scholarly journals Correlation between histopathologic and radiological changes in articular cartilage of the knee joint with degenerative joint disease

2017 ◽  
Vol 4 (2) ◽  
pp. 450
Author(s):  
Hakan Cift ◽  
Ali Seker ◽  
Bulent Kilic ◽  
Murat Demiroglu ◽  
Asli Erdogan Cakir ◽  
...  
Keyword(s):  
Subchondral Bone ◽  
The Elderly ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Lateral Condyle ◽  
Replacement Procedure ◽  
Tibial Condyle ◽  
Stage 4 ◽  
Significant Difference ◽  
The Difference

Background: Osteoarthritis (OA) of the knee is among the most common disabling diseases which may cause pain and decrease in functional status. It is the commonest form of arthritis and is most prevalent in the elderly, with 50% of adults aged 65-75 years and almost 70% of those 75+ years suffer from this disease. The aim of this study was to investigate consistency of radiologic findings with histomorphologic structure of bone in patients with severe gonarthrosis.Methods: 62 knees of 57 patients over 60 years old who had stage 3-4 gonarthrosis according to Kellgren-Lawrence classification were included in the study. Patients were separated into two groups as having stage 3 or stage 4 gonarthrosis. All the patients underwent total knee replacement procedure. During the operation distal femoral medial/lateral condyle and proximal tibial medial/lateral plateau were removed and sent to histologic examination for the measurement of thickness of cartilage layer and subchondral bone, number and thickness of trabeculae, space between two trabeculae.Results: Average thickness of subchondral bone was measured at stage 3 gonarthrosis and at stage 4 gonarthrosis. Only the difference between medial tibial condyle values of two groups was statistically significant. Average trabecula thickness was measured both at stage 3 and at stage 4 gonarthrosis. Only the difference between lateral tibial condyle values of two groups was statistically significant. Furthermore, as for the number of trabeculas and cavity between trabeculae, a significant difference couldn’t be found.Conclusions: Despite having radiological differences two groups can be said to show similar histopathological characteristics.

scholarly journals Comparison of early-stage changes of osteoarthritis in cartilage and subchondral bone between two different rat models

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e8934 ◽  
Author(s):  
Yutao Yang ◽  
Peiran Li ◽  
Songsong Zhu ◽  
Ruiye Bi
Keyword(s):  
Subchondral Bone ◽  
Early Stage ◽  
Cruciate Ligament ◽  
Cartilage Damage ◽  
Cartilage Degeneration ◽  
The Elderly ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Bone Change ◽  
Subchondral Bone Change

Osteoarthritis (OA) is a chronic degenerative joint disease and the major cause of joint pain and disability in the elderly. It is mainly characterized by articular cartilage degradation and subchondral bone remodeling. There are two main types of OA: natural occurring OA and secondary OA, mainly associated with aging and trauma, respectively. In this study, we established two OA models in rat knee joints to simulate the two types of OA, using the type II collagenase injection (CI) and anterior cruciate ligament transection (ACLT), respectively. After intervention for 2–6 weeks, cartilage and subchondral bone changes were detected in histological staining, immunochemistry, and micro-CT. Results showed that both models with typical pathology changes of OA were successfully induced, while the development and severity of OA process in the models were different. In ACLT rats, the cartilage damage was milder, lasted for a shorter time, and subchondral bone reconstruction occurred earlier, compared with the changes in CI rats. The cartilage damage was secondary to subchondral bone change in ACLT rats, while subchondral bone change was secondary to cartilage degeneration in CI rats. In conclusion, the interaction between cartilage and subchondral bone is different between the natural-occurring and secondary OA models. These two models not only suggest potential different mechanisms of the two types of OA, but also provide new directions for OA treatment and prevention.

scholarly journals Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis

2020 ◽  
pp. annrheumdis-2020-218089
Author(s):  
Wenhui Hu ◽  
Yueqi Chen ◽  
Ce Dou ◽  
Shiwu Dong
Keyword(s):  
Articular Cartilage ◽  
Subchondral Bone ◽  
Bone Destruction ◽  
The Elderly ◽  
Cell Types ◽  
Degenerative Joint Disease ◽  
Cellular Level ◽  
Joint Disease ◽  
Cellular Interactions ◽  
Bone Microenvironment

Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been considered as primarily a disease of the articular cartilage, the participation of subchondral bone in the pathogenesis of OA has attracted increasing attention. This review summarises the microstructural and histopathological changes in subchondral bone during OA progression that are due, at the cellular level, to changes in the interactions among osteocytes, osteoblasts, osteoclasts (OCs), endothelial cells and sensory neurons. Therefore, we focus on how pathological cellular interactions in the subchondral bone microenvironment promote subchondral bone destruction at different stages of OA progression. In addition, the limited amount of research on the communication between OCs in subchondral bone and chondrocytes (CCs) in articular cartilage during OA progression is reviewed. We propose the concept of ‘OC–CC crosstalk’ and describe the various pathways by which the two cell types might interact. Based on the ‘OC–CC crosstalk’, we elaborate potential therapeutic strategies for the treatment of OA, including restoring abnormal subchondral bone remodelling and blocking the bridge—subchondral type H vessels. Finally, the review summarises the current understanding of how the subchondral bone microenvironment is related to OA pain and describes potential interventions to reduce OA pain by targeting the subchondral bone microenvironment.

scholarly journals Assessment of functional capacity in elderly residents of an outlying area in the hinterland of Bahia/Northeast Brazil

2010 ◽  
Vol 68 (1) ◽  
pp. 39-43 ◽  
Author(s):  
Gilson de Vasconcelos Torres ◽  
Luciana Araújo dos Reis ◽  
Luana Araújo dos Reis
Keyword(s):  
Activities Of Daily Living ◽  
Functional Capacity ◽  
Daily Living ◽  
Age Groups ◽  
The Elderly ◽  
Cross Sectional ◽  
Instrumental Activities ◽  
Significant Difference ◽  
The Difference ◽  
Outlying Area

OBJECTIVE: To assess the functional capacity and to determine the difference between the means of functional capacity (basic and instrumental activities of daily living) and the age groups of elderly residents in an outlying area in the hinterland of Bahia/Northeast of Brazil. METHOD: Analytical study with cross-sectional design and a sample of 150 elderly individuals enrolled in four Health Units in the municipality of Jequié, Bahia, Brazil. The instrument consisted of sociodemographic and health data, the Barthel Index and the Lawton scale. RESULTS: In all, 78.00% of the elderly were classified as dependent in the basic activities and 65.33% in the instrumental activities of daily living. Using the Kruskal-Wallis test, we found a statistically significant difference between the means of instrumental activities and the age groups (p=0.011). CONCLUSION: An elevated number of elderly were classified as dependent in terms of functional capacity and increased age is related to greater impairment in the execution of instrumental activities of daily living.

scholarly journals Peptide-biofunctionalization of biomaterials for osteochondral tissue regeneration in early stage osteoarthritis: challenges and opportunities

2019 ◽  
Vol 7 (7) ◽  
pp. 1027-1044 ◽  
Author(s):  
D. Bicho ◽  
S. Ajami ◽  
C. Liu ◽  
R. L. Reis ◽  
J. M. Oliveira
Keyword(s):  
Articular Cartilage ◽  
Subchondral Bone ◽  
Tissue Regeneration ◽  
Early Stage ◽  
Degenerative Joint Disease ◽  
Synovial Inflammation ◽  
Joint Disease ◽  
Progressive Deterioration ◽  
Challenges And Opportunities ◽  
Osteochondral Tissue

Osteoarthritis is a degenerative joint disease characterized by the progressive deterioration of articular cartilage, synovial inflammation and changes in periarticular and subchondral bone, being a leading cause of disability.

scholarly journals Subchondral bone changes in patients with early degenerative joint disease

1970 ◽  
Vol 13 (4) ◽  
pp. 400-405 ◽  
Author(s):  
Eric L. Radin ◽  
Igor L. Paul ◽  
Marc J. Tolkoff
Keyword(s):  
Subchondral Bone ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Bone Changes

scholarly journals O38 Variations in orthopedic trauma presentation during COVID-19 lockdown

2021 ◽  
Vol 108 (Supplement_5) ◽  
Author(s):  
Mansoor N Chaudhry ◽  
Mahmood Ahmad ◽  
Abeeda Butt
Keyword(s):  
Alcohol Consumption ◽  
Trauma Team ◽  
The Elderly ◽  
Retrospective Data ◽  
Orthopedic Trauma ◽  
Significant Difference ◽  
Personal Wellbeing ◽  
The Difference ◽  
Sporting Activities ◽  
Increase Alcohol Consumption

Abstract Introduction The first national lockdown was imposed in Ireland from 27th March 2020, to combat the spread of Coronavirus. All non-essential travel, businesses, sporting activities and schools were closed. The elderly were advised to cocoon. The roadmap to easing the restrictions started in May. The lockdown measures resulted in people spending more time indoors, with impact on social and personal wellbeing. This had the potential to increase alcohol consumption, self inflicted injuries and neglect. The purpose of our study is to analyze the variations in orthopedic trauma presentations during the pandemic compared to similar period in 2018 and 2019. Method Retrospective data was collected from Orthopedic theatre registry of Our Lady of Lourdes Hospital, Drogheda, Co Louth, Ireland. Patients operated by orthopedic trauma team in three months period (March, April & May) in 2018, 2019 and 2020 were selected for analysis and comparison. Result Total number of surgeries performed in March-May 2018, 2019 and 2020 were 551, 505 and 373 showing a significant reduction in 2020 as compared to previous years. Trauma surgeries performed on children in March-May 2018,2019 and 2020 were 132,131 and 90 respectively, showing a similar downward trend. Surgeries were further categorized into Major +, Major, Intermediate and Minor according to their level of complexity. Although there was a significant reduction seen in Major, Intermediate and Minor surgeries, no significant difference was observed in Major + surgeries (73 in March-May 2020 vs. 79 in March-May 2019 and 57 in March-May 2018). Conclusion Significant reduction was seen in overall trauma surgeries which is attributable to lockdown measures. The difference in trend between Major + and other categories of surgeries can be explained by the reduction in sporting injuries and injuries in children whereas no significant difference was noted in hip fractures.

scholarly journals THE ERGONOMIC ELDERLY GYM IMPROVING PHYSICAL FITNESS AND INCREASING THE BONE MASS OF THE ELDERLY

2020 ◽  
Vol 1 (2) ◽  
pp. 1
Author(s):  
N.N. Ariati ◽  
N. Adiputra ◽  
K. Tirtayasa ◽  
I.P.G. Adiatmika ◽  
A. Pangkahila ◽  
...  
Keyword(s):  
Bone Mass ◽  
Physical Fitness ◽  
The Elderly ◽  
T Test ◽  
Wilcoxon Test ◽  
Whole Body ◽  
Distribution Data ◽  
Paired Sample ◽  
Significant Difference ◽  
The Difference

The public is increasingly aware of the importance of exercise for the elderly because exercise is an option to reduce complaints due to setbacks and improve the health of the elderly. In fact the implementation in the field is often wrong as in Banjar Benaya which implements routine exercises only once a week with a duration less than 30 minutes, does not pay attention to nutritional needs, does not use sports clothing, and displays that are not clear. The measurement of elderly physical fitness is still relatively low. Based on these problems, improvements were made to the application of ergonomic elderly gymnastics due to improve elderly’s physical fitness and increase the bone mass.  This study used a treatment by subject design conducted in April 2017-August 2018. The target population was all elderly in Denpasar and the affordable population was determined by multistage random sampling then selected Banjaya Benaya Peguyangan Village with a sample of 20 people who met the inclusion criteria. The data collection were physical fitness and bone mass. The difference in treatment effects were analyzed using a Paired Sample t-Test with α = 0.05 for data with normal distribution and Wilcoxon test, α = 0.05 for data with abnormal distribution. Data showed that there were differences in physical fitness improvement in Period I and Period II after 8 weeks of gymnastics at 43.43% with very bad categories being bad, the difference in increase in whole body bone mass was 16.76% and leg bone mass 68.67%. Analysis of Paired Sample-t-Test physical fitness data and Wilcoxon test for bone mass data in Period I and Period II after gymnastics for 8 weeks, found that there was a significant difference (p <0.05). It can be concluded that ergonomic elderly gym can significantly improve physical fitness and increase bone mass of the elderly. It is recommended that the elderly continue to exercise with a duration of 30-45 minutes, the frequency of 3 times a week to maintain elderly’s physical fitness.

Rate of Development of Hallucal Interphalangeal Degenerative Joint Disease After First Metatarsophalangeal Joint Arthrodesis: A Retrospective Radiographic Analysis

2018 ◽  
Vol 12 (4) ◽  
pp. 357-362
Author(s):  
Nisha N. Shah ◽  
Marcus P. Richardson ◽  
Anson K. Chu ◽  
Christopher F. Hyer
Keyword(s):  
Metatarsophalangeal Joint ◽  
Degenerative Joint Disease ◽  
Interphalangeal Joint ◽  
Joint Disease ◽  
Radiographic Analysis ◽  
First Metatarsophalangeal Joint ◽  
Rate Of Development ◽  
Significant Difference ◽  
Retrospective Comparative Study

The development of hallux interphalangeal joint (IPJ) arthritis after an arthrodesis of the first metatarsophalangeal joint has been established in the literature. However, the significance has not been well reported. A retrospective, radiographic review of patients who had undergone a first metatarsophalangeal joint arthrodesis was performed. The Coughlin classification for degree of arthritic degeneration, hallux abductus angle, and hallux interphalangeus angle were measured in 107 radiographs of 103 patients preoperatively and postoperatively. Postoperative angles were measured immediately following surgery at approximately 6 weeks, 3 months, 6 months, 12 months, and 24 months. We found that the hallux abductus angle had decreased in the patients postoperatively; however, the hallux abductus interphalangeus angle increased on average after first metatarsophalangeal fusion. The majority of patients started with a Coughlin classification I of the hallux IPJ, which remained unchanged over the postoperative period, with no statistically significant difference in IPJ degeneration in the patients with or without fusion of the first metatarsophalangeal joint. In addition, no patients had a symptomatic hallux IPJ postoperatively within our limited study period. Further prospective studies would be beneficial with longer follow-up times to assess IPJ degeneration following first metatarsophalangeal joint fusions. Levels of Evidence: Level III: Retrospective, comparative study

scholarly journals The Effects of Annatto Tocotrienol Supplementation on Cartilage and Subchondral Bone in an Animal Model of Osteoarthritis Induced by Monosodium Iodoacetate

2019 ◽  
Vol 16 (16) ◽  
pp. 2897 ◽  
Author(s):  
Kok-Yong Chin ◽  
Sok Kuan Wong ◽  
Fadhlullah Zuhair Japar Sidik ◽  
Juliana Abdul Hamid ◽  
Nurul Hafizah Abas ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Subchondral Bone ◽  
Sham Group ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Sprague Dawley ◽  
Joint Protection ◽  
Sprague Dawley Rats ◽  
Monosodium Iodoacetate ◽  
Inflammatory Component

Osteoarthritis is a degenerative joint disease which primarily affects the articular cartilage and subchondral bones. Since there is an underlying localized inflammatory component in the pathogenesis of osteoarthritis, compounds like tocotrienol with anti-inflammatory properties may be able to retard its progression. This study aimed to determine the effects of oral tocotrienol supplementation on the articular cartilage and subchondral bone in a rat model of osteoarthritis induced by monosodium iodoacetate (MIA). Thirty male Sprague-Dawley rats (three-month-old) were randomized into five groups. Four groups were induced with osteoarthritis (single injection of MIA at week 0) and another served as the sham group. Three of the four groups with osteoarthritis were supplemented with annatto tocotrienol at 50, 100 and 150 mg/kg/day orally for five weeks. At week 5, all rats were sacrificed, and their tibial-femoral joints were harvested for analysis. The results indicated that the groups which received annatto tocotrienol at 100 and 150 mg/kg/day had lower histological scores and cartilage remodeling markers. Annatto tocotrienol at 150 mg/kg/day significantly lowered the osteocalcin levels and osteoclast surface of subchondral bone. In conclusion, annatto tocotrienol may potentially retard the progression of osteoarthritis. Future studies to confirm its mechanism of joint protection should be performed.

Oleuropein inhibits the IL-1β-induced expression of inflammatory mediators by suppressing the activation of NF-κB and MAPKs in human osteoarthritis chondrocytes

2017 ◽  
Vol 8 (10) ◽  
pp. 3737-3744 ◽  
Author(s):  
Zhenhua Feng ◽  
Xiaobin Li ◽  
Jian Lin ◽  
Wenhao Zheng ◽  
Zhichao Hu ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Subchondral Bone ◽  
Inflammatory Mediators ◽  
Elderly Population ◽  
The Elderly ◽  
Joint Disease ◽  
Induced Expression ◽  
Bone Sclerosis ◽  
Osteoarthritis Chondrocytes

Osteoarthritis (OA) is the most common form of joint disease and is widespread in the elderly population and is characterized by erosion of articular cartilage, subchondral bone sclerosis and synovitis.

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