scholarly journals Severe androgenetic alopecia as a maker of metabolic syndrome in male patients of androgenetic alopecia: a hospital based case control study

2017 ◽  
Vol 5 (2) ◽  
pp. 601
Author(s):  
Mohd. R. Tilwani ◽  
Naina K. Dogra ◽  
Devraj Dogra ◽  
Suhail Raheem Rather ◽  
Parvaiz A. Rather
Keyword(s):  
Metabolic Syndrome ◽  
Case Control Study ◽  
Case Control ◽  
Androgenetic Alopecia ◽  
Control Group ◽  
Grade Ii ◽  
Male Patients ◽  
Age Range ◽  
Relationship Of ◽  
Control Study

Background: Several previous studies have investigated the association between androgenetic alopecia (AGA) and metabolic syndrome (MS), with inconsistent results. Objectives of the study were to study the prevalence of metabolic syndrome in male patients of androgenetic alopecia and compare with control population and study the relationship of metabolic syndrome with different grades of AGA.Methods: This prospective hospital based case control study included 100 new clinically diagnosed males of androgenetic alopecia, and age and sex matched control group. Assessment for presence of various components of metabolic syndrome was done following a uniform protocol in cases and controls. AGA was classified as per Hamilton –Narwood classification, grade I to III was classified as mild –moderate and grade IV and higher as severe AGA.Results: Of the 100 male AGA patients (age range 21-50, mean 34.49), 36 had grade II AGA, 24 had grade III AGA, 20 had grade IV AGA, 15 had grade V AGA and 5 had grade VI AGA. Among AGA patients, 60 of patients had mild-moderate AGA and 40 patients had severe AGA. Metabolic syndrome was statistically significantly more common in patients with AGA compared to controls. Among patients of AGA, metabolic syndrome was statistically significantly present in severe AGA compared to mild-moderate AGA. Among the evaluated parameters, like blood pressure, fasting blood sugar, dyslipedemia, abdominal obesity, all were significantly more common in AGA patients compared to controls except abdominal obesity.Conclusions: In the present study, metabolic syndrome was found to be 4.6 times more common in patients of androgenetic alopecia as compared to controls, being statistically significant, and more common in those with severe grades. This suggests that androgenetic alopecia patients especially with severe grades are at risk of metabolic syndrome and other cardiovascular diseases.

scholarly journals Inflammatory Biomarkers Predictive of Metabolic Syndrome in a Nigerian Population: A Case-Control Study

2020 ◽  
Vol 6 (4) ◽  
pp. 382-390
Author(s):  
EN Adejumo ◽  
OA Adejumo ◽  
OA Ogundahunsi
Keyword(s):  
Metabolic Syndrome ◽  
Case Control Study ◽  
Inflammatory Marker ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Case Control ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Hs Crp ◽  
Control Study

Background: Inflammation is linked to the aetiopathogenesis of Metabolic syndrome (MetS). Objective: To assess the ability of high sensitivity C-Reactive Protein (hs-CRP), Tumour Necrosis Factor-alpha (TNFα) and Interleukin-6 (IL-6) to predict MetS. Methods: A case-control study involving 123 subjects with MetS (cases) and age-matched 123 subjects. without MetS (controls) was conducted. The levels of TNFα, IL-6, and hs-CRP between independent groups were compared. The Receiver Operative Characteristic Curve was used to assess the ability of inflammatory markers to discriminately identify MetS. Results: The mean age of the case and control groups was 49.9±0.9 years and 48.1±1.1 years (p = 0.274) respectively. The median levels of TNFα, IL-6 and hS-CRP were significantly higher among the cases than the control group in both genders (p <0.001). There was a significant increase in the serum values of the markers with increasing components of MetS (p <0.001). The Area Under the Curve of TNFα, IL-6 and hs-CRP was > 0.9 in both males and females. Conclusion: TNFα, IL-6, and hs-CRP identified MetS. There is a need for further studies to determine the inflammatory marker most predictive of MetS.

scholarly journals Association of Ankle Brachial Pressure Index (ABPI) in Patients with Ischemic Stroke: A Case-Control Study

2013 ◽  
Vol 29 (1) ◽  
pp. 31-42
Author(s):  
Mohammad Selim Shahi ◽  
Aminur Rahman ◽  
Md Shaheen Wadud ◽  
Ak Takib Uddin Ahmed ◽  
Uttam Kumar Saha ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Case Control Study ◽  
Epidemiological Studies ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Medical College ◽  
The Difference ◽  
Relationship Of ◽  
Control Study

Background: Several epidemiological studies have identified the association of abnormal ABPI with ischemic stroke. So the goal of this study was to determine the actual relationship of ABPI with ischemic stroke in the context of our country. Materials and Methods: This case control study was carried out in the Department of Neurology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh. ABPI was measured by Doppler ultrasound machine of 100 patients who were admitted to the Mitford Hospital during the study period. Among them 50 patients with Ischemic stroke, confirmed by CT/MRI scan of brain were considered as ‘case’ and 50 age- sex matched individuals with one or more vascular risk factors (VRF) but without stroke were considered as ‘control’. Then the results of ABPI were compared between the two groups. Results: Among the 50 patients with ischemic stroke (case group) , 74% had normal ABPI and 26% had ABPI< 0.9; on the other hand among 50 age and sex matched individuals (control group) 90% had normal ABPI and 10% had ABPI <0.9. The difference was statistically significant between two groups (p=<0.05).This association remained significant even after adjustment for potential confounders (age, gender, high BMI, hypertension, diabetes mellitus, hyperlipidemia, smoking, ischemic heart disease and family history) in a multiple logistic regression model. Conclusion: The incidence of low ABPI is significantly higher in ischemic stroke patients than the age- sex matched control. Bangladesh Journal of Neuroscience 2013; Vol. 29 (1) : 31-42

scholarly journals Metabolic Syndrome Components and Acute pancreatitis: A Case-Control Study in China

2020 ◽  
Author(s):  
zhemin Shen ◽  
Xueqiao Wang ◽  
Zili Zhen ◽  
Yao Wang ◽  
Peilong Sun
Keyword(s):  
Metabolic Syndrome ◽  
Acute Pancreatitis ◽  
Incidence Rate ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Inflammatory Disorder ◽  
The Metabolic Syndrome ◽  
Metabolic Syndrome Components ◽  
Control Study

Abstract Background: Acute pancreatitis (AP) is a common inflammatory disorder of pancreas. Recent evidence has shown that metabolic syndrome was positively correlated with the severity of AP. However, only few studies have revealed the relationship between metabolic syndrome and the occurrence of AP. We therefore elucidated the association between the metabolic syndrome components and the incidence rate of AP. Methods: A hospital-based case-control study was conducted. 705 patients admitted to our hospital from January 2016 to December 2018 were included in the study. Subjects were divided into case and control group according to their diagnosis: (1) According to the revised Atlanta classification from 2012, patients diagnosed as AP were enrolled into case group. (2) Patients without history of AP or any disease related to metabolic syndrome were allocated into control group. Controls were matched to cases individually by sex and age (control/case ratio=1). Risk factors were determined by univariate and multivariate logistic regression analyses. Results: The incidence rate of metabolic syndrome with AP patients was 30.9%, which was more frequent than controls (13.2%) (OR=2.975; 95%CI 1.947-4.548, p<0.001). In multivariate regression analysis, histories of smoking or alcohol drinking, biliary stone were important predictors of AP. Besides, occurrence of AP was significantly associated with total cholesterol (TC) (OR=1.831; 95%CI 1.137-2.948, p=0.013), triglyceride (TG) (OR=2.058; 95%CI 1.332-3.179, p=0.001), fasting plasma glucose (FPG) (OR =2.345; 95%CI 1.395-3.940, p=0.001), as well as low values of apolipoprotein A (Apo A) (OR =0.247; 95%CI 0.146-0.416, p<0.001). Conclusion: Metabolic syndrome and its components portend high risks of occurrence of AP.

scholarly journals Metabolic Syndrome Components and Acute Pancreatitis: A Case-Control Study in China

2020 ◽  
Author(s):  
Zhemin Shen ◽  
Xueqiao Wang ◽  
Zili Zhen ◽  
Yao Wang ◽  
Peilong Sun
Keyword(s):  
Metabolic Syndrome ◽  
Acute Pancreatitis ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Inflammatory Disorder ◽  
Biliary Stones ◽  
History Of ◽  
Control Study

Abstract Background: Acute pancreatitis (AP) is a common inflammatory disorder of the pancreas. Recent evidence has shown that metabolic syndrome is positively correlated with the severity of AP. However, only a few studies have revealed the relationship between metabolic syndrome and the occurrence of AP. We therefore elucidated the association between metabolic syndrome and the occurrence of AP. Methods: A hospital-based case-control study was conducted. A total of 705 patients admitted to our hospital from January 2016 to December 2018 were included in the study. Subjects were divided into case and control groups according to their diagnosis: (1) According to the revised Atlanta classification from 2012, patients diagnosed with AP were enrolled in the case group. (2) Patients without a history of AP or any disease related to metabolic syndrome were allocated into the control group. Controls were matched to cases individually by sex and age (control/case ratio=1). Results: The incidence rate of metabolic syndrome in AP patients was 30.9%, which was more frequent than that in controls (13.2%) (OR=2.837; 95% CI 1.873-4.298, p<0.001). In the multivariate regression analysis, a history of smoking or alcohol consumption and biliary stones were significantly associated with AP (OR=2.441; 95% CI 1.865-5.172, p<0.001; OR=1.777; 95% CI 1.060-2.977, p=0.029; OR=28.995; 95% CI 13.253-63.435, p<0.001). In addition, the occurrence of AP was significantly associated with total cholesterol (TC) (OR=1.992; 95% CI 1.246-3.183, p=0.004), triglyceride (TG) (OR=2.134; 95% CI 1.403-3.245, p<0.001), hyperglycaemia (OR=2.261; 95% CI 1.367-3.742, p=0.001), and apolipoprotein A (Apo A) (OR=0.270; 95% CI 0.163-0.447, p<0.001). Conclusions: Metabolic syndrome and its components were associated with AP occurrence.

scholarly journals The association of metabolic syndrome and insulin resistance in early-onset androgenetic alopecia in males: A case–control study

2019 ◽  
Vol 64 (1) ◽  
pp. 23 ◽  
Author(s):  
MukundaRanga Swaroop ◽  
BManohara Kumar ◽  
BD Sathyanarayana ◽  
D Yogesh ◽  
JC Raghavendra ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Early Onset ◽  
Case Control Study ◽  
Case Control ◽  
Androgenetic Alopecia ◽  
Control Study

scholarly journals SELF CLEANING OF EARS BY VARIOUS OBJECTS CAUSES MULTIPLE DISEASES OF EXTERNAL EAR

2021 ◽  
Vol 71 (Suppl-3) ◽  
pp. S476-78
Author(s):  
Syed Muhammad Asad Shabbir Bukhari ◽  
Sohail Aslam ◽  
Mahrukh Afzal ◽  
Naeem Riaz ◽  
Asim Abbas ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Case Control Study ◽  
Case Control ◽  
External Ear ◽  
The Mean ◽  
Design Case ◽  
General Populations ◽  
Age Range ◽  
Relationship Of ◽  
Control Study

Objective: To find out the association of multiple diseases of external ear with the use of various objects and cotton buds. Study Design: Case control study. Place and Duration of Study: Ear Nose Throat Department, Pakistan Naval Ship Shifa Karachi, from Jan to Oct 2020. Methodology: All the patients having multiple diseases of external ear were included as cases. Controls were selected from the healthy volunteers from general populations. Results: Total number of subjects in this study was 140 with the mean age 25.11 ± 11.21 years (2-55 years of age range). Out of them, 82 were male and 58 were female. Odds ratio was 16.07. Conclusion: There is a solid relationship of illnesses of external ear with the utilization of cotton buds. This detrimental practice should be incapacitated by featuring the notice by brands owners of cotton bud and safety instructions at different instructive levels.

scholarly journals High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Sevgi Akarsu ◽  
Ozlem Ozbagcivan ◽  
Fatma Semiz ◽  
Sebnem Aktan
Keyword(s):  
Metabolic Syndrome ◽  
Lupus Erythematosus ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Discoid Lupus Erythematosus ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Impact ◽  
Control Study

Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control group. Additionally, we intended to determine the differences of sociodemographic and clinical data of the DLE patients with MetS compared to the patients without MetS. This was a cross-sectional, case-control study, including 60 patients with DLE and 82 age- and gender-matched control subjects. In DLE group, the presence of MetS was observed as more frequent (48.3% versus 24.4%, p=0.003), and hypertriglyceridemia (43.3% versus 22.0%, p=0.006) and reduced HDL-cholesterol (61.7% versus 23.2%, p<0.001) among the MetS components were found significantly higher when compared to the control group. DLE patients with MetS were at older age (50.45±11.49 versus 43.06±12.09, p=0.02), and hypertension, hyperlipidemia/dyslipidemia, and cardiovascular disease histories were observed at a higher ratio when compared to the patients without MetS. Between the DLE patients with and without MetS, no significant difference was observed in terms of clinical characteristics of DLE. Moreover, further large case-control studies with follow-up periods would be required to clearly assess the impact of MetS on the clinical outcomes of DLE.

scholarly journals Association of Ankle Brachial Pressure Index (ABPI) in Patients with Ischemic Stroke : A Case Control Study

2013 ◽  
Vol 12 (3) ◽  
pp. 27-33
Author(s):  
Mohammad Selim Shahi ◽  
Aminur Rahman ◽  
Md Shaheen Wadud ◽  
Uttam Kumar Saha ◽  
AK Takib Uddin Ahmed ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Case Control Study ◽  
Epidemiological Studies ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Medical College ◽  
The Difference ◽  
Relationship Of ◽  
Control Study

Background: Several epidemiological studies have identified the association of abnormal ABPI with ischemic stroke. So the goal of this study was to determine the actual relationship of ABPI with ischemic stroke in the context of our country. Methods: This case control study was carried out in the Department of Neurology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh. ABPI was measured by Doppler ultrasound machine of 100 patients who were admitted to the Mitford Hospital during the study period. Among them 50 patients with Ischemic stroke, confirmed by CT/MRI scan of brain were considered as ‘case’ and 50 age-sex matched individuals with one or more vascular risk factors (VRF) but without stroke were considered as ‘control’. Then the results of ABPI were compared between the two groups. Results: Among the 50 patients with ischemic stroke (case group), 74% had normal ABPI and 26% had ABPI< 0.9; on the other hand among 50 age and sex matched individuals (control group) 90% had normal ABPI and 10% had ABPI <0.9. The difference was statistically significant between two groups. (p=<0.05).This association remained significant even after adjustment for potential confounders (age, gender, high BMI, hypertension, diabetes mellitus, hyperlipidemia, smoking, ischemic heart disease and family history) in a multiple logistic regression model. Conclusion: The incidence of low ABPI is significantly higher in ischemic stroke patients than the age- sex matched control. Chattagram Maa-O-Shishu Hospital Medical College Journal Volume 12, Issue 3, September 2013: 27-33

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