scholarly journals Aspiration sclerotherapy: a novel and cost-effective approach to the management of hydroceles in a developing country

2017 ◽  
Vol 4 (12) ◽  
pp. 3884
Author(s):  
Arijit Roy ◽  
Vijay Jain ◽  
Jahar Majumdar
Keyword(s):  
Success Rate ◽  
Indirect Costs ◽  
Cost Effective ◽  
Prophylactic Antibiotics ◽  
Chi Square ◽  
Cost Effective Approach ◽  
High Satisfaction ◽  
Chi Square Test ◽  
A Prospective Study

Background: The present study was carried out with an aim to perform a prospective study to establish the role of sodium tetradecyl sulfate (3 %) (STDS) as a safe and effective sclerosant in the management of primary hydroceles.Methods: Sclerotherapy was performed with 3 % STDS on an outdoor basis. The amount of sclerosant injected depended on the amount of fluid drained. All patients were given prophylactic antibiotics. Patients were clinically reassessed at 1 week, 1 month, 3 months, and 6 months and earlier if complications occurred. All patients were given prophylactic antibiotics.  The data were analyzed using Statistical Package for Social Sciences Version 15.0. The data have been represented as frequencies and percentages. Chi-square test was used to compare the data. A total of 57 patients with primary vaginal hydrocele gave consent for being enrolled in the study. The age of patients ranged from 18 to 65 years with a mean age of 35.72±13.18 years.Results: The success rate at the end of the study was observed to be 84.2 %. As regards patient satisfaction, in present study, in a limited time period of follow up, all the patients who had a successful procedure were satisfied.Conclusion: Overall, sclerotherapy was observed to be a relatively cost-effective (including both direct and indirect costs) procedure with low complications, high satisfaction, faster return to work and a high success rate within the limited period of follow-up.

scholarly journals Treatment outcome of the retreatment tuberculosis patients under RNTCP in eastern Uttar Pradesh

2017 ◽  
Vol 4 (8) ◽  
pp. 2701
Author(s):  
Praveen B. Gautam ◽  
Ashwini Kumar Mishra ◽  
Santosh Kumar
Keyword(s):  
Treatment Outcome ◽  
Statistical Significance ◽  
Uttar Pradesh ◽  
Cost Effective ◽  
Control Programme ◽  
Chi Square ◽  
Loss To Follow Up ◽  
Tuberculosis Patients ◽  
Chi Square Test

Background: India has the highest tuberculosis (TB) burden in the world. The directly observed treatment strategy is the most systemic and cost-effective approach to the disease. Furthermore, understanding the reasons for treatment outcome is important for the improvement of treatment systems. The objective was to study the treatment outcome of retreatment tuberculosis patients under RNTCP in eastern UP.Methods: A longitudinal cohort study was undertaken among total 205 patients registered in category II under DOTS from June 2015 to May 2016. These patients were followed up to November 2016 till the completion of treatment. At the end of study period, treatment outcomes were analysed. The chi-square test was used to assess the statistical significance of each ratio. P<0.05 was considered significant.Results: Out of 205 re-treatment patients, 174 (84.4%) had pulmonary tuberculosis while 31 (15.1%) had extra-pulmonary TB. In the cohort of category II patients 93 (45.3%) were relapse, 58 (28.2%) belonged to others category, 31 (15.1%) were treatment after loss to follow-up and 23 (11.2%) were on treatment after failure. Maximum patients were male 133 (64.8%) and most of the patients were belonged to the age group of 20-40 years. Among retreatment cases the cure rate for relapse, treatment after failure, treatment after loss to follow-up and others cases were 74.1%, 60.8%, 35.4% and 55.1% respectively.Conclusions: The relapse cases were the most commonly found in the re-treatment category however these patients were more likely to be cured with the category II regimen and treatment after loss to follow-up had high risk of retreatment failure. Continuous monitoring, adherence and treatment completion are essential for controlling the need of retreatment as well as improvement of tuberculosis control programme. 

scholarly journals Functional outcome of endoscopic and external dacrocystorhinostomy in a teaching hospital

2019 ◽  
Vol 5 (2) ◽  
pp. 358
Author(s):  
Arvind Varma ◽  
Sushobhan Dasgupta
Keyword(s):  
Prospective Study ◽  
Success Rate ◽  
Nasolacrimal Duct ◽  
P Value ◽  
Chi Square ◽  
Chi Square Test ◽  
Endonasal Dcr ◽  
Post Traumatic ◽  
External Dcr

<p class="abstract"><strong>Background:</strong> The objective of the study was to compare &amp; analyse the results of two different techniques of dacrocystorhinostomy (endonasal and external) in different etiological groups.</p><p class="abstract"><strong>Methods:</strong> This prospective study was carried out for nasolacrimal duct obstruction from October 2016 to October 2018 who underwent dacrocystorhinostomy by two different methods. The patient was divided into two groups one who underwent endonasal DCR (n=55) and another group who underwent external DCR (n=55). In each group they were subdivided into 3 groups on the basis of aetiology into idiopathic, post traumatic and revision cases. The results were evaluated in follow up period of 6 months. At the end of the study, decoding of the groups was done and the results were analysed statistically, using Chi Square test and student t-test, using SSPS III software. P value of less than 0.05 was considered statistically significant.</p><p class="abstract"><strong>Results:</strong> The success rate in endonasal DCR and external DCR was almost same in all the three groups (p&gt;0.05).</p><p class="abstract"><strong>Conclusions:</strong> This prospective study shows that both the methods have almost same success rate. This study also emphasises proper case selection and interdepartmental cooperation for optimum results.</p>

scholarly journals Results of cartilage shield tympanoplasty in revision cases of myringoplasty

2020 ◽  
Vol 6 (4) ◽  
pp. 673
Author(s):  
Raman Wadhera ◽  
Keshav Gupta
Keyword(s):  
Quantitative Data ◽  
Pure Tone ◽  
Qualitative Data ◽  
Age Group ◽  
Chi Square ◽  
Hearing Outcome ◽  
Chi Square Test ◽  
The Mean ◽  
A Prospective Study

<p class="abstract"><strong>Background:</strong> Cartilage shield tympanoplasty (CST) is seen as a good option for revision surgery in cases of myringoplasty failure. Cartilage serves as rigid material which resists retraction. However, there have been concerns regarding hearing outcome and surveillance in follow up period.</p><p class="abstract"><strong>Methods:</strong> A prospective study was conducted at our tertiary institute. 25 patients of either sex in age group of 18-50 years with one or more failed tympanoplasties underwent CST. Pre-operative and post-operative audiograms were obtained, and patients were regularly followed up to calculate graft uptake and hearing outcome. Quantitative data was analyzed by using Student t-test and for qualitative data chi square test was used.  </p><p class="abstract"><strong>Results:</strong> The mean pre-operative pure tone air-bone gap was 25.09±8.10 dB while the mean postoperative pure tone air-bone gap was 13.47±5.18 dB, one case (4%) presented with failure as there was a residual perforation antero-inferiorly. Since it was a small residual perforation, it was planned for closure by fat myringoplasty. No complications were recorded. We obtained graft take rate of 96% and mean postoperative gain of 11.62±7.11 dB in PTA-ABG.</p><p class="abstract"><strong>Conclusions:</strong> We recommend CST for revision cases of tympanoplasty.</p><p class="abstract"> </p>

Adjuvant chemotherapy for gastric cancer: Less drug, same efficacy.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 114-114
Author(s):  
T. Liu ◽  
W. Li ◽  
Y. Sun ◽  
K. Shen
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Chemotherapy ◽  
Disease Free Survival ◽  
Cost Effective ◽  
Chi Square ◽  
Similar Disease ◽  
Chi Square Test ◽  
Grade 3 ◽  
Meta Analyses

114 Background: Adjuvant chemotherapy is proved to improve survival in gastric cancer by meta-analyses. However, no evidence showed the best regimen. We conducted a retrospective analysis to compare triplets with doublets in the adjuvant setting. Methods: We collected data from January 2004 to December 2008 from patients performed radical surgery and adjuvant chemotherapy. Doublets were defined as 5-FU 750 mg/m2 (d1- 5) or capecitabine 1,000 mg/m2 (d1-14) plus cisplatin 60 mg/m2 (d1) or oxaliplatin 130 mg/m2 (d1), while triplets had epirubicin 50 mg/m2 (d1) added. Chemotherapy was initiated within 6 weeks after surgery, repeated every three weeks and planned for 6 cycles. Patients were followed up in the outpatient clinic until death or April 30, 2010. Cox proportional-hazard model and chi-square test were used to test statistical difference. Results: A total of 316 patients (210 in doublets, 106 in triplets) had a median follow-up time of 47 months. 77 patients died at the end of follow-up (3-year survival of 67.4%).Two groups were well balanced except age (median age of 57 in doublets, 51 in triplets, p < 0.001). All the patients tolerated well, with few grade 3/4 side effects (21.9% in doublets, 30.2% in triplets, p = 0.107). Two groups had similar disease-free survival (median DFS, 16 months vs. 23 months, p = 0.656) and overall survival (3-year survival rate, 59.6% vs. 64.8%, p = 0.293). Subgroup analysis showed the same benefit on survival between the two groups. Conclusions: Our study suggested doublets and triplets had the same efficacy as the adjuvant chemotherapy. Furthermore, doublets seem more cost-effective. [Table: see text] No significant financial relationships to disclose.

scholarly journals Bacteriology and antibiotics treatment of maxillary sinusitis: a prospective study

2017 ◽  
Vol 3 (4) ◽  
pp. 979
Author(s):  
Santosh Malashetti ◽  
Abhay Havle ◽  
Rajesh Karembelkar
Keyword(s):  
Maxillary Sinusitis ◽  
Cost Effective ◽  
Nasal Endoscopy ◽  
P Value ◽  
Chi Square ◽  
X Ray ◽  
Chi Square Test ◽  
Diagnostic Modalities ◽  
A Prospective Study

<p class="abstract"><strong>Background:</strong> Sinusitis is one of the commonest causes of patients visit to the otorhinolaryngologist, around one in five cases. The prevalence of sinusitis (146/1000) has been reported. Estimates suggest that clinical condition of sinusitis is more widespread than arthritis and/or hypertension. Sinusitis significantly impacts quality of life, even in comparison to chronic debilitating diseases such as diabetes and congestive heart failure. Sinusitis is the fifth most common medical diagnosis for which antibiotics are prescribed. Sinusitis is usually managed with a 10 days complete course of appropriate sensitive antibiotics. To achieve this goal, there should be some diagnostic modalities which guide towards exact diagnosis as well as safe intervention and cost effective. Over past decade, x-ray paranasal sinuses (Water’s view) and nasal endoscopy have been used successfully as diagnostic modalities in sinus disease.</p><p class="abstract"><strong>Methods:</strong> 100 patients presenting with complaints of sinusitis to the ENT OPD KIMSDU Karad, Maharashtra India were selected randomly (more than 12 yrs of age). All of them were examined clinically and subjected to X -ray PNS (Water’s view) and diagnostic nasal endoscopy [DNE]. Antral lavage was done for all the patients and returning fluid sent for culture and sensitivity. Results were evaluated by statistical analysis using chi square test and evaluating p value tabulated and compared. Appropriate antibiotics were advised orally for 10 days, on the basis of culture reports, such as Amoxcillin-Clavulinate 625 mg BD, Cefpodoxime proxetil 200 mg BD, Levofloxacin 500 mg OD, Ciprofloxacin-Tinidazole (500:600 mg) BD.</p><p class="abstract"><strong>Results:</strong> Majority of the patients were in the age group of 20-29 years (46%) and females (53%). Most common organisms causing maxillary sinusitis was- <em>S.aureus</em> (coagulase+29%). It was found that Amoxicillin-Clavulinate<strong> </strong>has highest efficacy as compared to other antibiotics.</p><p class="abstract"><strong>Conclusions:</strong> According to our study, most common organisms causing acute maxillary sinusitis in this study are <em>S aureus</em> (coagulase+), <em>S pnemoniae </em>and <em>Enterobacteriacae</em>. Most common organisms isolated are anaerobic Peptostreptococcus, coagulase positive <em>S. aureus</em> and <em>fusobacterium</em> in chronic rhinosinusitis. Efficacy of Amoxicillin-Clavulinic acid was 96% clinically, 94% based on results on DNE findings and 87% by radiological success rate which is statistical more significant than other class of antibiotics. So amoxicillin clavulinic acid can be considered as first line of drug for treating bacterial rhinosinusitis. </p>

scholarly journals PROGNOSTIC FACTORS OF RENAL TUMOR RECURRENCE AFTER RADICAL NEPHRECTOMY

2021 ◽  
Vol 108 (Supplement_3) ◽  
Author(s):  
G Martínez Izquierdo ◽  
A R Arnaiz Pérez ◽  
E Escolano Fernández ◽  
M Merayo Álvarez ◽  
B Carrasco Aguilera ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Prognostic Factors ◽  
Radical Nephrectomy ◽  
Univariate Analysis ◽  
Malignant Neoplasms ◽  
Histopathological Analysis ◽  
Chi Square ◽  
Renal Sinus ◽  
Chi Square Test

Abstract INTRODUCTION Renal cell carcinoma (RCC) represents 3% of overall malignant neoplasms in adults. However, its aetiology has not been clearly established. Although surgery represents the cornerstone in treatment, recurrence postoperative rates are around 20-30%, what implies prognostic factors search must be mandatory in order to help to plan de follow-up and the different adjuvant therapy possibilities available in case they were necessary. MATERIAL AND METHODS A retrospective observational study was carried out in 110 patients who underwent radical nephrectomy between 2004 and 2018, with the aim of identifying possible prognostic factors of recurrence of RCC after these surgeries. Preoperative data (epidemiological, comorbidities and laboratory tests), surgical, pathological and variables related to follow-up were taken into account. A univariate and multivariate analysis were performed, using chi-square test and logistic regression, respectively. RESULTS The median follow-up time was 53.5 months (SD = 35.8), time in which 19 patients had a recurrence of RCC after radical nephrectomy (17.2%). Histopathological items such as the surgical piece size, the nodal and microvascular invasion, the renal sinus invasion and the presence of necrosis in the surgical piece were associated with RCC recurrence in the univariate analysis, while only the presence of necrosis in the surgical piece showed a significant result in the multivariate analysis (p = 0.004). CONCLUSIONS Histopathological analysis, highlighting the presence of necrosis in the histological sample, was proved to be the main risk factor of RCC recurrence.

scholarly journals Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mei-Zhen Dai ◽  
Yi Qiu ◽  
Xing-Hong Di ◽  
Wei-Wu Shi ◽  
Hui-Hui Xu
Keyword(s):  
Cervical Cancer ◽  
Cervical Carcinogenesis ◽  
Chi Square ◽  
Major Health Problem ◽  
Hpv16 E6 ◽  
Exact Test ◽  
Chi Square Test ◽  
E6 And E7

Abstract Background Human papillomavirus (HPV) type 16 accounts for a larger share of cervical cancer and has been a major health problem worldwide for decades. The progression of initial infection to cervical cancer has been linked to viral sequence properties; however, the role of HPV16 variants in the risk of cervical carcinogenesis, especially with longitudinal follow-up, is not fully understood in China. Methods We aimed to investigate the genetic variability of HPV16 E6 and E7 oncogenes in isolates from cervical exfoliated cells. Between December 2012 and December 2014, a total of 310 single HPV16-positive samples were selected from women living in the Taizhou area, China. Sequences of all E6 and E7 oncogenes were analysed by PCR-sequencing assay. Detailed sequence comparison, genetic heterogeneity analyses and maximum-likelihood phylogenetic tree construction were performed with BioEdit Sequence Alignment Editor and MEGA X software. Data for cytology tests and histological diagnoses were obtained from our Taizhou Area Study with longitudinal follow-up for at least 5 years. The relationship between HPV16 variants and cervical carcinogenesis risk was analysed by the chi-square test or Fisher’s exact test. Results In this study, we obtained 64 distinct variation patterns with the accession GenBank numbers MT681266-MT681329. Phylogenetic analysis revealed that 98.3% of HPV16 variants belong to lineage A, in which the A4 (Asian) sublineage was dominant (64.8%), followed by A2 (12.1%), A1 (11.4%), and A3 (10.0%). The A4 (Asian) sublineage had a higher risk of CIN2+ than the A1–3 (European) sublineages (OR = 2.69, 95% CI = 1.04–6.97, P < 0.05). Furthermore, nucleotide variation in HPV16 E6 T178G is associated with the development of cervical cancer. Conclusion These data could provide novel insights into the role of HPV16 variants in cervical carcinogenesis risk in China.

EVALUATION OF CLINICO-RADIOLOGICAL FACTORS PREDICTING DIFFICULT LAPAROSCOPIC CHOLECYSTECTOMY

2021 ◽  
pp. 63-66
Author(s):  
Wasif Mohammad Ali ◽  
Nazia Nanen ◽  
Atia Zaka Ur Rab ◽  
Syed Amjad Ali Rizvi ◽  
Mehtab Ahmad
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Gall Bladder ◽  
Open Cholecystectomy ◽  
Previous History ◽  
Safe Procedure ◽  
Chi Square ◽  
Preoperative Prediction ◽  
Conversion To Open Cholecystectomy ◽  
Chi Square Test ◽  
A Prospective Study

Introduction: Laparoscopic cholecystectomy has become procedure of choice for treatment of symptomatic gallstone [1] disease . Even though it is a safe procedure occasionally it can be difcult and requires conversion to open cholecystectomy for various problems faced during surgery. Preoperative prediction of difcult laparoscopic cholecystectomy and likelihood of conversion to open cholecystectomy will avoid such complications and overall cost of treatment. Aim: To evaluate the clinico-radiological factors predicting difcult laparoscopic cholecystectomy Methods: This was a prospective study conducted from October 2018 to November 2020. Total of 101 patients meeting inclusion criteria undergoing laparoscopic cholecystectomy were included in the study. Various clinical, radiological and biochemical parameters and intraoperative difculties during surgery were recorded. The statistical analysis was done using chi-square test and ANOVA test. Results: The parameters such as sex, age, duration of disease, co-morbid disease, previous history of cholecystitis, palpable gall bladder, BMI, TLC, thickness of gall bladder, largest stone size and impacted stone are found statistically signicant in predicting difcult laparoscopic cholecystectomy and conversion to open cholecystectomy preoperatively. Conclusion: Difcult laparoscopic cholecystectomy may be predicted preoperatively even with a good clinical judgement whereas both clinical and radiological parameters provide a better preoperative prediction of difcult cholecystectomy so that the surgeon can prepared in advance for the complications.

scholarly journals Comparison of blood plasma and gelatin solution in resuscitation of children with dengue shock syndrome

2009 ◽  
Vol 49 (6) ◽  
pp. 322
Author(s):  
Suryadi Nicolaas Napoleon Tatura ◽  
Novie Homenta Rampengan ◽  
Jose Meky Mandei ◽  
Ari Lukas Runtunuwu ◽  
Max FJ Mantik ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Dengue Shock Syndrome ◽  
Shock Rate ◽  
Gelatin Solution ◽  
Chi Square ◽  
Management Guidelines ◽  
Exact Test ◽  
Chi Square Test ◽  
A Prospective Study ◽  
To Receive

Background Dengue shock syndrome (DSS) is characterized bysevere vascular leakage and hemostasis disorder. It is the cause of death in 1 to 5 percent of cases. WH 0 management guidelines for resuscitation remain empirical rather than evidence-based.Objective To find out the alternative fluids to replace plasmaleakage in DSS.Methods We performed a prospective study and randomizedcomparison of plasma and gelatin solution for resuscitation ofIndonesian children with DSS. We randomly assigned 25 subjectswith DSS to receive plasma and 25 children to receive gelatinfluid. Statistical analyse were performed using chi-square test,Fisher's exact test, t test, Mann-Whitney test.Results The increment of pulse pressure width and the decrement of hematocrit in subjects treated with gelatin were higher than that of plasma atfour-hour therapy (P=0.002 and P=0.017). Only one patient died caused by unusually manifestation of DSS. The increment of body temperature in subjects treated with plasma was higher than that of gelatin at four-hour therapy (P=O.Oll). The decrement of platelet count in subjects treated with gelatin were less than that of plasma (P=0.018). The increment of diuresis rate in subjects treated with gelatin was higher than that of plasma at twenty-hour therapy (P<O.OOOl). The decrement of respiratory rate in subjects treated with gelatin was higher than that of plasmaat twenty-eight hour therapy (P=0.018). There was no differencein studied variables : total volume rate, blood pressure, pulse rate, re-shock rate, clinical fluid overload, allergy reactions, bleeding manifestations, and length of stay (P>0.05).Conclusions Gelatin solution can be used as volume replacementin resuscitation of DSS if blood plasma is not available especiallyat four-hour therapy.

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