scholarly journals Single center, observational study to analyze correlation between vitamin D-3 deficiency and age in patients with orthopedic disorders

2021 ◽  
Vol 8 (1) ◽  
pp. 64
Author(s):  
Girish Rathod ◽  
Nitin Raut ◽  
Pushkar Borole ◽  
Chandan Shetty ◽  
Vijaykumar Gawali
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Fractures ◽  
Age Groups ◽  
Long Bone ◽  
Increased Risk ◽  
High Prevalence ◽  
Vitamin D 3 ◽  
Risk Of Fall ◽  
Orthopedic Patients

<p><strong>Background:</strong> Vitamin D deficiency has been strongly associated with various health outcomes, including all-cause mortality. Chronic vitamin D deficiency in adults and in old age results in osteomalacia, osteoporosis, muscle weakness, and increased risk of fall and long bone fractures. <strong></strong></p><p><strong>Methods:</strong> We examined records of 1029 such patients and to analyze association of vitamin d-3 levels and categories of age groups (1-20, 21-30, 31-40, 41-50, 51-60, 61-70, 71-80, 81-90 years). We categorized mild, moderate and severe cases age wise.</p><p><strong>Results: </strong>During the study period records for 1029 patients were evaluated, of which 347 (33.72%) male and 682 (66.27) were female the mean age with standard deviation for male was 38.25±15.64 years and for female was 41.43±15.23 years. Vitamin D deficiency (&lt;20 ng/ml) was present in 623 patients (61%), 189 patients (18%) had vitamin D level 20-30 ng/ml and 217 patients (21%) had sufficient levels of vitamin D.</p><p><strong>Conclusions:</strong> Our study concludes that although there is high prevalence of vitamin D-3 deficiency across all age groups among orthopedic patients, age group 31-40 years, was found to be more affected.</p><p><strong> </strong></p>

The Prevalence of Vitamin D Deficiency in Iran: A Literature Review

2020 ◽  
Vol 16 (7) ◽  
pp. 1015-1027
Author(s):  
Mohammad Bagherniya ◽  
Zahra Khorasanchi ◽  
Mina S. Bidokhti ◽  
Gordon A. Ferns ◽  
Mitra Rezaei ◽  
...  
Keyword(s):  
Vitamin D ◽  
Literature Review ◽  
Vitamin D Deficiency ◽  
Medical Condition ◽  
Scientific Information ◽  
Age Groups ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Vitamin D Levels ◽  
High Prevalence

Background: Vitamin D deficiency is a common medical condition worldwide. In Iran, it has been reported that between 30-90% of people have vitamin D deficiency. However, its distribution in different parts of the country and among different age and regional groups is unclear. Therefore, the aim of this study was to review the recent literature on vitamin D deficiency in Iran. Methods: The literature review was performed using Web of Science, PubMed-Medline, Scopus and Scientific Information Database (SID) with a cut-off date of November 2016 to identify articles on vitamin D status in Iran published in the last 10 years. Studies in English and Persian that reported vitamin D levels in male and female subjects of all age groups and in healthy populations were included. Results: From 325 studies that were initially retrieved, 82 articles met the inclusion criteria. A high prevalence of vitamin D deficiency was reported, and in some regions, this was reported as >90% and was found in all age groups and in all regions of Iran. Conclusion: This review highlights the very high prevalence of vitamin D deficiency in Iran. It will be important to recognize the importance of vitamin D deficiency as a major public health problem in Iran.

scholarly journals Vitamin D deficiency and health

2010 ◽  
Vol 16 (3) ◽  
pp. 277-281 ◽  
Author(s):  
I. L. Nikitina ◽  
T. L. Karonova ◽  
E. N. Grineva
Keyword(s):  
Vitamin D ◽  
Clinical Trials ◽  
Vitamin D Deficiency ◽  
Wide Spectrum ◽  
Increased Risk ◽  
High Prevalence

The high prevalence of vitamin D defi ciency worldwide and the associated increased risk for different pathologies require re-evaluation of this problem and its signifi cance. The wide spectrum of the diseases associated with vitamin D defi ciency explains the high scientifi c interest and increasing number of clinical trials in this area, and the involvement of larger populations into studies.

scholarly journals A study on vitamin D status among orthopaedic patients

2020 ◽  
Vol 6 (2) ◽  
pp. 286
Author(s):  
Srinivasalu Santhanagopal ◽  
Matthew Sebastian ◽  
Madan Mohan Muniswamy ◽  
Anoop Pilar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Indian Population ◽  
Age Groups ◽  
Hypovitaminosis D ◽  
Vitamin D Status ◽  
Orthopaedic Patients ◽  
Vitamin D Levels ◽  
High Prevalence ◽  
Calcium Phosphorus

<p class="abstract"><strong>Background:</strong> There is an alarmingly high prevalence of hypovitaminosis D in orthopaedic patients, regardless of whether or not, they require surgical intervention. Vitamin D plays an essential role in bone formation, maintenance, and remodelling, as well as muscle function and deficiency could affect adversely in multiple ways. Many reports recently demonstrated high rates of vitamin D deficiency, in numerous segments of Indian population, but there is no study reported so far from India, which focuses specifically on vitamin D status in orthopaedic patients.</p><p class="abstract"><strong>Methods:</strong> It is a descriptive study to<strong> </strong>estimate vitamin D levels in patients scheduled to undergo orthopaedic surgery. Vitamin D, calcium, phosphorus and alkaline phosphatase (ALP) levels in 310 patients, who were admitted at our institution, from December 2015 to August 2017 were measured.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 310 patients included in our study, 189 (61%) were males and 121 (39%) females. Vitamin D deficiency (&lt;20 ng/ml) was present in 232 patients, insufficiency (&lt;30 ng/ml) was present in 63 patients and only 15 patients had desirable levels (&gt;30 ng/ml). Patients younger than 60 years and males had more prevalence of Vitamin D abnormality. 168 (72.4%) of the patients, with deficiency presented in winter, compared to 64 (27.6%) in summer.</p><p class="abstract"><strong>Conclusions:</strong> Statistically significant vitamin D deficiency was seen during winter months, in patients undergoing hip hemiarthroplasty, and in patients admitted for degenerative disease of the spine, hip and knee. Screening and treating hypovitaminosis D appears to be important in orthopaedic patients as vitamin D deficiency is prevalent across all age groups in the population studied.</p>

Study of Vitamin D Deficiency in Adolescent Females (10-18 years old) In Cairo

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
R M Botros ◽  
Y M Eid ◽  
B M Mostafa ◽  
Y H E Elmeligy
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Large Scale ◽  
Age Groups ◽  
Sun Exposure ◽  
Adolescent Females ◽  
Contributing Factors ◽  
Significant Difference ◽  
High Prevalence ◽  
Deficient Group

Abstract Background Vitamin D deficiency is a common problem among Egyptian females across all age groups, for whom contributing factors include inadequate sun exposure possibly related to cultural/social factors, and insufficient dietary calcium, wearing a sunscreen reduces vitamin D synthesis in the skin by more than 95%. Not only environmental factors, such as sun exposure and nutrition, but also genetic and possibly also epigenetic factors are determinants of serum 25(OH) D. Aim We sought to determine the frequency of occurrence of vit D deficiency in Egyptian adolescent females aged 10-18 years in Cairo. Methods Study was conducted on 90 healthy adult females aged (10-18) years and classified them into: Sufficient group: with vitamin D level &gt;30ng/ml, (40%) of participants. Mild deficient group: with vitamin D level between 21-29ng/ml (14.44%) of participants. Moderate deficient group: with vitamin D level between 10-20ng/ml (11.11%) of participants. Severe deficient group: with vitamin D level &lt;10ng/ml (34.44%) of participants. Results Our study showed a high prevalence of low vitamin D level among healthy adolescent females aged (10-18) years old. There were a significant difference On comparing vitamin D status groups as regard vitamin D rich food intake, duration of sun exposure and height for age (p &lt; 0.001), (p &lt; 0.001) and (p = 0.012) respectively. There were significant difference on comparing vit D status groups with s.Ca, PTH and Alk.Ph (p &lt; 0.001). Conclusion Vitamin D deficiency became endemic in Egypt. Large-scale studies are needed to properly evaluate the size of the problem.

scholarly journals The Impact of Obesity on the Association between Vitamin D Deficiency and Cardiovascular Disease

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2458 ◽  
Author(s):  
Paschou ◽  
Kosmopoulos ◽  
Nikas ◽  
Spartalis ◽  
Kassi ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
General Population ◽  
Vitamin D Deficiency ◽  
Strong Association ◽  
Vitamin D Supplementation ◽  
Obese Adults ◽  
Increased Risk ◽  
High Prevalence ◽  
The Impact

The aim of this article is to review the literature regarding the relationship between vitamin D deficiency and cardiovascular disease (CVD) and its modification in the presence of obesity. Despite the strong association between vitamin D status and cardiovascular outcomes, vitamin D supplementation trials in the general population have failed to decrease the incidence of cardiovascular events and mortality. A comprehensive study of the published literature and a comparison with experimental data lead to the conclusion that obesity, due to its high prevalence and strong association with both vitamin D deficiency and CVD, may act as a critical confounder, which is responsible for the different results on this association. Adoption of a vitamin D preventive supplementation strategy for CVD is unlikely to yield any benefit to the general population. However, it might be particularly useful in obese adults with increased risk for CVD.

scholarly journals Vitamin D Deficiency in Older Patients—Problems of Sarcopenia, Drug Interactions, Management in Deficiency

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1247
Author(s):  
Małgorzata Kupisz-Urbańska ◽  
Paweł Płudowski ◽  
Ewa Marcinowska-Suchowierska
Keyword(s):  
Vitamin D ◽  
Plasma Concentration ◽  
Vitamin D Deficiency ◽  
Bone Fractures ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Adverse Outcomes ◽  
Vitamin D Metabolism ◽  
Increased Risk ◽  
Vitamin D Levels

Vitamin D deficiency frequently occurs in older people, especially in individuals with comorbidity and polypharmacotherapy. In this group, low vitamin D plasma concentration is related to osteoporosis, osteomalacia, sarcopenia and myalgia. Vitamin D levels in humans is an effect of the joint interaction of all vitamin D metabolic pathways. Therefore, all factors interfering with individual metabolic stages may affect 25-hydroxyvitamin D plasma concentration. The known factors affecting vitamin D metabolism interfere with cytochrome CYP3A4 activity. There is another group of factors that impairs intestinal vitamin D absorption. The phenomenon of drugs and vitamin D interactions is observed first and foremost in patients with comorbidity. This is a typical situation, where the absence of “hard evidence” is not synonymous with the possible lack of adverse effects. Osteoporosis and sarcopenia (generalized and progressive decrease of skeletal muscle mass and strength) are some of the musculoskeletal consequences of hypovitaminosis D. These consequences are related to an increased risk of adverse outcomes, including bone fractures, physical disabilities, and a lower quality of life. This can lead not only to an increased risk of falls and fractures but is also one of the main causes of frailty syndrome in the aging population. Generally, Vitamin D plasma concentration is significantly lower in subjects with osteoporosis and muscle deterioration. In some observational and uncontrolled treatment studies, vitamin D supplementation resulted in a reduction of proximal myopathy and muscle pain. The most conclusive results were found in subjects with severe vitamin D deficiency and in patients avoiding large doses of vitamin D. However, the role of vitamin D in muscle pathologies is not clear and research has provided conflicting results. This is plausibly due to the heterogeneity of the subjects, vitamin D doses and environmental factors. This report presents data on some problems with vitamin D deficiency in the elderly population and the management of vitamin D deficiency D in successful or unsuccessful aging.

scholarly journals Interventional study to improve ionized Calcium levels among Postmenopausal Women to prevent Osteoporosis

2020 ◽  
Vol 11 (4) ◽  
pp. 7817-7821
Author(s):  
Anusha G ◽  
Sujatha V ◽  
Shalini R ◽  
Bhaskar Reddy K ◽  
Rajasekhar S
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Postmenopausal Women ◽  
Hormone Secretion ◽  
Age Groups ◽  
Study Groups ◽  
Test Results ◽  
Project Staff ◽  
Increased Risk ◽  
Post Test

This is due in part to vitamin D deficiency (vitamin D is a primary modulator of intestinal calcium and phosphate absorption), which is caused by a lack of sunlight combined with low vitamin D dietary intake and cutaneous synthesis. Secondary hyperparathyroidism is caused by low calcium intake and vitamin D deficiency, which is characterised as a serum 25-hydroxyvitamin D (25 (OH) D concentration below 12 ng/ml and is related to increased bone turnover and, indirectly, an increased risk of fracture. Furthermore, recent findings indicate that vitamin D deficiency is more widespread than previously thought, owing to a revision of the traditional 25 (OH) D threshold level below which parathyroid hormone secretion (PTH) begins to increase. Pre-prepared application forms were distributed among the study population to fill the required details, encouraged to fill the form by own. Those who are uneducated or unable to fill the form are helped by project staff. The value of z is 2.44949, the value of p is 0.01428 and the result is significant at p < 0.05 are obtained for the calcium levels of pre and post-test results of all study groups when compared against BMI. The value of z is 1.36471, the value of p is 0.00321 and the result is significant at p < 0.05 are obtained for the T-values of pre and post-test results of all study groups when compared against BMI. After observing the findings, it is clear that after eating prescribed nutritional food for three months, the ionised Calcium levels, overall Calcium levels, and bone density have increased significantly as compared to before taking nutritional food. As a result, the nutrient food given is a good source of calcium and helps postmenopausal women strengthen their bones. Furthermore, it is recommended that all age groups consume the recommended food kit to minimise the risk of osteoporosis and bone fracture.

High Prevalence of Vitamin D Deficiency among LVAD Patients

2015 ◽  
Vol 63 (S 01) ◽  
Author(s):  
M. von Stumm ◽  
D. Knappe ◽  
M.J. Barten ◽  
A. Bernhardt ◽  
F. Wagner ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
High Prevalence

Analysis of vitamin D deficiency in patients of different age groups

2020 ◽  
pp. 64-70
Author(s):  
Timur Minasov ◽  
Radik Nurlygayanov ◽  
Angela Vershinina ◽  
Yulia Soboleva ◽  
Damir Akhmeldinov ◽  
...  
Keyword(s):  
Vitamin D ◽  
Blood Serum ◽  
Vitamin D Deficiency ◽  
Russian Federation ◽  
Age Groups ◽  
Upper Limit ◽  
The Russian Federation ◽  
Physiological Values

The results of a study of the concentration of vitamin D in blood serum of 3455 residents of Ufa are presented. Physiological values of 25(OH)D were observed in 34.9 % (274) of men and 31.7 % (847) of women, which is 32.4 % (1121) of all examined. Vitamin D deficiency was detected in 67.1 % of the examined. The level of 25(OH)D in the blood serum of residents is on average 75 nmol/L, which is the upper limit of vitamin D deficiency. Vitamin D deficiency is extremely common among residents of this region of the Russian Federation (67.1 %).

scholarly journals Vitamin D and Cardiovascular Disease: An Updated Narrative Review

2021 ◽  
Vol 22 (6) ◽  
pp. 2896
Author(s):  
Armin Zittermann ◽  
Christian Trummer ◽  
Verena Theiler-Schwetz ◽  
Elisabeth Lerchbaum ◽  
Winfried März ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
High Risk ◽  
General Population ◽  
Vitamin D Deficiency ◽  
Specific Gene ◽  
Vitamin D Status ◽  
Cvd Risk ◽  
Severe Vitamin ◽  
Increased Risk

During the last two decades, the potential impact of vitamin D on the risk of cardiovascular disease (CVD) has been rigorously studied. Data regarding the effect of vitamin D on CVD risk are puzzling: observational data indicate an inverse nonlinear association between vitamin D status and CVD events, with the highest CVD risk at severe vitamin D deficiency; however, preclinical data and randomized controlled trials (RCTs) show several beneficial effects of vitamin D on the surrogate parameters of vascular and cardiac function. By contrast, Mendelian randomization studies and large RCTs in the general population and in patients with chronic kidney disease, a high-risk group for CVD events, largely report no significant beneficial effect of vitamin D treatment on CVD events. In patients with rickets and osteomalacia, cardiovascular complications are infrequently reported, except for an increased risk of heart failure. In conclusion, there is no strong evidence for beneficial vitamin D effects on CVD risk, either in the general population or in high-risk groups. Whether some subgroups such as individuals with severe vitamin D deficiency or a combination of low vitamin D status with specific gene variants and/or certain nutrition/lifestyle factors would benefit from vitamin D (metabolite) administration, remains to be studied.

Sign in / Sign up

Export Citation Format

Share Document