A study to assess the role of C reactive protein as a marker in diagnosing pleural effusion

2021 ◽  
Vol 6 (3) ◽  
pp. 169-172
Author(s):  
Raghurama Sharvegar ◽  
Chandrik Babu S R
Keyword(s):  
Pleural Effusion ◽  
Pleural Fluid ◽  
General Medicine ◽  
Cross Sectional Study ◽  
Respiratory Medicine ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Specificity And Sensitivity

The cause of pleural effusion is due to systemic or localized pathology and based on the etiology involved the pleural effusion is either classified into transudate and exudate supported by Light’s Criteria. Other than the marker used in Lights Criteria C reactive protein is said to be studied to determine its role in classifying exudate and transudate. The present study was done to assess the role of C reactive protein in diagnosing pleural effusion.The cross-sectional study was conducted by the Department of Chest and Respiratory Medicine at Chamarajanagara Institute of Medical Sciences from June 2019 to May 2020. A total of 120 cases of clinically confirmed cases of Pleural Effusion Cases were selected for the purpose of the study among the outpatient and inpatient in the Department of General Medicine and Respiratory Medicine Department. The Mean CRP of 1.05±1.09 was found to be cut off value for differentiating between transudate and exudate Pleural fluid. At the Cut off value of 1.05 CRP it was found to be having a sensitivity of 75.4% and 77.6% of sensitivity. From the present study we could conclude that the CRP Value of 1.05mg/dl was found to be having a good specificity and sensitivity in classifying the pleural fluid into transudate and exudate. Finally we could conclude that CRP can be used as a Biomarker to differentiate between Transudate and Exudate when Lights criteria falls in borderline.

scholarly journals Role of Pleural Fluid C-Reactive Protein in the Aetiological Diagnosis of Exudative Pleural Effusion

2020 ◽  
Author(s):  
Praveen Radhakrishnan ◽  
S Mathanraj
Keyword(s):  
Pleural Effusion ◽  
Pleural Fluid ◽  
Cross Sectional Study ◽  
Direct Access ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Aetiological Diagnosis ◽  
Exudative Pleural Effusion

Introduction: Pleural effusions, the result of the accumulation of fluid in the pleural space, are a major diagnostic problem due to its anatomical nature with no direct access. There is variation in management, depending on the pleural disease. The pleural effusion can either exhibit specific or nonspecific characteristics. Aim: To determine the clinical significance and diagnostic role of pleural fluid C-Reactive Protein (CRP) level in the aetiological diagnosis of exudative pleural effusion. Materials and Methods: This was a cross-sectional study performed during the study period of September 2013 to December 2014. A total of 53 Patients identified with pleural effusion were recruited in the study and pleural fluid was subjected for the measurement of CRP level. Pleural fluid CRP was assessed with CRP-Turbilatex-Quantitative turbidimetric immunoassay method which is based on the principle agglutination reaction. The data was subjected to statistical analysis using Epi info software version 3.4.3. The Receiver Operating Characteristic (ROC) curve was plotted to illustrate the diagnostic ability. The smallest cut-off value was the minimum observed test value minus 1, and the largest cut-off value was the maximum observed test value plus 1. All the other cut-off values were the averages of two consecutive ordered observed test values. Results: Among the 53 patients in the study, 42 had exudative effusions (79.20%) and 11 had transudative effusions (20.80%). The common cause of exudative effusion was tuberculosis 26 (61.90%), followed by 9 malignancy (21.40%) and 7 parapneumonic effusion (16.70%). In our study, the pleural fluid CRP was statistically significant (p<0.001) marker to differentiate exudative effusions with CRP-value <30 suggestive of malignancy, CRP-value 30-50 mg/L suggestive of tuberculosis and CRP-value >70 mg/L suggestive of parapneumonic effusions. Conclusion: Determination of pleural fluid CRP is a useful diagnostic marker for differentiating exudative and transudative effusions. Also, Pleural fluid CRP is a statistically significant marker in differentiating tubercular effusions from nontubercular exudative effusions.

scholarly journals Use of C-reactive protein level in diagnosis of tubercular pleural effusion

2019 ◽  
Vol 8 (1) ◽  
pp. 20-23
Author(s):  
Subash Pant ◽  
Sanjeet Krishna Shrestha ◽  
Lucky Sharma ◽  
Bibechana Shrestha
Keyword(s):  
Pleural Effusion ◽  
Pleural Fluid ◽  
Protein Level ◽  
College Teaching ◽  
C Reactive Protein ◽  
Biochemical Tests ◽  
Cross Sectional ◽  
Female Ratio ◽  
Protein Levels ◽  
Reactive Protein

Background: C-reactive protein in both pleural fluid and serum has been found to be higher in tubercular pleural effusion than in other causes of pleural effusion. Objectives: The main aim of this study was to find out the diagnostic value of C-reactive protein in patients withlymphocytic pleural effusion. Methodology: A cross-sectional study was conducted in 90 patients with pleural effusion who underwent thoracocentesis at Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal. The complete biochemical tests of pleural fluid and serum were performed. The C-reactive protein concentrations of both pleural fluid and serum were then measured from samples from patients with lymphocytic exudative pleural effusion. Results: Ninety patients with exudative lymphocytic pleural effusion were included. Male patients were 56 (62.2%) and female were 34 (37.8%) with the male to female ratio of 1.64. Mean age of the patients was 51±21.54 (Mean ± Standard Deviation). The pleural fluid C-reactive protein levels in tubercular pleural effusion were higher (48.87±24.19 mg/dl) compared to non-tubercular group (38.30±17 mg/dl; p<0.001). Similarly, the serum fluid C-reactive protein levels in tubercular pleural effusion were higher (29.60±13mg/dl) compared to non-tubercular group (18.14±9.2mg/dl; p< 0.001). The sensitivity of pleural fluid C-reactive protein level in diagnosing tubercular pleural effusion was 86%. Conclusion: Simple and inexpensive test like C-reactive protein is useful in the diagnostic workup of lymphocytic pleural effusions. High C-reactive protein levels are very suggestive of tubercular pleural effusion.

scholarly journals The role of education in the association between self-rated health and levels of C-reactive protein: a cross-sectional study in rural areas of China

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e027659 ◽  
Author(s):  
Raoping Tu ◽  
Kuan-Yu Pan ◽  
Guoxi Cai ◽  
Taro Yamamoto ◽  
Hui-Xin Wang
Keyword(s):  
Rural Areas ◽  
Protein A ◽  
Cross Sectional Study ◽  
Linear Regression Models ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Self Rated Health

ObjectivesThis study aims to examine the association between self-rated health (SRH) and levels of C-reactive protein (CRP) among adults aged 45 to 101 years old in rural areas of China, and to explore the role of education in the association.DesignCross-sectional study.SettingThe study population was derived from two databases in China: Nanping project (NP) and the China Health and Retirement Longitudinal Study (CHARLS).ParticipantsThere were 646 participants from a rural area of Nanping (NP) and 8555 rural participants from a national representative sample of China (CHARLS).MethodsCRP was measured using a high sensitivity sandwich enzyme immunoassay in the NP and immunoturbidimetric assay in the CHARLS. SRH was assessed by SRH questionnaires and categorised into good and poor. Education was measured by the maximum years of schooling and dichotomised into illiterate and literate. Multivariate linear regression models were used to study the associations.ResultsCompared to people with good SRH, those with poor SRH had higher levels of CRP in NP (β=0.16, 95% CI −0.02 to 0.34) and in CHARLS (β=0.07, 95% CI 0.02 to 0.11) after adjusting for potential confounders. Similar findings were observed in the pooled population (β=0.08, 95% CI 0.03 to 0.12), especially in men (β=0.13, 95% CI 0.06 to 0.20) and in literate people (β=0.12, 95% CI 0.06 to 0.18).ConclusionPoor SRH may be a predicator of elevated levels of CRP among middle-aged and older people in rural areas, especially in men and literate people.

scholarly journals Role of biomarkers in predicting prognosis of Coronavirus disease 2019 (COVID-19): A retrospective cross-sectional study: Perspective of a tertiary care hospital in India

2021 ◽  
Vol 11 (1) ◽  
pp. 081-090
Author(s):  
Arushi Mohan ◽  
Padmini SN ◽  
Brunda MS ◽  
Abhinaya Shekhar ◽  
Paul Matthew ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Oxygen Requirement ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
D Dimer

Background: COVID-19 is a novel disease triggered by the SARS-CoV-2 virus, a beta coronavirus similar to MERS-CoV and SARS CoV. Inflammatory markers have a vital role in the pathogenesis of nCOVID 19; understanding the importance of these inflammatory markers in determining disease status is essential given the impact of the disease on healthcare. Thus, being able to triage cases with minimal tests is momentous to capture, which we have investigated as per our study guidelines of the role of inflammatory markers such as D-dimer, CRP (C - reactive protein), Ferritin, LDH (Lactate Dehydrogenase) in patients with COVID 19. In addition, limited data is available comparing the utility of these inflammatory markers to predict the following parameters as the need for ICU, oxygen support requirement, and duration of in-hospital stay, which can help guide the management protocol. Aim: This study aims to determine markers associated with poor prognosis in patients with Coronavirus disease 2019 (COVID-19). Objectives: 1) To assess the inflammatory markers that are routinely investigated in COVID- 19 patients. 2) To determine the most probable factor to estimate severity in COVID- 19 and thus predict prognosis. Methods: This is a retrospective cross-sectional observational study of patients who tested SARS COV 2 positive by RT PCR. The laboratory inflammatory markers, namely Lactate Dehydrogenase, C reactive protein, D-dimer, Ferritin, were assessed in the selected patients, and their clinical data and demographic details were taken into account. The parameters considered for contributing to the severity included the number of days of stay in the hospital, oxygen requirement, and ICU needs. Analyses relied upon analysis of variance for cross-sectional study design and a P< 0.05 statistical significance criterion. Results: There was a statistically significant difference found between oxygen requirement and D dimer (p<0.001), LDH (p= 0.002), and CRP (p= 0.024). There was a statistically significant difference found between admission to ICU and D Dimer (p= 0.001). Conclusion: A statistically significant association between the increasing D-dimer levels and all the outcome measures considered was found. The D-dimer, LDH, and CRP help predict oxygen requirement, and all the inflammatory markers can predict the number of days of stay in the hospital.

scholarly journals Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross–sectional study from South India

2009 ◽  
Vol 2 (1) ◽  
pp. 2 ◽  
Author(s):  
Ghanshyam Shantha ◽  
Anita A Kumar ◽  
Vijay Jeyachandran ◽  
Deepan Rajamanickam ◽  
K Rajkumar ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
South India ◽  
Protein A ◽  
Cross Sectional Study ◽  
Primary Hypothyroidism ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein

scholarly journals Role of C Reactive Protein in Acute Appendicitis: A Cross-Sectional Study

2020 ◽  
Vol 12 (20) ◽  
pp. 66-69
Author(s):  
Lamture Yeshwant Ramrao ◽  
Varsha Gajbhiye ◽  
Vikram Panjabrao Vaidya ◽  
Md. Jawed Akther ◽  
Mangesh Padmawar
Keyword(s):  
Acute Appendicitis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein

scholarly journals THE IMPACT OF COMBINATION OF BREASTFEEDING AND EFFLEURAGE MASSAGE IN REDUCING PAIN RESPONSE IN INFANTS INDUCED BY BLOOD SAMPLING IN C-REACTIVE PROTEIN TEST: AN OBSERVATIONAL CROSS-SECTIONAL STUDY

2018 ◽  
Vol 4 (2) ◽  
pp. 242-248
Author(s):  
Alfi Maziyah ◽  
Diyah Fatmasari ◽  
Desak Made Wenten Parwati ◽  
Rr. Sri Endang Pujiastuti
Keyword(s):  
Intervention Group ◽  
Cross Sectional Study ◽  
Blood Sampling ◽  
Control Group ◽  
Pain Response ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Massage Group

Background: C-reactive protein test is one of clinical assessments to minimize risks of infection in infants. However, its procedure may cause pain. Pain in the infant may result in negative metabolic behavior, physiology and metabolic response. Objective: This study was to describe the infant's pain response by administering a combination of breastfeeding and an effleurage massage on the blood sampling procedure of C-reactive protein examination.         Methods: This was a descriptive observational cross-sectional study. There were 30 infants selected using consecutive sampling technique, which 15 samples assigned in an intervention group (combination of breastfeeding and effleurage massage) and a control group. Premature Infant Pain Profile (PIPP) instrument was used to measure pain. Univariate analysis was performed with the aim to describe data in mean and median.Results: The average of pain response at 1-minute observation in the combination of breastfeeding and effleurage massage group was 7.47 ± 1.356, and the average of pain response in the control group was 10.80 ± 1.897. The average pain at 5-minutes in the intervention group was 3.53 ± 1.922 and control group was 6.00 ± 1.852. Conclusions: Pain responses in the combination of breastfeeding and effleurage massage group were lower than the pain response in the control group.

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