scholarly journals Correlation between HbA1c level and LDL cholesterol level in ischemic stroke patients

2020 ◽  
Vol 7 (5) ◽  
pp. 741
Author(s):  
Gaurav Gupta ◽  
Mohammad Aquiqe ◽  
Richa Giri ◽  
Shivendra Verma

Background: Defects in insulin action and hyperglycemia could lead to Dyslipidemia in patients with diabetes.Methods: Cross sectional study carried out in patients presenting with ischemic stroke to medicine emergency unit of the LLRH Hospital from January 2018 to October 2019.Patient of age group 40-80 years The subjects in the present study were 450 patient comprised of 235 cases with ischemic stroke of age group of 40-80 years and 215 health y controls of age group of 40-80 years.Results: The correlation between these two variable as elicited from data obtained from study and, is significant (p<0.0001). The sensitivity of this correlation in the context of ischemic stroke is 75%, while the specificity is 60%. However, an impressive negative predictive value of 91% suggests a beneficial effect of normal or well controlled diabetes and Dyslipidemia. Conversely, a modest positive predictive value of 29% does not appear to help in utilizing this correlation as a measure of future likelihood of ischemic stroke. p value 0.00005 inference-highly significant.Conclusions: Study show statistically significant association (p < 0.001) of increased levels of HbA1c and LDL-C in patients of ischemic stroke.

Author(s):  
G Sindhujha Sekar ◽  
A Esther Ruby ◽  
P Lalitha

Introduction: In perimenopausal age group particularly, 70% of all gynaecological consultations are for Abnormal Uterine Bleeding (AUB). About 30% of women seek medical assistance for AUB during their reproductive age group and about one third of hysterectomies are carried out for AUB alone. Aim: To determine the sensitivity, specificity, positive predictive value and negative predictive value of Transvaginal Ultrasonography (TVS) versus hysteroscopy in detecting uterine abnormalities Materials and Methods: A cross-sectional study in patients with AUB, admitted to the Department of Obstetrics and Gynaecology at RGGWCH, Puducherry between February 2016 and February 2017 who met the inclusion criteria were included. Sample size was 85 cases. After taking detailed history and physical examination the patient was investigated to rule out organic causes of AUB and then TVS and hysteroscopy were done. Any intrauterine pathology was looked for and endometrial sampling was taken from the abnormal sites for Histopathological Examination (HPE). Both TVS and hysteroscopy results were compared with histopathology which is the gold standard. Results: The sensitivity of TVS in diagnosis of uterine fibroid in comparison to hysteroscopy was 94.74% and the specificity was 71.21%. The sensitivity of hysteroscopy in diagnosis of endometrial hyperplasia in comparison to HPE was 75% and the specificity was 87.01%. The sensitivity of TVS in diagnosis of endometrial hyperplasia in comparison to HPE was 37.5% and the specificity was 90.91%. The sensitivity of hysteroscopy in diagnosis of polyp in comparison to HPE was 100% and the specificity was 97.3%. The sensitivity and specificity of TVS in diagnosis of polyp in comparison to HPE were 9.09% and 93.24%, respectively. Conclusion: TVS had a high sensitivity to detect fibroids but its value in detecting hyperplasia and polyps was in question in this study. But hysteroscopy had a maximum sensitivity to detect polyps and high sensitivity to detect endometrial hyperplasia compared to histopathology which is a gold standard investigation.


Author(s):  
Meiriani . ◽  
Yuneldi Anwar ◽  
Puji Pinta Omas Sinurat

Background: Diabetes and higher HbA1c level have increased the incidence of stroke. Hemoglobin levels both high and low are associated with poor outcomes. Leukocytes play an important role in the initiation of the atherosclerosis process.Methods: This was a cross-sectional study with a sample size of 62 people selected by non-random sampling method on a consecutive basis, patients with acute stroke were taken blood to measure blood glucose levels, HbA1c, Hb and Leucocytes when entering the hospital room. Outcomes were assessed using NIHSS and MRS. The calculation of NIHSS and MRS scores was performed on the first day of admission and the fourteenth day. To analyze the correlation of blood sugar levels during HbA1c, Hb and leukocytes in acute stroke, this study used Spearman's correlation test. The p value <0.05 was considered statistically significant.Results: The study subjects of 62 acute stroke patients (acute ischemic stroke 31 people and 31 people hemorrhagic stroke). Acute stroke patients were consisted of 38 men (61.3%) and 24 women (38.7%). Of 31 people with hemorrhagic stroke, there were 16 men (51.6%) and 15 women (48.4%), ischemic stroke patients were consisted of 22 people (71, 0%) and women were 9 people. Spearrman repair test showed no symptoms between blood glucose levels, HbA1c, Hemoglobin and leukocytes with outcomes in acute stroke.Conclusions: There was no significant association between blood glucose levels, HbA1c, hemoglobin and leukocytes with outcomes in acute stroke.


2020 ◽  
Author(s):  
Xiaohua Yang ◽  
Huijuan Chen ◽  
Wanling Yang ◽  
Bin Deng ◽  
Jialing Zheng ◽  
...  

Abstract Background: Stroke-associated pneumonia (SAP) is a major complication after stroke, oral microorganisms are important contributors to SAP. Here, we aimed to investigate whether the oral hygiene was associated with SAP and related risk factors of them in patients with acute ischemic stroke. Methods: We performed a cross-sectional study that recruited 331 patients with acute ischemic stroke from two medical centers. A series of assessments were performed to evaluate the neurological status and habits of oral hygiene. According to whether the oral hygiene was abnormal and SAP occurred, univariate analyses were performed in cohort 1 (normal / abnormal oral hygiene groups) and cohort 2 (SAP / non-SAP groups). Multiple logistic regression analyses were conducted to confirm risk factors of oral cleanliness and SAP in stroke patients. Results: A total of 12 and 8 independent variables were included in the model 1 and 2 analysis. After adjusting for confounders, multivariable logistic regression analysis showed that oral cleanliness was not only closely related to SAP (OR=2.219, P=0.026), dental caries (OR=1.292, P=0.005) and age (OR=1.030, P=0.006) in model 1, but also an independent risk factor for predicting SAP (OR=1.678, P=0.001) in model 2. Barthel index was a protective factor for oral cleanliness (OR=0.986, P=0.019) and SAP (OR=0.977, P=0.002) in ischemic stroke patients. Conclusions: Mutually primary risk roles of abnormal oral cleanliness and SAP exist in patients with acute ischemic stroke. Dental caries and aging are important risk factors for oral health disorders. Improving the activities of daily living would have protective effects on both oral hygiene and SAP prevention in stroke patients.


2016 ◽  
Vol 59 ◽  
pp. e77 ◽  
Author(s):  
Sana Salah ◽  
Mariem Rekik ◽  
Soumaya Boudokhane ◽  
Houda Migaou ◽  
Anis Jellad ◽  
...  

2017 ◽  
Vol 24 (11) ◽  
pp. 1647-1651
Author(s):  
Riaz Ahmed Javid ◽  
Ayesha Ghafoor ◽  
Ifrah Ahmed

Objectives: To find out the frequency of hyponatremia in cases of hepaticencephalopathy. Study Design: Cross-sectional study. Setting: Department of Medicine DGKhan Hospital, DG Khan. Period: July 2016 to December 2016. Material and Methods: Total80 patients with hepatic encephalopathy either male or female were selected for this study.Hyponatremia was assessed in these selected patients. Results: Mean age of the patientswas 38.34 ± 11.140 years. Hyponatremia was found in 31 (39%) patients. Hyponatremia wasnoted in 13 (41.94%) patients of age group 18-36 years and 18 (36.73%) patients of age group37-55 years. Statistically insignificant association of hyponatremia with age was seen with pvalue 0.6467. Hyponatremia was found in 21 (40.38%) male patients and 10 (35.71%) femalepatients. But the difference of frequency of hyponatremia between male and female patients wasstatistically insignificant with p value 0.8109. Conclusion: Results of this study showed a higherpercentage of hyponatremia in patients with HE. Male were more victim of HE as compared tofemale but insignificant association of hyponatremia with gender is noted. Findings of presentstudy showed that there is insignificant association of hyponatremia with grade of HE, socioeconomicstatus, area of residence and age.


Author(s):  
Jalina Laishram ◽  
Mohammed Rafique ◽  
Kh. Sonarjit Singh ◽  
Brogen Singh Akoijam

Background: Tobacco use is one of the most common substance abuse indulged by adolescents worldwide. The current tobacco use among youths in the age group of 13-15 years was 14.6% (GYTS 2009, India). The tobacco situation in India is unique because of a vast spectrum of tobacco products available for smoking as well as smokeless use. This study was done to determine the prevalence of tobacco use among school students in Imphal, Manipur, India and to determine the association between tobacco use and socio-demographic characteristics.Methods: A cross sectional study was conducted among school students studying in class VII to class X in Imphal, Manipur using convenience sampling. Data were collected by questionnaire method. Descriptive statistics like mean, percentages and proportions were used. Chi-square test was used to determine the association and a p value of <0.05 was taken as significant.Results: The prevalence of ever use of tobacco among school students in Imphal was found to be 19.5%. And 43.4% of the ever users were current users. Ever use of tobacco was significantly associated with older age group (14-17 years), male gender, living in a nuclear family, studying in class X, being in a relationship and whose mother was educated below class X.Conclusions: Two out of every 10 students in the age group of 10-17 years in the study have ever used any kind of tobacco product. Smokeless form of tobacco was more commonly used as compared to smoked form.


Author(s):  
Aniruddh Ranga ◽  
J. P. Majra

Background: School-age children spend one-third of their time in schools. Teachers are key personnel to look after the health of school children. Teachers can provide health education to school children, assess the school environment for better health outcomes, provide health care services and help in the maintenance of school health records. Aim of the study was to assess the status of knowledge of school health services (SHS) among school teachers.Methods: Government and private schools in a Northern Indian state. A community-based cross-sectional study. It includes 50 randomly selected designated schoolteachers for SHS by the PPS methods from the schools which were functional since at least five years in the study area. A pre-tested self-administered questionnaire was used to assess the knowledge regarding SHS. Percentage, proportion and χ2 test were used as statistical methods. The p-value 0.05 was considered statistically significant.Results: 38% participants were of 41-50 years of age group, 54% were females and 48% had an experience of ≤10 years. 22% participants had training regarding SHS. 40% participants had moderately adequate knowledge (p-value=0.04). It was observed to be more among participants of rural, government, age group of 31-40 years, with experience of 21-30years, female and among trained teachers for school health.Conclusions: School teachers were lacking in knowledge regarding environment and sanitation; communicable and non-communicable diseases; and health education for school children. We also observed that training regarding SHS was a majorly missing component which could be the reason behind poor level knowledge among schoolteachers.


Author(s):  
Atul Tiwari ◽  
SK Piruwa ◽  
SK Agrawaal ◽  
GN Srivastava ◽  
Deepak Shah

Introduction: Metabolic Syndrome (MetS) is characterised by the clustering of central obesity, hypertension, dyslipidemia, and hyperglycemia that predisposes patients to Cardiovascular Disease (CVD). It is a representative group of conditions with systemic inflammation, which is a potential mechanism responsible for both Chronic Obstructive Pulmonary Disease (COPD) and MetS. Aim: To detect incidence of MetS in COPD patients and its correlation with severity of COPD. Materials and Methods: The present study was an observational cross-sectional study which was conducted on 62 COPD patients in SS Hospital, BHU, Varanasi, Uttar Pradesh, India, from June 2015 to June 2017, diagnosed on basis of Global initiative for Lung Disease (GOLD) guidelines. 62 age and sex matched control having no cardio-respiratory history were included. All relevant investigations were done for all selected subjects and modified Medical Research Council (mMRC) dyspnoea grading was done in all the subjects. Standardised treatment modules were followed and spirometry and post-bronchodialater spirometry was performed 15-30 mins after inhalation of 400 mcg Salbutamol. Patients obstruction was classified according to the severity of airflow limitation based on post-bronchodilator Forced Expiratory Volume in one second (FEV1) as follows: mild (≥80% predicted); moderate (80>FEV1 ≥50% predicted); severe (50%> FEV1 ≥30% predicted); very severe (<30% predicted). Complete work-up and data collection were analysed by using Statistical Package for the Social Sciences (SPSS) version 23.0 software, descriptive cross tables, univariate and multivariate analysis. Independent Student’s t-test was used to compare the means of cases and controls. The p-value <0.05 was considered statistically significant. Results: Total 62 patients along with age and sex matched 62 healthy control in 1:1 ratio have been taken in the study, majority were in age group of 50-70 years. On comparing the mean values of different parametres of MetS in COPD cases and controls, significantly raised triglyceride level and fasting blood sugar in COPD cases (p-value <0.001 and 0.005 respectively) were observed. MetS was present in 29 cases (46.8%) of COPD whereas in healthy control population only 19 people (30.6%) were positive for MetS. Total of 55.2% cases of COPD with MetS was in group D whereas 84.8% cases of COPD without MetS were in group B of GOLD staging. Statistically significant (p<0.001) higher incidence of acute exacerbation was observed in cases of COPD with MetS. Conclusion: MetS was more prevalent among the COPD patient in 50-70 years age group with mild to moderate airflow limitation. More waist circumference i.e., central obesity, impaired fasting glucose, dyslipidemia, increases the risk of cardiovascular complication in these patients. MetS is an important co-morbidity in patients of COPD which fasten the natural course of disease by increasing the frequency of acute exacerbation.


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