scholarly journals Retroperitoneal liposarcoma of the intestine: a rare cause of acute abdomen

2021 ◽  
Vol 8 (5) ◽  
pp. 1614
Author(s):  
Vikash C. Tiwari ◽  
Vaibhav Mudhale ◽  
Kulkarni S. Sharang ◽  
Jineshwar Nyamagoud ◽  
Malluru Srividya
Keyword(s):  
Sudden Onset ◽  
Wide Resection ◽  
Lumbar Region ◽  
Retroperitoneal Mass ◽  
Significant Past Medical History ◽  
Current Case ◽  
Retroperitoneal Liposarcoma ◽  
Malignant Mesenchymal Tumor ◽  
Well Differentiated ◽  
Left Lumbar Region

Retroperitoneal liposarcoma is a rare malignant mesenchymal tumor with an incidence of 2.5 per million individuals. It is usually asymptomatic until its large enough to compress the surrounding organs, so its early diagnosis is difficult. In current case a 41 year old male patient with no significant past medical history presented to emergency department with sudden onset of abdominal pain in the left lumbar region. On examination, the abdomen was distended, guarding and rigidity present with tenderness to palpation in the left lumbar region, and no mass was palpated. Abdominal USG revealed a large heterogeneous mass in the left lumbar region. As the origin of the mass was uncertain, the patient was evaluated with CECT of the abdomen which revealed a retroperitoneal mass highly s/o liposarcoma. Given the suspicion of a liposarcoma, the patient underwent an abdominal exploration and there was a retroperitoneal mass of 12x8 cm adherent to the left colon. Wide resection of this mass was done along with left colectomy and the specimen was sent for examination. The histopathology study determined lipomatous tumor well differentiated retroperitoneal liposarcoma. Retroperitoneal liposarcoma is a malignant tumor whose treatment is fundamentally surgical. These tumors tend to be resistant to radiotherapy and/or chemotherapy. Among the most important prognostic factors related to survival is surgery with non-affected margins.

scholarly journals Case report of giant retroperitoneal liposarcoma in a young woman

2018 ◽  
Vol 5 (8) ◽  
pp. 2917
Author(s):  
Fernando Mendoza Moreno ◽  
María del Rocío Díez-Gago ◽  
Javier Mínguez García ◽  
Diego Enjuto Martinez ◽  
Benjamín Tallón Iglesias ◽  
...  
Keyword(s):  
Lower Limbs ◽  
Histopathological Study ◽  
Retroperitoneal Liposarcoma ◽  
Abdominal Perimeter ◽  
Abdominopelvic Ct ◽  
Malignant Mesenchymal Tumor ◽  
History Of ◽  
Bulky Tumor ◽  
Well Differentiated ◽  
Specific Symptoms

Retroperitoneal liposarcoma is a rare malignant mesenchymal tumor with an annual incidence of approximately 2.5 cases per 100,000 inhabitants. It does not present specific symptoms, so its early diagnosis is difficult and in most cases it is performed when it has a large size. A 45-year-old patient with a history of increased abdominal perimeter and local discomfort was admitted in our center. After performing an abdominopelvic CT, she was diagnosed of a large, bulky tumor of lipomatous origin that significantly displaced the intestinal loops and the rest of neighboring organs. In view of the clinical suspicion of a liposarcoma, the patient underwent a resection of the lesion located in the retroperitoneum. The histopathological study determined a well differentiated retroperitoneal liposarcoma. The well-differentiated liposarcoma located in the lower limbs and the retroperitoneal space. Its age of presentation is between the fourth and sixth decade of life without finding differences between men and women. Its treatment is surgical and involves the resection of the tumor mass with non-affected surgical margins. Retroperitoneal liposarcoma is a malignant tumor whose treatment is fundamentally surgical. These tumors tend to be resistant to radiotherapy and / or chemotherapy. Among the most important prognostic factors related to survival is surgery with non-affected margins.

scholarly journals Retroperitoneal Liposarcoma Presenting as Bilateral Inguinal Hernias

2021 ◽  
Author(s):  
DO Haley S. Lehman ◽  
DO Ryan N. Qasawa ◽  
John J. Lim
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Mass Effect ◽  
Potential Space ◽  
Retroperitoneal Liposarcoma ◽  
Median Size ◽  
Inguinal Hernias ◽  
Retroperitoneal Tumors ◽  
Well Differentiated

Abstract Liposarcoma is one of the most common soft tissue sarcomas and has multiple subtypes, including atypical, well-differentiated, and dedifferentiated liposarcoma1. These tumors most commonly occur in the extremities and the retroperitoneum2, and account for 20% of all retroperitoneal tumors3. Retroperitoneal liposarcoma is very rare overall, occurring in 2.5 per one million people4. Patients will present from symptoms of mass effect due to the uncontrolled growth in the large potential space of the retroperitoneum, with its median size being around 30 cm5. The mainstay of treatment for this type of tumor is resection to a negative margin6. This is a case report describing a retroperitoneal liposarcoma presenting with bilateral inguinal hernias containing intraperitoneal fat from mass effect.

RETROPERITONEAL LIPOSARCOMA-EXCISION OF RETROPERITONEAL TUMOR AND RIGHT NEPHRECTOMY: A CASE STUDY

2020 ◽  
pp. 1-3
Author(s):  
NAMALA VENKATA YASESWI ◽  
VINAY KUMAR T ◽  
KOMMURI VYDURYAM ◽  
ZAKIRA BEGUM KOMMURI JOY SHALEM
Keyword(s):  
Inferior Vena ◽  
Vena Cava ◽  
Retroperitoneal Tumor ◽  
Retroperitoneal Mass ◽  
Computed Tomography Scan ◽  
Tumor Mass ◽  
Retroperitoneal Liposarcoma ◽  
Renal Vessels ◽  
Tomography Scan

A 64-year-old woman was referred to the hospital with complaints of abdomen right side tightness with discomfort for 1 month. Computed tomography scan of abdomen investigation revealed large retroperitoneal mass measuring 18.9 cm × 12.1 cm displacing the inferior vena cava right kidney and renal vessels in right hypochondriac and lumbar regions of the abdomen with large fat components. She underwent surgery, which involves the resection of tumor mass with non-affected surgical margins. These tumors tend to be resistant to radiotherapy or chemotherapy. Among the most important prognostic factor related to survival is surgery with non-affected margins. A review on etiology, pathophysiology, pathological classification, and grading is explained in literature review.

scholarly journals Jejunal Intussusception: A Rare Presentation of Carcinoid Tumor

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Umashankkar Kannan ◽  
Amir A. Rahnemai-Azar ◽  
Ashish N. Patel ◽  
Vinaya Gaduputi ◽  
Ajay K. Shah
Keyword(s):  
Primary Anastomosis ◽  
Exploratory Laparotomy ◽  
Sudden Onset ◽  
Pathological Examination ◽  
Rare Presentation ◽  
Metastatic Carcinoid ◽  
Diffuse Abdominal Pain ◽  
Well Differentiated ◽  
Small Bowel Segment ◽  
Distal Jejunum

A 55-year-old male presented to the emergency department with sudden onset of diffuse abdominal pain for one day. Physical examination was remarkable for tenderness in the umbilical region. A CT scan of the abdomen showed intussusception involving the jejunum without any mass. The patient then underwent an exploratory laparotomy. During surgery, the distal jejunum was intussuscepted with mesenteric lymphadenopathy. Liver showed nodular deposits in both lobes of the liver. The involved small bowel segment was resected with primary anastomosis and liver was biopsied. Pathological examination showed multifocal deposits of well-differentiated carcinoids in the jejunum. The liver and mesenteric deposits were positive for metastatic carcinoid. Patient recovered well without any complications.

Retroperitoneal Liposarcoma With Combined Well-Differentiated and Myxoid Malignant Fibrous Histiocytoma–Like Myxoid Areas

1999 ◽  
Vol 23 (12) ◽  
pp. 1480 ◽  
Author(s):  
Masanori Hisaoka ◽  
Yosuke Morimitsu ◽  
Hiroshi Hashimoto ◽  
Tsuyoshi Ishida ◽  
Hiroyuki Mukai ◽  
...  
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Retroperitoneal Liposarcoma ◽  
Well Differentiated

scholarly journals Primary Small Bowel Liposarcoma (Atypical Lipomatous Tumour) with Myogenic Differentiation

Sarcoma ◽  
2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
J. Patel ◽  
R. Deb ◽  
W. Speake ◽  
T. A. MacCulloch
Keyword(s):  
Small Bowel ◽  
Bowel Wall ◽  
Myogenic Differentiation ◽  
Iliac Fossa ◽  
Current Case ◽  
Lipomatous Tumour ◽  
Small Intestinal ◽  
Well Differentiated ◽  
The Right ◽  
Primary Small Bowel

Primary small intestinal liposarcomas originating in the small bowel are uncommon with a generally poor prognosis due to the advanced stage at the time of diagnosis. We describe a case of primary small bowel dedifferentiated liposarcoma presenting as a solid mass in the right iliac fossa. The current case is unusual as the tumour seemingly originated from the bowel and the well-differentiated component was seen extensively infiltrating the bowel wall including the small bowel submucosa.

scholarly journals Analysis of the Intratumoral Adaptive Immune Response in Well Differentiated and Dedifferentiated Retroperitoneal Liposarcoma

Sarcoma ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
William W. Tseng ◽  
Shruti Malu ◽  
Minying Zhang ◽  
Jieqing Chen ◽  
Geok Choo Sim ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Cd8 T Cells ◽  
Immune Checkpoint ◽  
Cd4 T Cells ◽  
Immune Cell ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Retroperitoneal Liposarcoma ◽  
Well Differentiated

Treatment options are limited in well differentiated (WD) and dedifferentiated (DD) retroperitoneal liposarcoma. We sought to study the intratumoral adaptive immune response and explore the potential feasibility of immunotherapy in this disease. Tumor-infiltrating lymphocytes (TILs) were isolated from fresh surgical specimens and analyzed by flow cytometry for surface marker expression. Previously reported immune cell aggregates known as tertiary lymphoid structures (TLS) were further characterized by immunohistochemistry. In all fresh tumors, TILs were found. The majority of TILs were CD4 T cells; however cytotoxic CD8 T cells were also seen (average: 20% of CD3 T cells). Among CD8 T cells, 65% expressed the immune checkpoint molecule PD-1. Intratumoral TLS may be sites of antigen presentation as DC-LAMP positive, mature dendritic cells were found juxtaposed next to CD4 T cells. Clinicopathologic correlation, however, demonstrated that presence of TLS was associated with worse recurrence-free survival in WD disease and worse overall survival in DD disease. Our data suggest that an adaptive immune response is present in WD/DD retroperitoneal liposarcoma but may be hindered by TLS, among other possible microenvironmental factors; further investigation is needed. Immunotherapy, including immune checkpoint blockade, should be evaluated as a treatment option in this disease.

Sign in / Sign up

Export Citation Format

Share Document