scholarly journals Chronobiology of hypertension and its chronotherapeutical management - A review

Author(s):  
S R Daisy P A ◽  
Swathy V Krishna

Hypertension / High blood pressure is a very common disease and is a major risk factor for total organ failure, cardiovascular diseases (CVD) and premature death around worldwide. Prevalence of hypertension varies across regions and country and is dramatically variable in presentation. Sometimes it act as a silent killer i.e. the patients are unaware that they have the condition. According to estimation 46.5% of adults are unaware about their hypertensive condition, 36.9% are diagnosed and treated and the remaining 13.8% with hypertension have it under control. The investigation regarding the chronobiology, chronotherapy and chronopharmacology in treatment of hypertension began a long back ago. Hypertension is a lifestyle disease largely exhibit circadian variation. Also the condition is more evident to surge during early morning hours. Hence this requires chronotherapy. The chronobiology of hypertension along with its treatment in relation to the circadian variation is reviewed in this article.

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Anand N. Shukla ◽  
Tarun Madan ◽  
Bhavesh M. Thakkar ◽  
Meena M. Parmar ◽  
Komal H. Shah

This epidemiological study was designed to evaluate the prevalence of undetected hypertension in an apparently healthy western Indian population having no history of major illness. 3629 individuals of ≥18 years of age were included in the study. Hypertension (HTN) was defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg and prehypertension (PHTN) as SBP ≥ 120–139 mmHg or DBP ≥ 80–89 mmHg, but without HTN. The prevalence of undiagnosed HTN in the total population was 26% and was 11% and 40% in the young (≤40-year) and old (>40-year) populations, respectively. The prevalence of PHTN, 40% in the overall population, was nearly the same in the young (39%) and the old population (42%). The risk factor most strongly associated with PHTN and HTN was obesity, showing the highest odds ratio in the overall (PHTN 2.14; 95% CI 1.20–3.81; HTN 2.72; 95% CI 1.53–4.85), the young (PHTN 2.29; 95% CI 1.25–4.21; HTN 2.92; 95% CI 1.59–5.35), and the old (PHTN 1.13; 95% CI 0.65–1.96; HTN 1.38; 95% CI 0.79–2.4) populations. Hypertension is a major risk factor for cardiovascular diseases which must not be ignored, especially in the western Indian population.


2021 ◽  
Vol p5 (4) ◽  
pp. 2965-2968
Author(s):  
Ruhi Zahir ◽  
Iqbal Khan

Essential hypertension is high blood pressure that doesn't have any known etiopathology. Most of sufferers (85%) are asymptomatic and as per available reports, in more than 95% cases of hypertension under lying cause is not found. It is estimated that 600 million people are affected worldwide. Hypertension is a major risk factor for the development of cardiovascular diseases (CVD). Its impact is greatest on stroke, MI and end stage is renal failure as it’s known as a Silent Killer. Hence there is no direct reference of hypertension in Ayurvedic classics by name as well as by its path physiological views. Many works have been carried out on hypertension to evaluate the perfect diagnosis and mode of treatment on the basis of Different nomenclatures also have been adopted by Ayurveda experts like Raktagata Vata, Raktagata Vyana Vaisamya, Uccha Rakta Chapa, Raktavrita Vata, Siragata Vata etc. Keywords: Essential hypertension, Raktagata Vyana Vaisamya, Uccha Rakta Chapa, Cardiovascular diseases, Silent Killer.


2009 ◽  
Vol 39 (8) ◽  
pp. 322 ◽  
Author(s):  
Dong-Hyeon Lee ◽  
Sang-Hyun Ihm ◽  
Ho-Joong Youn ◽  
Yun-Seok Choi ◽  
Chan-Seok Park ◽  
...  

2020 ◽  
Vol 22 (Supplement_H) ◽  
pp. H96-H99
Author(s):  
Kolawole W Wahab ◽  
Philip M Kolo ◽  
Mahmoud U Sani ◽  
Njide U Okubadejo ◽  
Johnson O Peter ◽  
...  

Abstract Hypertension remains the dominant cardiovascular risk factor worldwide. May Measurement Month (MMM) is an annual global programme of the International Society of Hypertension aimed at screening for undetected hypertension in the general population. We report the outcome of MMM 2018 in Nigeria. An opportunistic screening of adults aged at least 18 years was conducted in the six geopolitical zones of Nigeria in the month of May, 2018. Screening for hypertension was done by trained volunteers with the use of validated digital and mercury sphygmomanometers following the MMM protocol. Hypertension was defined as blood pressure (BP) ≥140/90 mmHg or the use of BP-lowering medication. There were 6398 participants (53.0% female) with a mean (SD) age of 41.7 (15.0) years. Hypertension was present in 36.4% of the participants with 51.1% of the hypertensives aware of their status, 41.8% on medication, of whom 43.1% were controlled. Overall, only 18.0% of all hypertensive participants had their BP under control. The proportion with hypertension is high, and awareness, treatment, and control rates are low. Concerted efforts are needed to improve awareness and treatment of hypertension in Nigeria in order to reduce the high rate of complications associated with uncontrolled BP.


2013 ◽  
Vol 1 (2) ◽  
pp. 14 ◽  
Author(s):  
Cornel V. Igna ◽  
Juhani Julkunen ◽  
Jari Lipsanen ◽  
Hannu Vanhanen

Research results suggesting that facets of negative affectivity, <em>i.e. </em>anxiety, anger-hostility, and depression, relate to incident cardiovascular diseases have been steadily increasing. Evidence for depression has been especially extensive. Elevated blood pressure, a major risk factor of cardiovascular diseases, is one probable mediator in this context. The purpose of this study was to clarify the relationship of specific key elements of depressive disposition, <em>i.e</em>. depressive symptoms, hopelessness and vital exhaustion, with health behavior and blood pressure. Study sample was comprised of 710 middle-aged men. Participants completed self-report questionnaires assessing health behavior, depressive symptoms, vital exhaustion and hopelessness. Statistical analyses involved descriptive analyses, correlations and path analysis. Depressive symptoms and vital exhaustion associated with several unfavorable lifestyles such as smoking, alcohol consumption, and inactivity (standardized solution coefficients: 0.10, 0.14, 0.17, accordingly). However, no significant direct associations with blood pressure could be found for depressive symptoms or vital exhaustion. Hopelessness associated only with unhealthy diet (standardized solution coefficient -0.10) Moreover, for hopelessness, results showed a direct but inverse association with systolic blood pressure (standardized solution coefficient -0.08). Results suggest that the previously reported relations of depression and vital exhaustion with blood pressure could be mediated by unfavorable lifestyles. The relation of hopelessness with adverse health behaviors seems to be less significant. Also, the role of hopelessness as a risk factor of elevated blood pressure is not supported by the results of this study.


2021 ◽  
Vol 71 (3) ◽  
pp. 1103-06
Author(s):  
Subhana Akber Khan

Hypertension is a risk factor that can cause hypertension leading to cardiovascular diseases. A high or persistent blood pressure level of 140/90mmHg is known as hypertension which is divided into further stages. Blood pressure is the pushing force with which the heart pumps blood against the walls of arteries. High blood pressure is a serious medical condition in which the force of blood against wall of an artery is elevated than the normal which is called as hypertension. Recent guidelines of ICD-11 categorizes blood pressure into four levels. In a clinical setting, an average of blood pressure measurements is usually taken by healthcare providers. These categories are labeled as normal blood pressure, elevated blood pressure, stage 1 hypertension and stage 2 hypertension according the blood pressure measurements. Hypertension is associated with cardiovascular diseases which results in significant morbidity and mortality. Hypertension for a long-term or chronic elevation of blood pressure causes organ damage, eventually. It can be divided into primary or essential hypertension which occurs in 95% of cases whereas; secondary hypertension occurs in 5% of the cases. There are several possible and interrelated factors that are involved in development of hypertension. Intake of sodium in diet, insulin resistance, genetics, and obesity are some of the non-modifiable risk factors for hypertension. Whereas; renin-angiotensin-aldosterone system, cardiac output, peripheral resistance are also implicated in hypertension development. It is a wide known considered risk factor not only for cardiovascular diseases but for renal diseases as well. In this review article.....


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