scholarly journals A clinico-epidemiological study of psoriasis patients with moderate to severe plaque type in tertiary care centre in South India

2020 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Suganya Sekar ◽  
Samuel J. Daniel
Keyword(s):  
Quality Of Life ◽  
Family History ◽  
Age Of Onset ◽  
Tertiary Care ◽  
Positive Family History ◽  
Severe Psoriasis ◽  
Tertiary Care Centre ◽  
Plaque Type ◽  
The Mean

<p class="abstract"><strong>Background:</strong> Psoriasis is a chronic disorder with the most common manifestation being the plaque-type. Nearly 20% of the plaque type suffer from a disease of moderate to severe intensity with immense effect on the quality of life. Aim was to study the clinical, socio-economic and demographic characteristics of patients with moderate to severe plaque type of psoriasis.</p><p class="abstract"><strong>Methods:</strong> This was an observational study conducted in about fourty patients diagnosed with moderate to severe plaque type of psoriasis based upon the clinical history, morphology of the lesions and assessed using psoriasis area and severity index (PASI), dermatology life quality index (DLQI) scoring and for comorbidities. Data was compiled and analyzed with statistical package for social science (SPSS) Version 20.0.</p><p class="abstract"><strong>Results:</strong> Mean age was 37.43±10.1 years. 22 were males (55%) and 18 were females (45%). The mean duration was 8.93 years and 15% had family history. The mean age of onset was earlier in the females (20.23 years) with a positive family history, as compared to males (25.36 years). About 62.5% had moderate psoriasis and 37.5% had severe psoriasis. At the baseline the PASI score was 31.98±6.08 and DLQI score was 36. About 67.5% had nail changes and 10% had psoriatic arthritis. Almost in half (47.5%) the duration of the disease was 1 to 5 years and scalp (32.5%) the most common initial site of involvement. Various comorbidities were documented, 72% in moderate psoriasis and 73.33% in severe psoriasis with dyslipidemia (67.5%) being commonest.</p><p class="abstract"><strong>Conclusions:</strong> Patients with moderate to severe psoriasis mostly have a low quality of life with multiple significant co-morbidities that increases the risk for morbidity and mortality.  </p>

scholarly journals Clinical profile of diabetes in young adults aged 15 to 30 years

2019 ◽  
Vol 6 (5) ◽  
pp. 1466
Author(s):  
Jimnaz P. A. ◽  
Nishad N. ◽  
Harris P.
Keyword(s):  
Age Of Onset ◽  
Total Cholesterol Level ◽  
Microvascular Complications ◽  
Tertiary Care ◽  
Positive Family History ◽  
Clinical Profile ◽  
Diabetic Patients ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
The Mean

Background: There is a shift in age of onset of diabetes to a younger age in the recent years. There are very few data available on diabetes in the youth. Hence the study has been undertaken. Objective of the study is to describe the clinical profile of young diabetics and to estimate burden of selected end organ complications at the time of study.Methods: A hospital based Cross sectional study was conducted at a tertiary care centre among 75 young diabetic patients (aged 15-30 years). After taking informed consent, detailed history clinical examination, biochemical investigations like FBS and 2 hours PPBS, HbA1c, lipid profile, screening for neuropathy, retinopathy and nephropathy were done.Results: The mean age of the study population was 26.35±3.8 years, majority were males (62.7 %), 77.3% have positive family history. Mean BMI was 24.8±4.6 kg/m2, 45.3% were overweight ,20 % were obese. The mean FBS levels was 216.63±73.46 mg/dl, 2 hr PPBS 261.51±80.0 mg/dl and mean HbA1c 8.66±1.34 %. The total cholesterol level was higher in 46.7%, with mean of 198.4±21.0. Mean triglyceride level was 136.99±38.9. Nephropathy was present in 25.3%, retinopathy in 13.3% and neuropathy in 9.3 % of the patients. 30.6% had at least one of the three complications. SBP was associated with neuropathy(p=0.030), DBP with retinopathy(p=0.029) and neuropathy(p=0.007) and high FBS levels with retinopathy(p<0.001) and neuropathy(p<0.001).Conclusion: Microvascular complications in young diabetes is alarmingly high. Regular screening, early detection, adequate control of FBS and BP may improve quality of life.

RETROSPECTIVE OBSERVATIONAL STUDY ON CLINICAL PROFILE OF CHILDHOOD PSORIASIS IN A TERTIARY CARE CENTRE OF NORTH INDIA.

2021 ◽  
pp. 9-11
Author(s):  
Sunita Arora ◽  
Sandeep Sidhu ◽  
Guneet Gandhi ◽  
Tejinder Kaur
Keyword(s):  
Family History ◽  
Observational Study ◽  
Tertiary Care ◽  
Positive Family History ◽  
North India ◽  
Retrospective Observational Study ◽  
Tertiary Care Centre ◽  
Northern India ◽  
Plaque Type ◽  
And Gender

Background: Psoriasis is a chronic inammatory, immunologically mediated disorder. Psoriasis in children is not rare. METHODS: This retrospective observational study was conducted in psoriasis clinic of dermatology outpatient department of tertiary care institute in Northern India over a period of 3 years from September 2016 to August 2019 wherein collected data of all children of age less than or equal to 14 years with psoriasis was statistically analysed. The ndings like distribution of age and gender, sites of onset, type of psoriasis, family history, exacerbational factors were assessed. RESULTS: Out of total 45 children with psoriasis, 26 were males (57.77%) and 19 were females (42.22%). Most of the cases were seen in the age group of 10-14 years (68.88%). Most common site of onset was lower extremities (28.88%). Most common type of psoriasis was plaque type (77.77%). Koebnerisation was seen in 12 (26.66%) cases. 5 children (11.11%) had positive family history.

scholarly journals Profile of allergic rhinitis patients in a tertiary care centre in Central Kerala

2021 ◽  
Vol 7 (5) ◽  
pp. 842
Author(s):  
Ike Thomas ◽  
Geethu Mathew ◽  
Tina Thomas ◽  
Mahika Anilkumar ◽  
Kalyan George
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Family History ◽  
Tertiary Care ◽  
Effective Control ◽  
Age Group ◽  
Factors Associated ◽  
Duration Of Disease ◽  
The Mean

<p class="abstract"><strong>Background:</strong> Allergic rhinitis (AR) is a major public health problem which has a significant impact on the quality of life. Around 20-30% of the Indian population suffers from AR. The objective was to study the clinical profile and find out the factors associated with severity.</p><p class="abstract"><strong>Methods:</strong> This retrospective record-based study was conducted among 182 patients with AR who visited Department of otorhinolaryngology in a tertiary care hospital in central Kerala. Variables collected included age, gender, family history of allergy, duration of disease and details of symptoms. The visual analogue scale (VAS) was used in identifying the severity of symptoms.</p><p class="abstract"><strong>Results:</strong> The mean age of participants was 39±19 years. Nearly 50% of them had positive family history and 77.5% were found to have severe symptoms. The mean total VAS score was 25±5.1. Sneezing and nasal block were the common symptoms reported. Among the participants who had family history, 77 (87.5%) of them reported severe symptoms (χ<sup>2</sup>=9.81, p=0.002). Almost all participants belonged to higher age group reported high severity (χ<sup>2</sup>=48.130, p&lt;0.0001). More than 80% of the participants who reported a longer duration of disease had severe symptoms (χ<sup>2</sup>=7.28, p=0.007).</p><p class="abstract"><strong>Conclusions:</strong> The study identified a significant proportion of sneezers and blockers among the study population. Older age group, family history and longer duration of disease were the factors associated with severity. Generating community awareness will help in early diagnosis, effective control with improvement in quality of life of these patients.</p>

scholarly journals Dermatoses in the hospital and their impact on quality of life

2021 ◽  
Vol 12 (4) ◽  
pp. 462-463
Author(s):  
Kaoutar Sof ◽  
Soraya Aouali ◽  
Sara Bensalem
Keyword(s):  
Quality Of Life ◽  
Alopecia Areata ◽  
Drug Eruption ◽  
Skin Tumors ◽  
Severe Psoriasis ◽  
Dermatology Department ◽  
Verneuil’S Disease ◽  
The Mean ◽  
The Impact

Sir, Dermatological pathologies may be responsible for the creation of a real handicap, affecting the patient’s self-esteem and their professional and social life. The aim of this study was to assess the impact of diseases on the quality of life of patients hospitalized at the dermatology department. The following was a retrospective study that included patients over eighteen years of age, hospitalized at the dermatology department of Hospital Mohammed VI in Oujda from January 2018 through December 2019. The Arabic version of the validated DLQI was used for all patients [1]. A total of 294 patients were collected, with a mean age of 53.95 years and a male-to-female ratio of 0.85. The most frequent reasons for hospitalization were infectious dermo-hypodermitis (n = 51), autoimmune bullous dermatosis (n = 23), severe drug eruption (n = 20), genodermatosis (n = 17), melanocytic (n = 9) and non-melanocytic skin tumors (n = 17), severe psoriasis (n = 17), cutaneous lymphoma (n = 11), alopecia areata (n = 10), dermatomyositis (n = 8), and Verneuil’s disease (n = 5). The DLQI was impossible to calculate in eleven patients. The mean DLQI in all patients was 10.20, corresponding to a moderate effect on quality of life. The mean DLQI was as follows: Verneuil’s disease at 17.4, severe psoriasis at 16.6, dermatomyositis at 14.42, genodermatosis at 12.37, cutaneous lymphoma at 11.45, severe drug eruption at 11, alopecia areata at 10.5, AIBD at 9.67, skin tumors at 7.76, and infectious dermo-hypodermitis at 7.52. The DLQI was the first index measuring quality of life in dermatology and is still widely used today[2]. The number of publications concerning the impact of dermatological pathologies on quality of life has increased in recent years [3]. Our results showed that the DLQI was higher in patients with Verneuil’s disease, severe psoriasis, and dermatomyositis. These results agree with the data of the literature, many publications have shown that psoriasis seriously impaired the quality of life and was responsible of social anxiety in patients [4]. Verneuil’s disease is also responsible of a significant impairment on quality of life mainly due to the sexual disorders caused by this pathology [5]. Another study on dermatomyositis showed that there is a significant correlation between the severity of skin signs and the quality of life of patients [6]. Dermatological pathologies are distinguished from other pathologies by their displaying character, which is responsible for a significant impact on the patient’s quality of life. The management of dermatology patients requires psychological support in addition to conventional therapy. However, these pathologies are still not recognized as long-term illnesses in Morocco.

scholarly journals Incidence and trends of ophthalmic cancer in Singapore: Data from Singapore Cancer Registry

2021 ◽  
Vol 50 (4) ◽  
pp. 297-305
Author(s):  
Chin Sheng Teoh ◽  
Preethi Jeyabal ◽  
Stephanie M Young ◽  
Vivien SY Lim
Keyword(s):  
Quality Of Life ◽  
Cancer Registry ◽  
Ciliary Body ◽  
Age Of Onset ◽  
Improve Quality ◽  
Limited Data ◽  
Specific Frequency ◽  
The Mean ◽  
Implementing Strategies

Introduction: Limited data are available on the incidence of primary ophthalmic cancers worldwide. We describe the incidence and trends of primary ophthalmic cancers in Singapore. Methods: Data on ophthalmic cancers diagnosed in Singapore from 1996 to 2016 were retrieved from the Singapore Cancer Registry for analysis. All were histologically proven primary ophthalmic cancers. Calculations of incidence and age-specific frequency of ophthalmic malignancy were made. Results: A total of 297 cases were included, with males constituting 59.9%. The race distribution was 78.5% Chinese, 16.5% Malay, 3.7% Indians and 1.3% others. There was an overall increase in ophthalmic malignancies. The mean age of onset was 47.4 years. The most common cancers were retinoblastoma (93.3%) in patients younger than 15 years, and lymphoma (71.3%) in patients aged 15 years and older. There has been an increase in lymphomas from 16.7% in 1968–1995 to 71.3% in 1996–2016 in those aged 15 years and older. The most common types of ophthalmic cancer according to location are lymphoma of the orbit, conjunctiva, cornea and lacrimal gland; retinoblastoma of the retina; and malignant melanoma of the choroid and ciliary body. Conclusion: Our study reported the incidence and trends of ophthalmic cancer in the Singapore population and showed an overall increase in ophthalmic malignancies in Singapore from 1996–2016. A substantial increase in lymphomas over the last 2 decades was noted. The data could aid clinicians, epidemiologists and policymakers in implementing strategies to address trends in ophthalmic cancers and spur aetiological research to improve quality of life in pa tients with such cancers. Keywords: Aetiology; epidemiology; malignancy; orbital cancers

scholarly journals Clinical, epidemiological and autoimmune associations in childhood vitiligo in Qatar

2020 ◽  
Vol 6 (2) ◽  
pp. 151
Author(s):  
Haya Al Mannai ◽  
Mohamed Allam ◽  
Hassan Riad
Keyword(s):  
Family History ◽  
Autoimmune Diseases ◽  
Age Of Onset ◽  
Positive Family History ◽  
Thyroid Peroxidase ◽  
Base Line ◽  
Adult Onset ◽  
Prognostic Features ◽  
History Of ◽  
The Mean

<p class="abstract"><strong>Background:</strong> Childhood vitiligo although clinically similar to adult onset vitiligo but it has distinct clinical, epidemiological and prognostic features compared to adult onset vitiligo.</p><p class="abstract"><strong>Methods:</strong> This is a retrospective study that was carried out on 85 pediatric patients up to age of 18 years old with the diagnosis of vitiligo, where the clinical and epidemiological data  including clinical type of vitiligo, family history of autoimmune diseases like thyroid disorders and diabetes mellitus and laboratory results including anti-thyroid peroxidase antibodies (anti-TPO antibodies), anti-parietal cell antibodies, antinuclear antibodies (ANA), Vitamin D and Vitamin B12 were retrieved from the files of these patients.<strong></strong></p><p class="abstract"><strong>Results:</strong> The mean age of the children affected by vitiligo was 10.4 years, the mean age of onset of vitiligo was 5.4 years, 54 (63.5%) percent were girls and 31 (36.5%) were boys. A positive family history of vitiligo was found in 44.7% of the participants, family history of DM was found in 64.7% of patients and family history of thyroid disease was found in 32.9% of the participants. The prevalence of thyroid autoimmunity was found to be in 22.4% of total participants.</p><p class="abstract"><strong>Conclusions:</strong> Childhood vitiligo has distinct clinical features, more common family history for autoimmune diseases and thyroid autoantibodies rather than overt clinical diseases, which raise the necessity to perform a routine initial immunological and thyroid screening in children with vitiligo and to repeat them at annual bases if there were abnormal values at base line or strong family history.</p>

scholarly journals Comparative study on effect of oral hypoglycemics and insulin treatment on quality of life among diabetic subjects

2017 ◽  
Vol 4 (5) ◽  
pp. 1246
Author(s):  
Harish Kumar S. ◽  
Srinivasa S. V. ◽  
Prabhakar K.
Keyword(s):  
Quality Of Life ◽  
Communicable Disease ◽  
Tertiary Care ◽  
Physical Domain ◽  
Tertiary Care Centre ◽  
Social Domain ◽  
Insulin Group ◽  
Oral Hypoglycemics ◽  
Oral Group

Background: Diabetes is a chronic non-communicable disease with variable presentation and complications. It is well known that over a period of time complications sets in and causes substantial decrease in the patient’s quality of life (QoL). QoL domains plays and important factor in prediction of outcome of diabetic treatment. Hence this study was conducted with the objectives to find the difference in quality of life (QoL) domains in diabetics on oral hypoglycaemic agents and Insulin.Methods: Longitudinal Study was undertaken in tertiary care centre, for duration of 6 months. Type 2 Diabetics on treatment with oral hypoglycemics and Insulin were included in the study. Socio - demographic profile, laboratory investigations were collected using structured and pretested questionnaire. Quality of life was assessed by WHOQOL-BREF. SPSS 22 version, EPI Info and Open EPI software were used for Statistical analysis. Chi-square and Students t-test were the statistical tests.Results: 59 diabetic subjects were included in Oral and insulin group respectively. Mean age of oral hypoglycemics was 59.6±8.7 years and Insulin group was 61.4±8.2 years. Age and gender were matched between two groups. Glycemic profile was significantly higher in Oral group than in Insulin group. Physical domain was significantly higher (better) in oral group than in Insulin group. Psychological and Social domain was significantly higher (better) in Insulin group. Hence QoL is affected by type of hypoglycaemic agent used among diabetics.Conclusions: Quality of life with respect to physical domain was reduced in Insulin group, were as psychological and social domain was reduced in Oral group.

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