scholarly journals Conception rate with or without hCG trigger in clomiphene induced cycles

2021 ◽  
Vol 10 (8) ◽  
pp. 3142
Author(s):  
Aruna Verma ◽  
Abhilasha Gupta ◽  
Monika Kashyap ◽  
Juveriya Meraj
Keyword(s):  
Clomiphene Citrate ◽  
Conception Rate ◽  
Lh Surge ◽  
Medical College ◽  
Follicle Rupture ◽  
Group A ◽  
Follicle Size ◽  
Group B ◽  
Hcg Trigger

Background: Clomiphene citrate (CC) is still the most common drug for ovulation induction. Most physicians use hCG trigger routinely for follicle rupture. Ideally hCG is recommended only where there is no spontaneous LH surge. Hence this study was conducted to see the role of hCG for follicle rupture in CC induced cycle. Aims and objectives of the study were to compare the ovulation rate in CC induced cycle with or without hCG trigger and finally the conception rate.Methods: Study was conducted in the department of OBG, LLRM medical college Meerut on women with anovulatory infertility. All women were given 50-100 mg CC. Follicular study from D-9 was done till follicle rupture. Women in group A were observed without any trigger and women in group B were given inj. hCG trigger 10,000 IU when follicle size reached 20-22 mm.Results: Conception rates were 25% Vs 31% in group A and group B. Follicle rupture was seen in 84% cases in group A and 71% in group B. Results were comparable in both the groups.Conclusions: By adding inj. hCG for ovulation trigger does not increase the conception rate. LH surge is already there in CC induced cycles. It is having role only in cases where no LH surge is there. 

“A PROSPECTIVE STUDY: ROLE OF TRACTION ON FOLEY’S CATHETER IN TURP PATIENTS”

2021 ◽  
pp. 27-29
Author(s):  
Prashant Lavania ◽  
Ankush Gupta ◽  
Rahul Chaudhary
Keyword(s):  
Blood Loss ◽  
Early Discharge ◽  
Common Condition ◽  
Medical College ◽  
Duration Of Hospital Stay ◽  
Group A ◽  
Foley’S Catheter ◽  
Group B ◽  
A Prospective Study

INTRODUCTION: Benign prostatic hyperplasia (BPH) is the most common condition affecting men those are 50 years of age and above.TURP is still the widely used technique for management of BPH. TURPwith advent of newer technologies in diathermy and visual scope, has turned into a relatively safe one. AIM:To study role of catheter traction on blood loss and complications in patients with TURP. MATERIALS AND METHODS: This study was done among patients of BPH admitted in the Department of Surgery at S.N. Medical College, Agra during the period from January 2019 to February 2020. Total 60 cases were enrolled in the study and divided into two groups. Group A(30 patients) with traction on catheter after TURPand Group B(30 patients) without traction on catheter. DISCUSSION: Blood loss and irrigation uid was signicantly less in the group with traction on foley's catheter. Duration of hospital stay and complications were also lesser in group with traction. CONCLUSION: Traction on foley's catheter post TURP is effective in managing BPH with the merits of higher safety due to less blood loss and early discharge.

scholarly journals EFFECT OF ADJUVANT MELATONIN WITH CLOMIPHENE CITRATE ON OVULATORY AND FERTILITY RATES IN PCOS INFERTILE PATIENTS.

2020 ◽  
pp. 58-60
Author(s):  
Meenal Jain ◽  
Richa Singh ◽  
Rachna Agarwal
Keyword(s):  
Clomiphene Citrate ◽  
Pregnancy Rates ◽  
Control Group ◽  
P Value ◽  
Fertility Rates ◽  
Group A ◽  
Anti Oxidant ◽  
Group B ◽  
Oxidant Effect

AIM: To study the effect of adjuvant melatonin with clomiphene citrate on ovulution and fertility rates in infertile PCO patients. MATERIAL AND METHODS: A total of 107 cases participated in the study out of which 7 women were excluded from the study. So the results of 100 women were analyzed. Out of 100 women 50 were of group A i.e. clomiphene supplemented with melatonin group and 50 were in group B which was clomiphene only group with no supplementation. Cases were followed for three cycles and pregnancy rates in both groups were evaluated. RESULTS: Study demonstrated the potential benefit of melatonin supplementation in naturally conceived cycles where ovulation induction was given by en-clomiphene citrate. The ovulation rates were comparable in both study Vs control group (68% Vs 66%) while there was increase in pregnancy rate in melatonin group (36% Vs 24%). However difference between pregnancy rates in both the groups failed to reach statistically significant levels (p value 0.4065). CONCLUSION: The adjuvant role of melatonin with en-clomiphene citrate in cases of Infertile PCO patients is in improving pregnancy rates; which is due to strong anti-oxidant effect of melatonin which in turn reduces oxidative stress thus resulting in good quality oocyte production.

scholarly journals Role of tamsulosin in the management of lower ureteric stone at tertiary care hospital in Western Rajasthan, India

2017 ◽  
Vol 4 (5) ◽  
pp. 1721
Author(s):  
Parikshit Singh Chandawat ◽  
Ashok Kumar ◽  
Mahendra Kumar ◽  
Lalit Kumar ◽  
Sunder Kishore ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Care Hospital ◽  
Ureteric Stone ◽  
Expulsion Rate ◽  
Medical College ◽  
Experienced Pain ◽  
Group A ◽  
Extracorporeal Lithotripsy ◽  
Group B

Background: Many minimally invasive interventional techniques as well as expectant treatments exist for the management of lower ureteric calculi.Methods: 100 patients [group A (50 patients) patients given capsule tamsulosin 0.4mg, 1 daily up to 4 weeks while group B (50 patients) patients given regularly practiced treatment without Tamsulosin] with distal ureteric stone included in the study. Study duration was 6 months and study performed at S.P. Medical College. Bikaner, Rajasthan, India.Results: Group A showed a statistically significant advantage in terms of the stone expulsion rate. 41 patients (82%) in group A and 30 patients (60%) in group B expelled stones. Overall patients in group A had mean expulsion time of 7.86 days, whereas in group B mean expulsion time was 18.64 days. In group A stone expulsion rate was higher as compared to group B. In group A only 12 (24%) patients experienced pain relapses whereas in group B 32 (64%) patients reported pain relapses. The diclofenac dosage required in group A was observed to be 1.62 tablets whereas in group B it was 2.6 tablets.Conclusions: It is concluded that tamsulosin should be considered for uncomplicated distal ureteral calculi before ureteroscopy or extracorporeal lithotripsy. Tamsulosin has been found to increase and hasten stone expulsion rates, decrease acute attacks by acting as a spasmolytic, reduces mean days to stone expulsion and decreases analgesic dose usage.

scholarly journals Role of Flutamide on Acinar Diameter in Testosterone Induced Prostatic Hyperplasia

2010 ◽  
Vol 14 (Number 1) ◽  
pp. 3-8
Author(s):  
Md. A Rahman ◽  
H Naushaba ◽  
Md. N Ahmed ◽  
Md. M Rahman
Keyword(s):  
Treated Group ◽  
Prostatic Hyperplasia ◽  
Control Group ◽  
Medical College ◽  
Group A ◽  
Male Sex ◽  
Long Evans ◽  
Group B ◽  
Control Group Group

Testosterone is the male sex hormone responsible for growth of secondary sexual characters and accessory sex organs. Despite the effectiveness as a male sex i101711011C, testosterone causes benign preemie hyperplasia (BPH) resulting in urinary dysfinction. On the other hand. Bromide is a pure anthestosterone, which blockw the effects of dihydnoestosterone (DHT)at the testosterone receptor and presents BM. The objective of the study was to observe the effects of flutamide on testosterone induced promatic hypetplasia in Long Evans rats. This experimental study was carried or I e Department of Anatomy. Sir Salimullah Medical College. Dhaka from January to December 2006. Forty five matured male Long Evans rats of age 8-10 weeks and weighing 200-300 gnu were used in this study. They were divided into three equal groups. Group A was vehicle (olive oil) control group. Group B was testosterone treated group and Group C was testosterone and flu:amide treated group. Comparative study in different groups were done microscopically. There was significant reduction (p<0.001) qproslatic hypetplasia. The mean diameter of acini of prostate in flutamide treated rats was loner than the testosterone treated rats. It can be concluded from this study that flatamide is an effective drug against testosterone induced prostatic hyperplasia.

scholarly journals Correlation between microscopic and endoscopic approach to tympanoplasty: a comparative study

2020 ◽  
Vol 6 (10) ◽  
pp. 1787
Author(s):  
Jitendra Rathod ◽  
Reena Vare ◽  
Annju Thomas
Keyword(s):  
Tympanic Membrane ◽  
Endoscopic Approach ◽  
Suppurative Otitis Media ◽  
Hearing Results ◽  
Medical College ◽  
Group A ◽  
Middle Ear Anatomy ◽  
Group B ◽  
Microscopic Tympanoplasty

<p><strong>Background:</strong> The objective of the study was to evaluate the role of endoscopes in the management of dry central perforations of the tympanic membrane, compare the visualization of middle ear anatomy, time taken for the procedure and each step of the surgery and preoperative and postoperative hearing results/improvement.</p><p><strong>Methods: </strong>Fifty patients of chronic suppurative otitis media without cholesteatoma who came to ENT OPD at MGM medical college and hospital Aurangabad were included. They were divided into 2 groups with 25 patients each. Group A underwent microscopic approach to tympanoplasty and group b underwent endoscopic approach to tympanoplasty. Patients were assessed pre and postoperatively after 7 days, 14 days, 1 month, 3 months and 6 months with postoperative audiometry in the third month. <strong></strong></p><p><strong>Results: </strong>There was an improvement in the post-operative audiometry air bone gap (ABG) in both the groups. The operative time for group A was comparatively lesser than group B. Residual perforation were detected in one patient in group A at postoperative months 3 and 6, and for group B at postoperative month 3 and in two patients at postoperative month 6.<strong></strong></p><p><strong>Conclusions: </strong>A shorter operative duration is an advantage of microscopic tympanoplasty technique. One handed technique is one of the disadvantages of endoscope. The endoscopic approach gave better results in terms of easy visualization of the entire tympanic membrane and ossicular system. Tympanoplasty using endoscope was found to be an effective method for management of dry central perforations of the tympanic membrane.<strong></strong></p>

scholarly journals Relationship between pregnancy rate and number of intrauterine insemination cycles during the study of comparative efficacy of letrozole and clomiphene citrate adjuvants to gonadotropin stimulation in controlled ovarian stimulation cycles combined with intrauterine insemination therapy

2021 ◽  
Vol 11 (1) ◽  
pp. 106
Author(s):  
Pankaj Sharma ◽  
Ashok Verma ◽  
Kritika Katoch
Keyword(s):  
Pregnancy Rate ◽  
Intrauterine Insemination ◽  
Clomiphene Citrate ◽  
Randomized Study ◽  
Good Alternative ◽  
Human Menopausal Gonadotropin ◽  
Male Factor ◽  
Medical College ◽  
Group A ◽  
Group B

Background: Infertility is commonly defined as the failure of conception after at least twelve months of unprotected intercourse. Factors contributing are both male and female in which unexplained etiology accounts for 51%, male factor 28%, endometriosis 17% and ovulatory disorders 4%.Methods: Prospective, randomized study was conducted at DRRPG medical college, Tanda, Kangra, Himachal Pradesh. In our study, patients were randomized into two groups of 30 each. Women in group A received clomiphene citrate 100mg/day and group B received letrozole 2.5 mg/day from day 3-7 of menstrual cycle. All the patients received human menopausal gonadotropin 75 U given every alternate day from day 5 until HCG administration. Ovulation was triggered with recombinant HCG (5000 IUIM) when the dominant follicles reached 18 mm in diameter. A single IUI was performed 36 hours later. A maximum of four cycles were given.Results: In our study, total number of induction cycles given in group A and B were 120 and 114 respectively. Out of these, 112 and 111 IUI cycles were done in group A and B respectively. A pregnancy rate of 1.66% and 7.87% per IUI cycle was observed in group A and B respectively.Thus it is concluded that the pregnancy rates were significantly higher in letrozole group (30%) in comparison to clomiphene citrate group (6.66%).Conclusions: Aromatase inhibitor letrozole appears to constitute a good alternative to clomiphene citrate in patients with unexplained infertility undergoing gonadotropin-stimulated COS cycles combined with IUI therapy.

scholarly journals Role of FRIOS (free radical induced oxidative stress) in outcome of pregnancy induced hypertension cases

2017 ◽  
Vol 6 (8) ◽  
pp. 3287
Author(s):  
Anjana Choudhary ◽  
Nidhi Tripathi
Keyword(s):  
Preterm Birth ◽  
Antioxidant Status ◽  
Mode Of Delivery ◽  
Control Group ◽  
Study Group ◽  
Medical College ◽  
Significant Difference ◽  
Group A ◽  
Group B

Background: The anti-oxidant and the per oxidation product levels both are increased in pregnancy. Much recent works has focused on the role of oxidative disturbance in the preeclampsia and eclampsia. Preeclampsia remains a leading cause of maternal and fetal morbidity and mortality.Methods: This prospective study was conducted in upper India sugar exchange and maternity hospital, department of Obstetrics and Gynecology, GSVM Medical College, Kanpur in Collaboration with department of pathology, GSVM Medical College, Kanpur (UP), India. All the patients selected for the present study, both from control and study group was in detail with regard the clinical history, general examination, local examination, basic investigation and Specific Investigation, Super Oxide Dismutase (SOD). Blood samples would be collected with the informed consent from control as well as study group for assessment of antioxidant status by determining levels of superoxide dismutase.Results: The mean age and BMI of control as well as study group is almost same. The incidence of pre-eclampsia and eclampsia in primipara was 29.31 and in multiparous it was 9.52 in all groups. It implies that 95% cases will have improvement in SOD value with mean difference in improvement of at least 0.297807. There is statistically significant difference in mode of delivery by LSCS in study group A as compared to study group B and control in PIH patients. The incidence of complications is significantly higher in Study Group A as compared to control group and Study Group B. There is statistically significant difference in the incidence of preterm birth in study group A as well as Study Group B as compared to control. However, there was no statistically significant difference in the incidence of preterm birth after giving intervention to the study group. When cut off value of SOD enzyme as < 0.578U/mg of protein, sensitivity is 66.07% and specificity as 51.85%.Conclusions: Vitamin-c supplementation will only prevent PIT in PIH with already reduced antioxidant status.

scholarly journals Comparison of fertility rates of combination of enclomiphene citrate and melatonin with fertility rates of plain enclomiphene citrate in cases of dysovulatory infertility

2020 ◽  
Vol 9 (4) ◽  
pp. 1700
Author(s):  
Monika Singh ◽  
Shipra Kumari
Keyword(s):  
Clomiphene Citrate ◽  
Pregnancy Rates ◽  
Control Group ◽  
P Value ◽  
Fertility Rates ◽  
Group A ◽  
Anti Oxidant ◽  
Group B ◽  
Oxidant Effect

Background: Clomiphene citrate, a non-steroidal triphenylethylene compound, is the first line medicine used for ovulation in anovulatory women Worldwide. Objective of this study was to study fertility rates of combination of enclomiphene citrate and melatonin and compare it with fertility rates of plain enclomiphene citrate in cases of dysovulatory infertility.Methods: A total of 107 cases participated in the study out of which 7 women were excluded from the study. So, the results of 100 women were analyzed. Out of 100 women 50 were of Group A i.e., clomiphene supplemented with melatonin group and 50 were in Group B which was clomiphene only group with no supplementation. Cases were followed for three cycles and pregnancy rates in both groups were evaluated.Results: Study demonstrated the potential benefit of melatonin supplementation in naturally conceived cycles where ovulation induction was given by enclomiphene citrate. The ovulation rates were comparable in both study versus control group (68% versus 66%) while there was increase in pregnancy rate in melatonin group (36% versus 24%). However, difference between pregnancy rates in both the groups failed to reach statistically significant levels (p value 0.4065).Conclusions: The adjuvant role of melatonin with enclomiphene citrate in cases of dysovulatory infertility in improving pregnancy rates, which is due to strong anti-oxidant effect of melatonin which in turn reduces oxidative stress thus resulting in good quality oocyte production.

scholarly journals HEPATOTOXICITY;

2017 ◽  
Vol 24 (08) ◽  
pp. 1200-1205
Author(s):  
Aamna Khokhar ◽  
Aisha Qayyum ◽  
Momina Khokhar
Keyword(s):  
Controlled Trial ◽  
Protective Role ◽  
Alanine Transaminase ◽  
Blood Samples ◽  
Medical College ◽  
Randomized Controlled ◽  
Group A ◽  
Group B ◽  
Group D

Objectives: To evaluate the protective role of silymarin against methotrexate(MTX) induced hepatotoxicity in mice. Study design: Randomized controlled trial on animalmodel. Period: 06 months from March 2016 to August 2016. Settings: Department ofPharmacology and Therapeutics, Army Medical College, Rawalpindi. Material and Methods:Thirty male BALB/c mice were randomly divided into five groups (n=6). Group A received 0.2 mlnormal saline intraperitoneally served as control for MTX. Group B received 0.2 ml distilled waterorally for 7 days served as control for oral silymarin. Group C received single intraperitonealinjection of MTX 20 mg/kg. Group D received silymarin 25 mg/kg orally for seven days. GroupE received silymarin 25 mg/kg orally for 7 days with MTX 20 mg/kg intraperitoneally at day 4.Blood samples for measuring serum ALT (Alanine Transaminase), AST (Aspartate transaminase)and ALP (Alkaline Phosphatase) along with liver samples for hepatic histological examinationwere taken after 24 hours of last dose. Results: Silymarin show hepatoprotective effect againstMTX induced hepatotoxicity. Conclusion: Silymarin has hepatoprotective potential whenadministered along with MTX.

scholarly journals Role of Pharmacology in self medication practices among undergraduate medical students in a medical college and hospital in North India

2019 ◽  
Vol 8 (4) ◽  
pp. 657
Author(s):  
Sanchali Jindal ◽  
Preeti Garg
Keyword(s):  
Medical Students ◽  
Medical Training ◽  
North India ◽  
Undergraduate Medical Students ◽  
Self Medication ◽  
Medical College ◽  
Group A ◽  
Group B ◽  
And Behavior

Background: Self medication is an important component of primary health care. It involves treatment of common ailments on ones own initiative or on the advice of a pharmacist. With the easy accessibility to information regarding use of drugs, there is an alarming increase in the self medication practices. Medical students, during their course of study gain considerable knowledge of drugs and it may have an influence on their self medication practices. The present study was designed to gather the knowledge, attitude and behavior of medical students towards self medication and whether an increased knowledge of drugs further promoted self medication.Methods: A questionnaire based study was carried out on students of 2nd semester students relating to their knowledge, attitude and practice of self medication.Results: Though the knowledge regarding drugs is quite comparable in both the first and third year medical students, 39% students in group A took the medicine without doctors’ advice in the last month whereas 58% 5th semester students in group B did the same.Conclusions: The frequency of self medication is higher among third year students as they believe that the medical training makes them capable enough to self medicate easily without any harm. Hence, there is need to promote rational self medication practice to bring awareness about irresponsible self medication.

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