scholarly journals Placental pathology and its correlation with immediate feto neonatal outcome

2019 ◽  
Vol 6 (3) ◽  
pp. 1108
Author(s):  
Ashoka A. ◽  
Manjunatha Sarthi ◽  
Basavraj A. C. ◽  
Mahesh T. K.
Keyword(s):  
Growth And Development ◽  
Neonatal Outcome ◽  
Histopathological Examination ◽  
Prognostic Significance ◽  
Term Infant ◽  
Placental Pathology ◽  
Plastic Container ◽  
Hematoxylin Eosin ◽  
Gross Examination ◽  
Small Alteration

Background: Placenta plays a major role in growth and development of the fetus as it helps in both exchange of nutrients and removal of waste. Even though it yields a valuable information of prognostic significance for the newborn, majority of the time it will be discarded after the gross examination. Hence the present study was conducted to determine the placental pathology and its correlation with fetal outcome.Methods: The present study was carried out in Davangere for a period of 2 years. The placenta of 100 parturients, more than 28 weeks of gestation were included for the present study. The data was collected after detailed review of the obstetric case records. Placentas were examined soon after delivery. After the gross examination was complete, the placentas were put in a labelled plastic container. The placentas were re-examined macroscopically again by the pathologist. Cut-section examination was done. Then, at least 4 appropriate blocks were taken for each placenta. They were stained with hematoxylin-eosin stain and examined under the microscope. The histopathological examination was conducted as per proforma.Results: One hundred placentae belonging to one hundred babies were studied among which 80% of the maternal cases had anaemia, 68% were term infant, 37% had IUGR. Eccentric insertion of the cord was observed to be the commonest (51). Marginally inserted membranes were seen most frequently (97).Conclusions: In the present study we conclude that placental reserve is large and small alteration do not affect the pregnancy outcome. The placental changes are not specific to a particular condition affecting the pregnancy.

Primary stromal sarcoma of breast: A case report and literature review

2021 ◽  
pp. 1-7
Author(s):  
Mohammad Al-Wiswasy ◽  
Mahmoud Al-Balas ◽  
Raith Al-Saffar ◽  
Hamzeh Al-Balas
Keyword(s):  
Malignant Tumors ◽  
Histopathological Examination ◽  
Prognostic Significance ◽  
Total Duration ◽  
Young Patients ◽  
Soft Tissue Sarcomas ◽  
Breast Mass ◽  
Resection Margins ◽  
Stromal Sarcoma ◽  
First Case

INTRODUCTION: Primary breast sarcoma (PBS) was first described in 1887 as a rare heterogeneous neoplasm arising from the mesenchymal tissue of the mammary gland accounting for less than 5% of all body soft-tissue sarcomas and less than 0.1% of all malignant tumors of the breast. CASE PRESENTATION: A 31-year old lady presented with left breast mass which she felt four years before during which the mass increased in size from 1 to 6 cm in the largest diameter, diagnosed clinically as a benign fibroadenoma without any further cytological or histopathological confirmation. Histopathological examination of the excised breast mass reveals undifferentiated, primary stromal sarcoma of the breast (PSSB), which was followed by mastectomy three weeks later with reconstructive breast surgery with a total duration of follow-up of 3 years thereafter. This is the first case of PSSB reported in Jordan. DISCUSSION/CONCLUSION: PSSB is the generic term given to malignant breast tumors thought to arise from the specialized mesenchymal stroma of the breast but lacking an epithelial component with a phylloides pattern. PSSB is difficult to diagnose preoperatively due to its rarity and inadequate imaging methods to establish an exact diagnosis. The histology of the patient mass may be the leading factor for the management of these tumors. Even in very young patients, a progressively growing breast mass should alert the clinician to investigate for malignancy and verify the results by biopsy. Surgery with adequate resection margins represents the only potentially curative modality with prognostic significance. Adjuvant chemotherapy and radiotherapy are not very beneficial. The prognosis is dismal for patients with lymph node involvement and the size of the tumor has a lesser bearing on the outcome.

scholarly journals In vivo evaluation of ziram induced acute toxicity on pathomorphology of broiler chicken

2016 ◽  
Vol 8 (4) ◽  
pp. 2206-2211
Author(s):  
Majid Shafi ◽  
Shayaib A. Kamil ◽  
Masood S. Mir ◽  
S. Adil ◽  
Showkat A. Shah ◽  
...  
Keyword(s):  
Broiler Chicken ◽  
Neuronal Degeneration ◽  
Histopathological Examination ◽  
Lymphoid Cells ◽  
Bursa Of Fabricius ◽  
Poultry Feed ◽  
In Vivo Evaluation ◽  
Vascular Congestion ◽  
Gross Examination

Fungicides are usually used in agriculture and often find their way in poultry feed. Therefore, a study was undertaken to study the in vivo effect of one such fungicide (ziram) induced intoxication on pathomorphology of broiler chicken. After 2 weeks of age the birds were given fungicide (Ziram) in feed as a single oral dose of 100 mg/kg body weight. Out of 10 birds, 3 died due to ziram intoxication (30% mortality rate). Birds that died rapidly showed pronounced neurological signs like convulsions. The carcasses of ziram intoxicated birds appeared dehydrated and their mucous membrane was pale in colour. Marked vascular congestion was observed in brain on gross examination. The livers showed congestion and haemorrhages with necrotic foci. Kidneys and lungs had ecchymotic haemorrhages and heart revealed gelatinization of pericardium, distention and pericarditis. Atrophy of bursa of Fabricius and thymus; hypertrophy of thyroid was found. Histopathological examination revealed neuronal degeneration and necrosis associated with mild gliosis in brain. Lungs, pericardium and epicardium had severe congestion and there was degeneration with separation of myofibers. Glomeruli were congested and frequently revealed hypercellularity. There were sinusoidal congestion and varying degrees of hepatocellular degeneration. Bursa revealed mild depletion of lymphoid cells in few lobules while as thymus showed hypoplasia with depletion of lymphocytes. Thyroid had mild mononuclear cell infiltration and caecum showed marked necrosis and denudation of the mucosa. In conclusion, the depletion of lymphoid tissue from lymphoid organs was suggestive of immunosuppressive and immunomodulatory effects of ziram toxicity in broiler chicken.

scholarly journals Surgical cause of respiratory distress in a newborn

2021 ◽  
Vol 8 (9) ◽  
pp. 1629
Author(s):  
Vishnu Vardhan Reddy M. ◽  
Suguna Reddy C. ◽  
Yoga Nagendhar ◽  
Vardhini Sree D.
Keyword(s):  
Respiratory Distress ◽  
Growth And Development ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Normal Growth ◽  
Surgical Excision ◽  
Term Infant ◽  
Congenital Heart Diseases ◽  
Common Causes ◽  
Lobar Emphysema

Common causes of respiratory distress in a term infant include transient tachypnoea of newborn, sepsis/congenital pneumonia and congenital heart diseases. Surgical causes of distress in a newborn are rare and should be considered when other causes have been ruled out. We report a case of an early term female neonate who developed respiratory distress immediately after birth which was gradually progressive and required respiratory support. On evaluation with chest radiography and CT, a diagnosis of congenital lobar emphysema (CLE) was made. Immediate surgical resection was planned and done on day 8 of life. Post operatively she had no respiratory distress and discharged within a week. Baby is now healthy with normal growth and development. Half of the cases of CLE are diagnosed within the first 6 months of life but very few cases present with respiratory distress since birth. Timely diagnosis and early surgical excision in neonates <2 months improve the outcome, as seen in our case.

scholarly journals Histomorphologic Analysis of the Late-term Rat Fetus and Placenta

2018 ◽  
Vol 46 (2) ◽  
pp. 158-168 ◽  
Author(s):  
Phanie L. Charest ◽  
Vanessa Vrolyk ◽  
Pauline Herst ◽  
Maryse Lessard ◽  
Deborah M. Sloboda ◽  
...  
Keyword(s):  
Cutting Planes ◽  
Whole Body ◽  
Future Research ◽  
Serial Sectioning ◽  
Sprague Dawley ◽  
Rat Fetus ◽  
Rat Fetuses ◽  
Toxicological Studies ◽  
Hematoxylin Eosin ◽  
Gross Examination

Histological examination of the rat placenta and fetus is uncommon. Toxicological studies mainly rely on gross examination of the fetus and on fetal and placental weights. These are often insufficient to assess the fetal and placental toxicity of xenobiotics. The small size of the fetus makes its dissection labor-intensive. Thus, our objective was to develop a simple and accurate technique to evaluate the rat fetus and placenta. Sprague-Dawley rat fetuses at gestational day 19.5 ( n = 18) and their placentas ( n = 32) were fixed in formalin. Placentas were cut transversally in the center. Fetuses were cut following a freehand whole-body serial sectioning diagram adapted from Wilson’s method. Sections were stained with hematoxylin–eosin–phloxine–saffron, and histomorphometry was used to measure the area of the fetal placental region (27.2 ± 1.7 mm2), including the labyrinth (22.2 ± 1.0 mm2) and the basal zone (4.8 ± 0.8 mm2). Our whole-fetus serial sectioning technique resulted in 12 precise cutting planes that fit on 3 histological slides, enabling the examination of most organs without labor-intensive dissection. Quantitative analysis of placental areas improves the understanding of the pathogenesis of treatment-related changes. This technique provides a standardized method for future research in pertinent fields such as developmental biology and toxicology.

scholarly journals Pulmonary adenocarcinoma in cattle

2014 ◽  
pp. 4358-4363 ◽  
Author(s):  
Diogo Sousa Z ◽  
Luis Rivera C ◽  
Didier Quevedo C ◽  
Ana Claudia Gorino ◽  
Simone Biagio C ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Tumor Cells ◽  
Adult Female ◽  
Histopathological Examination ◽  
Abdominal Cavity ◽  
Pulmonary Adenocarcinoma ◽  
Immunohistochemical Examination ◽  
Histopathological Findings ◽  
Hematoxylin Eosin ◽  
Neoplastic Epithelial Cells

ABSTRACTThe Macroscopic, histological and immunohistochemical aspects of lung acinar adenocarcinoma and the presence of nodules in the abdominal cavity of an adult female bovine are reported. In the necropsy analysis samples were collected from the: lung, heart, spleen, liver, pancreas, kidney, uterus, intestine, brain, and from nodules found in the lung and abdominal cavity, which were routinely processed to be stained by hematoxylin-eosin and for an immunohistochemistry exam with the antibodies: cytokeratin (dilution 1:200 μL) and vimentin (dilution 1:1000 μL). The histopathological examination revealed neoplastic epithelial cells with acini formation. The immunohistochemical examination of the tumor cells showed positive marking for cytokeratin and the absence of marking for vimentin. According to anatomical, morphological, and histopathological findings, as well as the result of the immunohistochemical examination, the tumor was characterized as lung acinar adenocarcinoma.

POTENTIAL OF ETHANOL EXTRACT OF MAHKOTA DEWA LEAVES (PHALERIA MACROCARPA (SCHECFF.) BOERL.) TO INHIBIT INFLAMMATION IN MOUSE DISTAL COLON INDUCED BY DEXTRAN SODIUM SULFATE (DSS) AND AZOXYMETHANE (AOM)

2020 ◽  
pp. 101-105
Author(s):  
MUHAMMAD ILHAM DHIYA RAKASIWI ◽  
KUSMARDI KUSMARDI ◽  
ARI ESTUNINGTYAS ◽  
ARYO TEDJO
Keyword(s):  
Leaf Extract ◽  
Histopathological Examination ◽  
Ethanol Extract ◽  
Distal Colon ◽  
Goblet Cells ◽  
Sodium Sulphate ◽  
Dextran Sodium Sulphate ◽  
Phaleria Macrocarpa ◽  
Hematoxylin Eosin

Objective: To demonstrates the ability of P. macrocarpa leaf extract to reduce inflammation of the distal colon in DSS/AOM-induced mice. Methods: In vivo experimental research using Balb/c mice induced by 0.2 ml azoxymethane (AOM) 0.1% once and 1% dextran sodium sulphate (DSS) for one week; additionally, ethanol extract of P. macrocarpa leaves, 25 mg and 50 mg, and 0.84 mg acetosal were given orally. The mice were sacrificed after 20 w. Histopathological examination (hematoxylin-eosin staining) was conducted by counting the average number of goblet cells per crypt, inflammatory focus and angiogenesis. Results: Ethanol extract of P. macrocarpa leaves was able to prevent the decrease in the number of goblet cells (p<0.05). However, the administration of ethanol P. macrocarpa leaf extract could not reduce focal inflammation and angiogenesis in inflammation of the distal colon. Conclusion: Ethanol extract of the Mahkota Dewa leaves is able to prevent inflammation of the distal colon by preventing the decrease in the number of goblet cells.

scholarly journals Lung tuberculosis in a horse caused by Mycobacterium avium subsp. avium of serotype 2: a case report

2008 ◽  
Vol 53 (No. 2) ◽  
pp. 111-116 ◽  
Author(s):  
I. Pavlik ◽  
P. Jahn ◽  
M. Moravkova ◽  
L. Matlova ◽  
F. Treml ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Mycobacterium Avium ◽  
High Resistance ◽  
Histopathological Examination ◽  
Mediastinal Lymph Nodes ◽  
Mycobacterial Infections ◽  
Lung Tuberculosis ◽  
High Age ◽  
Gross Examination

Interstitial pneumonia (2/3 of the lungs were affected) and diffusely enlarged bronchial and mediastinal lymph nodes were diagnosed by gross examination of a dead 16-year-old mare. Based on histopathological examination and the detection of acid-fast rods after staining by the Ziehl-Neelsen technique, tuberculosis was suspected. <I>Mycobacterium avium</I> subsp. <I>avium</I> of serotype 2 and IS<I>901</I>+/IS<I>1245</I>+ genotype was isolated from the pulmonary lymphnode after five-week incubation at 37°C. Due to the fact that horses have a naturally high resistance to mycobacterial infections, the high age of the mare most likely contributed to the development of the disease.

501: Differences in neonatal outcome and placental pathology in relation to the severity of fetal growth restriction

2018 ◽  
Vol 218 (1) ◽  
pp. S300
Author(s):  
Ohad Gluck ◽  
Yossi Mizrachi ◽  
Adi Marciano ◽  
Letizia Schreiber ◽  
Jakob Bar ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Neonatal Outcome ◽  
Growth Restriction ◽  
Placental Pathology

A mystery mass on the placenta

2019 ◽  
Vol 40 (2) ◽  
Author(s):  
Evelyn Lee Pian Ting ◽  
Soon Leong Yong ◽  
Ganapaty Suhashini ◽  
Marcus Kang
Keyword(s):  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Neonatal Outcome ◽  
Preterm Labour ◽  
Histopathological Examination ◽  
Good Condition ◽  
Transabdominal Ultrasound ◽  
Antenatal Corticosteroids ◽  
Extremely Preterm ◽  
Adverse Pregnancy

Abstract Chorioangioma or chorangioma is a benign placental tumour which occurs in 1% of the pregnancies. Large lesions of more than 4–5 cm in size, also known as giant chorangiomas, are rare with the incidence of 1:3500 and 1:9000 birth. Unlike small tumours, the giant chorangiomas are highly associated with pregnancy complications. We report a case of multiple large chorangiomas resulting in an extremely preterm delivery. A 24-year-old primigravida presented at 25 weeks of gestation for threatened preterm labour. Transabdominal ultrasound revealed an echogenic mass on the placenta measuring 8.7 × 4.4 cm. Following a successful tocolysis and administration of a course of antenatal corticosteroids, she was discharged home. At 27 weeks of gestation, she developed a second episode of preterm contractions. Besides, the foetus was found to be small for gestational age. In the second episode of preterm contractions, intravenous magnesium sulfate infusion was commenced for foetal neuroprotection. Tocolysis was commenced for severe prematurity. She went into spontaneous preterm labour. Placenta examination revealed multiple solid masses with fleshy and congested dark red surface. A histopathological examination of the placenta confirmed the diagnosis of chorangiomas. The baby was discharged in good condition at 5 months of age. Placental chorangiomas, notably when they are multiple and large in size, are associated with adverse pregnancy outcomes. Therefore, close antenatal surveillance is necessary to allow timely recognition and intervention of pregnancy complications. Our case portrays an unexpected favourable neonatal outcome associated with a giant chorangiomas.

Sign in / Sign up

Export Citation Format

Share Document