07-242.17); decrease - female gender - OR=0.14 (95%CI:0.03-0.70) and married - OR=0.01(95%CI:0.00-0.08); Conclusion: The ability to predict the risk of developing IHD in young people on the basis of traditional RFs, most of which are modifiable, as well as the study of "new" RFs opens up new perspectives in the formation of a strategic approach to the management of young patients in the presence of high risk.

Abstract 1690: Pre-Beta HDL and Lecithin:Cholesterol Acyltransferase Levels Are Strong Positive Diagnostic Risk Markers for Ischemic Heart Disease in Subjects with Both High and Low HDL-C Levels in the Copenhagen City Heart Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Amar A Sethi ◽  
Maureen Sampson ◽  
Russel Warnick ◽  
Boerge G Nordestgaard ◽  
Anne Tybjaerg-Hansen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Characteristic Curve ◽  
Ischemic Heart ◽  
Lipid Lowering ◽  
Lcat Activity ◽  
Lecithin:Cholesterol Acyltransferase ◽  
Low Hdl ◽  
Conventional Risk Factors

Objective: We hypothesize that patients with high HDL-C levels and Ischemic Heart Disease (IHD) may have dysfunctional HDL or unrecognized non-conventional risk factors. Methods: Subjects with IHD and either high HDL-C (n = 53; women:≥ 73.5mg/dL; men: ≥ 61.9mg/dL) or low HDL-C (n = 42; women: ≤ 38.7mg/dL; men: ≤ 34.1mg/dL) were compared with subjects without IHD and matched HDL-C levels (n = 110). All subjects had normal LDL-C (< 160mg/dL) and triglyceride levels (< 150mg/dL) and none were treated with lipid-lowering medications. Pre-beta HDL and Phospholipid Transfer Protein (PLTP) levels were measured using commercial kits and Lecithin:Cholesterol Acyltransferase (LCAT) activity, using a proteoliposome cholesterol esterification assay. Results: Pre-beta HDL levels were 2–3 fold higher in subjects with IHD in the high (p < 0.0001) and low HDL-C (p = 0.001) groups. Interestingly, low LCAT activity was found in the same subjects with IHD and high (p = 0.002) or low (p = 0.03) HDL-C. Furthermore, higher PLTP levels were observed in the group with high HDL-C and IHD when compared to individuals without disease (p < 0.0001). Receiver operating characteristic curve for pre-beta HDL in the high HDL-C groups yielded an area under curve of 0.71 for predicting IHD, which increased to 0.92 when LCAT values were included. Similar results were obtained for the low HDL-C groups. A strong inverse correlation between LCAT activity and pre-beta HDL-C ( r 2 = 0.30, p < 0.0001), which was especially strong in the low HDL-C group ( r 2 = 0.56, p < 0.0001) was observed. Individuals with high HDL-C and IHD had approximately 15% more apoA-I (p = 0.001) and apoA-II (p = 0.002) and nearly 10% more phospholipid (p = 0.007) than subjects with similar HDL-C and no IHD. Likewise, the group with low HDL-C had 30% more apoE (p = 0.035) and approximately 10% more phospholipid (p = 0.047) than the group with similar HDL-C levels and no IHD. Conclusions: IHD was associated with high pre-beta HDL and low LCAT levels. Measuring both gave correct classification in 92% of cases with IHD, thus making pre-beta HDL and LCAT activity a powerful diagnostic tool for IHD, particularly in commonly found patients wtih isolated low HDL-C levels with low to intermediate risk of IHD based on conventional risk factors.

scholarly journals RISK FACTORS PROFILE FOR MYOCARDIAL INFARCTION: FOCUS AT A YOUNG AGE

2021 ◽  
pp. 160-166
Author(s):  
I.A. Novikova ◽  
◽  
O.V. Khlynova ◽  
L.A. Nekrutenko ◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Age Groups ◽  
Young Patients ◽  
Young Age ◽  
Ischemic Heart ◽  
Cardiac Infarction ◽  
Regional Center ◽  
Male Sex

The paper focuses on examining peculiarities of risk factors causing cardiac infarction at a young age. Although car- diac infarction primarily occurs among patients older than 45, its frequency at a young age has been growing recently. Risk factors that cause cardiac infarction at a young and old age are quite different. Examining risk factors profiles in different age groups provides wider opportunities for implementing primary and secondary prevention strategies aimed at reducing frequency and negative outcomes of ischemic heart disease.108 patients aged from 18 to 45 and 35 patients aged from 60 to 75 took part in the research; they all had confirmed cardiac infarction with or without rise in ST segment and were treated in a regional center for cardiovascular pathology treatment in a period from January 01, 2017 to January 01, 2019. Basic risk factors of cardiac infarction were assessed when a patient was admitted to a clinic for treatment. The research results indicate high prevalence of risk factors that could cause ischemic heart disease among young pa- tients. 92.2 % young patients have dyslipidemia, 70.2 % smoke, 68.5 have low physical activity, 68.2 % suffer from over- weight and obesity, 58.8 % have arterial hypertension, 7.4 % suffer from type II pancreatic diabetes, and disorders in toler- ance to carbohydrates was reveled in 15.7 % cases. Such factors as male sex (85.2 vs. 37.1 %, р=0,000), smoking (70.2 vs. 20.6 %, р=0.000) and burdened heredity as per early ischemic heart disease occurrence (54.6 vs. 16.0 %, р=0.001) were significantly more frequent among young patients than among older ones. Data obtained via the present research allowed creating risk factors profile for cardiac infarction associated with car- diac infarction occurrence at a young age; this profile included such factors as male sex, early ischemic heart disease occur- rence in family history, and smoking

scholarly journals Selected risk factors for ischemic heart disease and the success of treatment in patients with STEMI myocardial infarction treated with percutaneous coronary

2020 ◽  
Vol 14 (2) ◽  
pp. 1-8
Author(s):  
Piotr Jerzy Gurowiec
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Acute Coronary Syndromes ◽  
Ischemic Heart ◽  
Coronary Syndrome ◽  
Percutaneous Coronary ◽  
Coronary Syndromes ◽  
Success Of Treatment

Background: Coronary heart disease is one of the most common causes of hospitalization and premature deaths in Europe. ST segment elevation myocardial infarction (STEMI) has been a clinical problem for many years, particularly in the aspect of choosing the optimal treatment method. The success of treatment is determined by many factors, including: risk factors for ischemic heart disease, time between onset of symptoms and initiation of treatment, number and degree of coronary stenosis, and many more. Aim of the study: The aim of the study was to identify risk factors for ischemic heart disease affecting the success of STEMI patients treated with percutaneous coronary intervention (PCI). Material and method: The applied research method was a retrospective analysis of medical records of patients treated in the Department of Acute Coronary Syndromes of St Hedvig Provincial Hospital No. 2 in Rzeszow in 2009-2014. The research tool used in this paper was the author's questionnaire. A retrospective study included a total of 508 patients with STEMI myocardial infarction treated in the Department of Acute Coronary Syndromes (ACS) in 2009-2013. The inclusion criteria were the complete and clear files of patient treatment in the ACS department in 2009-2013 due to acute coronary syndrome treated invasively by the PCI method. Results: Hypertension dominated in the study group of patients - 334 subjects (65.7%). The most commonly found risk factors for ischemic heart disease were: dyslipidemia - 176 subjects (34.6%) and smoking - 163 (32.1%). This paper presents the results of the analysis of the success of treatment in relation to risk factors for ischemic heart disease. There was a statistically significant relation of hypertension with successful treatment. The success of treatment in the group of patients diagnosed with hypertension was p = 0.0425. More cases in which treatment was unsuccessful were observed in the group of patients who had no previous treatment for lipid disorders (20.2% vs 4.0%) (p = 0.0000). Significantly more cases of treatment failure were found among people who denied smoking (17.4% vs 8.6%). P value = 0.0087. Conclusions: Among the analyzed behavioral and somatic risk factors for failure in patients subjected to treatment were: untreated hypertension, hyperlipidemia and a negative history of cigarette smoking

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