Nutritional Assessment and Serum Zinc Level in Children with Acute Lymphoblastic Leukaemia

Background: Acute lymphoblastic leukaemia (ALL) is a common malignancy in children which may cause significant nutritional problem as well as micronutrient deficiency like zinc. These deficiencies ultimately affect the outcome of the patient.Objective: The present study was done to identify the relationship of height, weight and serum zinc with acute lymphocytic leukemia in pediatric patients.Methods: This observational study was carried out in the Department of Pediatric Haematology and Oncology, Dhaka Medical College Hospital, Dhaka over a period of one year from July 2013 to June 2014. All children ranging from 1-10 years with newly diagnosed acute lymphocytic leukaemia were enrolled as case. An equal number of healthy children of similar age and sex were also included as control. The outcome measures were weight for height (wasting) and height for age (stunting) in children 5 or below 5 years of age and BMI in children > 5 years of age. The serum zinc level was also studied as a measure of micronutrient status.Result: Majority (80%) of the cases and 60% of the controls were 5 or < 5 years old. The mean ages of the children of cases and controls were almost similar (4.2 ± 2.3 vs. 4.8 ± 1.8 years, p >0.05). The groups were significantly different in terms of sex with male children being more prone to develop leukaemia than the females (p <0.05). Anaemia was invariably present. Majority (83.3%) of the children in the case group was wasted (weight for height Z-score lie below -2SD) as opposed 22.2% in the control group (p < 0.001). About 37% the children in the case group were stunted (height for age Z-score lies -2SD) as opposed to 16.7% in the control group (p< 0.05). The mean BMI was significantly lower in the case group than that in the control group (8.8 ± 2.7 vs. 17.1 ± 1.8, p < 0.001). Serum zinc level was also significantly lower in the former group than that in the latter group (0.7 ± 0.1 vs. 1.5 ± 0.5 mg/dl, p< 0.05).Conclusion: A good number leukaemia patients present with wasting and stunting and low BMI. Serum zinc level is significantly reduced which, in turn, may hamper various enzymatic functions in the body thereby reducing growth.Bangladesh J Child Health 2016; VOL 40 (1) :12-16

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Study on serum zinc and copper levels in pulmonary tuberculosis patients before starting Directly Observed Treatment, Short-course

Mediscope ◽

10.3329/mediscope.v8i2.55319 ◽

2021 ◽

Vol 8 (2) ◽

pp. 122-127

Author(s):

Prithwy Shankar Biswas ◽

Abu Md Mayeenuddin Al Amin ◽

Syed Didarul Haque

Keyword(s):

Serum Zinc ◽

Zinc Level ◽

Serum Copper ◽

Copper Level ◽

Control Group ◽

Case Group ◽

Serum Zinc Level ◽

Mean Values ◽

Short Course ◽

Directly Observed Treatment

Background: Tuberculosis is a major public health concern throughout the world including Bangladesh. The prevalence of tuberculosis (TB) is increasing day by day. Around one-third of world population is infected with M. tuberculosis. Still pulmonary tuberculosis (PTB) remains one of the important causes of mortality throughout the world with economic burden. Objective: To evaluate levels of the serum zinc and serum copper in smear positive PTB patients before starting Directly Observed Treatment, Short-course (DOTs) therapy. Methods: This was a cross-sectional type of observational study. A total of 100 subjects were included in this study. Among them 50 were smear positive PTB patients denoted as case group and 50 were apparently healthy individuals denoted as control group. Biochemical tests were carried out in the department of biochemistry of Mymensingh Medical College, Mymensingh. All the statistical analyses were performed by using SPSS version 21. Results were evaluated by using Student’s t-test. Results: After careful evaluation there was significant decrease in serum zinc level along with significant increase in serum copper level among the case group when compared with the control group. The mean values of serum zinc level were 93.96±10.04 μg/dl and 72.84±7.73 μg/dl in control and case group respectively. Serum zinc level decreased significantly (p <0.001) in PTB patients. The mean values of serum copper were 111.81±21.26 μg/dl and 125.99±27.93 μg/dl in control and case group respectively. There was significant (p <0.001) rise of serum copper level in PTB patients. Mediscope 2021;8(2): 122-127

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Association of Serum Zinc Level with Febrile Seizures in Children

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i55b33866 ◽

2021 ◽

pp. 200-203

Author(s):

Maryum Naveed ◽

Rimsha Mohsin ◽

Palwasha Khan

Keyword(s):

Febrile Seizure ◽

Serum Zinc ◽

Febrile Convulsion ◽

Febrile Seizures ◽

Cross Sectional Study ◽

Zinc Level ◽

Control Group ◽

Case Group ◽

Serum Zinc Level ◽

Cross Sectional

Introduction: Febrile seizure (FS), previously known as febrile convulsion, is the most common seizure in children. FS usually occurs between six months and five years of age. Aims and objectives: The main objective of the study is to find the association of serum zinc level with febrile seizures in children of Pakistan. Material and methods: This cross sectional study was conducted at Mayo Hospital, Lahore during June 2020 to January 2021. The data was collected from 164 patients of both genders. Results: The data was collected from 164 patients. In the case group, 46 children were male (53.3%), and 36 children (46.7%) were female. In the control group 44 children were male (43.3%) and 38 children were female (56.7%). The age of all participants was between one months and six years. Conclusion: It is concluded that low serum zinc levels are fairly un-sufficient to support the hypothesis that Zinc deficiency could not be a potential risk factor for febrile seizure in children.

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Zinc Serum Maternal Levels as a Risk Factor for Preeclampsia

BioScientia Medicina ◽

10.32539/bsm.v5i4.390 ◽

2021 ◽

Vol 5 (4) ◽

pp. 1110-1118

Author(s):

Abarham Martadiansyah ◽

Peby Maulina ◽

Putri Mirani ◽

Tia Kaprianti ◽

Theodorus

Keyword(s):

Pregnant Women ◽

Dietary Habits ◽

Serum Zinc ◽

Zinc Level ◽

Maternal Serum ◽

Control Group ◽

Case Group ◽

Serum Zinc Level ◽

Zinc Levels ◽

Serum Zinc Levels

Background. Preeclampsia is defined as gestational hypertension and proteinuria which can be measured by the elevation of liver transaminases to twice normal concentration, and the symptoms of increased intracranial pressure such as dizziness, blurred vision, and seizures. Zinc is an essential mineral for many biological functions and one of the trace elements that is directly involved in the oxidative/antioxidant balance, a pathogenesis process in preeclampsia that is highly dependent on dietary habits and supplements. This study was aimed to assess the association between serum zinc level with preeclampsia (PE). Methods: This observational, case-control study was performed on 90 women with singleton pregnancies at 28 to 42 weeks of gestation which were referred to the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital, Palembang, between August 2020 to November 2020. 30 pregnant women with PE were selected as cases and 60 healthy pregnant women were selected as controls. Maternal serum zinc samples were collected. The collected data were entered into the master table. Tabulation, coding, and statistical data analysis were performed using SPSS version 20.0 for Windows. Results: The mean serum zinc levels in the case group and control group were 43,90 ± 15,79 µg/dL (ranged from 15 to 86 µg/dL) and 48,77 ± 10,54 µg/dL (ranged from 22 to 83 µg/dL), respectively. A value of serum zinc levels with the best sensitivity and specificity was 45,5 µg/dL. Conclusion: There was a significant association between maternal serum zinc level with PE. The risk of PE was 3,2 times higher in pregnant women with serum zinc levels of ≤45,5 mcg/dL compared to pregnant women with serum zinc levels of >45,5 mcg/dL. In this case it is necessary to supplement zinc earlier in pregnancy to reduce the risk of preeclampsia.

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Zinc Serum Maternal Levels as a Risk Factor for Preeclampsia

BioScientia Medicina ◽

10.32539/bsm.v5i7.390 ◽

2021 ◽

Vol 5 (7) ◽

pp. 693-701

Author(s):

Abarham Martadiansyah ◽

Peby Maulina ◽

Putri Mirani ◽

Tia Kaprianti ◽

Theodorus

Keyword(s):

Pregnant Women ◽

Dietary Habits ◽

Serum Zinc ◽

Zinc Level ◽

Maternal Serum ◽

Control Group ◽

Case Group ◽

Serum Zinc Level ◽

Zinc Levels ◽

Serum Zinc Levels

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Serum zinc levels in children with simple febrile seizures

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20192173 ◽

2019 ◽

Vol 6 (4) ◽

pp. 1480

Author(s):

Malavika P. Santappanawar ◽

Habeeb U. Khan ◽

Jaidev M. Devdas ◽

Sujonitha John ◽

Pavan Hegde

Keyword(s):

Serum Zinc ◽

Febrile Seizures ◽

Zinc Level ◽

Nutritional Deficiencies ◽

Control Group ◽

Serum Zinc Level ◽

Chi Square ◽

The Mean ◽

Zinc Levels ◽

Serum Zinc Levels

Background: Febrile seizures are the most common seizures in childhood and are often associated with nutritional deficiencies. The present study was done to find any correlation of serum zinc levels in children with simple febrile seizures.Methods: This study was a hospital based prospective case control study, involving 60 children (30 cases and 30 controls) aged between 6 months to 60 months. Serum zinc level was measured in all subjects by atomic absorption spectrophotometer. Data was analysed by using frequency, percentage and Pearson’s chi square test..Results: Most cases (80%) had serum zinc levels <90 mcg/dl, in comparison with children in the control group where only 30% had serum zinc levels <90 mcg/dl. The mean serum zinc level was 78.9±14.26 mcg/dl in cases with simple febrile seizures and 96.7±12.12 mcg/dl in the control group.Conclusions: The mean serum zinc level was significantly lower in children with simple febrile seizures in comparison with controls.

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Acute Diarrhea in Exclusively Breast Fed Infants in relation to Zinc Level

10.53350/pjmhs211551431 ◽

2021 ◽

Vol 15 (5) ◽

pp. 1431-1435

Keyword(s):

Zinc Deficiency ◽

Acute Diarrhea ◽

Serum Zinc ◽

Zinc Level ◽

Healthy Control Group ◽

Control Group ◽

Serum Zinc Level ◽

Healthy Control ◽

The Mean ◽

Breast Fed

Background: Zinc deficiency is associated with alteration in gastrointestinal tract structure, function, and impaired immune function. Aim: To analyze the effects of zinc deficiency on the occurrence of acute diarrhea in exclusively breast-fed infants. Methods: In a case-control study, including a total of 72 exclusively breast-fed infants aged ≤ 6 months, 34 of them with acute diarrhea were in the study group and 38 infants as the healthy control group. Demographic characteristics of all infants and their parents were studied. Serum Zinc level was measured for all participants. Results: Zinc level had significant (p-value =0.000) differences between infants with acute diarrhea and the healthy control group. The mean serum zinc value ± SEM in children with acute diarrhea was 63.11 ± 1.7 which was significantly (p = 0.000) different from the mean serum zinc value ± SEM (78.6 ± 1.6) in healthy infants. A cut-off value 60.6μg/dl of total serum zinc level was significantly (p = 0.000) associated with a sensitivity of 100 % with the occurrence of acute diarrhea among exclusively breast-fed infants. Conclusions: Low serum zinc level is associated with the occurrence of acute diarrhea in exclusively breast-fed infants. A cutoff serum zinc value of 60.6 μg/dl has 100% sensitivity with the occurrence of acute diarrhea among breast-fed infants. Keywords: Zinc deficiency, diarrhea, infants, breastfeeding.

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Effects of Iron and Amloki (EmblicaOfficinalis) on Serum Zinc Level in Anaemia with Pregnancy

Bangladesh Medical Journal ◽

10.3329/bmj.v49i1.52587 ◽

2021 ◽

Vol 49 (1) ◽

pp. 33-37

Author(s):

Tahmina Akter ◽

Qazi Shamima Akther ◽

Saima Haque Lisa ◽

Mst Ariza Sultana ◽

Farhana Sultana ◽

...

Keyword(s):

Side Effects ◽

Iron Deficiency Anaemia ◽

Iron Supplementation ◽

Serum Zinc ◽

Zinc Level ◽

Control Group ◽

Serum Zinc Level ◽

Deficiency Anaemia ◽

Medical College ◽

And Control

Pregnancy is associated with several trace elements deficiency in developing countries. Supplementation of iron in iron deficiency anaemia (IDA) has several side effects including alterations of serum zinc level. Traditionally, amloki is used as a well known supplement in pregnancy, which is rich in trace elements.To determine the effects of iron and amloki on serum zinc level in IDA with pregnancy. The study was a non blind, non random sampling interventional type of clinical trial. This study was performed in the Department of Physiology, Dhaka Medical College, Dhaka on 43 pregnant women between 13th to 20th weeks of gestation with IDA from July 2016 to June 2017. They were recruited from Outpatient Department of Obstetrics and Gynaecology of Dhaka Medical College Hospital. Anaemic pregnant women supplemented with oral iron and amloki were considered as study group (A) and control group (B) were with only iron supplementation for 45 days. Serum zinc level was estimated in the laboratory of the Department of Soil, Water and Environment, University of Dhaka, Bangladesh. For statistical analysis, Paired Student’s‘t’ test and Unpaired Student’s‘t’ test were considered using SPSS 22.0 version. Significant decrease (p<0.001) of serum zinc level was observed after intervention of iron in both groups. In this study, there was no significant difference in serum zinc level in between study and control group. It can be concluded that oral iron supplementation causes decrease in serum zinc level in IDA with pregnancy. Amloki shows no significant role in preventing decrease of serum zinc level in this study. Emblicaofficinalis (amloki) is traditionally used to treat iron deficiency anaemia. It can increase haemoglobin concentration and decrease side effects of iron supplementation. Bangladesh Med J. 2020 Jan; 49 (1): 33-37

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Correlation between Serum Zinc Level and Erythrocyte Superoxide Dismutase (SOD) Activity in Non-frail and Frail Geriatric Patients

World Nutrition Journal ◽

10.25220/wnj.v01i1.0008 ◽

2017 ◽

Vol 1 (1) ◽

pp. 34

Author(s):

Rosnah Pinontoan ◽

Savitri Sayogo ◽

Arya Govinda Roosheroe

Keyword(s):

Oxidative Stress ◽

Superoxide Dismutase ◽

Venous Blood ◽

Serum Zinc ◽

Zinc Level ◽

Zn Deficiency ◽

Serum Zinc Level ◽

Physical Measurements ◽

Significant Difference ◽

The Mean

Introduction: Frailty syndrome (FS), as a health problem in elderly, can interfere with the quality of life. Many factors play roles in its occurrence, one of which is oxidative stress. Superoxide dismutase (SOD), in which one of its components is zinc (Zn), is one of the endogenous antioxidants that plays a role in preventing oxidative stress. This study was aimed to know the correlation between serum zinc level (sZn) and erythrocyte SOD (eSOD) activity in non-frail and frail geriatric patients.Methods: This was cross-sectional study with consecutive sampling method conducted in the Geriatric Clinic Cipto Mangunkusumo hospital, from August through September 2014, on 60 patients (30 patients for each group of non-frail and frail). Data were collected from interviews, physical measurements, and venous blood sampling.Results: Among 90% of the subjects had low Zn intake, at the same time, the mean of sZn was 8.41 ± 1.36mol/l and 93.3% of the subjects had experienced Zn deficiency. The mean of eSOD activity was 1526 ± 508U/gHb, and there was no significant difference between the groups. There were no significant correlation between sZn and eSOD activity both in the overall subject (r = -0.04; p = 0.076), as well as the non-frail group (r = -0.099; p=0.604) and frail group (r = 0.01; p = 0.957).Conclusion: Serum zinc level did not have any significant correlation with the eSOD activity, neither on overall or both non-frail and frail groups.

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Comparison of birth weights of neonates of mothers receiving vs. not receiving zinc supplement at pregnancy

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-03598-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Hassan Boskabadi ◽

Gholamali Maamouri ◽

Javad Akhondian ◽

Farah Ashrafzadeh ◽

Abbas Boskabadi ◽

...

Keyword(s):

Birth Weight ◽

Essential Element ◽

Serum Zinc ◽

Zinc Level ◽

Maternal Serum ◽

Control Group ◽

Serum Zinc Level ◽

Zinc Supplement ◽

Neonatal Birth Weight ◽

Zinc Supplements

Abstract Background Zinc is an essential element for normal embryogenesis and embryonic and neonatal development. Therefore, we compared the birth weights of neonates born to mothers who consumed zinc supplement during pregnancy with that of neonates born to mothers who did not. Methods In a cross-sectional study, we divided 200 pregnant mothers into two groups: case group (mothers receiving zinc supplement during pregnancy) and control group (mothers not receiving zinc supplement during pregnancy) Then, the neonate’s cord zinc level and mother’s serum level were measured and neonate’s growth charts (weight, height and head circumference)were completed. Results In this study, both groups of mothers were observed to have zinc deficiency; 35% of the mothers who consumed zinc supplements and 81% of the mothers who did not consume zinc supplements (P < 0.001). Based on the results, maternal serum of zinc (P < 0.001), neonatal birth weight (P = 0.008), maternal age (P < 0.001) and parity (P < 0.01) in zinc-supplemented group were higher. Neonatal birth weight was associated moderately with mother’s zinc serum levels and poorly with neonatal serum zinc levels. Conclusion Zinc consumption during pregnancy increases serum zinc level of mother and neonatal weight. Neonatal weight has a higher correlation to maternal serum zinc level.

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Assessment of Salivary Zink Level and its impact on Periodontal Health among Children and Adolescence with Sickle Cell Anemia

10.21203/rs.3.rs-821539/v1 ◽

2021 ◽

Author(s):

Rogyia Eltayeb Hassan ◽

Lamis AbdelGadir Kaddam

Keyword(s):

Sickle Cell ◽

Sickle Cell Anemia ◽

Serum Zinc ◽

Zinc Level ◽

Control Group ◽

P Value ◽

Periodontal Health ◽

Low Level ◽

The Mean ◽

The Impact

Abstract Background: Sickle cell anemia (SCA) is the most common inherited disorder around the world. It affects red blood cells resulting in severe hemolysis and painful crisis with multi-organ damage. Sickle cell anemia patients showed an impaired antioxidant status due to a reduced antioxidant defense mechanism that depends indirectly on zinc micronutrient. Several studies revealed a low level of serum zinc among sickle patients. However, none of them investigates the impact of SCA on salivary zinc level. This study aims to measure zinc level in saliva and its influence on the periodontal health of Sudanese children with SCA in Khartoum state. Up to our knowledge, this the first study conducted to measure salivary Zink level and its impact on periodontal health among sickle patients Subjects and Methods: Cross-sectional study was conducted among children and adolescents aged 5-18 years old. Sixty individuals were involved, 30 with SCA compared to 30 healthy controls groups. An Atomic Absorption spectrophotometer quantified the salivary level of zinc. Periodontal examinations were assessed in SCA children using the periodontal community index.Results: The mean ages in the sickle cell anemic group were 10.37 ± 4.13 years old, while the mean ages of subjects in the control group were 9.37 ± 3.6 years (P.Value: 0.169). Salivary zinc level was significantly lower among SCA patients (P.Value <0.001) than in the healthy control group. None of the participants were diagnosed with periodontitis. The less salivary zinc level was significantly higher in SCA with standard pocket depth and no clinical attachment loss than patients diagnosed with gingivitis ( P. Value:0.025).Conclusions: Sickle patients have a low level of zinc in saliva, which may contribute to some manifestations of sickle cell disease and may make them more susceptible to periodontal disease in the future. We recommend conducting more research on oral and periodontal health among children affected with SCA to improve their quality of life.

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