scholarly journals Maternal serum zinc levels and urinary tract infections among pregnant women at a tertiary hospital in Lusaka, Zambia: a cross-sectional study

2021 ◽  
Vol 10 (9) ◽  
pp. 1062
Author(s):  
John Musaba ◽  
Moses Mukosha ◽  
Lubinda Mukololo ◽  
Bellington Vwalika
Keyword(s):  
Logistic Regression ◽  
Urinary Tract ◽  
Pregnant Women ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Maternal Serum ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Zn ◽  
Tract Infections

Background: Micronutrient deficiency is one of the leading public health problems, particularly in lower-middle-income countries. The link between serum zinc (Zn) levels and urinary tract infections (UTIs) among pregnant women is still poorly understood. We investigated the association between maternal serum Zn levels and UTIs among pregnant women at women and newborn hospital in Lusaka, Zambia.Methods: We conducted an analytical cross-sectional study among 228 pregnant women aged 18 to 45 years between 1 September and 30 November 2019. Serum Zn levels were measured using atomic absorption spectrophotometry (AAS), whereas UTIs were determined based on the local hospital guidelines. We used the logistic regression model to determine the association between Zn levels and UTIs. The analysis was done at a significance level of 5% and 95% confidence interval.Results: Of the total participants, 118/228 (51.75%) tested positive for UTIs from urine culture. The mean serum Zn levels in the group diagnosed with UTIs were 53.95 ug/dl (SD=35.10), while in those who had no UTIs, it was 50.05 ug/dl (SD=35.10). In a multivariable logistic regression analysis, we found no evidence of an association between serum Zn levels and UTIs (p=0.435).Conclusions: From the study findings, there was no association between serum Zn levels and UTIs. This result suggests that Zn may not have any role in urinary tract infection. Nevertheless, more extensive studies are needed to confirm our findings.

scholarly journals Predictors of Premature Rupture of Membranes among Pregnant Women in Rural Uganda: A Cross-Sectional Study at a Tertiary Teaching Hospital

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Simon Byonanuwe ◽  
Emmanuel Nzabandora ◽  
Baltazar Nyongozi ◽  
Theophilus Pius ◽  
David Santson Ayebare ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Pregnant Women ◽  
Gestational Age ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
History Of ◽  
Tract Infections

Background. Premature rupture of membranes (PROM) is a common condition in developed and developing countries and poses a serious threat to the maternal and fetal well-being if not properly managed. This study delineated the prevalence and predictors of PROM in the western part of Uganda so as to guide specific preventive measures. Methods. A cross-sectional study design was conducted in the months of September 2019 to November 2019. A total of 334 pregnant women above 28 weeks of gestation admitted at the maternity ward of KIU-TH were consecutively enrolled. Interviewer-administered questionnaires were used to obtain the data. Descriptive statistics followed by binary logistic regression were conducted. All data analyses were conducted using STATA 14.2. Results. Of the 334 pregnant women enrolled, the prevalence of PROM was found to be 13.8%. The significant independent predictors associated with lower odds of PROM were no history of urinary tract infection (UTI) in the month preceding enrollment into the study (aOR=0.5, 95% CI: 0.22-0.69, p=0.038) and gestational age of 37 weeks or more (aOR=0.3, 95% CI: 0.14-0.71, p=0.01) while history of 3 or more abortions (aOR=13.1, 95% CI: 1.12-153.62, p=0.05) was associated with higher likelihood of PROM. Conclusions. Majorly urinary tract infections, low gestational age, and abortions influence premature rupture of membranes among women. There is a great need for continuous screening and prompt treatment of pregnant women for UTI especially those with history of 3 or more abortions at less than 34 weeks of gestation.

scholarly journals Urinary Tract Infection in Pregnant Women at Kathmandu, Nepal

2020 ◽  
Vol 3 (9) ◽  
pp. 454-458
Author(s):  
Shikha Thakur ◽  
Dr. Komal Lata Nagpal
Keyword(s):  
Risk Factors ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Associated Risk Factors ◽  
Tract Infections

Background: Urinary tract infections “UTIs” are one of the frequently encountered problems during pregnancy. Untreated UTI can be associated with serious obstetric complications.  Hence the management and prevention of UTI in pregnancy is the crucial factor for the sustained pregnant period. Hence the present study was designed to identify the pathogenic agents of UTI and its associated risk factors in antenatal mothers in two private hospitals at Kathmandu city. Aim: The main objective of the study was to identify the etiological agent and associated risk factor in Urinary tract infection among pregnant women attending the antenatal care service visit in a selected hospital. Study Design: Cross-sectional descriptive study. Place and Time of Study: The study was carried out under the supervision of University and field study was carried out in Kathmandu, Nepal from March 2019 to October 2019. Methods: The cross-sectional study was performed at the Norvic Hospital and Baidya and Banskota hospital from March 2019 to October 2019. In this cross-sectional study, a total of 510, clean catch midstream urine (MSU) samples were collected aseptically and analyzed using standard microbiology methods. Data for the factors associated with UTI were obtained by use of questionnaires and standard laboratory tests for selected underlying conditions concerning associated risk factors were collected using structured questionnaires and the sample was also processed for antimicrobial drug susceptibility testing. Results: The study revealed 193/510(37.84%) UTI prevalence among patients attending two hospitals in Kathmandu valley. Escherichia coli was the most prevalent bacterial uropathogen with 119/193(61.6%) followed by Klebsiella pneumoniae 35/193(18.13%), Staphylococcus aureus 22/193 (11.39%), Proteus mirabilis 7/193 (3.6%), Enterococcus faecalis 2/193 (1.0%), Enterobacter aerogenes2/193(1.0%) Serratia odorifera 3/193(1.5%), Streptococcus species3/193(1.5%). Conclusions: The high prevalence of urinary tract infection in pregnant women warrant the need to screen all pregnant women and treat those infected with appropriate antimicrobial regimens in order to reduce its complications. Urinary Tract Infection screening is essential in pregnant women.

scholarly journals Adherence to guideline recommendations for urinary tract infections in adult women: a cross-sectional study

2021 ◽  
Vol 22 ◽  
Author(s):  
Rian Lelie- van der Zande ◽  
Marcel Bouvy ◽  
Martina Teichert
Keyword(s):  
Urinary Tract ◽  
Clavulanic Acid ◽  
Cross Sectional Study ◽  
Adult Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
First Choice ◽  
Febrile Uti ◽  
Amoxicillin Clavulanic Acid ◽  
Tract Infections

Abstract Aim: To study whether changes in drug preferences in the Dutch guideline for the treatment of Urinary Tract Infection (UTI) for General Practitioners (GPs) in 2013, resulted in corresponding changes in antibiotic dispensing. Background: For the treatment of uncomplicated UTI, nitrofurantoin remained the first choice, while fosfomycin became the second choice and changed ranks with trimethoprim. For a subsequent febrile UTI, ciprofloxacin became the first choice and changed ranks with amoxicillin/clavulanic acid, co-trimoxazole remained the third choice. Methods: In this observational cross-sectional study, routinely collected dispensing data from the Dutch Foundation of Pharmaceutical Statistics from 2012 to 2017 were used. The number of women 18 years and older, treated with one of the guideline antibiotics for uncomplicated UTI and subsequent febrile UTI were analysed annually. Proportions were calculated. Data were stratified for age categories. Failure of uncomplicated UTI treatment was defined as the dispensing of an antibiotic for febrile UTI within 14 days after the dispensing of an antibiotic for uncomplicated UTI. Findings: Data were available from 81% of all pharmacies in 2012 to 89% in 2017. Percentages of women dispensed nitrofurantoin were relatively stable with 87.4% in 2012 and 84.4% in 2017. Percentages of women dispensed fosfomycin increased from 5.4% in 2012 to 21.8% in 2017, whereas percentages of women dispensed trimethoprim decreased from 17.8% to 8.0%. Within age categories, the percentage of women dispensed fosfomycin increased from 12.4% in women 18–30 years old to 36.7% in women above 80 years old. Percentages of women dispensed antibiotics for febrile UTI remained stable at 5% annually. Percentages of women receiving ciprofloxacin increased from 1.9% in 2012 to 3.3% in 2017, while those receiving amoxicillin/clavulanic acid decreased from 2.9% to 1.8%. New guideline recommendations resulted in corresponding changes in dispensed antibiotics for uncomplicated UTI and subsequent febrile UTI. Drug choices differed for age categories.

scholarly journals Serum Concentrations of Selected Organochlorines in Pregnant Women and Associations with Pregnancy Outcomes. A Cross-Sectional Study from Two Rural Settings in Cambodia

2020 ◽  
Vol 17 (20) ◽  
pp. 7652
Author(s):  
Margit Steinholt ◽  
Shanshan Xu ◽  
Sam Ol Ha ◽  
Duong Trong Phi ◽  
Maria Lisa Odland ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Pregnant Women ◽  
Gestational Age ◽  
Low Income ◽  
Cross Sectional Study ◽  
Maternal Serum ◽  
Sectional Study ◽  
Serum Samples ◽  
Cross Sectional ◽  
Rural Settings

We conducted a cross-sectional study among 194 pregnant women from two low-income settings in Cambodia. The inclusion period lasted from October 2015 through December 2017. Maternal serum samples were analyzed for persistent organic pollutants (POPs). The aim was to study potential effects on birth outcomes. We found low levels of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCP), except for heptachlors, β-hexachlorocyclohexane (HCH), heptachlor epoxide, and p,p’-DDE. There were few differences between the two study locations. However, the women from the poorest areas had significantly higher concentrations of p,p’-DDE (p < 0.001) and hexachlorobenzene (HCB) (p = 0.002). The maternal factors associated with exposure were parity, age, residential area, and educational level. Despite low maternal levels of polychlorinated biphenyls, we found significant negative associations between the PCB congeners 99 (95% CI: −2.51 to −0.07), 138 (95% CI: −1.28 to −0.32), and 153 (95% CI: −1.06 to −0.05) and gestational age. Further, there were significant negative associations between gestational age, birth length, and maternal levels of o,p’-DDE. Moreover, o,p’-DDD had positive associations with birth weight, and both p,p’-DDD and o,p’-DDE were positively associated with the baby’s ponderal index. The poorest population had higher exposure and less favorable outcomes.

Local characteristics associated with higher prevalence of ESBL-producing Escherichia coli in community-acquired urinary tract infections: an observational, cross-sectional study

2020 ◽  
Author(s):  
Stéphanie Larramendy ◽  
Aurélie Gaultier ◽  
Jean-Pascal Fournier ◽  
Jocelyne Caillon ◽  
Leïla Moret ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Agricultural Land ◽  
Cross Sectional Study ◽  
Urine Samples ◽  
Sectional Study ◽  
Cross Sectional ◽  
E Coli ◽  
Animal Farming ◽  
Tract Infections

Abstract Objectives The prevalence of ESBL-producing Escherichia coli (ESBL-E. coli) in community-acquired urinary tract infections (UTI) has been increasing worldwide since 2000, but with large geographical variations. The aim of this study was to determine whether the ESBL-E. coli rate in urine samples from individuals with community-acquired UTI was associated with the local socio-economic, environmental, agricultural and healthcare characteristics. Methods This was a cross-sectional study in western France using data on antibiotic susceptibility of E. coli isolated from urine samples of individuals with community-acquired UTI analysed in non-hospital laboratories from 2015 to 2017. The ESBL-E. coli rate was calculated for each laboratory. Data on socio-economic characteristics, human antibiotic consumption, hospital bed density, animal farming density and percentage of agricultural land and surface water were retrieved at the municipality level and aggregated by study area. Their association with ESBL-E. coli prevalence was quantified using multivariate linear regression models with a backward selection. Results From 358 291 E. coli isolates from urine samples tested in 92 laboratories, the mean ESBL-E. coli prevalence for the study period was 3.30%. In an adjusted model, the ESBL-E. coli rate was significantly (P &lt; 0.05) and positively associated with the local percentage of people &gt;65 years old, third-generation cephalosporin use (DDD/1000 inhabitants), number of hospital beds/km2, poultry density, pig density and percentage of agricultural land. Lower deprivation was associated with a higher ESBL-E. coli rate. Conclusions Several anthropogenic factors (primary care, hospitals and animal farming) are associated with the local ESBL-E. coli rate in community-acquired UTI. These results could contribute to improve risk management, including identification of at-risk patient groups.

scholarly journals Immunosenescence in persons with spinal cord injury in relation to urinary tract infections -a cross-sectional study-

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
David Pavlicek ◽  
Jörg Krebs ◽  
Simona Capossela ◽  
Alessandro Bertolo ◽  
Britta Engelhardt ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cord Injury ◽  
Tract Infections

scholarly journals Access to sanitation and risk of developing urinary tract infections among women from low socio-economic settings

2019 ◽  
Vol 6 (7) ◽  
pp. 2939
Author(s):  
Rama Kawade ◽  
Anjali Radkar ◽  
Abhilash Thadathil ◽  
Deepa Thakur
Keyword(s):  
Logistic Regression ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Cross Sectional Study ◽  
Individual Characteristics ◽  
Cross Sectional ◽  
Younger Women ◽  
Increased Risk ◽  
Restricted Use ◽  
Tract Infections

Background: Poor sanitation facilities are root cause of many health problems of people residing in slums. The present study estimates the prevalence of urinary tract infections (UTI) and identifies factors associated with an increased risk of UTI among women.Methods: A cross-sectional study was conducted among 616 women aged between 18 to 60 years residing in 33 slums across four cities in Maharashtra, India. Data related to individual characteristics of women, housing condition, access to sanitation facilities, behaviors adopted by the women that could lead to UTI and an episode of symptomatic UTI in the previous one month were recorded through structured questionnaire. Logistic regression analysis was performed to find out risk factors for UTI among women.Results: The prevalence of UTI was found to be 19.6%. The prevalence was higher among young women aged upto 30 years (23.2%). In absence of individual toilet, women had adopted certain behaviors such as urine holding (21.3%), modify dinner to avoid toilet use at night (26.6%) and avoid intake of liquids (10.7%) to reduce frequency of visits to toilet. All these behaviors were significantly associated with UTI. Multiple logistic regression indicated that UTI was strongly and independently associated with age (OR=1.64, 95%CI: 1.08, 2.47), no access to bathroom (OR=2.21, 95%CI: 1.08, 4.49) and avoid intake of liquids (OR=2.70, 95%CI: 1.53, 4.75) (p<0.05).Conclusions:Behavior modifications by women to adjust with restricted use of place of urination may affect their health and increase the likelihood of developing UTI. Younger women are more at risk of developing UTI.  

scholarly journals Urinary Tract infection, Drug Resistance Profile and Fetal Outcomes among Pregnant women in Selected Health Facilites of Addis Ababa, Ethiopia: A cross-sectional study design

2020 ◽  
Author(s):  
Wegayehu zebene ◽  
Dawit Dessalegn ◽  
Abebe Aseffa ◽  
Yohannis Yitagesu ◽  
Hamdiya yussuf ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Fetal Outcomes ◽  
Cross Sectional ◽  
Drug Resistance Profile ◽  
Study Participants

Abstract Background: Urinary tract infection (UTI) is a commonly encountered health problem among pregnant women. Untreated UTI may result in fetal complications like preterm birth, low birth weight, intra uterine growth retardation and intrauterine fetal death.One of the major problems with bacterial pathogens is their ability to develop drug resistance. Determining drug susceptibility pattern of bacteria from urinary tract helps to identify effective drugs and minimize further adverse perinatal outcomes. The purpose of this study was to describe the magnitude and drug resistance profile of pregnant women and related fetal outcomes.Methods: A cross-sectional study was conducted from March to June 2019. Socio-demographic data of the study participants was collected by administering structured questionnaire after obtaining full consent of the participants. Clean catch mid-stream urine was collected from the study participants and the samples were transported to the laboratory with screw-capped container. Blood and MacConkey agar were used to cultivate bacteria from urine sample. Bacterial colonies were isolated and identified using standard biochemical properties. Antibacterial susceptibility test was done on Muller-Hinton agar using antibiotic discs. At the time of delivery, infant’s birth weight and gestational age was recorded on the log book as part of the daily work. Fetal outcome data were recorded from the log book and entered to EPI data management software then transferred to SPSS for analysis.Results: Out of 424 urine samples processed, 63 (14.9%) yielded significant bacteriuria. Fifty-nine out of 63 (93.7%) cases of UTIs were recorded among age group of 15-34 years. Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus were the three dominant bacterial isolates.Most of the gram negative bacterial isolates were resistant to ampicillin and ceftazidime (43.2% each) while gram positive was resistant for tetracycline (36.8%). The result of this study showed that UTI had statistical association with the occurrence of Intrauterine Fetal Death (IUFD) and Prerupture of Membrane (PROM) (P<.05).Conclusion: Adverse fetal outcomes are significantly linked with the presence of UTI during pregnancy. The condition can be managed if early diagnosis and treatments are made for the mother.

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