scholarly journals Huge yolk sac tumor in an adolescent girl: a case report

2017 ◽  
Vol 6 (7) ◽  
pp. 3192
Author(s):  
Amrita J. Jain ◽  
Rekha G. Daver ◽  
Anjali M. Patil
Keyword(s):  
Febrile Illness ◽  
Yolk Sac ◽  
Final Outcome ◽  
Acute Febrile Illness ◽  
Age Group ◽  
Aggressive Disease ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
The Common ◽  
Yolk Sac Tumour

Germ cell tumours form a minority of all malignancies of the ovary. The common age group affected by yolk sac tumours is 11 to 24 years. Here, we present a case of yolk sac tumour in a 13-year-old girl who came with complaints of abdominal pain, distension and acute febrile illness. Fertility sparing surgery (Unilateral salpingo-oophorectomy) was done while the contra lateral ovary and uterus was conserved followed by combination chemotherapy postoperatively. As pprognosis of yolk sac tumours is highly stage-dependent, an early diagnosis can result in a drastic difference in the final outcome of the treatment of this highly aggressive disease. Besides the rarity of the tumour, the importance of the fact, that a vigilant and informed clinician can make an early and timely diagnosis of this condition even in girls of such a young age and make a drastic difference in the final outcome of the treatment, compels us to present this case.

scholarly journals Pure yolk sac tumour, post-pubertal type, arising from cryptorchid testes

2019 ◽  
Vol 12 (7) ◽  
pp. e229541 ◽  
Author(s):  
Hemant Janugade ◽  
Jeffrey Monteiro ◽  
Shekhar Gouda
Keyword(s):  
Alkaline Phosphatase ◽  
Ct Scan ◽  
Microscopic Examination ◽  
Germ Cell Tumour ◽  
Exploratory Laparotomy ◽  
Yolk Sac ◽  
Pelvic Cavity ◽  
Age Group ◽  
Yolk Sac Tumour ◽  
In Infants And Children

Yolk sac tumour (YST), the most common germ cell tumour (GCT) in infants and children, accounts for 80% of GCTs in this age group. 1 It is observed in only 2.4% of adult patients in their pure form since up to 42% of mixed GCTs have some component of the yolk sac. 2 We present a 46-year-old cryptorchid man who presented with complaints of abdominal lump, pain and altered bowel habits since 1 month. CT scan of the abdomen revealed a mass arising from the pelvic cavity with feeders predominantly from the left gonadal vessel. Mass was excised via exploratory laparotomy and sent for histological examination. Microscopic examination was suggestive of pure YST. Immunohistochemistry stained positive for cytokeratin, placental-like alkaline phosphatase, Glypican 3 and alpha fetoprotein. The patient succumbed prior to commencing chemotherapy. Pure YSTs of post-pubertal origins are extremely rare and are more aggressive than their prepubertal counterparts.

scholarly journals Yolk sac tumour of ovary with fever and overt hypothyroidism: rare clinical presentation

2020 ◽  
Vol 13 (1) ◽  
pp. e232114
Author(s):  
Megha Kansara ◽  
Garima Yadav ◽  
Meenakshi Gothwal ◽  
Pratibha Singh
Keyword(s):  
Germ Cell ◽  
Clinical Presentation ◽  
Early Stage ◽  
Yolk Sac ◽  
Gravid Uterus ◽  
Overt Hypothyroidism ◽  
Germ Cell Tumours ◽  
High Grade Fever ◽  
Fertility Sparing ◽  
Yolk Sac Tumour

Yolk sac tumours of the ovary are rare and highly malignant germ cell tumours, which comprise of only 10%–15% of all malignant germ cell tumours. They have various clinical presentations most common being subacute pelvic pain and feeling of lump but sometimes high-grade fever can be one of the rare presentations. Here, we present a case report of a 26-year-old nulliparous woman with 36 weeks gravid uterus size advanced stage yolk sac tumour of one ovary with fever as main clinical presentation and overt hypothyroidism. We did staging laparotomy with total abdominal hysterectomy with bilateral salpingo-oophorectomy and omentectomy with multiple peritoneal biopsies. Postoperatively, we had started adjuvant chemotherapy. Since yolk sac tumours are highly aggressive tumours as they rapidly increase in size, their early diagnosis and appropriate surgical management is required particularly in young women where fertility sparing surgery is possible in early stage with good prognosis.

Is fertility sparing surgery a treatment option for young patients with yolk sac tumor?

2018 ◽  
Vol 70 (6) ◽  
Author(s):  
Christos Iavazzo ◽  
George Vorgias ◽  
Paraskevi E. Iavazzo ◽  
Evelyn E. Minis ◽  
Ioannis D. Gkegkes
Keyword(s):  
Treatment Option ◽  
Young Patients ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

Reproductive outcomes of fertility sparing surgeries in germ cell tumours

2017 ◽  
Vol 6 (2) ◽  
pp. 5266
Author(s):  
Ujwala Prakash Wakpaijan
Keyword(s):  
Overall Survival ◽  
General Population ◽  
Germ Cell ◽  
Germ Cell Tumour ◽  
Young Patients ◽  
Age Group ◽  
Germ Cell Tumours ◽  
Reproductive Outcome ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

The main aim of the study is to observe the reproductive outcome in patient of germ cell tumour after fertility preserving surgery. In which retrospective records of patients diagnosed with malignant GCT in young patients treated with fertility sparing surgery and chemotherapy for ten years from 2000 to 2009. From the careful observations concluded the overall survival with the patients treated with fertility sparing surgery is excellent and the reproductive outcome is more or less equivalent to the general population of same age group.

Neoadjuvant BEP regimen in the treatment of extensively advanced yolk sac tumor: A single institutional experience.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 5570-5570
Author(s):  
Gong-Yi Zhang ◽  
Rong Zhang ◽  
Ling-Ying Wu ◽  
Shu-min Li ◽  
Bin Li
Keyword(s):  
Residual Disease ◽  
Tumor Regression ◽  
Medical Science ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
Biological Behavior ◽  
Considerable Proportion ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Ecog Ps

5570 Background: Due to the highly aggressive biological behavior and early intra-abdominal spread potential of ovarian yolk sac tumor (YST), a considerable proportion of patients were inoperalbe at initial diagnosis. The aim of this study was to investigate the role of neoadjuvant chemotherapy (NACT) in this cohort of patients. Methods: Between July 1982 and December 2015, 58 patients diagnosed as YSTs were initially treated at Cancer Hospital of China Academy of Medical Science (CAMS), among which 18 were evaluated to be inoperable and received NACT. They were either too debilitated by the disease (ECOG ps≥2) to undergo a major surgery, or were with too extensively disseminated lesions to be optimally debulked. Massive ascites, pleural effusion, dyspnea, neoplastic fever, hypoproteinemia, or electrolyte disturbance were also common in these 18 patients. This cohort of patients was retrospectively reviewed. Results: One or 2 cycles of BEP regimens were prescribed to the majority of patients preoperatively. At the completion of NACT, all the 18 patients had ECOG ps≤1 . Seventeen of them (94.4%) exhibited clinical partial tumor regression and 1(5.6%) had clinical stable disease. Pathological complete tumor regression was observed in 2 (11.1%) patients, whereas the remaining 16(88.9%) had nearly complete pathological response. All these 18 patients were rendered operable at the completion of NACT, yielding a resection rate of 100%. Seventeen patients (94.4%) were cytoreduced to no macroscopic residual disease, 1 (5.6%) patient was cyto-reduced to macroscopic residual disease ≤2 cm. No major surgical complications occurred in our series. After a median follow-up of 83.5 months, 17 patients were free of recurrence. Five-year DFS and OS were both 94.4%. Fertility-sparing surgery was carried out in all the 17 patients with fertility desire, and 5 infants were delivered in 6 patients who attempted conception. Conclusions: One or 2 cycles of NACT followed by early cyto-reductive surgery offers a chance for cure in patients with extensively advanced YSTs. It allows for a more through and safe cyto-reductive surgery, improves survival outcomes, and helps pave the way for fertility-sparing surgery.

scholarly journals Yolk sac tumor in an antenatal patient: a challenging case

2018 ◽  
Vol 7 (10) ◽  
pp. 4318
Author(s):  
Anu Namgyal ◽  
Anjali Soni ◽  
Suresh Verma ◽  
Indu Chauhan ◽  
Shikha Sharma ◽  
...  
Keyword(s):  
Ovarian Neoplasms ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
Common Occurrence ◽  
Stage Iiic ◽  
Adnexal Masses ◽  
Antenatal Ultrasound ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

Pregnancy complicated with adnexal masses is a very common occurrence. However, most of these adnexal masses encountered in pregnancy are benign in nature and are found incidentally during routine antenatal ultrasound. Malignant ovarian neoplasms account for 1%-8% of all persistent adnexal masses diagnosed during pregnancy. Yolk sac tumor (YST) complicating pregnancy is very rare and has no proper guidelines for its diagnosis and management hence causing a therapeutic dilemma for the clinicians. Therefore, an individualised approach is preferred in such cases. It is very important to report such cases for better understanding and management of these cases. Here we present a case report of a 23-year-old primigravida at 30 weeks gestation with yolk sac tumor of right ovary, surgical stage IIIc who responded well to fertility sparing surgery with cisplatin-based combination chemotherapy. She has no evidence of disease post treatment and has been put on regular follow up.

STUDY OF OVARIAN TUMOR IN YOUNG GIRLS

2011 ◽  
Vol 18 (01) ◽  
pp. 41-45
Author(s):  
SAADIA TARIQ ◽  
RUBINA SOHAIL
Keyword(s):  
Surgical Management ◽  
Case Series ◽  
Age Group ◽  
Young Girls ◽  
Presenting Symptoms ◽  
Fertility Sparing Surgery ◽  
Pain Abdomen ◽  
Fertility Sparing ◽  
Ovarian Pathology ◽  
Histology Report

Objective: To analyze various clinical presentation and the surgical management of ovarian pathology in young girls ranges from 15-25 years. Design: Case series. Setting: Gynae Department 1, Lahore General Hospital Lahore. Period: From January 2008 to December 2009. Patients and Methods: All young girls in the age group mentioned above having an ovarian pathology and managed during study period were included. Age of patients, presenting symptoms, USG findings, surgical management and finally histological diagnosis were noted. Results: There were 20 cases with ovarian lesions. Most of patients presented at the age of 20-25 years (55%). Mass abdomen seen in (30%) cases, followed by pain abdomen in (20%). Lapratomy was done in most of cases and main aim was toward ovary sparing surgery as Cystectomy was done in (50%) cases and Oophorectomy was done in (30%) cases. 85% cases were benign on histology report and 15% were malignant. Conclusions: Ovarian tumors are rare in young age group. Benign lesions such as simple ovarian cysts are very common in this age. In young girls main interest is toward conservative and fertility sparing surgery.

scholarly journals Treatment outcomes in malignant ovarian germ cell tumors

2017 ◽  
Vol 6 (12) ◽  
pp. 5256
Author(s):  
Ram Kumar B.
Keyword(s):  
Germ Cell ◽  
Chemotherapy Regimen ◽  
Primordial Germ Cells ◽  
Germ Cell Tumour ◽  
Germ Cell Tumors ◽  
Cystic Teratoma ◽  
Germ Cell Tumours ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Yolk Sac Tumour

Background: Malignant ovarian germ cell tumours are rare group of ovarian neoplasms derived from primordial germ cells of the ovary. Objective of present study was to evaluate the outcome of treatment in malignant germ cell tumours.Methods: 21 Patients of malignant ovarian germ cell tumours registered at Department of Medical Oncology, Institute of Obstetrics and Gynaecology, Chennai for the period from January 2012 to December 2015 were retrospectively analyzed for treatment outcomes.Results: The median age at presentation was 21 years with age range between 14 and 40 years. 9patients (43%) presented with mixed germ cell tumour, 6 patients (29%) with dysgerminoma, 3 patients (14%) with yolk sac tumour and 3 patients (14%)with mature cystic teratoma. 13 patients (62%) presented with Stage I disease, 5 patients (24%) with Stage III and 3 patients (14%) with Stage II. Fertility sparing surgery was done in 15 patients (71%), and 4 patients (19%) who completed family had TAH with BSO done. Adjuvant Chemotherapy was given for 16 patients (76%) and as Neoadjuvant in 2patients (10%) who had biopsy alone performed. 4patients (19%) developed recurrence and was taken for salvage PVI chemotherapy.Conclusions: Malignant ovarian germ cell tumours are relatively uncommon neoplasms characterized by high chemo sensitivity. This study confirms that malignant ovarian germ cell tumours have excellent prognosis and the effectiveness of BEP chemotherapy regimen. Fertility sparing surgery is feasible in most cases. Advanced Stage configured as an important risk factor for survival. The chemotherapy regimen was associated with significant but manageable toxicity.

scholarly journals Thrombocytopenia; Frequency and Association at the Time of Diagnosis in Dengue Fever, Peshawar

2020 ◽  
Vol 6 (2) ◽  
pp. 10-15
Author(s):  
Nauman Wazir ◽  
Ayesha Malook ◽  
Shafaq Naz ◽  
Mohammad Arshad ◽  
Shafqat Ur Rehman ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Teaching Hospital ◽  
High Frequency ◽  
Complete Blood Count ◽  
Specific Antigen ◽  
Febrile Illness ◽  
Acute Febrile Illness ◽  
Age Group ◽  
Age And Gender ◽  
And Gender

ABSTRACT: OBJECTIVES: To determine the frequency of thrombocytopenia in dengue fever at the time of diagnosis and to see its association with age and gender. METHODOLOGY: It was a descriptive retrospective study of dengue cases admitted to the Medical Unit of Naseer Teaching Hospital Peshawar during the 2019 outbreak was performed. Only confirmed dengue by serology (IgM) or dengue NS1 (Non-Specific Antigen 1) by Immunochromatographic Technique (ICT) cases were analysed. Complete Blood Count (CBC) was done for all the cases on admission and prevalence of thrombocytopenia on admission was extracted from the records. SPSS version 23 was used to analyse the data and to calculate Odds Ratio of a gender or age group to have thrombocytopenia at the presentation of dengue fever. RESULTS: A total of 69 confirmed dengue cases were admitted in Naseer Teaching Hospital in the 2019 outbreak. Out of these 69 cases, 51 (73.9%) were males and 18 (26.1%) were females. The ages of these patients ranged from 10-58 years. Fifty-one (51) patients were more than 20 years of age and eighteen (18) were 20 years or less. Thrombocytopenia (platelet count<150,000×109/L) was present in 57 (82.6%) patients. Patients older than 20 years of age were more likely to have thrombocytopenia at presentation of dengue fever OR=16, (p=0.0003), whereas difference amongst genders in this regard was not statistically significant OR=1.07, (p=0.09). CONCLUSION: There is a high frequency of thrombocytopenia (82.6%) in early dengue fever. Patients older than 20 years are more likely to have thrombocytopenia in early dengue fever. KEYWORDS: Dengue Fever, Acute Febrile Illness, Thrombocytopenia

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