Fetal and neonatal outcomes in early onset versus late onset pre-eclampsia-a comparative study

Background: Pre-eclampsia is typed as two different entities: early-onset preeclampsia occurring at less than 34 weeks of gestation, and late-onset occurring at 34 or more weeks of gestation. The aim of this study is to compare the fetal and neonatal outcomes in early versus late onset preeclampsia.Methods: 208 patients diagnosed with pre-eclampsia in Shri Sathya Sai medical college and research institute over a period of three years (From January 2016 to January 2019) were retrospectively studied. Patients were classified as early onset and late onset pre-eclampsia based on the gestational age of onset. Data on fetal and neonatal outcomes were collected and analysed using Chi square and Fisher’s test and compared.Results: Early onset and late onset pre-eclampsia were 34.6% and 65.3%. The incidence of oligohydramnios, SGA, low APGAR at 5 minutes of birth were high in early onset type. 64.9% of early onset type required NICU admission whereas only 38.23% new born of mothers with late onset type required NICU admissions.10.8% of babies of patients with early onset type were still born. The incidence of NICU admissions, requirement of respiratory support, duration of NICU stay were significantly high in early onset type.Conclusions: Patients with early onset pre-eclampsia are found to have higher rates of specific fetal and neonatal morbidity when compared to the late onset type. Prudent and close scrutinizing and follow up and delaying delivery in stable and appropriately selected patients with pre-eclampsia would be advantageous for neonates.

Download Full-text

Maternofetal outcomes in early versus late onset pre-eclampsia: a comparative study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20190282 ◽

2019 ◽

Vol 8 (2) ◽

pp. 548

Author(s):

Poornima Shankar ◽

Kavitha Karthikeyan ◽

Amrita Priscilla Nalini ◽

Sindhura M. ◽

Gowtham Kim

Keyword(s):

Risk Factors ◽

Gestational Age ◽

Early Onset ◽

Age Of Onset ◽

Late Onset ◽

Fetal Outcomes ◽

Chi Square ◽

Onset Type ◽

Significant Difference ◽

Early Onset Preeclampsia

Background: Preeclampsia is being increasingly recognized as two different entities: early-onset preeclampsia occurring at less than 34 weeks of gestation, and late-onset disease occurring at 34 or more weeks of gestation. Early-onset and late-onset pre-eclampsia are found to have different implications for the mother and neonate. The aim of this study is to compare the risk factors, maternal and fetal outcomes in early (<34 weeks) versus late (≥34weeks) onset preeclampsia.Methods: 208 patients diagnosed with pre-eclampsia in Chettinad Academy of Research and Education over a period of three years (From January 2014 to December 2016) were retrospectively studied. Patients were classified as early onset and late onset pre-eclampsia based on the gestational age of onset. Data on risk factors, maternal and fetal outcomes were collected and analyzed using Chi Square and Fisher’s test and compared.Results: The overall preeclampsia rate was 6.3%. Early onset and late onset were 34.6% and 65.3% respectively and the rate increased with increasing gestational age.35.3% of patients with late onset preeclampsia and 55.6% patients of early onset type required more than one drug which is a statistically significant difference. Proteinuria more than 3gm/l/day was significantly more in late onset preeclampsia than in early onset preeclampsia. 55.5% of patients with early onset pre-eclampsia required MgSO4 when compared to 17.4%. There was no statistically significant difference in the rate of caesarean section (61.1% vs 73.5%). Altered coagulation profile was significantly more in early onset preeclampsia (11.1%). The incidence of oligohydramnios, SGA and low APGAR at 5 minutes of birth were significantly high in early onset pre-eclampsia when compared to late onset type.Conclusions: Patients with early onset pre-eclampsia are found to have significantly higher rates of specific maternal and fetal morbidity when compared to the late onset type.

Download Full-text

Early onset and late onset preeclampsia-maternal and perinatal outcomes in a rural teritiary health center

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20182333 ◽

2018 ◽

Vol 7 (6) ◽

pp. 2266 ◽

Cited By ~ 7

Author(s):

Gomathy E. ◽

Lahari Akurati ◽

Kondareddy Radhika

Keyword(s):

Early Onset ◽

Perinatal Outcome ◽

Late Onset ◽

Perinatal Outcomes ◽

Retrospective Data ◽

Perinatal Complications ◽

Medical College ◽

Gestation Age ◽

Early Onset Preeclampsia ◽

Singleton Pregnancies

Background: Preeclampsia is main cause of morbidity and mortality both mother and fetus. Preeclampsia occurs in 10-17% of pregnancies. Preeclampsia was divided into early onset preeclampsia is occur at less <34 weeks of gestation age and late onset preeclampsia is occur at >34 weeks of gestation age. Early and late onset preeclampsia have different etiology and should be considered as different disease as there are difference in clinical manifestation, maternal and perinatal outcome, prognosis and complication.Methods: An analytic observational study involving retrospective data done at RL Jalappa Hospital, Sri Devaraj Urs Medical College, Kolar. 217 women with singleton pregnancies with Pre eclampsia who were admitted and delivered in our hospital between June 2016 and May 2017 were recruited for this retrospective study.Results: The results showed that the incidence of EOPE (27.6%) was lower than LOPE (72.4%). Diastolic blood pressure is significantly higher in EOPE compared to LOPE. Complications in perinatal outcomes such as low birth weight (<2500 gram) are more in EOPE (98.3%) compared to LOPE (45.2%) and asphyxia is more on EOPE (11.7%) compared to LOPE (1.3%). Stillbirth in EOPE (15%) is more than LOPE group (3.2%).Conclusions: It is observed that EOPE incidence rate is lower than LOPE. Maternal and perinatal complications are greater in the EOPE group.

Download Full-text

Faculty Opinions recommendation of Cardiovascular disease risk factors after early-onset preeclampsia, late-onset preeclampsia, and pregnancy-induced hypertension.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725298358.793542862 ◽

2018 ◽

Author(s):

Andrew Shennan ◽

Kate Duhig

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Early Onset ◽

Disease Risk ◽

Late Onset ◽

Cardiovascular Disease Risk ◽

Cardiovascular Disease Risk Factors ◽

Pregnancy Induced Hypertension ◽

Induced Hypertension ◽

Early Onset Preeclampsia

Download Full-text

Faculty Opinions recommendation of Risk of non-fatal cardiovascular diseases in early-onset versus late-onset type 2 diabetes in China: a cross-sectional study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726040074.793514750 ◽

2016 ◽

Author(s):

Carlos Aguilar-Salinas

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Diseases ◽

Early Onset ◽

Late Onset ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Onset Type

Download Full-text

Age, Age of Onset and Course of Primary Depressive Illness in the Elderly*

The Canadian Journal of Psychiatry ◽

10.1177/070674378302800204 ◽

1983 ◽

Vol 28 (2) ◽

pp. 102-104 ◽

Cited By ~ 32

Author(s):

Martin G. Cole

Keyword(s):

Elderly Patients ◽

Depressive Episode ◽

Early Onset ◽

Age Of Onset ◽

Late Onset ◽

The Elderly ◽

Depressive Illness ◽

Physical Illness ◽

Course Of Illness

Thirty-eight elderly patients with primary depressive illness (Feighner criteria) were followed up for 7–31 months. In the absence of persistent organic signs and severe physical illness, age of onset (first depressive episode after 60) but not age was significantly related to course of illness. Compared to early onset depressives, late onset depressives were more likely to remain completely well during the follow-up period and less likely to have frequent or disabling relapses.

Download Full-text

Early and Late Onset Bipolar Disorders in Older Adults

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.2179 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S211-S211

Author(s):

N. Smaoui ◽

L. Zouari ◽

N. Charfi ◽

M. Maâlej-Bouali ◽

N. Zouari ◽

...

Keyword(s):

Older Adults ◽

Bipolar Disorder ◽

Early Onset ◽

Age Of Onset ◽

Late Onset ◽

Age At Onset ◽

Bipolar Disorders ◽

Medical Diagnoses ◽

The Mean ◽

Bipolar Patients

IntroductionAge of onset of illness may be useful in explaining the heterogeneity among older bipolar patients.ObjectiveTo examine the relationship of age of onset with clinical, demographic and behavioral variables, in older patients with bipolar disorder.MethodsThis was a cross-sectional, descriptive and analytical study, including 24 patients suffering from bipolar disorders, aged 65 years or more and followed-up in outpatient psychiatry unit at Hedi Chaker university hospital in Sfax in Tunisia. We used a standardized questionnaire including socio-demographic, behavioral and clinical data. Age of onset was split at age 40 years into early-onset (< 40 years; n = 12) and late-onset (≥ 40 years; n = 12) groups.ResultsThe mean age for the entire sample was 68.95 years. The mean age of onset was 39.95 years. The majority (60%) of patients were diagnosed with bipolar I. Few meaningful differences emerged between early-onset and late-onset groups, except that tobacco use was significantly higher in the late-onset group (66.6% vs. 16.6%; P = 0.027). No significant differences between the early-onset and late-onset groups were seen on demographic variables, family history and number of medical diagnoses or presence of psychotic features.ConclusionOur study found few meaningful behavioral differences between early versus late age at onset in older adults with bipolar disorder.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Download Full-text

473: Early onset preeclampsia and neonatal outcomes

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2007.10.492 ◽

2007 ◽

Vol 197 (6) ◽

pp. S138

Author(s):

Angie Child ◽

Yvonne Cheng ◽

Brian Shaffer ◽

Anjali Kaimal ◽

Sarah Little ◽

...

Keyword(s):

Early Onset ◽

Neonatal Outcomes ◽

Early Onset Preeclampsia

Download Full-text

Clinical and Molecular Comparative Study of Colorectal Cancer Based on Age-of-onset and Tumor Location: Two Main Criteria for Subclassifying Colorectal Cancer

International Journal of Molecular Sciences ◽

10.3390/ijms20040968 ◽

2019 ◽

Vol 20 (4) ◽

pp. 968 ◽

Cited By ~ 6

Author(s):

Edurne Álvaro ◽

Juana M. Cano ◽

Juan L. García ◽

Lorena Brandáriz ◽

Susana Olmedillas-López ◽

...

Keyword(s):

Colorectal Cancer ◽

Early Onset ◽

Age Of Onset ◽

Late Onset ◽

Cpg Island ◽

Low Frequency ◽

Tumor Location ◽

Molecular Characteristics ◽

Braf Mutations ◽

Rectal Cancers

Our aim was to characterize and validate that the location and age of onset of the tumor are both important criteria to classify colorectal cancer (CRC). We analyzed clinical and molecular characteristics of early-onset CRC (EOCRC) and late-onset CRC (LOCRC), and we compared each tumor location between both ages-of-onset. In right-sided colon tumors, early-onset cases showed extensive Lynch syndrome (LS) features, with a relatively low frequency of chromosomal instability (CIN), but a high CpG island methylation phenotype. Nevertheless, late-onset cases showed predominantly sporadic features and microsatellite instability cases due to BRAF mutations. In left colon cancers, the most reliable clinical features were the tendency to develop polyps as well as multiple primary CRC associated with the late-onset subset. Apart from the higher degree of CIN in left-sided early-onset cancers, differential copy number alterations were also observed. Differences among rectal cancers showed that early-onset rectal cancers were diagnosed at later stages, had less association with polyps, and more than half of them were associated with a familial LS component. Stratifying CRC according to both location and age-of-onset criteria is meaningful, not only because it correlates the resulting categories with certain molecular bases, but with the confirmation across larger studies, new therapeutical algorithms could be defined according to this subclassification.

Download Full-text

Maternal ABO Blood Type and Factors Associated With Preeclampsia Subtype

Biological Research For Nursing ◽

10.1177/1099800419833782 ◽

2019 ◽

Vol 21 (3) ◽

pp. 264-271 ◽

Cited By ~ 1

Author(s):

Adriane Burgess ◽

Teresa S. Johnson ◽

Amanda Simanek ◽

Theodore Bell ◽

Sandra Founds

Keyword(s):

Early Onset ◽

Late Onset ◽

Risk Identification ◽

Blood Type ◽

Tertiary Referral Center ◽

South Central ◽

Central Pennsylvania ◽

Subtype Identification ◽

Abo Blood Type ◽

Early Onset Preeclampsia

Background: The pathophysiology of preeclampsia remains unclear. The disorder is heterogeneous, and the pathophysiology may vary by subtype. Identification of relevant biomarkers will help to better elucidate the pathophysiologic basis of each preeclampsia subtype. Blood type may be a biomarker that allows risk identification for preeclampsia. Objective: The purpose of this study was to investigate the associations among maternal ABO blood type and preeclampsia subtype and fetal growth restriction (FGR). Method: Medical records of 126 women with early-onset preeclampsia (≤33 6/7 weeks’ gestation), 126 women with late-onset preeclampsia (≥34 0/7 weeks’ gestation), and 259 controls who gave birth between January 2012 and June 2016 were retrospectively abstracted from a large suburban tertiary referral center in South Central Pennsylvania for this hospital-based case–control study. Results: Women with AB blood type had >3 times the odds of late-onset preeclampsia (odds ratio [ OR] = 3.35, 95% confidence interval (CI) = [1.02, 11.05]) compared to those with O blood type. Among women with early-onset preeclampsia, those with B blood type had 5 times the odds of having a growth-restricted fetus than did women with O blood type ( OR = 5.44, 95% CI [1.65, 17.94]). Discussion: Our findings suggest that AB blood type may be an important risk factor for late-onset preeclampsia and that among women with early-onset preeclampsia, those with B blood type have increased odds of FGR. These findings warrant further study in women and their offspring to identify the pathophysiologic processes that may link ABO blood type, preeclampsia subtype, and FGR.

Download Full-text