scholarly journals Drug utilization pattern and selected biochemical parameters in pre- and post-hemodialysis state in the end stage renal disease patients: a cross sectional study at a tertiary care hospital

2019 ◽  
Vol 8 (9) ◽  
pp. 2074
Author(s):  
S. P. Gokulraj ◽  
Surendra Kumar Bouddh ◽  
J. Rajesh
Keyword(s):  
Serum Albumin ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Significant Difference ◽  
Blood Haemoglobin ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Background: Chronic kidney disease can progress to end-stage kidney failure (ESRD), which is fatal without artificial filtering (dialysis) or a kidney transplant.Methods: The ESRD patients of either gender age >18 years who were diagnosed by nephrologist as ESRD and are on haemodialysis regularly included for the study.Results: The blood urea, serum creatinine, phosphorous, potassium levels were reduced significantly in post – haemodialysis condition, but, there was not much weight reduction after haemodialysis. Serum albumin, serum sodium and blood haemoglobin levels were almost unchanged in post – haemodialysis state. There was no significant difference between the pre and post haemodialysis parameters- serum Na+ serum albumin and blood hemoglobulin. Out of 75 ESRD patients, almost all patients 74 (98.7%) prescribed tablet Livogen, 73 (97.3%) patients given Inj. EPO, 55 (73.3%) tab Nicardia, 54 (76%) tab Sodamint, 43 (57.3%) capsule Alpha D3, 40 (53.3%) tab Shelcal. While between 12 (16%) to 20 (26%) patients prescribed tab Nodosis, tab Metoprolol, tab Febuget, tab Ecosprin, and tab Rantac. Only 1 (1.3%) to 9 (12%) patients received tablet Augmentin, tab Arkamine, tab Carvedilol, tab Para 500, tab Atorvas, Human mixtard, tab Calcicard, tab Minipress XL, tab Dytor, and tab Clopilet.Conclusions: The available two models of treatment, i.e., haemodialysis and poly pharmacy at hospital setup to face the challenges associated with the ESRD, and even outcome after application of both these two models of therapies did not provide optimal normal healthy life status to ESRD patients.

scholarly journals Acute Intradialytic Complications in End Stage Renal Disease on Maintenance Hemodialysis

2012 ◽  
Vol 52 (187) ◽  
Author(s):  
R K Agrawal ◽  
S Khakurel ◽  
R Hada ◽  
D Shrestha ◽  
A Baral
Keyword(s):  
Renal Failure ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Maintenance Hemodialysis ◽  
Care Hospital ◽  
Cross Sectional ◽  
Stage Renal Disease ◽  
End Stage

Introduction: Hemodialysis is the preferred method of treatment for Nepalese patients with End Stage Renal Disease. Despite the technological advances and better understanding of physiology associated with hemodialysis, a number of complications are known to be associated with hemodialysis. This study was undertaken to study the frequency of acute intradialytic complications in patients undergoing hemodialysis. Methods: A cross-sectional study was conducted at Nephrology unit of a tertiary care hospital from 15 June, 2007 to 15 December, 2007. A total of 28 patients were included in the study. Patients with acute renal failure and acute on chronic renal failure were excluded from the study. Results: Total sessions of hemodialysis during the period were 1455. Hypotensive episode were 66 (4.5%) and was the commonest complication and followed by hypertensive episodes were 58 (3.8%). Other problems encountered were transfusion reactions were 23 episodes (1.5%), rigors not related to transfusions were 13 episodes (0.8%), nausea/vomiting were 20 episodes (1.4%), muscle cramps were 12 episodes (0.8%), hypoglycemia were 6 episodes 5(0.4%). Conclusions: The frequency of intradialytic complications is low and many of them are not life threatening. Keywords: complications; end stage renal disease; hemodialysis; hypertension; hypotension.

scholarly journals Outcome of Cuffed Tunneled Dialysis Catheters for Hemodialysis Patients at a Tertiary Care Hospital: A Descriptive Cross-sectional Study

2020 ◽  
Vol 58 (226) ◽  
Author(s):  
Kajan Raj Shrestha ◽  
Dinesh Gurung ◽  
Uttam Krishna Shrestha
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Severe Bleeding ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Stage Renal Disease ◽  
End Stage

Introduction: Arteriovenous fistula is the most common vascular access for patients requiringhemodialysis, but it is not always possible or practical hence cuffed tunneled dialysis cathetercomes into play. The aim of the study was to determine the outcome of cuffed tunneled dialysiscatheter used for hemodialysis at a teaching hospital. Methods: A descriptive cross-sectional study was conducted between January 2014 and December2019 on 103 chronic dialysis patients with end-stage renal disease presenting to a tertiary carehospital. Ethical approval was received from the institutional review board (2/(6-11) E2/076/77).Whole sampling was done. Data entry and analysis were done in Microsoft Excel 10. Results: The study included 103 patients with 117 cuffed tunneled dialysis catheters placed forhemodialysis. On assessing the outcome of the catheters, the primary and secondary patencyrates of the catheters were 5.85±4.87 and 1.21±3.77 months. Thirty-one (30.1%) patients requiredone intervention, and 11 (10.68%) catheters required 3 or more interventions to maintain patency.Eighteen (17.48%) patients presented with catheter dysfunction while in 11 (10.68%) cases, thecatheter was kinked or malpositioned at the notch. In one patient, procedure was abandoned dueto severe bleeding and in 2 (1.94%) patients dialysis catheters could not be negotiated into the rightatrium and left in brachiocephalic junction. Conclusions: Cuffed tunneled dialysis catheter is effective for maintenance hemodialysis in patientswith the end-stage renal disease if used with proper care during dialysis even in our setup. Theresults and outcomes of the procedure are at par with standards.

scholarly journals Diabetic nephropathy as a cause of end-stage renal disease in Egypt: a six-year study

2004 ◽  
Vol 10 (4-5) ◽  
pp. 620-626 ◽  
Author(s):  
A. Afifi ◽  
M. El Setouhy ◽  
M. El Sharkawy ◽  
M. Ali ◽  
H. Ahmed ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Large Scale ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

The prevalence of diabetic nephropathy as a cause of end-stage renal disease [ESRD] in Egypt has been examined in small cross-sectional studies, with conflicting results. The need for a large-scale study prompted us to perform this 6-year multiple cross-sectional study. A sample of ESRD patients enrolled in the Egyptian renal data system was evaluated during the period 1996-2001 for the prevalence of diabetic nephropathy. Prevalence gradually increased from 8.9% in 1996, to 14.5% in 2001. The mean age of patients with diabetic nephropathy was significantly higher than that of patients with ESRD from other causes. Mortality was also significantly higher in diabetic patients with ESRD

scholarly journals Bone mineral density in Palestinian patients with end-stage renal disease and the related clinical and biochemical factors: Cross-sectional study

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241201
Author(s):  
Zaher Nazzal ◽  
Shahd Khader ◽  
Hiba Zawyani ◽  
Mazen Abdallah ◽  
Osama Sawalmeh ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
End Stage Renal Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Introduction End-Stage Renal Disease (ESRD) is the ultimate result of chronic kidney disease (CKD). In Palestine, the prevalence of ESRD was 240.3 PMP which is comparable with the nearby countries. Accelerated bone loss among ESRD patients is attributed to abnormal bone turn over that leads to osteoporosis and osteopenia. The risk of fractures is increased four-fold in men and women on hemodialysis, which explains the importance of assessing the bone mineral density among these population. The goals of this study were to find the prevalence of osteoporosis in ESRD patients as determined by bone mineral density (BMD) at different sites and to determine whether BMD correlates with many other clinical parameters. Methods A cross-sectional study of 194 ESRD patients were recruited from the dialysis unit in An-Najah National University Hospital, Nablus, Palestine. The patients were on regular hemodialysis or peritoneal dialysis. BMD was measured at the lumbar spine and the hip using the dual-energy X-Ray absorptiometry (DEXA) and the value is expressed as T-score. The data were analyzed using SPSS, version 26. The relationship between BMD and the clinical and biochemical parameters among the ESRD patients was assessed. Results We found that 42.8% of ESRD patient had osteoporosis and 40.2% had osteopenia. There were significantly higher proportions of osteoporosis and osteopenia among patients >60 years of age (p<0.005). Patients with osteoporosis and osteopenia had significantly higher serum levels of PTH (792.9 and 469.7) (p<0.05). BMD decreases as the duration of dialysis (39.0 months Vs. 56.8 months), (p<0.05). We found no significant difference between patients on hemodialysis or peritoneal dialysis. Conclusion This study showed that Palestinian patients with ESRD have low BMD at the hip and spine. The observed high serum level of PTH was associated with low BMD. Those patients should be closely monitored especially those with more than one risk factor. Moreover, more attention should be paid for these category of patients to decrease the incidence of falling down and the resulting fractures that might lead to mortality and morbidity.

ASSOCIATION OF HEMATOCRIT-PLATELET INDEX AND HEMATOCRIT SHIFT WITH WARNING SIGNS AND HOSPITAL STAY IN DENGUE PATIENTS AT A TERTIARY CARE HOSPITAL

2021 ◽  
Vol 71 (Suppl-1) ◽  
pp. S277-82
Author(s):  
Muhammad Fahd Bin Haider ◽  
Humaira Zafar ◽  
Syed Zubair Hussain Shah ◽  
Mobaila Akram ◽  
Kamran Malik ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Warning Signs ◽  
Care Hospital ◽  
Cross Sectional ◽  
Duration Of Stay ◽  
Platelet Indices ◽  
Significant Difference ◽  
Duration Of Hospitalization

Objective: To determine the relationship between hematocrit, platelet count, warning signs and duration ofhospitalization in indoor dengue patients. Study Design: Analytical, cross sectional study. Place and Duration of Study: Department of Medicine, Pakistan Air Force Hospital Islamabad and Departmentof Biochemistry and Molecular Biology, AM College, Rawalpindi, from Sep 2019 to Jun 2020. Methodology: A total of 100 indoor patients were recruited using convenience sampling. Their platelets, hema-tocrit and warning signs were recorded on arrival in the hospital. First two parameters were checked every day for the whole duration of stay in the hospital. The WHO standard treatment of dengue was given to the patients. Patient were divided into two groups based upon duration of hospitalization using cut-off of 3 days. Linear regression was used to analyze association of hematocrit-platelet index and hematocrit shift with presence of one or more warning signs and duration of hospital stay. Results: There was statistically significant difference in 3rd day Hematocrit Platelet Indices of patients with short and long hospital stay (p=0.003). 3rd day Hematocrit-platelet indices of patients with and without warning signs also showed statistically significant difference when compared with eachother (p=0.0001). It was stronger than Hematocrit Shift (p=0.82) and platelets considered alone. Conclusion: Day 3 Hematocrit Platelet Indexis more strongly associated with warning signs and duration of stay rather than hematocrit alone. It means both need to be taken into account while monitoring dengue patients. Hematocrit platelet index for severity and duration of hospitalization while Hematocrit shift for fluid therapy.

scholarly journals Psychiatric co morbidities in ESRD Patients Recently Placed on Haemodialysis : A Prospective Observational Study from a Tertiary Care Hospital

2016 ◽  
Vol 4 (1) ◽  
pp. 28-32
Author(s):  
Sarwar Iqbal ◽  
Umme Salma Talukder ◽  
Tufayel Ahmed Chowdhury ◽  
Md Mostarshid Billah ◽  
Mehruba Alam Anana ◽  
...  
Keyword(s):  
Acute Stress ◽  
Tertiary Care ◽  
Adjustment Disorder ◽  
Cross Sectional Study ◽  
Maintenance Hemodialysis ◽  
Care Hospital ◽  
Newly Diagnosed ◽  
Cross Sectional ◽  
Co Morbidity ◽  
Esrd Patients

Background: Psychiatric co-morbidity especially anxiety and depression are common in patients who are recently placed on dialysis, but very little research has been done on this subject. Mental illness results in increased non-compliance in accepting dialysis and this results in increased mortality in End Stage Renal Disease (ESRD) patients.Methodology: This cross- sectional study was done on ESRD patients newly diagnosed and initiated hemodialysis in the department of Nephrology of Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh with informed written consent and maintaining privacy. Diagnostic and Statistical Manual of Mental Disorders (DSM-V) was used for diagnosis of psychiatric disorders. Patients on maintenance hemodialysis for more than 1 month and patients on Chronic Ambulatory Peritoneal Dialysis were excluded in this study.Results: There were total 83 patients out of whom there were 50 (62.2%) males and 33(39.38%) females. Mean age of study patients was 56.8±9.96 years. Bulk of the patients was clinically depressed (68.7%), followed by anxiety disorder (13.3%) rest were acute stress disorder, adjustment disorder and one case of psychosis. 8.4% participants denied any symptoms.Conclusion: Significant psychiatric co-morbidities developed in newly diagnosed ESRD subjects when they were prescribed hemodialysis. This study showed majority of the patients with renal failure on initiating hemodialysis who develop different psychiatric problems that need prompt diagnosis and appropriate treatment. These interventions will improve the quality of life of ESRD patientsBangladesh Crit Care J March 2016; 4 (1): 28-32

scholarly journals FVC, FEV1, FEV1/FVC ratio and FEF25-75% in End-stage renal disease (ESRD) patients undergoing maintenance haemodialysis

2013 ◽  
Vol 8 (1) ◽  
pp. 33-36
Author(s):  
Farhana Hoque ◽  
Shelina Begum ◽  
Abdul Latif ◽  
Afroza Begum ◽  
Shamima Sultana
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Cross Sectional Study ◽  
Pulmonary Complications ◽  
Cross Sectional ◽  
Maintenance Haemodialysis ◽  
Lung Functions ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Background: End-stage renal disease causes multiple pulmonary complications and lung functions are decreased in ESRD patients undergoing maintenance haemodialysis. Objectives: To observe FVC, FEV1, FEV1/FVC ratio and FEF25-75% in ESRD patients undergoing maintenance haemodialysis to evaluate their lung functions status. Methods: This cross sectional study was carried out in the Department of Physiology, BSMMU, Dhaka, from July 2011 to June 2012. For this, 30 ESRD patients aged 25-55 years undergoing maintenance haemodialysis with less than 1 year duration were studied and 30 age, sex matched healthy subjects were taken as control. Patients were selected from the Nephrology department of BSMMU, Dhaka. FVC, FEV1, FEV1/FVC ratio and FEF25-75% were measured by a Digital Spirometer. For statistical analysis Independent Sample‘t’ test and One way ANOVA test were performed as applicable. Results: The mean percentage of predicted values of FVC, FEV1 and FEF25-75% were significantly lower in patients except FEV1/FVC ratio which was almost similar to control. 63.33% patients had restrictive and 36.67% patients had both restrictive and obstructive (small airway obstruction) feature. Conclusion: This study concluded that some pulmonary functions were markedly reduced in ESRD patients undergoing maintenance haemodialysis. In addition most of the patients were suffering from restrictive and some of them were affected with both obstructive and restrictive type of pulmonary disorders. DOI: http://dx.doi.org/10.3329/jbsp.v8i1.16645 J Bangladesh Soc Physiol. 2013, June; 8(1): 33-36

scholarly journals Myeloperoxidase: indicator of cardiovascular disease in chronic kidney disease patients of tertiary care hospital of Karachi

2021 ◽  
pp. 1-11
Author(s):  
Sabeela Noor ◽  
Faiza Alam ◽  
Fasiha Fatima ◽  
Shehryar Orakzai ◽  
Admin
Keyword(s):  
Inflammatory Marker ◽  
Tertiary Care ◽  
Positive Association ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Significant Difference ◽  
Hs Crp ◽  
Group B

Objective: To estimate the levels of myeloperoxidase (MPO) in various stages of CKD and correlate them with inflammatory marker (CRP) and lipid profile.Methods: This cross-sectional study was conducted in the Biochemistry Department, Basic Medical Sciences Institute, Jinnah Post Graduate Medical Centre (J.P.M.C.) with collaboration of the Nephrology Department of J.P.M.C from January 2013 to September 2014. 150 participant were allocated into Group A: healthy subjects (GFR >90 ml/min/1.73m2, n=66) and Group B: CKD patients (GFR<90 ml/min/1.73m2, n=84). Serum cholesterol, triglycerides, HDL-c, CRP and myeloperoxidase were estimated. Data was presented in Mean±SD. Comparison of means within groups was performed by Mann-Whitney U test, where p-values <0.05 were considered significant.Results: With mean age of 55.64 ± 5.63 years, weight and BMI, TG, VLDL C-reactive proteins and MPO was significantly higher in in group B (p<0.001), however cholesterol and LDL-C showed no significant difference between the groups.). CRP and MPO levels demonstrated an increasing trend with decreasing GFR. Serum myeloperoxidase was found to have a significantly positive association with C-reactive protein (r = 0.710, p<0.01), cholesterol (r = 0.240, p <0.01), triglycerides (r = 0.509, p <0.01), LDL- cholesterol (r = 0.226, p <0.01) and VLDL-cholesterol (r = 0.494, p <0.01), while negative correlation with HDL- cholesterol (r= -0.370, p <0.01).Conclusion: Myeloperoxidase concentration and its relationship with lipid profile and hs-CRP in CKD patients prompts a mechanistic relationship between cardiovascular burdens in CKD patients. How ever detailed studies are required for further exploration of this link. Continuous...

scholarly journals Rational and irrational use of intra-venous infusions: a cross-sectional study among patients of a tertiary care hospital

2019 ◽  
Vol 6 (4) ◽  
pp. 1286
Author(s):  
Amber G. ◽  
Muhammad J. Khan ◽  
Amina K. ◽  
Warda G. ◽  
Murtaza G. ◽  
...  
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Age Groups ◽  
Female Gender ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Adult Age ◽  
Significant Difference

Background: Intravenous infusions (IV) are a rapid mean of administering drugs. Hospitals are commonplace for their use, but at the same time they have many serious potential complications. This study aims to know the justified use of intravenous infusion among patients of a tertiary care hospital and awareness about its use.Methods: It was a cross-sectional study in which 249 subjects were conveniently studied. Nil per oral, severity of dehydration, vomiting, and diarrhoea was used as confirmatory criteria for using IV Infusions. Questionnaire with verbal consent was used to collect the data. Descriptive statistical analysis was applied to analyse the data and presented as means, frequencies and percentages in the form of tables and figure.Results: Total n249 (100%) subjects, n68 (27.3%) males and n181 (72.7%) females with average age was 24.05±14.21 years participated. Among n116 (46.6%) irrational users, females n76 (30.5%) were more then males n40 (16.1) with significant difference, p= 0.018. However, no significant difference was found among other variables (age groups, profession, education, awareness and rational or irrational use of IV infusion). Majority n249, n204 (81.9%) were not aware of the IV infusion medication error and doctors were most common unjustified prescribers of IV infusion, n105 (90.5%).Conclusions: The study concluded with the more prevalent irrational IV infusion use in our setup. Doctors appeared the dominant prescriber of irrational IV infusion. This statement is astonishing and must not be overlooked. Female gender, adult age, under-grade patients and students are more exposed to irrational IV infusion.

scholarly journals Assessment of Quality of Life among Children with End-Stage Renal Disease: A Cross-Sectional Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Arwa M. El Shafei ◽  
Ibrahim Soliman Hegazy ◽  
Fatina Ibrahim Fadel ◽  
Eman M. Nagy
Keyword(s):  
Quality Of Life ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
Stage Renal Disease ◽  
End Stage

Background. Measuring health-related quality of life is considered an important outcome indicator in evaluating health-care interventions and treatments and in understanding the burden of diseases.Objectives. This study aimed at assessing quality of life among children with end-stage renal disease, either undergoing hemodialysis or had renal transplantation therapy and comparing it with healthy controls.Methods. A cross-sectional study was conducted between December 2016 and May 2017 in Abo El-Reesh Pediatric Hospital using parent/child reports of generic module for QoL assessment: PedsQLTMInventory version 4 for both cases and controls. Disease-specific module: PedsQLTMESRD version 3 was used for ESRD cases. 55 ESRD cases and 86 controls were enrolled in the study.Results. Statistically significant difference between ESRD cases and controls regarding all aspects of QoL was found; total QoL mean score was 58.4 ± 15.3 and 86.8 ± 10 among cases and controls, respectively. All individual QoL domains were significantly worse in ESRD cases. Transplantation group had better Spearman’s correlation between child and parents’ scores which showed significant positive moderate correlation.Conclusions. ESRD and its treatment modalities are affecting negatively all aspects of quality of life; incorporating QoL assessment and management is highly recommended.

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