scholarly journals Evaluation of histopathology of cervix in women with unhealthy cervix

Author(s):  
Sathiyakala Rajendiran ◽  
Ushadevi Gopalan ◽  
Ranganathan Karnaboopathy

Background: Carcinoma of cervix is the third most common cancer in women worldwide and most common female cancer in India. Most cervical cancers can be detected at pre-invasive state with an adequate screening and treated, preventing overt progression to invasive cancer and hence decreasing morbidity and mortality. This study was conducted to evaluate the histopathological diagnosis of cervix biopsy in unhealthy cervix and to determine the incidence of the various precancerous and cancerous lesions.Methods: It was a prospective study in the department of Obstetrics and Gynecology in a tertiary care hospital over a period of two years. 802 women with unhealthy cervix were included in the study. Punch biopsy was taken from the cervix and sent for histopathological examination.Results: Total of 802 women were included in the study. They were in the age group of 26-75years. 53.4% were in the age group of 40-49 years followed by 20% in the age group of 30-39 years. The most common finding was chronic cervicitis in 89.4% followed by CIN I in 4.1%, CIN II in 0.9% of patients, squamous cell carcinoma in 2.1% and endocervical carcinoma in 0.4%.Conclusions: Cancer cervix is an ideal malignancy for screening, can be detected early and the premalignant lesion can be treated to prevent the progress to invasive disease. Hence all women with unhealthy cervix should be subjected to punch biopsy to detect early cases of cancer & carcinoma in situ.

2020 ◽  
Vol 7 (4) ◽  
pp. 582
Author(s):  
Appu Patil

Background: Anaemia is a major public health problem worldwide especially in developing countries like India. Nutritional cause of anaemia continues to predominate as the most common cause of anaemia. Objective of this study is to determine the clinical and laboratory profile of anaemia among patients admitted to our hospital.Methods: Our study was a prospective study in which thirty nine patients of anemia admitted to Medicine ward in SNMC and HSK hospital were studied for their clinical and laboratory characteristics. Duration of the study was 7 months from July 2019 to January 2020.Results: Anaemia was more common among females (65.1% of total patients). Patients aged less than 60 years contributed to 85% of patients. Pallor was the universal finding present in 100% of patients. On systemic examination haemic murmurs on auscultation was the most common finding present in 28.2% followed by hepatomegaly (17.94%). Microcytic and dimorphic anaemia constitute the bulk of anaemia.Conclusions: Nutritional anaemia particularly iron deficiency anaemia is the most common cause of anaemia. It tends to affect the working age group and females predominantly. Patients continue to present with severe anaemia to the hospital.


Author(s):  
Ajay J. Panchal ◽  
Rakesh Kumar ◽  
Megha Desai

<p class="abstract"><strong>Background:</strong> Fat graft myringoplasty (FGM) is a procedure with a short learning curve, cost effective, with minimal morbidity in properly selected patients. It is useful to relieve the patient of annoyance caused by a small perforation in terms of ear discharge and hearing loss. The aim was to assess postoperative hearing improvement and investigate influence of factors like age, gender and location of perforation on audiological outcomes.</p><p class="abstract"><strong>Methods:</strong> This study was a prospective study done on 25 patients at a tertiary care hospital who underwent FGM. All patients had small dry central perforation. Air and Bone conduction (AC/BC) thresholds and air-bone gap (ABG) were evaluated both preoperatively and postoperatively.  </p><p class="abstract"><strong>Results:</strong> Mean hearing improvement was 14.4762 dB in &lt;40 yrs age group whereas it was 11.2500 dB in &gt;40 yrs age group. Mean hearing improvement in females was 13.75 dB whereas it was 14.154 dB in males. Mean hearing improvement was 15 dB in posterior, 14.7 dB in inferior and 14.46 dB in anteriorly located perforation.</p><p class="abstract"><strong>Conclusions:</strong> FGM is effective in improving postoperative hearing thresholds hence it can be used in small dry central perforations of tympanic membrane in patients irrespective of patient variables such as age, gender, and location of perforation. As no significant statistical difference was observed in terms of gender, location or aetiology of perforation, we consider it a procedure to be recommended across all spectrums of patients.</p>


2020 ◽  
pp. 63-64
Author(s):  
Srenivas. A ◽  
Sathiya Suresh

Seizures represent signal of neurological disease in the newborn period and these convulsive phenomena are the most frequent of the overt manifestation of neonatal neurological disorders.. The objective of this study was to study the incidence of pediatrics (0-12 years) seizures. To study the etiology and pattern of seizures. Methods: 200 Subjects who had seizures were included in the study. Relevant history was ascertained from a patient’s parents or a reliable relative or attendant, medical records and the referring physicians note, specifically from mother in case of neonatal seizures i.e. age at onset of seizures, seizure activity with special emphasis on occurrence of 1st seizures, duration of seizures, number and type of seizures, associated autonomic changes, medications required to control seizures, response time to medications, and possible causes for determination of etiology. A detailed antenatal, natal and postnatal history was taken. Results: Out of 200 study subjects 35.89% were in neonatal age group, of which 64.10% and 35.90% were male and female respectively and 64.11%. out of neonatal seizures, 64.10% neonates were male and 35.90% were female. Male: Female ratio was 1.79:1. The seizures were common in male neonates. Subtle seizures were the commonest type of seizures observed both in term and preterm neonates. Conclusions: The various types of seizure were compared with the preterm and term neonates and it was found statistically significant


Author(s):  
Shikha Raghuwanshi ◽  
Dharmendra Singh Bhadouria ◽  
Surendra Raghuwanshi ◽  
Arun Saxena ◽  
S.K. Nema

Background: The present study was aimed to obtain insight into the varied histopathological patterns of lesions of uterus and cervix in hysterectomy specimens and their age-wise distribution in Index MedicalCollege, Hospital and Research Center. Methodology: This was anobservational study conducted on 100 cases of hysterectomy specimens received at tertiary care hospital Indore. All the specimen was subjected to detailed gross and histopathological examination. Results: Mean age of patients was 44.78±8.64 years. The most common age group was 41-50yrs (42%). Maximum cases were diagnosed as AUB/ DUB/Menorrhagia (31%) followed by fibroid uterus (28%). Uterus was bulky in 70%, cut sections revealed single fibroid in majority i.e. 39% cases and endometrium was in proliferative phase (early 12%, mid 30%, late 19%). Most common histopathological diagnosis of uterus was leiomyoma in 39% cases whereas chronic nonspecific cervicitis (47%) was most common histological diagnosis of cervix. Intramural leiomyoma were most common and were associated with degenerative changes in 33 cases. Hyaline degeneration was observed in maximum cases. Conclusion: The most common indication for hysterectomies in our institution is excessive uterine bleeding. Fibroid uterus as the cause of bleeding is the most common pathology for which hysterectomy is performed. Chronic cervicitis is the most common finding and Adenomyosis continued to be missed preoperatively and diagnosed postoperatively on histopathological examination. Every hysterectomy specimen should be subjected to histopathological examination to confirm various pathological lesions. Keywords: Leiomyoma, histopathology, spectrum, uterus, cervix, hysterectomy


Author(s):  
Henry Daniel Raj T ◽  
Sylvia A. ◽  
Chidambaranathan S. ◽  
Nirmala P.

Objective: Epilepsy or seizure disorder is a common neurologic disorder in the pediatric age group and occurs with a frequency of 4-6 cases per thousand children. Epilepsy, particularly childhood epilepsy, remains a challenge to treat. The management of epilepsy is primarily based on theuse of anti-epileptic drugs. Surgery and diet therapy are the other modes of treating childhood seizures. To get an insight into the utilization pattern of anti-epileptic drugs (AEDs) used in pediatric seizures.Methods: This prospective, longitudinal study was conducted for a period of 8months in Paediatric Neurology Department of a tertiary care teaching hospital. The data collected from 50 children at the end of the study, were compiled in a specially designed data form and were analyzed.Results: The distribution of paediatric seizures was found to be high in male children (62%) and in the age group of 2 to 5 y (46%). The majority of the children (70%) were diagnosed with Generalized Tonic-clonic seizures. Sodium valproate was the commonly prescribed AED in all forms of seizures followed by Carbamazepine (18%), Phenobarbitone (4%) and Phenytoin Sodium (4%). AEDs were mostly prescribed as monotherapy (82%). Adverse reactions noted during this study was minimal (12%).Conclusion: Sodium valproate, a conventional AED still remains the commonly prescribed AED for all types of seizures in children aged 2 to 16 y and also was found to be effective and safe.


Author(s):  
Bikram Bhardwaj ◽  
S. K. Rath

Background: Menorrhagia is one of the most common gynecologic complaints in contemporary gynecology. It is defined as total blood loss exceeding 80 ml per cycle or menses lasting longer than 7 days. Current gynecological survey reports that 30% of all pre-menopausal women perceive their menses to be excessive. So, the main aim of this study was to correlate clinical profile of patients with menorrhagia, etiological factors of menorrhagia, endometrial patterns in cases of menorrhagia, sonography findings in these patients.Methods: This is a prospective study of 100 patients with complaints of menorrhagia that were randomly selected from out-patient department of a tertiary care hospital. In all cases of menorrhagia, detailed history followed by examination and a particular set of investigations including USG was done. All women were subjected to D and C and histo-pathological report taken into account. However all cases of Puberty menorrhagia were excluded from this study as D and C could not be done in them. Treatment was given depending upon cause/age/parity/ family/completion/patient’s desire.Results: AUB is the most common cause of menorrhagia in this study group (60%) with leiomyomas as the second commonest cause (24%). Other causes found were adenomyosis (8%), polyp (4%), IUCD (4%). Maximum cases of menorrhagia are in 40-50 years age group.Conclusions: To conclude AUB (60%) was the commonest cause of menorrhagia followed by leiomyomas (24%), adenomyosis (8%), IUCD (4%) and polyps (4%). Menorrhagia was most common in multiparous (78%) and peri-menopausal age group (40-49 years). Proliferative endometrium was most commonly observed histo-pathological pattern in 58% cases. Leiomyoma was the commonest sonological finding seen in 24% cases followed by adenomyosis in 8% cases.


2019 ◽  
Vol 6 (6) ◽  
pp. 2032
Author(s):  
Shabir Ahmad Mir ◽  
Mohd Riyaz Lattoo ◽  
Waseem Ahmad Dar ◽  
Mumtazdin Wani

Background: Although malrotation of gut presenting in adolescents and adults is rare, but exists. Also its presentation is nonspecific.  Hence its diagnosis needs high index of suspicion.Methods: This prospective study was done in the department of surgery at SMHS hospital (GMC Srinagar) over a period of 5.5 years from July 2012 to December 2017. The patients included all  the adolescent and adult patients who proved  to be the cases of malrotation of gut on intraoperative  visualisation.Results: During the study period, 14 patients with malrotation of gut (belonging to adolescent and adult age group) were recorded. Age of the patients ranged from 16 to 54 years with an average of 26.21±11.15years. Majority of the patients belonged to adolescent age group. Preoperatively CT (computed tomography) scan was done only in 4 patients, thereby making the diagnosis of malrotation preoperatively in these 4 patients. In all other patients, the diagnosis was made only after laparotomy (for acute abdomen) and intraoperative visualisation. Ladd´s procedure was done successfully in majority of patients with two patients requiring resection of gangrenous small bowl and stoma formation.Conclusions: Malrotation of gut presenting in adolescents and adults is a rare phenomenon and also the symptoms are similar to several other abdominal pathologies, hence it represents a diagnostic challenge. Hence a high index of suspicion is needed to diagnose this rare entity early without undue delay. Threshold for CT scan should be kept a little low in suspicious cases so as to diagnose and intervene in time.


2017 ◽  
Vol 3 (3) ◽  
pp. 338-343
Author(s):  
Mohammad Didar Khan ◽  
Md. Ibrahim ◽  
Md. Mizanur Rahman Moghal ◽  
Dipti debnath ◽  
Asma Kabir ◽  
...  

Objective: The present epidemiological study was conducted with the objectives of providing an insight into the current use of antidiabetic medications to diabetics and hypertensive diabetics in urban areas and determining how the patient factors influence the prescribing of antidiabetic medications. Methodology: Data of patients of past two years were collected from Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital, Dhaka, Bangladesh. The details were entered in the structured patient profile form. Data were statistically analyzed using the Microsoft Excel 2007 software. Result: A total of 958 patient’s data were collected and analyzed of which 632 (65.97 %) were males and 326 (34.03 %) were females. These patients were further categorized based on their age. 330 patients (34.45 %) belonged to the age group 20 – 44 years, 504 (52.61 %) to the age group 45 – 65 years and 124 (12.94 %) to the age group 65 – 80 years. 684 (71.4%) patients out of the 958 patients studied were suffering from coexisting hypertension. Co-existing hypertension was found to be more prevalent in the age group 45 – 65 years (67.69%) and was found more in females (84.04%). Conclusion: Metformin was the oral hypoglycemic which was the highest prescribed. In hypertensive diabetics Metformin and Pioglitazone were most frequently prescribed drugs. Biguanides and Insulin were the most commonly prescribed antidiabetics. A combination of two or more drugs of different classes was prescribed to hypertensive diabetics. It is necessary to have an improved understanding of the etiology and pathophysiology of diabetes to focus on research efforts appropriately.


Author(s):  
Anjani Teja Ch ◽  
Ramesh babu K ◽  
Leela subramanyam S ◽  
Janani Y ◽  
Eswar Sai Kiran K ◽  
...  

The descriptive observational study was conducted over six months among inpatients of the orthopaedics department. The aim is to observe the prescribing pattern of drugs, to find out the percentage of analgesics given and most commonly prescribed analgesic, to compare the prescribed drugs whether they are in NLEM, WHO list and calculate DDD/100 Bed-days and to analyze the drugs for WHO prescribing drugs. A total of 250 patients were included in the study. Out of this, 168 were male, and 82 were female. Most of the patients were in the age group of 31-40[45 in number with 18%]. The most common condition was found to fracture [113 in number with 95.2%]. Commonly prescribed drugs were analgesics 447 with 26.76%. Among all the NSAID's, PCM was most commonly prescribed analgesic with 34.4%. The highest no, of drugs was found to be 4drugs/prescription with 24%. Monthly one analgesic was prescribed per prescription with 38.8%. Utilization of analgesics in term of DDD/100 Bed-days was 55.26; Drugs will be evaluated per prescription as per prescribing indicators of WHO was done, the average no. of drugs per prescription was found to be 0.45, percentage of drugs prescribed by generic name was found to be 13.3%, percentage of encounters with antibiotics prescribed were found to be 94.4%, In ratio percentage of drugs prescribed from the national list of essential medicine was found to be 92.6%. This study would help to facilitate better health care delivery.


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