scholarly journals Early onset and late onset preeclampsia-maternal and perinatal outcomes in a rural teritiary health center

2018 ◽  
Vol 7 (6) ◽  
pp. 2266 ◽  
Author(s):  
Gomathy E. ◽  
Lahari Akurati ◽  
Kondareddy Radhika
Keyword(s):  
Early Onset ◽  
Perinatal Outcome ◽  
Late Onset ◽  
Perinatal Outcomes ◽  
Retrospective Data ◽  
Perinatal Complications ◽  
Medical College ◽  
Gestation Age ◽  
Early Onset Preeclampsia ◽  
Singleton Pregnancies

Background: Preeclampsia is main cause of morbidity and mortality both mother and fetus. Preeclampsia occurs in 10-17% of pregnancies. Preeclampsia was divided into early onset preeclampsia is occur at less <34 weeks of gestation age and late onset preeclampsia is occur at >34 weeks of gestation age. Early and late onset preeclampsia have different etiology and should be considered as different disease as there are difference in clinical manifestation, maternal and perinatal outcome, prognosis and complication.Methods: An analytic observational study involving retrospective data done at RL Jalappa Hospital, Sri Devaraj Urs Medical College, Kolar. 217 women with singleton pregnancies with Pre eclampsia who were admitted and delivered in our hospital between June 2016 and May 2017 were recruited for this retrospective study.Results: The results showed that the incidence of EOPE (27.6%) was lower than LOPE (72.4%). Diastolic blood pressure is significantly higher in EOPE compared to LOPE. Complications in perinatal outcomes such as low birth weight (<2500 gram) are more in EOPE (98.3%) compared to LOPE (45.2%) and asphyxia is more on EOPE (11.7%) compared to LOPE (1.3%). Stillbirth in EOPE (15%) is more than LOPE group (3.2%).Conclusions: It is observed that EOPE incidence rate is lower than LOPE. Maternal and perinatal complications are greater in the EOPE group.

scholarly journals Perinatal outcome in uncomplicated pregnancies with oligohydramnios

2018 ◽  
Vol 8 (1) ◽  
pp. 215
Author(s):  
Snehal Gaware ◽  
V. B. Bangal
Keyword(s):  
Birth Weight ◽  
Amniotic Fluid ◽  
Perinatal Outcome ◽  
Perinatal Outcomes ◽  
Induction Of Labor ◽  
P Value ◽  
Amniotic Fluid Index ◽  
Medical College ◽  
Time Of Admission ◽  
Singleton Pregnancies

Background: Oligohydramnios refers to amniotic fluid volume that is less than expected for gestational age. We aimed to assess the perinatal outcomes in pregnancies with oligohydramnios.Methods: The prospective study was conducted in the Department of Obstetrics and Gynecology, Pravara Medical College, Loni in which 200 consecutive singleton pregnancies delivered vaginally, with intact membranes were included. Amniotic fluid index was determined using the Phelan’s technique at the time of admission and women were diagnosed with oligohydramnios if AFI was five or less, which formed the first group and the rest of mother formed the second group. Perinatal outcomes were noted in the proforma as well.Results: Of the 200 mothers included in the study, 38 had AFI ≤ 5. Baseline characteristics was similar in both the groups. Most common antenatal risk factors studies were pregnancy induced hypertension (29% vs 12%; p value <0.05), intrauterine growth restriction (34% vs 10%; p value <0.001) and severe anemia (21% vs 9%; p value <0.05). Proportion of pregnancies needing induction of labor and birth weight less than 2.5 kgs were significantly higher among mothers with oligohydramnios.Conclusions: Authors observed that induction of labor and low birth weight were significantly associated with oligohydramnios. Prospective randomized trials are needed to establish whether early induction of labor in the presence of a oligohydramnios improves perinatal outcome.

HtrA3 Isoform–Specific ELISAs for Early Detection of Preeclampsia

2016 ◽  
Vol 23 (10) ◽  
pp. 1092-1099 ◽  
Author(s):  
Yao Wang ◽  
Ying Li ◽  
Jonathan Hyett ◽  
Fabricio da Silva Costa ◽  
Guiying Nie
Keyword(s):  
Early Detection ◽  
Early Onset ◽  
Late Onset ◽  
Pdz Domain ◽  
First Trimester ◽  
Potential Utility ◽  
Third Trimester ◽  
The Third ◽  
Early Onset Preeclampsia ◽  
Singleton Pregnancies

Preeclampsia is a serious disorder of human pregnancy occurring after 20 weeks of gestation. It can be divided into subtypes of early onset (<34 weeks of gestation) and late onset (>34 weeks). Presymptomatic detection to identify those at high risk is important for managing this disease. HtrA3, a serine protease with high expression in the developing placenta, exists in long (HtrA3-L) and short (HtrA3-S) isoforms. They are identical, except HtrA3-S lacks the C-terminal PDZ domain. We have previously shown by Western blot analysis that serum HtrA3 levels at the end of the first trimester are significantly higher in women who later develop preeclampsia than in controls. In this study, using highly specific HtrA3 monoclonal antibodies, we established and fully validated two enzyme-linked immunosorbent assays to detect both HtrA3 isoforms together (HtrA3-T) and HtrA3-L alone in the human serum. We then determined serum HtrA3 at 11 to 13 weeks of gestation in a cohort of singleton pregnancies that proceeded without complications or developed preeclampsia in the third trimester. Compared with controls, those who developed late-onset preeclampsia had significantly higher levels of HtrA3-L, whereas those who developed early-onset preeclampsia had significantly lower ratios of HtrA3-L/HtrA3-T. These data support a potential utility of these HtrA3 ELISAs for early detection of preeclampsia.

scholarly journals Perinatal outcome of stage-based management of fetal growth restriction in a government tertiary care hospital in Kerala, India

2021 ◽  
Vol 10 (6) ◽  
pp. 2354
Author(s):  
Bhargavi Rangarajan ◽  
Lalithambica Karunakaran
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Perinatal Outcome ◽  
Late Onset ◽  
Medical Condition ◽  
Tertiary Care ◽  
Perinatal Outcomes ◽  
Growth Restriction ◽  
Care Hospital ◽  
Medical College

BACKGROUND: Fetal Growth Restriction (FGR) is the largest contributing factor to perinatal morbidity, mortality and impaired neurodevelopment. This research strives to elucidate the perinatal outcomes of stage based management of fetal growth restriction using Obstetric Doppler and its  association with maternal sociodemographic profile.METHODS: The research was  conducted among 320 antenatal women whose Estimated Fetal weight was  <10th centile. Periodic follow up with Doppler was done and managed as per the stage of FGR. Perinatal outcomes were compiled.RESULTS: The incidence of FGR in T.D Medical College, Alappuzha  was 15.23%. SGA  accounted for 47 %.  The proportion of early and late onset FGR was  10.3%    &   89.7%    respectively.  57.18% of the newborns were admitted to NICU.  The common complications were: Low birth weight – 47.8% ARDS – 21% , Sepsis – 9.6%, Necrotizing enterocolitis – 4%, Hyperbilirubinemia – 4.9%. The incidence of Neonatal death and stillbirth were 1.56% and 0.3% respectively. Mothers who were underweight, inadequate weight gain during pregnancy and short inter pregnancy interval had increased risks. Hypertensive disorders of pregnancy was the commonly associated medical condition. CONCLUSION: Prolongation of pregnancy  even by one day results in 2% increased chances of survival of the newborn. Hence, it becomes imperative to identify the benign forms of FGR  to prevent iatrogenic prematurity. Antenatal women should be screened for risk factors and undergo vigilant antepartum surveillance to bring about favourable perinatal outcome. 

scholarly journals Study of maternal and perinatal outcome of caesarean delivery in late first stage and second stage of labour

2021 ◽  
Vol 10 (4) ◽  
pp. 1503
Author(s):  
Shweta Bhatia ◽  
Vijaya M. Revankar
Keyword(s):  
Perinatal Outcome ◽  
Prospective Observational Study ◽  
Intraoperative Complications ◽  
Perinatal Outcomes ◽  
Perinatal Complications ◽  
Medical College ◽  
Second Stage ◽  
Second Stage Of Labour ◽  
Operative Complications ◽  
Febrile Morbidity

Background: Second-stage caesarean sections are known to be associated with increased maternal and perinatal complications as compared to late first stage caesarean sections. The objective of the study was to evaluate the maternal and perinatal outcome of caesarean deliveries in the late first stage and second stage of labour.Methods: The prospective observational study of caesarean deliveries done in the late first stage (~8 cm of cervical dilatation) and second stage of labour was conducted at Lady Goshen Hospital, Mangalore and Kasturba Medical College Attavar, Mangalore from August 2018 to June 2020. Comparison of maternal and perinatal outcomes were assessed in late first stage and second stages of caesarean delivery.Results: In the present study intraoperative complications such as extensions of uterine incisions, atonic PPH and bladder base injury and post-operative complications like need for blood transfusion, febrile morbidity and prolonged catheterisation were found more in second stage of labour. Perinatal complications such as hyperbilirubinemia and respiratory distress were found to be more in second stage of labour.Conclusions: As caesarean deliveries are increasing, it is better to make an institutional protocol regarding duration of second stage of labour, use of instrumental delivery to guide us about timely intervention (operative vaginal/caesarean) in advanced labour, thereby aiming to reduce the maternal and perinatal complications. 

scholarly journals Fetal and neonatal outcomes in early onset versus late onset pre-eclampsia-a comparative study

2021 ◽  
Vol 8 (5) ◽  
pp. 900
Author(s):  
Vikram R.
Keyword(s):  
Early Onset ◽  
Age Of Onset ◽  
Late Onset ◽  
Neonatal Morbidity ◽  
Neonatal Outcomes ◽  
Chi Square ◽  
Onset Type ◽  
Medical College ◽  
Early Onset Preeclampsia ◽  
Nicu Admission

Background: Pre-eclampsia is typed as two different entities: early-onset preeclampsia occurring at less than 34 weeks of gestation, and late-onset occurring at 34 or more weeks of gestation. The aim of this study is to compare the fetal and neonatal outcomes in early versus late onset preeclampsia.Methods: 208 patients diagnosed with pre-eclampsia in Shri Sathya Sai medical college and research institute over a period of three years (From January 2016 to January 2019) were retrospectively studied. Patients were classified as early onset and late onset pre-eclampsia based on the gestational age of onset. Data on fetal and neonatal outcomes were collected and analysed using Chi square and Fisher’s test and compared.Results:  Early onset and late onset pre-eclampsia were 34.6% and 65.3%. The incidence of oligohydramnios, SGA, low APGAR at 5 minutes of birth were high in early onset type. 64.9% of early onset type required NICU admission whereas only 38.23% new born of mothers with late onset type required NICU admissions.10.8% of babies of patients with early onset type were still born. The incidence of NICU admissions, requirement of respiratory support, duration of NICU stay were significantly high in early onset type.Conclusions: Patients with early onset pre-eclampsia are found to have higher rates of specific fetal and neonatal morbidity when compared to the late onset type. Prudent and close scrutinizing and follow up and delaying delivery in stable and appropriately selected patients with pre-eclampsia would be advantageous for neonates.

THE RELATIONSHIP BETWEEN THE ONSET OF SEVERE PREECLAMPSIA AND PERINATAL COMPLICATIONS AT RUMKITAL Dr. RAMELAN IN SURABAYA

2021 ◽  
Vol 5 (2) ◽  
pp. 139
Author(s):  
Widya Retno ◽  
Ivon Diah Wittiarika ◽  
Muhammad Aldika Akbar
Keyword(s):  
Preterm Delivery ◽  
Early Onset ◽  
Late Onset ◽  
Previous History ◽  
Severe Preeclampsia ◽  
P Value ◽  
Chronic Hypertension ◽  
Perinatal Complications ◽  
Exact Test ◽  
The Relationship

 Abstract Background: Preeclampsia is one of the biggest causes of maternal-fetal morbidity and mortality. Based on the prognosis, the classification of Preeclampsia is early onset (<34 weeks) and late onset (> 34 weeks). Purpose: to investigate the relationship between the onset of severe Preeclampsia and perinatal complications. Method: This research is a quantitative study with a retrospective observational analytic study type and collected medical record data. The study population was severe Preeclampsia  patients who gave birth at RUMKITAL Dr. Ramelan Surabaya for the period January 2018 - June 2020 and has no previous history of chronic hypertension. The research sample was 79 subjects with 44 subjects early onset, and 35 subjects late onset. Perinatal complications  examined are preterm delivery, asphyxia, LBW, IUGR, stillbirth. The chi-square test or Fisher’s Exact Test was used to analyze relationships. Result: From the results of the study, the comparison of the percentage from early onset and late onset that experienced complications was 93.2% vs 48.6%, p-value = 0.000, OR = 14.5, CI = 3,764–55,635.  At preterm delivery, it was found that 75% vs 28.6%, p-value = 0.000,  OR = 7.5, CI = 2,754-20,422. . In asphyxia, it was found 41.7% vs 31.4%, p-value = 0.46. At LBW, it was found 72.7% vs 17.1%, p-value = 0,000, OR = 12.9, CI = 4,285-38,771. In IUGR, it was found that 15.9% vs 2.9%, p-value = 0.000. In stillbirth, it was found 18.2% vs 0% and p-value = 0.008. Conclusion: the onset of severe Preeclampsia is related with perinatal complications. Complications associated with the onset severe Preeclampsia are preterm, LBW, stillbirth. Meanwhile, complications that are not related with the onset severe Preeclampsia are asphyxia and IUGR  

scholarly journals Effect of hydration therapy on oligohydramnios

2017 ◽  
Vol 6 (5) ◽  
pp. 1800
Author(s):  
Cicily T. J. ◽  
Sherin Sams ◽  
Anitha K. Gopal
Keyword(s):  
Perinatal Outcome ◽  
Intervention Group ◽  
Randomised Control Trial ◽  
Intravenous Route ◽  
Perinatal Complications ◽  
Fixed Amount ◽  
Medical College ◽  
Invasive Method ◽  
The Impact ◽  
Hydration Therapy

Background: Oligamnios is defined as an AFI <5cm, SDP <2cms or an AFI below the 5th centile for the gestational age and is associated with many maternal and perinatal complications. An effective, non-invasive method of increasing AFV is the hydration therapy. The objective of present study was to determine the impact of hydration therapy in patients complicated by oligamnios and to measure the maternal and perinatal outcome in oligamnios corrected by Intravenous hydration therapy.Methods: It is a randomised control trial done at Government Medical College, Kottayam, Kerala, India from Jan 2012 to May 2013. 136 singleton pregnant females with gestation age >34 weeks with AFI <5 cms were randomised into an Intervention group who receive 1 litre of ringer lactate i.v given daily for 5 days and nonintervention group who were kept under observation by serial ultrasound and antepartum fetal surveillance. All were followed-up till delivery to obtain maternal and perinatal outcomes.Results: Among the 68 who were given intervention, 61 responded and 7 were non responders. With hydration therapy, mean increase in AFI was 4 cm and minimum duration needed for improvement was one week. Hydration therapy showed significant improvement in the maternal and fetal outcomes. Intravenous route of maternal hydration has the advantage that a fixed amount of fluid can be infused at a relatively constant rate with ensured compliance.Conclusions: From the study, it was concluded that Hydration therapy is an excellent method to improve AFI in Oligohydramnios and maternal and perinatal outcome.

Maternal and Perinatal Outcomes of Early-onset and Late-onset Preeclampsia at a Tertiary Center Hospital

2021 ◽  
Vol 13 (5) ◽  
pp. 338-342
Author(s):  
Muhammad IA Akbar ◽  
Hapsari Kinanti ◽  
Ernawati E Ernawati ◽  
Pudji Lestari
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Perinatal Outcomes ◽  
Tertiary Center ◽  
Center Hospital
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