scholarly journals A randomised, open label comparative study of hydroxychloroquine with betamethasone oral mini pulse in the management of patients with alopecia areata

2021 ◽  
Vol 10 (2) ◽  
pp. 187
Author(s):  
Jeyasudha Jambusayee ◽  
Kulur Mukhyaprana Sudha
Keyword(s):  
Alopecia Areata ◽  
Life Quality ◽  
Autoimmune Disorder ◽  
Study Groups ◽  
Pulse Therapy ◽  
The Body ◽  
Control Group ◽  
Study Group ◽  
Open Label ◽  
Significant Difference

Background: Alopecia areata is an autoimmune disorder causing patchy hair loss on scalp and other parts of the body and leading to poor self-esteem and anxiety in patients. Treatment with topical or systemic drugs like steroids or other immunosuppressants is associated with adverse effects. Hydroxychloroquine is an antimalarial drug, with T cell modulating function. This study was undertaken to assess the safety, efficacy and tolerability of Hydroxychloroquine in Alopecia areata compared to betamethasone oral mini pulse (OMP) therapy. Methods: 60 patients with alopecia areata were randomized into two groups of 30 each. Control group received tab. betamethasone 5 mg/day on two consecutive days of week for 12 weeks and Study group received tab. hydroxychloroquine 200 mg/day for 12 weeks. They were followed-up for further 12 weeks. Scale of alopecia tool, dermatology life quality index and global assessment at baseline, 12 weeks and 24 weeks were used to assess the outcome.Results: 94 patients were screened and 60 patients were included. All patients completed the study. At the end of 12 weeks, there was a statistically significant reduction in SALT and DLQI scores in both control and study groups. But at the end of 24 weeks, the study group showed an increase in the scores. Relapses were more in the study group. No significant difference in the incidence of adverse events was noted between the two groups.Conclusions: Hydroxychloroquine 200 mg/day is less efficacious in the management of alopecia areata in comparison to betamethasone oral mini pulse therapy.

scholarly journals Keefektifan ekstra putih telur terhadap peningkatan albumin dan penurunan IL-1β pada pasien tuberkulosis dengan hipoalbuminemia

2014 ◽  
Vol 10 (3) ◽  
pp. 111
Author(s):  
Agus Prastowo ◽  
Wiryatun Lestariana ◽  
Siti Nurdjanah ◽  
Retno Sutomo
Keyword(s):  
High Energy ◽  
Egg White ◽  
The Body ◽  
World Health ◽  
Bivariate Analysis ◽  
Control Group ◽  
Study Group ◽  
Research Results ◽  
Significant Difference ◽  
And Control

Background: Tuberculosis (TB) is world health problem which still needs attention. Recently, Indonesia ranks the third in TB prevalence after India and China. Research revealed that albumin decreases significantly in TB patients, due to lack of nutritious intakes such as low-calorie intake, anorexia, increased catabolism, enteropathy and acute protein reaction. Low albumin was associated with increased IL-1β and cytokines inflammation in TB patient. Albumin had a very important role in the body and white egg known as a good quality source of protein.Objective: To assess the effect of white egg supplementation in TB patient towards the level of albumin and the level of IL-1β.Method: A single-blind randomized controlled trial was conducted with 75 patient selected for the study and divided to 37 patient as the study group and 38 as a control group. Both groups received high energy high protein diet, while the study group received, additionally, an oral egg white-based on formula calculation Baxter for 14 days. Control group received, additionally, an extra soybean curd and mungbean powder. Albumin and IL-1β were checked before and after the intervention. Data is analyzed by using Mann-Whitney.Results: Research results show that average albumin pre-intervention in the study group was 2.82 g/dL and control group was 2.85 g/dL. Average albumin difference in the study group was 3.47 g/dL and control group was 2.81 g/dL. Bivariate analysis results show significant of increasing albumin between study group and control group (p<0.05). Research results show average IL-1β pre-intervention difference in study group (0.9 pg/mL) and control group (0.67 pg/mL). The average IL-1β difference in the study group was -0.39 pg/mL and control group was 0.76 pg/mL. Bivariate analysis results show a significant difference of IL-1β depletion between study group and control group (p<0.05).Conclusion: Egg white increase albumin level and IL-1β depletion in tuberculosis patients effectively.

scholarly journals Deficits in central auditory processing among migraine patients

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Somia Tawfik ◽  
Randa Amin ◽  
Sahar Ibrahim ◽  
Tayseer Taha Abdel Rahman
Keyword(s):  
Auditory Processing ◽  
Study Groups ◽  
Statistical Correlation ◽  
Control Group ◽  
Study Group ◽  
Central Auditory Processing ◽  
Test Results ◽  
Memory Tests ◽  
Significant Difference ◽  
Noise Test

Abstract Background Migraine is a neurological disease associated with abnormal excitability in visual, somatosensory, and motor cortex. This study aimed to verify and compare auditory processing performance in migraine patients with and without dizziness and healthy controls. Results Sixty subjects were divided into 3 groups: control group, twenty normal healthy subjects, and study group I (twenty subjects diagnosed with migraine) and study group II (twenty subjects diagnosed with vestibular migraine). They were evaluated using the Central Auditory Processing Questionnaire for adults, tympanometry, pure tone audiometry, Psychophysical Central Auditory Tests, including Arabic Speech Intelligibility in Noise Test for adults, Arabic Dichotic Digit Test [version II], Gap in Noise Test, Duration Pattern Test, and Arabic Memory Tests. No significant difference was found between the two study groups I and II, but the significant difference was found between the study groups and the control group in all central auditory test results. Statistically significant difference was found between the control group and study groups I and II regarding all memory tests. The highest percentage of abnormality was present in temporal resolution and selective auditory attention in both study groups. There was no significant statistical correlation between the number of attacks/month and central auditory test results. There was no significant statistical correlation between the frequency of attacks in VM patients and central auditory test results. Conclusions Patients with migraine and vestibular migraine had an inferior performance in all psychophysical central auditory tests when compared with control. Also, there was no significant difference between the 2 study groups regarding central auditory test results which may support that both migraine with and without dizziness have the same pathophysiology.

Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study

Dermatology ◽  
2018 ◽  
Vol 235 (2) ◽  
pp. 130-136 ◽  
Author(s):  
Nawaf Almutairi ◽  
Tarek M. Nour ◽  
Nasser Haji  Hussain
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Kinase Inhibitors ◽  
Autoimmune Disorder ◽  
Janus Kinase ◽  
Open Label ◽  
Janus Kinase Inhibitors ◽  
Hair Regrowth ◽  
Significant Difference

Background: Alopecia areata (AA) is a common autoimmune disorder characterized by patchy hair loss. There are many treatments available for AA. However, treatments of severe forms of AA are not satisfactory. Recently, oral Janus kinase (JAK) inhibitors were found to be effective for the treatment of severe AA variants. Objective: The aim of this work was to evaluate and compare the efficacy, side effects, and durability of two oral JAK inhibitor medications (ruxolitinib and tofacitinib) in the treatment of severe AA. Methods: This study included 75 patients with AA with more than 30% scalp hair loss, alopecia totalis, and alopecia universalis randomized into 2 groups. The first group (n = 38) received ruxolitinib 20 mg twice daily, and the second group (n = 37) received oral tofacitinib 5 mg twice daily. The treatment continued for 6 months followed by 3 months of follow-up off therapy. Efficacy of treatment was assessed by monitoring the change in the Severity of Alopecia Tool (SALT) score. Results: Both tofacitinib and ruxolitinib induced remarkable hair regrowth, with a mean change in SALT score of 93.8 ± 3.25 in the ruxolitinib group and 95.2 ± 2.69 in the tofacitinib group. However, the ruxolitinib group showed a shorter duration for initial hair regrowth. There was no statistically significant difference between the groups regarding hair regrowth at the end of the 6-month treatment and relapse rate at the end of the 3-month follow-up. Around two thirds of cases experienced relapse. Both drugs were well tolerated, with no reported serious adverse effects. Conclusion: Both ruxolitinib and tofacitinib could be considered effective and well-tolerated treatments for extensive AA.

scholarly journals A Placebo-Controlled Study on the Treatment of Metabolic Syndrome of Qi Stagnation and Dampness Obstruction Related to Atypical Antipsychotics with Traditional Chinese Medicine (TCM)

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Fengli Sun ◽  
Zhibin Ren ◽  
Yonghong Jiang ◽  
Xiangming Fang ◽  
Naixin Wang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Negative Symptoms ◽  
Glycosylated Hemoglobin ◽  
The Body ◽  
Control Group ◽  
Study Group ◽  
Hip Circumference ◽  
Significant Difference ◽  
Qi Stagnation

Backgroud. To observe the effects of Liuyu decoction on qi stagnation and dampness obstruction syndrome of metabolic syndrome related to atypical antipsychotics . Methods. 154 schizophrenics who met both the diagnostic criteria of metabolic syndrome and qi stagnation and dampness obstruction syndrome were randomly divided into 2 : 1 groups. The PANSS and Tess were assessed before treatment and at the end of first month, second month, and third month after treatment; blood pressure, weight, waist circumference, hip circumference, blood glucose, glycosylated hemoglobin, high-density lipoprotein, low-density lipoprotein, triglyceride, and cholesterol were also measured at the same four time points. On the basis of continuous antipsychotic treatment, the study group took Liuyu decoction, and the control group took placebo. Results. Of the 154 cases, 102 were in the study group and 52 in the control group. Before and after treatment, there was a slight increase but no significant difference in blood pressure, blood sugar, glycosylated hemoglobin, cholesterol, TG, DHL, and LHL in two groups (P>0.05) and also between the two groups (P>0.05). The body weight, waist circumference, hip circumference, and BMI in the study group decreased, while that in the control group increased from the dividing group to the end of study. At the end of the third month, there was a significant difference in the body weight, waist circumference, hip circumference, and BMI between the two groups (P<0.05). Before and after treatment, there was a significant difference in positive symptoms, negative symptoms, general symptoms, and PANSS in two groups, respectively (P<0.05). The negative symptoms, general symptoms, PANSS, and TESS in the study group were lighter than that in the control group after treatment. Conclusion. Liuyu decoction is not only beneficial to the treatment in body constitution of metabolic syndrome in qi stagnation and dampness obstruction but also beneficial to the improvement of such patients’ mental symptoms and side effects.

Evaluation Of Central Auditory Function In Migraine Patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Somia Tawfik ◽  
Tayseer Taha Abdel Rahman ◽  
Randa Mohammed Ameen ◽  
Sahar Ibrahim Abdel Ghany Tolba
Keyword(s):  
Auditory Processing ◽  
Study Groups ◽  
Vestibular Migraine ◽  
Control Group ◽  
Study Group ◽  
Test Duration ◽  
Central Auditory Processing ◽  
Group I ◽  
Significant Difference ◽  
Brainstem Response

Abstract Background Migraine is a neurological disease associated with abnormal excitability in visual, somatosensory and motor cortex. Previous researches reported abnormalities in the auditory brainstem response (ABR) and in vestibular functions. These results are an indicator of impending auditory malfunction in Migraine and disruption of central auditory processing mechanisms. Objectives This study aimed to assess and compare central auditory processing (CAP) performance in migraine patients with and without dizziness and healthy controls. Subjects and method Sixty subjects aged between18 and 60 years divided into 3 groups; control group (twenty normal healthy subjects), study group I (twenty subject diagnosed with migraine) and study group II (twenty subjects diagnosed with vestibular migraine). They were subjected to a headache sheet, central auditory processing questionnaire and Psychophysical central auditory tests: including Arabic Speech Intelligibility In Noise (SPIN) test for adults, Arabic Dichotic digit test, Gap In Noise (GIN) test, Duration pattern test and Arabic memory tests. Results Statistically significant difference was found between the 2 study groups and control group regarding right dichotic (p = 0.004),right and left duration pattern tests (p = 0.01) with highly statistically significant difference(p &lt; 0.001) Gap In Noise (GIN) test, left dichotic digit test, right and left speech in noise. But there was no statistically significant difference between the two study groups regarding all tests. Conclusions Patients with migraine and vestibular migraine had poor performance in all central auditory tests when compared with control this mean that migraine lead to impaired central auditory processing in adults. Also, there was no significant difference between the 2 study groups regarding central auditory test results which may support that both migraine with and without dizziness have the same pathophysiology.

scholarly journals Clinical Effect of Posterior Internal Fixation and Fusion in the Treatment of Thoracolumbar Fractures

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Tianhui Liu ◽  
Jianmin Cui
Keyword(s):  
Internal Fixation ◽  
Clinical Effect ◽  
The Body ◽  
Control Group ◽  
Study Group ◽  
Thoracolumbar Fractures ◽  
Significant Difference ◽  
Table Model ◽  
Random Number Table ◽  
And Control

Objective: To evaluate the clinical effect of posterior internal fixation and fusion in the treatment of thoracolumbar fractures. Methods: 36 patients with thoracolumbar fractures from January 2018 to December 2020 were selected and divided into study group and control group according to the random number table model. The control group was treated with anterior internal fixation, while the study group was treated with posterior internal fixation and fusion. The indexes of the two groups were compared and analyzed. Results: Compared with the operation related indexes of the two groups, the study group had more advantages (P< 0.05);The postoperative kyphosis Cobb angle, height of anterior and posterior vertebral body, wedge index of the two groups were better than those before operation (P< 0.05), and there was no significant difference between the two groups (P> 0.05);There was no significant difference between the two groups (P> 0.05). Conclusion: The clinical effect of posterior internal fixation and fusion in the treatment of thoracolumbar fractures is significant, and the body damage is slight, which is worthy of comprehensive promotion.

scholarly journals Relation of cytomegalovirus to alopecia areata: therapeutic trial with oral ganciclovire drug

2020 ◽  
Vol 7 (2) ◽  
pp. 12-19
Author(s):  
Wisam M. Kattoof ◽  
Ahmed A. Kawen
Keyword(s):  
Family History ◽  
Alopecia Areata ◽  
Positive Family History ◽  
Study Groups ◽  
The Body ◽  
Control Group ◽  
Therapeutic Trial ◽  
Cmv Infection ◽  
High Concentration ◽  
And Control

Alopecia areata (AA) is lost hair from a few or all regions of the body, for the most part from the scalp. Etiology and pathogenesis of alopecia areata being not totally comprehended, is accepted to be multifactorial in ancestry. Recently, studies suggested an association between alopecia and types of viruses, therefore we concerned to investigate the association between CMV infection and alopecia areata. This study included of 100 individuals (50 alopecia patients and 50 healthy). Mean age of study groups were 20.90 ± 11.07 and 22.64±12.29 years of cases and control group respectively. Mean of age onset of patients were 20.83 ± 10.0. Out of 50 patients 52{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47} were male, the rest were female. However, 1:1 of control group was male: female. 40{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47} of patients had a positive family history for this disease. Alopecia areata affected on scalp in 78{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47} of cases. All patients had a high concentration of CMV IgM. With treatment of oral ganciclovire drug, a decrease of anti-CMV IgM levels and an increase of CMV IgG levels were observed.

scholarly journals The effect of bilingualism on cognitive and auditory abilities in normally hearing adults

Revista CEFAC ◽  
2018 ◽  
Vol 20 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Geise Corrêa Ferreira ◽  
Enma Mariángel Ortiz Torres ◽  
Michele Vargas Garcia ◽  
Silvio José Lemos Vasconcellos ◽  
Natalia Schopf Frizzo ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Abilities ◽  
Study Groups ◽  
Brazilian Portuguese ◽  
Control Group ◽  
Study Group ◽  
Bilingual Speakers ◽  
Significant Difference ◽  
Mechanical Reasoning ◽  
Specific Cognitive Abilities

ABSTRACT Purpose: to evaluate and compare cognitive and auditory abilities in normally hearing monolingual and bilingual individuals. Methods: the sample consisted of 21 normally hearing individuals ranging in age between 18 and 25 years, divided into a control group of eight monolingual speakers of Brazilian Portuguese and a study group composed of 13 bilingual speakers of Brazilian Portuguese and German or Italian. The individuals underwent basic audiological assessments as well as assessments of cognitive and auditory figure-background abilities with the BPR-5 and SSW tests, respectively. Results: the assessment of cognitive abilities showed that bilinguals had a better performance for the general cognitive function, with a statistically significant difference, as well as for cognitive abilities of verbal, spatial and mechanical reasoning. Also, for auditory figure-background abilities, there was a statistically significant difference between the study groups, with bilinguals showing a better performance. Conclusions: based on the study groups, it was found that the bilingual subjects had a better performance of their general cognitive function, as compared with monolingual speakers, as well as in their specific cognitive abilities of verbal, spatial and mechanical reasoning, and in the auditory figure-background abilities.

scholarly journals SPATIAL PARAMETERS OF STATOGRAMS IN DIAGNOSING PATHOLOGIES OF THE HUMAN LOCOMOTOR SYSTEM

2020 ◽  
Vol 10 (3) ◽  
pp. 17-21
Author(s):  
Sergii Pavlov ◽  
Yurii Bezsmertnyi ◽  
Stanislav Iaremyn ◽  
Halyna Bezsmertna
Keyword(s):  
High Sensitivity ◽  
Study Groups ◽  
The Body ◽  
Projection Area ◽  
Control Group ◽  
Body Angle ◽  
Locomotor System ◽  
Double Support ◽  
Significant Difference ◽  
Spatial Parameters

The analysis of the spatial parameters of statograms in terms of the projection area of the common center of mass (CCM) in single and double support was performed, along with the magnitude of the total maximum area of the statogram and its relation to the area of the projection spot for each type of standing, and the area of the statogram according to the mathematical expectation. The high sensitivity of the spatial parameters of statograms is indicated by the values of the CCM spot plane in the case of single support, the ratio of the planes, and the angular asymmetry. The analysis of the parameters of statograms showed that for all types of standing volunteers of the control group, the area of the projection spot of the CCM was the smallest in both two-pronged standing, and in single support standing. In patients with osteochondrosis and with coxarthrosis (CA), the area of the spots was much larger, with a statistically significant difference observed in single support (p < 0.05). The ratio of the planes was statistically different between groups (р = 0.043): in the control group it was the maximum (0.38), which reflects the highest ability to maintain equilibrium, and the minimum (0.25) – in the group of patients with CA. An analysis of variance revealed a significant difference (p = 0.025) of asymmetry in body angle  between the study groups. The angle of the body rotation  in the case of single support is not statistically different in the study groups (p = 0.294), but this indicator can be considered as prognostic in terms of the diagnosis of pathology of the musculoskeletal system.

scholarly journals TL 18141 - Isolated gastrocnemius tightness

2019 ◽  
Vol 13 (Supl 1) ◽  
pp. 90S
Author(s):  
Kelly Cristina Stéfani ◽  
Leonardo Vinicius De Matos Moraes ◽  
Vinícius Quadros Borges ◽  
Gabriel Ferraz Ferreira
Keyword(s):  
Plantar Fasciitis ◽  
Plantar Flexion ◽  
Age Groups ◽  
The Body ◽  
Control Group ◽  
Study Group ◽  
Calcaneal Tendon ◽  
Significant Difference ◽  
The Mean ◽  
The Difference

Introduction: The objective of this study was to evaluate the difference in muscle strength between flexion and ankle extension to test the hypothesis that this predisposes to a dynamic equine and, thus, to evaluate this correlation with pain in the forefoot (metatarsalgias) and hindfoot (plantar fasciitis, tendinopathy of the tendon insertional and non-insertional calcaneus). Methods: In this prospective cohort study, 50 patients were consecutively diagnosed with forefoot pain (metatarsalgias) or pain in the hindfoot (plantar fasciitis, tendonopathy of the insertional and non-insertional calcaneal tendon), and 50 patients had no foot diseases. The body mass index (BMI) was evaluated, and IGT was evaluated through the Silfverskiöld test. The parameter of gastrocnemius contracture was considered in cases of limitation of ankle extension <10. The intervention was to measure flexion strength and ankle extension with a manual dynamometer, evaluating isometric contraction based on the method suggested by Kahn et al. Results: One hundred patients participated in the study, with 50 patients in the study group and 50 in the control group. The mean age was 63.42 years, and the mean BMI was 28.53 in the study group and 62.26 and 28.84 in the control group, with no difference in distribution between age groups (p = 0.634) and for BMI (p = 0.709). The difference was significant between the groups in relation to the Silfverskiöld test (p = 0.019), the ankle force variation in dynamometry (p <0.001) and normalized variation (p <0.001). In addition, a significant difference between groups was observed in the dynamometry of plantar flexion (p <0.001). Conclusion: The hypothesis of causes for sural triceps shortening considered as idiopathic are as follows. The difference in strength between the dorsiflexion musculature and the one that performs the plantar flexion, the delay in neuromuscular activation of the dorsiflexors, or even a combination of these two factors. We demonstrated the possibility of the evaluation of the force through a manual dynamometer that can be used in routine outpatient visits, which proved to be effective and reproducible.

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