Deficits in central auditory processing among migraine patients

Abstract Background Migraine is a neurological disease associated with abnormal excitability in visual, somatosensory, and motor cortex. This study aimed to verify and compare auditory processing performance in migraine patients with and without dizziness and healthy controls. Results Sixty subjects were divided into 3 groups: control group, twenty normal healthy subjects, and study group I (twenty subjects diagnosed with migraine) and study group II (twenty subjects diagnosed with vestibular migraine). They were evaluated using the Central Auditory Processing Questionnaire for adults, tympanometry, pure tone audiometry, Psychophysical Central Auditory Tests, including Arabic Speech Intelligibility in Noise Test for adults, Arabic Dichotic Digit Test [version II], Gap in Noise Test, Duration Pattern Test, and Arabic Memory Tests. No significant difference was found between the two study groups I and II, but the significant difference was found between the study groups and the control group in all central auditory test results. Statistically significant difference was found between the control group and study groups I and II regarding all memory tests. The highest percentage of abnormality was present in temporal resolution and selective auditory attention in both study groups. There was no significant statistical correlation between the number of attacks/month and central auditory test results. There was no significant statistical correlation between the frequency of attacks in VM patients and central auditory test results. Conclusions Patients with migraine and vestibular migraine had an inferior performance in all psychophysical central auditory tests when compared with control. Also, there was no significant difference between the 2 study groups regarding central auditory test results which may support that both migraine with and without dizziness have the same pathophysiology.

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Evaluation Of Central Auditory Function In Migraine Patients

QJM ◽

10.1093/qjmed/hcab094.020 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Somia Tawfik ◽

Tayseer Taha Abdel Rahman ◽

Randa Mohammed Ameen ◽

Sahar Ibrahim Abdel Ghany Tolba

Keyword(s):

Auditory Processing ◽

Study Groups ◽

Vestibular Migraine ◽

Control Group ◽

Study Group ◽

Test Duration ◽

Central Auditory Processing ◽

Group I ◽

Significant Difference ◽

Brainstem Response

Abstract Background Migraine is a neurological disease associated with abnormal excitability in visual, somatosensory and motor cortex. Previous researches reported abnormalities in the auditory brainstem response (ABR) and in vestibular functions. These results are an indicator of impending auditory malfunction in Migraine and disruption of central auditory processing mechanisms. Objectives This study aimed to assess and compare central auditory processing (CAP) performance in migraine patients with and without dizziness and healthy controls. Subjects and method Sixty subjects aged between18 and 60 years divided into 3 groups; control group (twenty normal healthy subjects), study group I (twenty subject diagnosed with migraine) and study group II (twenty subjects diagnosed with vestibular migraine). They were subjected to a headache sheet, central auditory processing questionnaire and Psychophysical central auditory tests: including Arabic Speech Intelligibility In Noise (SPIN) test for adults, Arabic Dichotic digit test, Gap In Noise (GIN) test, Duration pattern test and Arabic memory tests. Results Statistically significant difference was found between the 2 study groups and control group regarding right dichotic (p = 0.004),right and left duration pattern tests (p = 0.01) with highly statistically significant difference(p < 0.001) Gap In Noise (GIN) test, left dichotic digit test, right and left speech in noise. But there was no statistically significant difference between the two study groups regarding all tests. Conclusions Patients with migraine and vestibular migraine had poor performance in all central auditory tests when compared with control this mean that migraine lead to impaired central auditory processing in adults. Also, there was no significant difference between the 2 study groups regarding central auditory test results which may support that both migraine with and without dizziness have the same pathophysiology.

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A randomised, open label comparative study of hydroxychloroquine with betamethasone oral mini pulse in the management of patients with alopecia areata

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20210189 ◽

2021 ◽

Vol 10 (2) ◽

pp. 187

Author(s):

Jeyasudha Jambusayee ◽

Kulur Mukhyaprana Sudha

Keyword(s):

Alopecia Areata ◽

Life Quality ◽

Autoimmune Disorder ◽

Study Groups ◽

Pulse Therapy ◽

The Body ◽

Control Group ◽

Study Group ◽

Open Label ◽

Significant Difference

Background: Alopecia areata is an autoimmune disorder causing patchy hair loss on scalp and other parts of the body and leading to poor self-esteem and anxiety in patients. Treatment with topical or systemic drugs like steroids or other immunosuppressants is associated with adverse effects. Hydroxychloroquine is an antimalarial drug, with T cell modulating function. This study was undertaken to assess the safety, efficacy and tolerability of Hydroxychloroquine in Alopecia areata compared to betamethasone oral mini pulse (OMP) therapy. Methods: 60 patients with alopecia areata were randomized into two groups of 30 each. Control group received tab. betamethasone 5 mg/day on two consecutive days of week for 12 weeks and Study group received tab. hydroxychloroquine 200 mg/day for 12 weeks. They were followed-up for further 12 weeks. Scale of alopecia tool, dermatology life quality index and global assessment at baseline, 12 weeks and 24 weeks were used to assess the outcome.Results: 94 patients were screened and 60 patients were included. All patients completed the study. At the end of 12 weeks, there was a statistically significant reduction in SALT and DLQI scores in both control and study groups. But at the end of 24 weeks, the study group showed an increase in the scores. Relapses were more in the study group. No significant difference in the incidence of adverse events was noted between the two groups.Conclusions: Hydroxychloroquine 200 mg/day is less efficacious in the management of alopecia areata in comparison to betamethasone oral mini pulse therapy.

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P3 Cognitive Potential in Cochlear Implant Users

International Archives of Otorhinolaryngology ◽

10.1055/s-0037-1613687 ◽

2018 ◽

Vol 22 (04) ◽

pp. 408-414 ◽

Cited By ~ 2

Author(s):

Signe Grasel ◽

Mario Greters ◽

Maria Goffi-Gomez ◽

Roseli Bittar ◽

Raimar Weber ◽

...

Keyword(s):

Speech Recognition ◽

Cochlear Implant ◽

Auditory Processing ◽

Evoked Potential ◽

Control Group ◽

Central Auditory Processing ◽

Speech Discrimination ◽

Significant Difference ◽

Cortical Responses ◽

Peripheral Auditory System

Introduction The P3 cognitive evoked potential is recorded when a subject correctly identifies, evaluates and processes two different auditory stimuli. Objective to evaluate the latency and amplitude of the P3 evoked potential in 26 cochlear implant users with post-lingual deafness with good or poor speech recognition scores as compared with normal hearing subjects matched for age and educational level. Methods In this prospective cohort study, auditory cortical responses were recorded from 26 post-lingual deaf adult cochlear implant users (19 with good and 7 with poor speech recognition scores) and 26 control subjects. Results There was a significant difference in the P3 latency between cochlear implant users with poor speech recognition scores (G-) and their control group (CG) (p = 0.04), and between G- and cochlear implant users with good speech discrimination (G+) (p = 0.01). We found no significant difference in the P3 latency between the CG and G+. In this study, all G- patients had deafness due to meningitis, which suggests that higher auditory function was impaired too. Conclusion Post-lingual deaf adult cochlear implant users in the G- group had prolonged P3 latencies as compared with the CG and the cochlear implant users in the G+ group. The amplitudes were similar between patients and controls. All G- subjects were deaf due to meningitis. These findings suggest that meningitis may have deleterious effects not only on the peripheral auditory system but on the central auditory processing as well.

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Application Value of Coagulation Function Test in Prognosis of Patients with Cardiovascular and Cerebrovascular Diseases

Advanced Emergency Medicine ◽

10.18686/aem.v9i4.181 ◽

2021 ◽

Vol 9 (4) ◽

pp. 89

Author(s):

Jing Luo

Keyword(s):

Cerebrovascular Diseases ◽

Good Prognosis ◽

Control Group ◽

Study Group ◽

Test Results ◽

Coagulation Function ◽

Significant Difference ◽

Function Test ◽

Group A ◽

Group B

<p><span lang="EN-US">Objective: to explore the application value of coagulation function test in the prognosis of patients with cardiovascular and cerebrovascular diseases. Methods: from December 2018 to December 2019, 100 patients with cardiovascular and cerebrovascular diseases were randomly selected as the study group. According to the follow-up results of patients, they were divided into study group A (good prognosis, n = 64) and study group B (disability or death, n = 36) 100 subjects served as the control group. The test results of coagulation function of the two groups were analyzed retrospectively. The test results of the study group before and after treatment were compared with those of the control group, and the test results of the study group A and study group B after treatment were compared. Results: the coagulation function of the study group after treatment was significantly improved compared with that before treatment (P < 0.05), and there was a significant difference between the two groups before treatment (P < 0.05), and there was no difference after treatment (P > 0.05); after treatment, the coagulation function of study group A and study B was significantly different (P < 0.05). Conclusion: coagulation function test has a certain application value for the prognosis of patients with cardiovascular and cerebrovascular diseases, and can be used as an index to judge the patient’s condition and treatment effect, which has good application value in clinical practice.</span></p>

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Development and evaluation of a computer-based auditory training program for rehabilitation of children with decoding deficit

Auditory and Vestibular Research ◽

10.18502/avr.v27i3.56 ◽

2018 ◽

pp. 143-149

Author(s):

Azam Aghaie ◽

Ali Akbar Tahaei ◽

Farnoush Jarollahi ◽

Mohammad Kamali

Keyword(s):

Training Program ◽

Auditory Processing ◽

Auditory Training ◽

Face Validity ◽

Control Group ◽

Central Auditory Processing ◽

Speech In Noise ◽

Significant Difference ◽

Before And After ◽

Computer Based

Background and Aim: Decoding deficit is the most common central auditory processing disorder (CAPD). Given the benefits of computer-based auditory training programs for treatment of central disorders and the lack of such programs in Persian language, this study aimed to develop a computer-based auditory training program for decoding skill. We also evaluated this program in 8 to12 year old children with CAPD.Methods: The first stage of research was to develop a computer-based auditory training program. This program consists of three levels of phonological discrimination, syllable discrimination, and word discrimination. The second stage was to determine the content and face validity of the program. The third stage was to assess the program effect on five children with decoding deficit. The research method was interventional and had a pretest and post-test design with another five children as control group. The staggered spondaic word, phonemic synthesis (PS) and speech in noise tests was used to assess the children performance before and after training.Results: Mean scores of staggered spondaic word (SSW) and PS tests of the experimental group were significantly difference before and after the auditory training (p<0.05) as compared to control group. However, there was no significant difference with regard to the speech-in-noise test results (p>0.05).Conclusion: This computer-based auditory training program can be considered as a preliminary tool for the rehabilitation and treatment of decoding deficits in children with CAPD.

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Correlation between cognitive functions and central auditory processing in adolescents with non-cholesteatomatous chronic otitis media

Dementia & Neuropsychologia ◽

10.1590/1980-57642018dn12-030013 ◽

2018 ◽

Vol 12 (3) ◽

pp. 314-320 ◽

Cited By ~ 1

Author(s):

Márcia Salgado Machado ◽

Adriane Ribeiro Teixeira ◽

Sady Selaimen da Costa

Keyword(s):

Executive Function ◽

Otitis Media ◽

Cognitive Functions ◽

Auditory Processing ◽

Chronic Otitis Media ◽

Assessment Instrument ◽

Control Group ◽

Study Group ◽

Central Auditory Processing ◽

Pattern Sequence

Abstract Auditory deprivation associated with early otitis media with effusion has been considered a risk factor for central auditory processing (CAP), as well as for the development of a number of cognitive functions. Objective: To study the neuropsychological functions of attention, working memory and executive function in adolescents with and without non-cholesteatomatous chronic otitis media (NCCOM) and analyze their interrelationships with the behavioral evaluation of CAP. Methods: Sixty-eight adolescents were recruited, 34 were diagnosed with NCCOM (study group - SG), and 34 had no otological history (control group - CG). The Neupsilin Brief Neuropsychological Assessment Instrument was used. CAP was assessed by: Masking Level Difference, Synthetic Sentence Identification, Random Gap Detection Test, Duration Pattern Sequence Test and Dichotic Digits Test. Results: The results of Neupsilin showed lower scores in the study group when compared to the control group on the following tests: digit sequence repetition, ascending digit ordering, auditory sentence span, and phonemic verbal fluency. An association was found between central auditory processing tests and Neupsilin subtests. Conclusion: The effects of NCCOM on attention, memory and executive function related to central auditory processing disorder in adolescents seem to be enhanced by the severity of the disease.

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Auditory Processing Abilities of Parkinson’s Disease Patients

BioMed Research International ◽

10.1155/2017/2618587 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 16

Author(s):

Robert L. Folmer ◽

Jay J. Vachhani ◽

Sarah M. Theodoroff ◽

Rachel Ellinger ◽

Amy Riggins

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Hearing Loss ◽

Auditory Processing ◽

Study Groups ◽

Control Group ◽

Central Auditory Processing ◽

Control Subjects ◽

Age Related ◽

Auditory Functions

Since Parkinson’s Disease (PD) primarily affects older people, a majority of PD patients have age-related hearing loss (HL) that will worsen over time. The goal of this study was to assess peripheral and central auditory functions in a population of PD patients and compare the results with a group of age-matched control subjects. Study participants included 35 adults with PD (mean age = 66.9 ± 11.2 years) and a group of 35 healthy control subjects (mean age = 65.4 ± 12.3 years). Assessments included questionnaires, neuropsychological tests, audiometric testing, and a battery of central auditory processing tests. Both study groups exhibited patterns of sensorineural hearing loss (slightly worse in the PD group) which were typical for their age and would contribute to difficulties in communication for many participants. Compared to the control group, PD patients reported greater difficulty in hearing words people are speaking. Although 27 PD patients (77%) were good candidates for amplification, only 7 (26%) of these hearing aid candidates used the devices. Because it is important for PD patients to optimize communication with their family members, caregivers, friends, and clinicians, it is vital to identify and remediate auditory dysfunction in this population as early as possible.

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The effect of bilingualism on cognitive and auditory abilities in normally hearing adults

Revista CEFAC ◽

10.1590/1982-0216201820112417 ◽

2018 ◽

Vol 20 (1) ◽

pp. 21-28 ◽

Cited By ~ 1

Author(s):

Geise Corrêa Ferreira ◽

Enma Mariángel Ortiz Torres ◽

Michele Vargas Garcia ◽

Silvio José Lemos Vasconcellos ◽

Natalia Schopf Frizzo ◽

...

Keyword(s):

Cognitive Function ◽

Cognitive Abilities ◽

Study Groups ◽

Brazilian Portuguese ◽

Control Group ◽

Study Group ◽

Bilingual Speakers ◽

Significant Difference ◽

Mechanical Reasoning ◽

Specific Cognitive Abilities

ABSTRACT Purpose: to evaluate and compare cognitive and auditory abilities in normally hearing monolingual and bilingual individuals. Methods: the sample consisted of 21 normally hearing individuals ranging in age between 18 and 25 years, divided into a control group of eight monolingual speakers of Brazilian Portuguese and a study group composed of 13 bilingual speakers of Brazilian Portuguese and German or Italian. The individuals underwent basic audiological assessments as well as assessments of cognitive and auditory figure-background abilities with the BPR-5 and SSW tests, respectively. Results: the assessment of cognitive abilities showed that bilinguals had a better performance for the general cognitive function, with a statistically significant difference, as well as for cognitive abilities of verbal, spatial and mechanical reasoning. Also, for auditory figure-background abilities, there was a statistically significant difference between the study groups, with bilinguals showing a better performance. Conclusions: based on the study groups, it was found that the bilingual subjects had a better performance of their general cognitive function, as compared with monolingual speakers, as well as in their specific cognitive abilities of verbal, spatial and mechanical reasoning, and in the auditory figure-background abilities.

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Does Adjuvant Intracameral Triamcinolone Acetonide Increase the Effectiveness of Phacotrabeculectomy? A Case-Control Study

Czech and Slovak Ophthalmology ◽

10.31348/2020/14 ◽

2020 ◽

Vol 76 (2) ◽

pp. 68-76

Author(s):

Fatih Aslan ◽

Çağlar Öktem

Keyword(s):

Triamcinolone Acetonide ◽

Case Control Study ◽

Anterior Segment ◽

Study Groups ◽

Control Group ◽

Study Group ◽

Surgical Success ◽

Significant Difference ◽

Intracameral Injection ◽

Control Study

Aims: To investigate the effect of intracameral triamcinolone acetonide (TA) on surgical success in 5-fluorouracil (5-FU) supported primary phacotrabeculectomy (PT) cases. Material and Methods: This retrospective study included 23 eyes (study group) of 23 patients who underwent TA during PT and 26 eyes (control group) of 26 patients without TA. PT patients in the study group received 1 mg TA intraoperatively at the end of surgery. Pre- and postoperative visual acuity, intraocular pressure (IOP), and number of antiglaucoma drugs used were compared. Postoperative complications and need for 5-FU injection were evaluated for both groups. Results: Mean age was 64.1 2 ± 1.91 (48–86) years in the control group and 66.52 ± 2.02 (52–86) years in the study group (p = 0.824). Comparison of pre- and postoperative IOP values showed significant decreases in postoperative IOP levels at all-time points in both the control and study groups (p < 0.001). The only significant difference between groups was on postoperative first day (study group: 9.22 ± 1.41 mmHg; control group: 6.35 ± 2.17 mmHg, p < 0.001). Need for postoperative 5-FU injection was significantly more common in the control group (p = 0.023). Conclusion: Intracameral injection of 1 mg TA at the end of PT surgery did not yield superior results in postoperative IOP compared to PT alone, and the two groups showed similar IOP reduction. When given as an adjunct to PT, 1 mg TA suppresses anterior segment inflammation and reduces the need for 5-FU injection.

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The Effect of Telomerase Antisense for the Differentiation of Embryonic Stem Cells to Hemopoietic Stem Cells.

Blood ◽

10.1182/blood.v104.11.4201.4201 ◽

2004 ◽

Vol 104 (11) ◽

pp. 4201-4201

Author(s):

Kyong Hwa Park ◽

Byung Soo Kim ◽

In Keun Choi ◽

Seok Jin Kim ◽

Sang Cheul Oh ◽

...

Keyword(s):

Stem Cells ◽

Embryonic Stem Cells ◽

Embryonic Stem ◽

Viable Cell ◽

Study Groups ◽

Control Group ◽

Study Group ◽

Hematopoietic Stem ◽

Cell Percentage ◽

Significant Difference

Abstract Background: This study was designed to evaluate the effect of adenovirus-mediated telomerase antisense(TA) expression on cellular proliferation and apoptosis of the ex-vivo culture from human embryonic stem cells to hematopoietic stem cells. Methods: Cultured embryonic stem cell lines (SNU-3 cell line) to hemopoietic stem cells were classified to control and study groups. Control group was that of which embryonic body were cultured to LTC-IC assay not treated with telomerase antisense oligonucleotides(TA). Study group was that of which embryonic body were cultured to LTC-IC assay treated with TA. We evaluated CD34+ cell number and viable cell percentage and the degree of apoptosis of each samples at 5 days after LTC-IC assay and the results were compared between each groups. These studies were tried for 17 times. Results: The number of CD34+ cells in study group 0.8–2.4(median: 1.5X103) showed no significant difference with that in control group 0.6–2.9(median: 1.6X103). Viable cell percentage of control and study groups were 76–89(median: 83) % and 78–90(median: 85) %, respectively, without significant difference. And there was no difference in the degree of apoptosis (absorbance, A405nm – A490nm) between control and study groups; 0.092–0.134(median: 0.129) vs 0.087–0.152(median 0.138), with reference to negative control: 0.020, positive control: 0.186. The colony count of CFU-GM in control and study group was 0.1–0.5(medium: 0.3) X103 and 0.2–0.5(medium: 0.3) X103, respectively without no significant difference. Conclusion: We found that adenovirus-mediated antisense expression of telomerase RNA didn’t interrupt the differentiation of embryonic stem cells to hematopoietic stem cells without significant effect on the degree of apoptosis. Further studies will be warranted to confirm these results and verify the mechanism of these phenomena.

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