The study of serum uric acid in cerebrovascular accident patients and correlation with hypertension

Background: Cerebrovascular accident (CVA) is also called Stroke. These is a well-recognized epidemiological link between elevated serum uric acid and increased cerebrovascular risk. Several studies have identified as elevated serum uric acid concentration as a predictor of cerebrovascular events. The aim of this study was to correlate serum uric acid in cerebrovascular accident (CVA) patients with Hypertension.Methods: A prospective study was conducted on 100 patients aged >18 years of admitted with new onset focal/global neurological deficit/event with cerebrovascular accident (CVA). Brain imaging (CT/MRI) was performed on the patients within 24-48 hrs of admission. Data was collected with regards to patient’s demography, medical history, risk factors for stroke or vascular disease. Serum uric acid was measured as part of fasting biochemical profile taken within 24-48 hrs of admission by standard analytical methods in Biochemistry department.Results: Out of 100 patients included in this study 74 of them were male and 26 were female. Among 100 patients 61 patients had hemorrhage, out of which 45 (73.77%) were male and 16 (26.23%) were female, followed by 39 patients had infract, out of which 29 (74.35%) were male and 10 (25.65%) were female. Mean value of serum uric acid levels in hypertensive patients was significantly high in comparison to normotensive patients.Conclusions: Concluded that correlation of serum uric acid in cerebrovascular accident (CVA) patients with Hypertension was found statistically significant.

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Serum uric acid concentration (SUAC): A useful tool to assess extent and severity of chronic plaque psoriasis in Pakistani population.

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.11.692 ◽

2019 ◽

Vol 26 (11) ◽

pp. 1825-1828

Author(s):

Hafiz Bashir Ahmed ◽

Deepa Mohan Lal ◽

Muhammad Suleman Pirzado ◽

Ajmal Rashid ◽

Irfan Anwar ◽

...

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Acid Concentration ◽

Plaque Psoriasis ◽

Critical Role ◽

Elevated Serum ◽

Control Group ◽

Uric Acid Concentration ◽

Chronic Plaque Psoriasis ◽

Serum Uric Acid Concentration

Objectives: Psoriasis is a systemic chronic inflammatory autoimmune disease. Psoriasis can lead to multiple complications and co-morbidities. It has also been observed that raised serum uric acid levels predispose to gouty arthritis and also thought to be a risk factor for cardiovascular mortality and morbidity. The basic aim of this study was to ascertain level of serum uric acid in patients with chronic plaque psoriasis and control cases which might be a useful tool for assessing the extent and severity of chronic plaque psoriasis. Study Design: Case control study. Setting: At Outpatient’s Department (OPD) of Department of Dermatology, PNS Shifa, Karachi. Period: From January 2013 to December 2016. Material & Methods: One hundred and ninety four (194) patients were taken in this study and 97 patients were biopsy proven cases of psoriasis and 97 other participants included as control cases reporting to OPD with other complaint like acne, hair fall and fungal infections. After written and informed consent, 5ml of venous blood was drawn in sterile syringe and using gel sample tube to see the serum uric acid levels. On the basis of laboratory reports the elevated serum uric acid level in psoriatic versus normal controls was recorded on a pre-designed proforma. Results: There were 54.6% (106/194) male and 45.4% (88/194) female. Elevated serum uric level was 4.5 times (Approximate of 4.46) more common in cases than control group (OR: 4.46 95%CI: 1.83 to 10.91). Conclusion: Raised levels of serum Uric acid have been seen frequently in psoriatic patients. Early treatment for higher levels of serum uric acid might play a critical role in the better treatment of psoriatic patients. These results revealed that serum uric acid concentration (SUAC) of psoriasis may play a vital role in assessing the complex multifactorial etiology of the psoriasis, severity and other possible metabolic factors.

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Elevated serum uric acid concentration at discharge confers additive prognostic value in elderly patients with acute heart failure

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2017.12.009 ◽

2018 ◽

Vol 28 (4) ◽

pp. 361-368 ◽

Cited By ~ 4

Author(s):

S. Coiro ◽

E. Carluccio ◽

P. Biagioli ◽

G. Alunni ◽

A. Murrone ◽

...

Keyword(s):

Heart Failure ◽

Uric Acid ◽

Elderly Patients ◽

Serum Uric Acid ◽

Acute Heart Failure ◽

Acid Concentration ◽

Prognostic Value ◽

Elevated Serum ◽

Uric Acid Concentration ◽

Serum Uric Acid Concentration

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Serum uric acid as a prognostic indicator in acute ischemic stroke

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20201338 ◽

2020 ◽

Vol 8 (4) ◽

pp. 1435

Author(s):

Chandana Kaspa ◽

Shankar Govindu

Keyword(s):

Uric Acid ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Serum Uric Acid ◽

Elevated Serum ◽

Prognostic Indicator ◽

Uric Acid Concentration ◽

Risk Of Death ◽

Increased Risk ◽

Serum Uric Acid Concentration

Background: Association between serum uric acid (SUA) and the outcome of acute ischemic stroke is debated and needs to be evaluated. The present study was conducted to study the serum uric acid concentration as an indicator of outcome among acute ischaemic stroke and to determine the role of serum uric acid as a risk factor for acute ischemic stroke.Methods: An observational study where 50 patients who presented within 48 hours of onset of stroke admitted to medical wards of government general Hospital Guntur were selected for the study.Results: Out of 50 patients included for the study, 6 belonged to the age group of 30-40 years. Majority were male (66%) and 44.5% of the males and 76.5% of females showed raised serum uric acid levels. 25 out of 50 patients were diabetic (i.e. 50%) Among them 16 had serum uric acid >6 mg% (ie.64%), 56% of the patients were hypertensive and among them 71% were found to have uric acid levels greater than 6mgs%, 38 out of 50 patients had bad outcome, with elevated uric acid levels found 30 among them. In the present study, BMI and outcome of Stroke were significantly associated with Serum Uric acid levels.Conclusions: Serum uric acid levels can be used as a prognostic indicator as a marker for increased risk of stroke. Elevated serum urate concentration may stratify risk of death after acute stroke.

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Serum Uric Acid Concentrations Can Predict Hypertension: A Longitudinal Population-Based Epidemiological Study

Hormone and Metabolic Research ◽

10.1055/s-0043-119129 ◽

2017 ◽

Vol 49 (11) ◽

pp. 873-879 ◽

Cited By ~ 3

Author(s):

Rongjiong Zheng ◽

Tianmeng Yang ◽

Qingmei Chen ◽

Changxi Chen ◽

Yushan Mao

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Chinese Population ◽

Cox Regression ◽

Elevated Serum ◽

Population Based ◽

High Serum ◽

Uric Acid Concentration ◽

Serum Uric Acid Concentration ◽

Hypertension Development

AbstractAn elevated serum uric acid concentration may be associated with hypertension, which is the leading cause of death worldwide. However, whether the elevation is causal or a consequence of hypertension among the Chinese population remains unclear. This study was designed to investigate the longitudinal relationship between the serum uric acid concentrations and hypertension among Chinese individuals. This study included 5105 subjects, initially without hypertension, who were followed up for 9 years. The subjects were divided into four groups based on the serum uric acid quartile. Cox proportional hazard models were used to analyse the risk factors for hypertension development. Over the 9 years, 2259 of the subjects developed hypertension. The overall 9-year cumulative incidence of hypertension was 44.3%, ranging from 36.3% in quartile 1 to 42.4%, 44.1%, and 54.5% in quartiles 2, 3, and 4, respectively (p for trend<0.001). The Cox regression analyses indicated that the serum uric acid concentrations were independently and positively associated with the risk of incident hypertension. This longitudinal study demonstrated that high serum uric acid concentrations increase the risk of hypertension among the Chinese population.

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The Use of Serum Uric Acid Concentration as an Indicator of Laparoscopic Sleeve Gastrectomy Success

International Surgery ◽

10.9738/intsurg-d-13-00186.1 ◽

2015 ◽

Vol 100 (1) ◽

pp. 173-179 ◽

Cited By ~ 6

Author(s):

Evangelos Menenakos ◽

Georgia Doulami ◽

Irene P. Tzanetakou ◽

Maria Natoudi ◽

Nikolaos Kokoroskos ◽

...

Keyword(s):

Weight Loss ◽

Uric Acid ◽

Sleeve Gastrectomy ◽

Laparoscopic Sleeve Gastrectomy ◽

Serum Uric Acid ◽

Gut Hormones ◽

Uric Acid Concentration ◽

Positive Correlation ◽

Serum Uric Acid Concentration ◽

A Prospective Study

Abstract Laparoscopic sleeve gastrectomy (LSG) effectively reduces weight by restricting gastric capacity and altering gut hormones levels. We designed a prospective study to investigate the correlation of serum uric acid (SUA) concentration and weight loss. SUA and body mass index (BMI) were measured preoperatively and on first postoperative month and year in patients who underwent LSG in our department of bariatric surgery. Data on 55 patients were analyzed. Preoperative SUA concentration had a significant positive correlation with percentage of total weight loss (TWL) on first postoperative month (P = 0.001) and year (P = 0.002). SUA concentration on first postoperative month had a positive correlation with percentage of TWL on first postoperative year (P = 0.004). SUA concentration could be used as a predictor of LSG's success and could help in early detection of patients with rapid loss of weight, in order to prevent complications.

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Elevated serum uric acid, hyperuricaemia and dietary patterns among adolescents in mainland China

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2019-0265 ◽

2020 ◽

Vol 33 (4) ◽

pp. 487-493 ◽

Cited By ~ 3

Author(s):

Hang Zhou ◽

Zheng Feei Ma ◽

Yiming Lu ◽

Yanyan Du ◽

Jian Shao ◽

...

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Dietary Patterns ◽

Elevated Serum ◽

Principal Component ◽

Normal Body Mass Index ◽

Uric Acid Concentration ◽

Limited Information ◽

Cross Sectional ◽

Serum Uric Acid Concentration

AbstractBackgroundElevated serum uric acid concentrations have been associated with metabolic syndrome. However, only limited information is available on the prevalence of hyperuricaemia in adolescents. Therefore, the aim of our cross-sectional study was to study the prevalence of hyperuricaemia and dietary patterns in adolescents aged 13–16 years living in Yangzhou, China.MethodsAdolescents were asked to complete a 20-item food frequency questionnaire (FFQ) and provide an overnight fasting finger-prick sample. Principal component analysis (PCA) with varimax rotation was used to derive the dietary patterns that might be associated with high uric acid concentrations.ResultsA total of 1070 adolescents were recruited. Of these, 53.6% (n = 574) were females, and 58.5% (n = 625) were within the normal body mass index (BMI) range. The males had a significantly higher serving size and frequency in their weekly food consumption, including meat, poultry, Chinese cereal staple foods and Western-style fast foods, than the females (all p < 0.02). The overall mean serum uric acid concentration and prevalence of hyperuricaemia were 368.6 ± 114.5 μmol/L and 37.9%, respectively. The prevalence of hyperuricaemia was 4.633 times greater among the participants who were overweight and obese than among those who were underweight. On the other hand, the prevalence of hyperuricaemia was 0.694 times lower among the participants who had normal weight than those who were underweight.ConclusionsThe prevalence of hyperuricaemia was relatively high in Chinese adolescents. The prevention of hyperuricaemia measures should be strengthened in adolescents to effectively control for obesity and gout, which tend to persist into adulthood.

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Effect and Mechanism of Total Saponin of Dioscorea on Animal Experimental Hyperuricemia

The American Journal of Chinese Medicine ◽

10.1142/s0192415x06003655 ◽

2006 ◽

Vol 34 (01) ◽

pp. 77-85 ◽

Cited By ~ 25

Author(s):

Guang-Liang Chen ◽

Wei Wei ◽

Shu-Yun Xu

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Acid Concentration ◽

Serum Uric Acid Level ◽

Urate Oxidase ◽

Uric Acid Concentration ◽

Total Saponin ◽

Test Kit ◽

Serum Uric Acid Concentration ◽

Potassium Oxonate

In this study, we investigated the effects and mechanisms of Total Saponin of Dioscorea (TSD) on animal experimental hyperuricemia. Mouse and rat hyperuricemic models were made by orally administering yeast extract paste once a day (30 and 20 g/kg, respectively), for 7 days. Yeast would disturb normal purine metabolism by increasing xanthine oxidase (XOD) activity and generating large quantities of uric acid. This model is similar to human hyperuricemia, which is induced by high-protein diets, due to a purine and nucleic acid metabolic disturbance. Another mouse hyperuricemia model was generated by intraperitoneal injection once with uric acid 250 mg/kg or potassium oxonate 300 mg/kg. Potassium oxonate, a urate oxidase inhibitor, can raise the serum uric acid level by inhibiting the decomposition of uric acid. Likewise, injecting uric acid can also increase serum uric acid concentration. The concentration of uric acid in serum or urine was detected by the phosphotungstic acid method, and the activity of XOD was assayed by a test kit. The results showed that TSD (240, 120 and 60 mg/kg, ig) could significantly lower the level of serum uric acid in hyperuricemic mice. TSD (120 and 60 mg/kg, ig) could also lower the level of serum uric acid in hyperuricemic rats, reduce the activity of XOD in the serum and liver of hyperuricemic rats, and increase the level of urine uric acid concentration as well as 24-hour total uric acid excretion. In conclusion, TSD possesses a potent anti-hyperuricemic effect on hyperuricemic animals, and the mechanism may be relevant in accelerating the excretion and decreasing the production of uric acid.

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