scholarly journals Study the effect of mifepristone on fibroid and uterine volume

2018 ◽  
Vol 7 (12) ◽  
pp. 5016
Author(s):  
Umbreen Seher ◽  
Nidhi Chauhan ◽  
Mishu Mangla
Keyword(s):  
Premenopausal Women ◽  
Reproductive Age ◽  
Medical Sciences ◽  
Antagonistic Action ◽  
Receptor Modulator ◽  
Obstetrics And Gynaecology ◽  
Common Benign Tumour ◽  
Fibroid Volume ◽  
Reproductive Age Group ◽  
Uterine Volume

Background: Fibroid is the most common benign tumour of the uterus affecting 20% of women of reproductive age group and is the most common indication for hysterectomy accounting for about 40% of all hysterectomies in premenopausal women. This study was undertaken to study the effect of Mifepristone, which is a progesterone receptor modulator with antagonistic action, on fibroid and uterine volume.Methods: The study was conducted in the Department of Obstetrics and Gynaecology, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Dehradun over a period of 12 months. A total of 40 patients were included in the study.Results: Mean baseline fibroid volume decreased by 49.17% at 1 month and by 77.4% and 3months of treatment with Mifepristone. Mean baseline uterine volume decreased by 34.13% at 1 month, and further reduction by 58.3% at the end of treatment.Conclusions: The study shows that there is a significant reduction in fibroid and uterine volume in patients treated with mifepristone.

scholarly journals Role of Mifepristone in treatment of uterine fibroid: an experience from tertiary care centre in South India

2019 ◽  
Vol 8 (3) ◽  
pp. 974
Author(s):  
S. V. Nachiketha ◽  
Veena Hadi
Keyword(s):  
Side Effects ◽  
Uterine Fibroid ◽  
Tertiary Care ◽  
Reproductive Age ◽  
Tertiary Care Centre ◽  
Common Benign Tumour ◽  
Fibroid Volume ◽  
Reproductive Age Group

Background: Uterine fibroid are the most common benign tumour of the uterus and is seen in 20% of women in their reproductive age group. The aim of the study was to evaluate effect of Mifepristone on uterine fibroid with reference to reduction in size of fibroid and change in symptomatic profile.Methods: It is a hospital based interventional study conducted at KIMS Hubli hospital. 98 patients with symptomatic fibroid uterus were given 50mg of Mifepristone on alternate day for 3 months.Results: Mifepristone treatment significantly reduced mean PBAC score from baseline score of 212.61 to 20.39 at the end of 3rd month of therapy. Mean fibroid volume also reduced significantly from baseline value of 237.95cm3 to 30.45cm3 after 3 months of treatment. At the end of therapy hemoglobin was raised from 9.57g/dl at baseline to 10.42g/dl after 3 months of treatment. No major side effects were observed, and 7% patients had hysterectomy.Conclusions: Mifepristone is very useful option in perimenopausal women with symptomatic fibroid. It reduces fibroid size and its symptoms without any major side effects. However, future long term RCTs are needed to assess the safety and efficacy of Mifepristone.

Adnexal Masses in Premenopausal Reproductive Age Women

2018 ◽  
Vol 15 (1) ◽  
pp. 32-40
Author(s):  
Henny Liwan ◽  
Steve Hong
Keyword(s):  
Tumor Markers ◽  
Premenopausal Women ◽  
Reproductive Age ◽  
First Line ◽  
Diagnostic Dilemma ◽  
Adnexal Masses ◽  
Reproductive Age Women ◽  
Imaging Characteristics ◽  
Line Imaging ◽  
Reproductive Age Group

Background: Adnexal masses in premenopausal women are common reason for referral to OB-GYN. The etiologies vary from non-gynecologic to gynecologic. Once the mass is determined to be gynecologic in its origin, the gynecologist needs to predict if the mass is more likely to be benign or malignant which could lead to a diagnostic dilemma. Objective: This article reviews different histologic type of ovarian tumors, its epidemiology, clinical presentation, imaging appearance and ovarian tumor markers. Familiarity with these patterns will help the clinician narrow the differential diagnosis thus facilitating further management. Results: The incidence of malignancy increases with age. Vast majority of adnexal masses that are ovarian in etiology, 90.5% are benign. The first line imaging is usually a pelvic ultrasound. There are imaging characteristics that could assist in categorizing a mass as more likely to be benign or suspicious for malignancy. Furthermore, there are tumor markers that are approved by FDA to be used as tools to evaluate adnexal masses. Conclusion: Adnexal masses in the reproductive age group demonstrate the greatest histologic variance that is mostly benign. Clinical judgement is important to predict if a mass is likely to be benign or malignant based on risk factors, imaging appearances, and tumor markers. If suspicion of malignancy is high, referral to a gynecologic oncologist is warranted as this may improve patient’s survival.

scholarly journals Awareness of sexually transmitted diseases (STDs) among married women of reproductive age group in Barahi, Chiraigaun, India

1970 ◽  
Vol 6 (3) ◽  
pp. 8-14
Author(s):  
S Thapa ◽  
H Hassan
Keyword(s):  
Sexually Transmitted Diseases ◽  
Health Workers ◽  
Effective Means ◽  
Transmitted Disease ◽  
Married Women ◽  
Reproductive Age ◽  
Medical Sciences ◽  
Medical Practitioners ◽  
Sexually Transmitted ◽  
Reproductive Age Group

A survey was conducted using 139 rural married women to know awareness of sexually transmitted diseases (STDs) in Barahi, Chiraigaun, a rural primise in India. About one-fifth of the respondents were aware of STD, of which there was only one female who had heard of STD. Very few people sought for help from medical practitioners and less than one-fifth of the diseased people failed taking medicine regularly. Treatment cost ranged from Rs 10 to 5,000. Mass media like TV was not popular among rural people. Health workers were effective means of propagating knowledge and creating awareness. None of the diseased persons were using condom while 10% of non-diseased respondents used condom. No awareness program on health was conducted in the locality within a year. None of the respondents were able to tell whether STD’s and HIV were same or different. Key words: Sexually transmitted disease (STD); health worker; condom. DOI: 10.3126/jcmsn.v6i3.4068Journal of College of Medical Sciences-Nepal, 2010, Vol. 6, No. 3 pp.8-14

scholarly journals Profile of infection in women with vaginal discharge in North India

2018 ◽  
Vol 7 (10) ◽  
pp. 4184
Author(s):  
Nishi Sood ◽  
Shyam Sunder Sud
Keyword(s):  
Trichomonas Vaginalis ◽  
Vaginal Discharge ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
North India ◽  
Obstetrics And Gynaecology ◽  
History Of ◽  
Posterior Fornix ◽  
Common Infection ◽  
Reproductive Age Group

Background: The objective of the present study was to observe the profile of infection in women with vaginal discharge.Methods: The present study was conducted between October 2013 and September2014. The respondents were females in reproductive age group (15-45 years) attending Obstetrics and Gynaecology OPD with history of vaginal discharge. After detailed clinical examination of the patient, pH was determined, and the posterior fornix was swabbed with a cotton tip applicator. Further a Whiff (amine) test done; wet mount was immediately prepared and examined. Another swab was sent for Gram’s stain and culture.Results: A total of 200 women with vaginal discharge were studied, of which 146 were diagnosed with pathogens. The most common form of infection was mixed infection which was diagnosed in 69 patients (34.5%). As a single pathogen, the next most common infection was Bacterial vaginosis seen in 43 patients (15.5%) and Trichomonas vaginalis seen in 3 patients (1.5%).Conclusions: The clinical manifestations of vaginits are diverse. By knowing the microbiology of the vaginal flora, we could come to the conclusion of the etiology of vaginitis.

scholarly journals Comparison of adnexal torsion in different phases of women’s life: a retrospective cohort study

2020 ◽  
Vol 9 (4) ◽  
pp. 1482
Author(s):  
Karthiga Prabhu J. ◽  
Shanmugapriya C. ◽  
Sunita Samal ◽  
Balaji Ramraj
Keyword(s):  
Reproductive Potential ◽  
Premenopausal Women ◽  
Ovarian Torsion ◽  
Reproductive Age ◽  
Research Centre ◽  
Age Group ◽  
Adnexal Torsion ◽  
Polycystic Ovaries ◽  
College Hospital ◽  
Reproductive Age Group

Background: Ovarian torsion is one of the most common causes of emergency surgery in gynecology. Though it is more common in reproductive age group, it can occur in extremes of age group. So, we had analysed the clinical presentation, surgical characteristics, and causes of adnexal torsion among adolescent population, reproductive-age women, and postmenopausal women.Methods: Patients with adnexal torsion who were treated in department of obstetrics and gynecology, SRM Medical College Hospital and Research Centre from October 2016 to March 2019 were retrospectively analyzed.Results: Among the 53 cases of adnexal torsion during the study period, maximum (38, 71.6%) were in the reproductive age group. There were three patients with ovarian torsion during pregnancy. Acute pain abdomen was the significant presenting symptom in adolescent group compared to other two group (100% versus 80.6% versus 40%, p = 0.03). Adnexal pathology was in the ovary in 76% and isolated tubal pathology in 5%. Bilateral salpingo-oophorectomy with or without total abdominal hysterectomy was more commonly performed in postmenopausal patients (100%), as opposed to conservative surgery- detorsion and cystectomy in premenopausal women (56%). In Adolescent patients 62% had polycystic ovaries as intraoperative finding. Histopathology were benign except for a patient in postmenopausal age group who had granulosa cell tumour.Conclusions: An early identification of adnexal torsion is necessary in order to achieve conservative treatment in order to maximize the future reproductive potential in younger patients.

scholarly journals To Assess the KAP Study about HPV Vaccination among Women of Reproductive Age Group

2021 ◽  
pp. 238-244
Author(s):  
G. Shivani ◽  
M. Rajalekshmi
Keyword(s):  
Human Papillomavirus ◽  
Hpv Vaccination ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Obstetrics And Gynaecology ◽  
Reproductive Age Group

Background: Human papillomavirus vaccines prevent infection by certain types of human papillomavirus. HPV vaccine is recommended at age 11-12 years. Objectives: This study aims to assess the knowledge, attitude and practice about HPV vaccination among Women of reproductive age group. Materials and Methods: This community based cross sectional study was conducted over a period of three months from January 2021- March 2021 at the Obstetrics and Gynaecology Department OPD at Saveetha Medical College and Hospital. A total of 193 women who attended the Obstetrics and Gynaecology Department were included as study participants. A pretested, semi-structured data tool was used. Descriptive variables were presented as proportions and frequencies. Chi-square test was used to ascertain the associations. Results: About 55.9% of them had knowledge about HPV vaccination and 52.6% with the risk factors, signs and symptoms, and prevention of cervical carcinoma among the study population. Conclusion: Advancement of health facilities, encouragement of service provider, sustainable health programs and creating awareness will support to achieve decrease in incidence of cervical cancer.

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