scholarly journals Study on prevalence of hepatitis B in pregnant women and its effect on maternal and fetal outcome at tertiary care centre

Author(s):  
Sunita Mishra ◽  
Priyali Purandre ◽  
Ratna Thakur ◽  
Shweta Agrawal ◽  
Madhuri Alwani

Background: Hepatitis-B is caused by double stranded DNA virus. Prevalence of hepatitis B in pregnant woman worldwide is 2.5 to 1.5% whereas in India it is 2 to 7.7%.Methods: This is a retrospective study conducted at SAMC and PGI, Indore between January 2016 to December 2016. Hepatitis- B prevalence and outcome was assessed by doing routine screening of hepatitis B antigen in our indoor patients and finding out their maternal and fetal outcome.Results: Total 3567 deliveries were conducted during study period, out of them 39 were diagnosed as HbsAg positive pregnant patient; so, prevalence was found to be 1.09%. out of these, 84.6% were booked cases, mode of delivery was vaginal in 66.67% cases, preterm Delivery was in 10.26% of cases, meconium stained liquor was found in 5.13% cases, maternal mortality was nil, perinatal mortality was found in 2.56% cases and 5.13% cases were admitted in NICU.Conclusions: Screening of all pregnant women for HbsAg irrespective of risk factors will definitely help to know the correct prevalence and reduce the transmission of hepatitis B infection. Hepatitis B is a major public health problem in India and will continue to be until appropriate nationwide vaccination programs and other control measures are established.

2020 ◽  
pp. 1-3
Author(s):  
Anup Latne ◽  
Prabhakar Jirvankar

Hypertension is a major public health problem all over the world. The incidence of hypertension is increasing year after year and the prevalence of hypertension is increasing day by day due to increased life expectancy and aging population and their sedentary lifestyle. Hypertension is known to cause microvascular changes and increased cardiovascular risk from it. Microalbuminuria possibly reflects a state of increased renal endothelial permeability and is an easily measured marker of rather diffuse endothelial dysfunction, low grade inflammation and vascular disease burden2. Microalbuminuria has been determined as an important prognostic indicator and has been reported to be associated with increased cardiovascular risk and progressive renal damage. Reliable data on the prevalence of microalbuminuria in the general population and its association with cardiovascular risk factors is limited. Till now, there is little data available regarding screening and early treatment of hypertensive patients with microalbuminuria, as in the case of microalbuminuric non diabetic subjects. With these perspective this cross sectional study of microalbuminuria in non-diabetic hypertensive patients was undertaken to study prevalence of microalbuminuria in Non Diabetic hypertensive patients. Objectives: To determine the prevalence of microalbuminuria in non-diabetic hypertensive patients and to correlate the presence of microalbuminuria with the patients of different clinical profiles. Materials and Methods: This was observational, cross sectional study of Patients diagnosed with hypertension either admitted in ward or attending OPD of Medical College and Tertiary Care Centre. Urine microalbumin creatinine ratio was used for estimation of microalbuminuria. Conclusion: It was proved that microalbuminuria prevalence was directly proportional to the duration of hypertension, the stage of hypertension. Prevalence of microalbuminria was low in ACE inhibitor and ARB treated hypertensive patients.


2021 ◽  
pp. 31-32
Author(s):  
Sweety Sinha ◽  
Anjana Sinha ◽  
Ankita Ankita

Background: With the exponential increase in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) worldwide, an increasing proportion of pregnant women are now infected during their pregnancy. The knowledge gained from previous human coronavirus outbreaks suggests that pregnant women and their fetuses are particularly susceptible to poor outcomes. The aim of this study was to summarize the maternal and perinatal outcomes of pregnant women infected with COVID-19 during their pregnancy. Methods:Eligibility criteria included pregnant women positive for COVID-19 as detected by real-time polymerase chain reaction (PCR). Results: Atotal of 40 pregnant women positive for COVID-19 as conrmed by RT-PCR, were included in the study. 5% cases had preterm deliveries and LSCS was the preferred mode of delivery in 28 of 40 i.e., 70% cases. There was a tendency for low Apgar score at birth, higher rates of fetal distress, meconium, NICU admissions. There was one IUD only in this study. The treatment patterns of COVID-19 infection among pregnant women during their pregnancy or following delivery was mostly supportive in the form of oxygen and antibiotic therapy. Conclusions: Although the majority of mothers were discharged without any major complications, severe maternal morbidity as a result of COVID-19 were reported. Vertical transmission of the COVID-19 could not be ruled out. Pregnant infected women had different symptoms, and they were given mostly supportive treatments than the general infected population. Careful monitoring of pregnancies with COVID-19 and measures to prevent neonatal infection are warranted.


Author(s):  
Radha Kumari Paladugu ◽  
Srinivas Jagath Pentakota ◽  
Sushma N.

Background: Anaemia in pregnancy is now considered as a major public health problem, caused by iron deficiency. WHO has estimated that prevalence of anaemia in developed and developing countries in pregnant women is 14% in developed countries and 51 percent in developing countries and 65-75% in India. Various programmes regarding anaemia prophylaxis and maternal health have been implemented but still the prevalence of anaemia related complications among pregnant women continues to be high. Hence the present study was conducted to study the prevalence and pregnancy outcome as a result of anaemia in a tertiary care center in Visakhapatnam. Methods: A cross sectional descriptive study was carried out from June 2016 to August 2016 in the Department of Obstetrics and Gynecology among postnatal women in King George hospital, Visakhapatnam. A semi-structured questionnaire was prepared and information regarding age, socioeconomic status, parity, gestational age interval between pregnancies and outcome and complication of pregnancy were collected. Results: Mean age of study population is 22.4 years. Out of 100 women involved in the study 65 are from urban areas 29 from rural areas and 6 from tribal areas. Majority of the study population 66% were having HB% between 8-11% i.e. mild anaemia. When Outcome of pregnancy was seen in relation to anaemia majority of the women had live births (90%) followed by 7% IUDs and 2% still births. Conclusions: Majority of the women are in the age group of 20-24 years. Socioeconomic status is directly related to anaemic status of the women. Majority of the women had complication of puerperal sepsis. 


2020 ◽  
Vol 7 (5) ◽  
pp. 1535
Author(s):  
Ashish Anand ◽  
Surender Verma ◽  
Pradeep Garg ◽  
M. Taquedis Noori ◽  
Ankur Kajal ◽  
...  

Background: Head injury is a major public health problem worldwide and requires appropriate attention both regionally and globally. This study was done to find the patterns and to evaluate prognostic factors for final outcome of cranio-cerebral trauma.Methods: A prospective study of 200 cases of head injury was conducted in a tertiary care hospital during one year duration. Apart from patient’s demographic profile detailed history and examination was recorded. Final outcome of all patients was noted at discharge and during follow up, various prognostic factors were studied by taking Glasgow outcome scale (GOS) at 3 months of head injury.Results: This study included 156 (78%) males and 44 (22%) females with average age of 35.95 years. Assault followed by RTI was the main cause of TBI. The factors which correlated with poor prognosis are presence of increasing age, less GCS at admission, alcohol intoxication and multiple lesions on CT scan.Conclusions: Prognostication of patients with head injury will help to provide timely multimodality approach which will ultimately help in improving outcome of these patients. 


2021 ◽  
pp. 32-34
Author(s):  
Kumar Vikram ◽  
Gyan Bhaskar ◽  
Shailesh Kumar ◽  
Rakesh Kumar ◽  
Namrata Kumari

Introduction: Corneal blindness is a major public health problem worldwide and fungal keratitis is one of its predominant causes. The etiological and epidemiological pattern of fungal keratitis varies signicantly with patient population, geographical region and prevailing socioeconomic conditions. Objectives:The objective of the study was to identify the specic pathogenic agents and to study epidemiological characteristics of fungal keratitis presenting at a tertiary care centre in Patna, Bihar. Materials And Methods: Corneal scrapings were obtained from clinically suspected patients of keratomycosis during the period of 18 months from May 2015 to October 2016. The scraping material was processed and identied by standard laboratory techniques. Demographic and clinical features of the patients were also collected. Results: Out of total 115 suspected fungal corneal ulcers, 63(54.78%) were positive for fungal etiology. Of these, 53(84.13%) were positive on KOH mount. 40(63.49%) and 35(55.56%) were positive in Gram stain and culture respectively. In culture, aspergillus spp (16;45.71%) were the predominant fungal species, followed by fusarium spp (12;34.29%). Males (35/63;55.56%) were more commonly affected. 22 out of 63 patients (34.92%) were of age group 31-45 years. Majority of patients were farmers (68.25%). Corneal trauma (50.79%) was the most common predisposing factor in which trauma due to vegetative matter (53.13%) was most signicant. Conclusion: Fungal keratitis continues to be a cause of concern to ophthalmologists. Agricultural activity and related ocular trauma are principal causes of mycotic keratitis. A potassium hydroxide (KOH) wet mount preparation is a simple, and sensitive, method for diagnosis.


Author(s):  
Poojan Dogra ◽  
Reena Sharma

<p><strong>Background: </strong>The rising rate of caesarean section is the subject of concern worldwide. The aim of our study was to know the knowledge, attitude and preferences of pregnant women towards the mode of delivery in a tertiary care centre and hence to see weather this is a contributing factor towards rinsing trend of caesarean delivery or not.  </p><p><strong>Methods: </strong>This was a prospective questionnaire study conducted on 100 antenatal women in third trimester who attended the antenatal clinic in SLBS GMC Mandi at Nerchowk from 1<sup>st</sup> June, 2017 to 1<sup>st</sup> September 2017.The information regarding socio-demographic profile, obstetric history, knowledge and attitude statements towards vaginal delivery and caesarean section was collected and analysed.</p><p><strong>Results: </strong>Total of 100 women was interviewed in our study. Out of these, majority (85%) had received education up to High school and above. Majority of the women (90%) had the positive attitude towards vaginal delivery. The most frequently mentioned source of information about the mode of delivery was relatives and friends. Almost half of women agreed to the statement that vaginal delivery creates a more affectionate mother and baby relationship.  Majority of women co-relate that caesarean section was associated with more complications and not good in long term outcome. Economic factors did not play an important role in deciding caesarean birth.</p><p><strong>Conclusions: </strong>Majority of pregnant women interviewed were interested to deliver vaginally, while some women were indecisive due to lack of knowledge and some due to apprehension of labor pains during vaginal delivery wanted to undergo a caesarean section. Appropriate counselling of pregnant women and their partners will help in changing their outlook and make them a better judge while choosing their preferences.</p>


Author(s):  
C. O. Onwuliri ◽  
C. C. Onyenekwe ◽  
M. H. Yeldu ◽  
A. A. Panti ◽  
A. B. Shuaibu ◽  
...  

Hepatitis B virus (HBV) is a major public health problem in sub-Saharan Africa with high morbidity and mortality. Vertical transmission is a significant contributor of new cases. The aim of this study was to determine the prevalence of HBV infection, to assess the immune competence of Hepatitis B (HB) viral infected pregnant women using lymphocyte transformation. It was a cross sectional comparative observational study. Simple random sampling technique was applied. One hundred HB infected pregnant women and one hundred controls were recruited. Data were analysed using SPSS (version 23) software. A P-value ≤ 0.05 was considered statistically significant. The results recorded showed a prevalence of 6.6%. The percentage lymphocyte transformation was significantly lower (p < 0.05) for HBV infected subjects compared with control. The rate of lymphocyte transformation with Phytohaemagglutinin was significantly lower (p < 0.05) when compared with Concanavalin A. Conclusively HB infection affects the adaptive immune response. Pregnant women should be screened for Hepatitis B surface Antigen (HBsAg) during routine Antenatal clinic and Concanavalin A based drugs should be recommended for HB infected pregnant women.


Author(s):  
Vandana Verma ◽  
Soniya Vishwakarma ◽  
Ramesh Chand ◽  
Umesh Kumar Gupta

Background: Anaemia is a major public health problem especially among low socioeconomic class of the population in developing countries. Prevalence of anaemia among pregnant women in developing countries is 51%. Anaemia is defined by the WHO as haemoglobin levels of less than 11 gm. %   in pregnancy. The present study was aimed to find out prevalence of anaemia in rural tertiary care centre to see the foetal outcome in anaemic women.Methods: This is a retrospective observational study done in the Department of Obstetrics and Gynaecology, University of medical sciences Saifai, Etawah from June 2017 to November 2017. All the women admitted to labour room in third trimester and delivered here were included in the study excluding the patients with pre-eclampsia, eclampsia, gestational diabetes mellitus, heart disease, patients with other medical disorders and patients with twin pregnancy, antepartum haemorrhage and the patients who did not deliver here.Results: Prevalence of anaemia was 87.3 %. severe anaemia was found in 3.5 % women. The percentage of preterm births was more in anaemic women that is 16.9 %.Conclusions: Anaemia in pregnancy is a major public health problem in India. The number of IUGR and LBW babies were more in anaemic women. Anaemia is related to serious consequences in mother and baby if not diagnosed and treated timely. It can be prevented by increasing the awareness regarding need of iron intake during pregnancy.


Author(s):  
Nazia Hassan ◽  
Mudasir Muzamil ◽  
Dawood Banday

Background: With the exponential increase in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) worldwide, an increasing proportion of pregnant women are now infected during their pregnancy. The knowledge gained from previous human coronavirus outbreaks suggests that pregnant women and their fetuses are particularly susceptible to poor outcomes. The aim of this study was to summarize the maternal and perinatal outcomes of pregnant women infected with COVID-19 during their pregnancy.Methods: Eligibility criteria included pregnant women positive for COVID-19 as detected by real-time polymerase chain reaction (PCR) or dual fluorescence PCR-confirmed SARS-CoV-2 infection.Results: A total of 38 pregnant women positive for COVID-19 as confirmed by RT-PCR, were included in the study. 21% cases had preterm deliveries and LSCS was the preferred mode of delivery in 23 of 38 i.e., 60.5% cases. There was a tendency for low Apgar score at birth, higher rates of fetal distress, meconium, NICU admissions. There was one IUD and one neonatal death. The treatment patterns of COVID-19 infection among pregnant women during their pregnancy or following delivery was mostly supportive in the form of oxygen and antibiotic therapy.Conclusions: Although the majority of mothers were discharged without any major complications, severe maternal morbidity as a result of COVID-19 and perinatal deaths were reported. Vertical transmission of the COVID-19 could not be ruled out. Pregnant infected women had different symptoms, and they were given mostly supportive treatments than the general infected population. Careful monitoring of pregnancies with COVID-19 and measures to prevent neonatal infection are warranted.


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