scholarly journals Role of biomarkers in predicting prognosis of Coronavirus disease 2019 (COVID-19): A retrospective cross-sectional study: Perspective of a tertiary care hospital in India

2021 ◽  
Vol 11 (1) ◽  
pp. 081-090
Author(s):  
Arushi Mohan ◽  
Padmini SN ◽  
Brunda MS ◽  
Abhinaya Shekhar ◽  
Paul Matthew ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Oxygen Requirement ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
D Dimer

Background: COVID-19 is a novel disease triggered by the SARS-CoV-2 virus, a beta coronavirus similar to MERS-CoV and SARS CoV. Inflammatory markers have a vital role in the pathogenesis of nCOVID 19; understanding the importance of these inflammatory markers in determining disease status is essential given the impact of the disease on healthcare. Thus, being able to triage cases with minimal tests is momentous to capture, which we have investigated as per our study guidelines of the role of inflammatory markers such as D-dimer, CRP (C - reactive protein), Ferritin, LDH (Lactate Dehydrogenase) in patients with COVID 19. In addition, limited data is available comparing the utility of these inflammatory markers to predict the following parameters as the need for ICU, oxygen support requirement, and duration of in-hospital stay, which can help guide the management protocol. Aim: This study aims to determine markers associated with poor prognosis in patients with Coronavirus disease 2019 (COVID-19). Objectives: 1) To assess the inflammatory markers that are routinely investigated in COVID- 19 patients. 2) To determine the most probable factor to estimate severity in COVID- 19 and thus predict prognosis. Methods: This is a retrospective cross-sectional observational study of patients who tested SARS COV 2 positive by RT PCR. The laboratory inflammatory markers, namely Lactate Dehydrogenase, C reactive protein, D-dimer, Ferritin, were assessed in the selected patients, and their clinical data and demographic details were taken into account. The parameters considered for contributing to the severity included the number of days of stay in the hospital, oxygen requirement, and ICU needs. Analyses relied upon analysis of variance for cross-sectional study design and a P< 0.05 statistical significance criterion. Results: There was a statistically significant difference found between oxygen requirement and D dimer (p<0.001), LDH (p= 0.002), and CRP (p= 0.024). There was a statistically significant difference found between admission to ICU and D Dimer (p= 0.001). Conclusion: A statistically significant association between the increasing D-dimer levels and all the outcome measures considered was found. The D-dimer, LDH, and CRP help predict oxygen requirement, and all the inflammatory markers can predict the number of days of stay in the hospital.

scholarly journals The role of education in the association between self-rated health and levels of C-reactive protein: a cross-sectional study in rural areas of China

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e027659 ◽  
Author(s):  
Raoping Tu ◽  
Kuan-Yu Pan ◽  
Guoxi Cai ◽  
Taro Yamamoto ◽  
Hui-Xin Wang
Keyword(s):  
Rural Areas ◽  
Protein A ◽  
Cross Sectional Study ◽  
Linear Regression Models ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Self Rated Health

ObjectivesThis study aims to examine the association between self-rated health (SRH) and levels of C-reactive protein (CRP) among adults aged 45 to 101 years old in rural areas of China, and to explore the role of education in the association.DesignCross-sectional study.SettingThe study population was derived from two databases in China: Nanping project (NP) and the China Health and Retirement Longitudinal Study (CHARLS).ParticipantsThere were 646 participants from a rural area of Nanping (NP) and 8555 rural participants from a national representative sample of China (CHARLS).MethodsCRP was measured using a high sensitivity sandwich enzyme immunoassay in the NP and immunoturbidimetric assay in the CHARLS. SRH was assessed by SRH questionnaires and categorised into good and poor. Education was measured by the maximum years of schooling and dichotomised into illiterate and literate. Multivariate linear regression models were used to study the associations.ResultsCompared to people with good SRH, those with poor SRH had higher levels of CRP in NP (β=0.16, 95% CI −0.02 to 0.34) and in CHARLS (β=0.07, 95% CI 0.02 to 0.11) after adjusting for potential confounders. Similar findings were observed in the pooled population (β=0.08, 95% CI 0.03 to 0.12), especially in men (β=0.13, 95% CI 0.06 to 0.20) and in literate people (β=0.12, 95% CI 0.06 to 0.18).ConclusionPoor SRH may be a predicator of elevated levels of CRP among middle-aged and older people in rural areas, especially in men and literate people.

scholarly journals Leukocyte count and C reactive protein as diagnostic factors in febrile convulsion

2017 ◽  
Vol 8 (2) ◽  
pp. 56-58
Author(s):  
Garima Biyani ◽  
Swapan Kumar Ray ◽  
Kripasindhu Chatterjee ◽  
Sukanta Sen ◽  
Pradyut Kumar Mandal ◽  
...  
Keyword(s):  
Leukocyte Count ◽  
Febrile Convulsion ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Medical Sciences ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
Time Of Admission

Background: Febrile convulsion (FC) is the most common seizure disorder in childhood. White blood cell (WBC) and C reactive protein (CRP) are commonly measured in FC. Add a paragraph on Aims and Objectives of the study.Aims and Objectives: To compare WBC and CRP in febrile children, aged 6 months to five years, with and without FC, in order to determine whether leukocytosis and elevated CRP can be used as diagnostic tool for febrile seizure.Materials and Methods: In this cross sectional study 214 children (112 with FC), aged 6 months to 5 years, admitted to in the first 48 hours of their febrile disease, either with or without seizure, were evaluated over a 12 months period. Age, sex, temperature; WBC, CRP and hemoglobin were recorded in all children. There was a significant increase of WBC (P<0.001) in children with FC so we can deduct that leukocytosis encountered in children with FC can be due to convulsion in itself.Results: When comparing FC and non-FC children, we encountered a significant increase of WBC (P =0.0005) in children with FC, measured at the time of admission to pediatric medicine ward. There was no significant difference regarding CRP between the two groups. In fact, elevated CRP is a result of underlying pathology.Conclusion: In stable patients, if there’s no reason to suspect a bacterial infection or who don’t have any indication of lumbar puncture, there’s no need to assess WBC as an indicator of underlying infection. Any child with febrile seizure with a high CRP value should be evaluated for infection.Asian Journal of Medical Sciences Vol.8(2) 2017 56-58

scholarly journals Evaluation of C-reactive protein and hematological parameters in smokeless tobacco users: A comparative cross-sectional study

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Sikander Munir Memon ◽  
Naresh Kumar ◽  
Aneela Atta Ur Rahman ◽  
Binafsha Manzoor Syed
Keyword(s):  
Smokeless Tobacco ◽  
Hematological Parameters ◽  
White Blood Cells ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Long Term Effects ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference

Objective: To investigate the changes in levels of C-reactive protein (CRP) and hematological parameters among smokeless tobacco (SLT) users. Methods: A comparative cross-sectional study was conducted at the community level in the coastal districts of Sindh province namely Badin, Thatta, and Sujawal from January 2017 to December 2019. The CRP and hematological parameters were evaluated by well-established methods among SLT and non-SLT users. Results: There was a statistically significant difference between SLT users (mean CRP = 0.77) versus non-users (mean CRP = 0.18), p = <0.001. Among hematological parameters, white blood cells (SLT users median = 7.85 versus non-SLT users median = 8.50, p = 0.004), monocytes (SLT users median = 6.00 versus non-SLT users median = 6.00, p = 0.001) and erythrocyte sedimentation rate (SLT users median = 15.00 versus non-SLT users median = 10.00, p = 0.006) showed statistically significant difference. Conclusions: Significantly elevated CRP was observed in SLT users similarly hematological parameters also showed changes. WBCs, monocytes and ESR were significantly deranged among SLT users. Further studies looking into long term effects of these changes would be helpful. doi: https://doi.org/10.12669/pjms.37.4.3841 How to cite this:Memon SM, Kumar N, Atta-Ur-Rahman A, Syed BM. Evaluation of C-reactive protein and hematological parameters in smokeless tobacco users: A comparative cross-sectional study. Pak J Med Sci. 2021;37(4):---------.    doi: https://doi.org/10.12669/pjms.37.4.3841 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Study of serum traditional and nontraditional biomarkers in Rheumatoid arthritis patients

2020 ◽  
Vol 11 (4) ◽  
pp. 7585-7592
Author(s):  
Vinod A N ◽  
Leena Chand ◽  
Preeti R Y ◽  
Harshitha S ◽  
Prahaladh R
Keyword(s):  
Rheumatoid Arthritis ◽  
Inflammatory Markers ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference

The study of biomarkers in Rheumatoid arthritis (RA) is highly indispensable to understand mechanisms of pathogenesis, diagnosis, prognosis, and treatment of disease. The role of traditional biomarkers like Anti-CCP, RF, and inflammatory markers like ESR and CRP is well established. In this study, we aimed to measure nontraditional biomarkers like Hyaluronic acid (HA), Cartilage oligomeric matrix protein (COMP), and Osteocalcin in the serum of RA patients and also to establish an association with traditional markers. It was a cross-sectional study involving 152 RA patients based on the 1987 ACR criteria for the diagnosis of RA and 68 age‑ and sex-matched healthy controls. After the clinical examination, traditional markers were assessed to measure the disease activity along with non traditional markers in RA patients. All the values were expressed as median (25th–75th percentile). In our study, there was a significant increase in serum HA levels in RA patients compared to healthy controls (p  < 0.03), whereas no significant difference in serum COMP and osteocalcin levels. The traditional inflammatory markers were significantly increased in RA patients than controls with (p  < 0.001). The serum HA levels were significantly correlated with traditional markers in RA patients. Conclusion: Significant increase in serum HA level in RA patients indicating synovial inflammation, but there were no notable changes in COMP and osteocalcin level in serum presuming the combination of these markers may be useful along with traditional markers in the different stages of RA.

scholarly journals Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross–sectional study from South India

2009 ◽  
Vol 2 (1) ◽  
pp. 2 ◽  
Author(s):  
Ghanshyam Shantha ◽  
Anita A Kumar ◽  
Vijay Jeyachandran ◽  
Deepan Rajamanickam ◽  
K Rajkumar ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
South India ◽  
Protein A ◽  
Cross Sectional Study ◽  
Primary Hypothyroidism ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein

scholarly journals Role of C Reactive Protein in Acute Appendicitis: A Cross-Sectional Study

2020 ◽  
Vol 12 (20) ◽  
pp. 66-69
Author(s):  
Lamture Yeshwant Ramrao ◽  
Varsha Gajbhiye ◽  
Vikram Panjabrao Vaidya ◽  
Md. Jawed Akther ◽  
Mangesh Padmawar
Keyword(s):  
Acute Appendicitis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein

scholarly journals Association between severity of COVID-19 and clinical and biochemical characteristics: a cross-sectional study

2020 ◽  
Author(s):  
Dan Wang ◽  
Rui-Fang Li ◽  
Juan Wang ◽  
Qun-Qun Jiang ◽  
Chang Gao ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Serum Potassium ◽  
Serum Amyloid A ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Amyloid A ◽  
D Dimer

Abstract Background: Coronavirus Disease 2019 (COVID-19) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan and has quickly spread across the world. The mortality rate in critically ill patients with COVID-19 is high. This study analyzed clinical and biochemical parameters between mild and severe patients, helping to identify severe or critical patients early.Methods: In this single center, cross-sectional study, 143 patients were included and divided to mild/moderate and sever/critical groups. Correlation between the disease criticality and clinical features and peripheral blood biochemical markers was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve.Results： Significantly, disease severity was associated with age (r = 0.458, P < 0.001) , comorbidities (r = 0.445, P < 0.001) , white cell counts (r = 0.229, P = 0.006) , neutrophil count (r = 0.238, P = 0.004) , lymphocyte count (r = -0.295, P < 0.001) , albumin (r = -0.603, P < 0.001) , high-density lipoprotein cholesterol (r= -0.362, P < 0.001) , serum potassium (r = -0.237, P = 0.004) , plasma glucose (r = 0.383, P < 0.001) , total bilirubin (r = 0.340, P < 0.001) , serum amyloid A (r = 0.58, P < 0.001) , procalcitonin (r = 0.345, P < 0.001) , C-reactive protein ( r = 0.477, P < 0.001) , lactate dehydrogenase (r = 0.548, P < 0.001) , aspartate aminotransferase (r = 0.342, P < 0.001) , alanine aminotransferase (r = 0.264, P = 0.001) , erythrocyte sedimentation rate (r = 0.284, P = 0.001) and D-dimer (r = 0.477, P ＜ 0.001) .Conclusion: With following parameters such as age > 52 years, C-reactive protein > 64.79 mg/L, lactate dehydrogenase > 245 U/L, D-dimer > 0.96 ug/mL, serum amyloid A > 100.02 mg/L, or albumin ＜ 36 g/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Lymphocyte count, serum potassium and procalcitonin may also be a prognostic indicator.

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