scholarly journals Platelet analogues in periodontal regeneration: A narrative review

Author(s):  
Vinayaka Ambujakshi Manjunatha ◽  
Ankitha Anil Jadhav ◽  
Chaitanya Sree Chalichamala ◽  
Annavarapu Sahithi ◽  
Harsha Madakaripura Dasegowda

Platelet analogues (PA; platelet rich plasma and platelet rich fibrin) are autologous bioactive compounds that have a wide range of medical and dental applications, including periodontal, maxillofacial, Plastic surgery and sports medicine. The aim of these technologies is to collect all the constituents of a patient's blood sample so that they can be used to promote tissue regeneration and improve healing. Since 1954, PA has come a long way. Periodontology and implant dentistry have both benefited from the use of PAs. However, the non-standard preparation technique, processing time, transfer of concentrates, centrifugation temperature, vibration, etc. are all variables that contribute to the various results described in the literature. This study will retrace the evolution of PAs, their preparation procedures, their clinical and technological characteristics and their uses.

Author(s):  
Rodrigo Resende

Resumo            Nos últimos anos em todo o mundo, diversas pesquisas científicas realizadas nas áreas de Medicina e Odontologia tem tido como seu tema central à engenharia tecidual envolvendo biomateriais. Essas pesquisas estão sendo realizadas para que possa responder algumas lacunas encontradas no tratamento de lesões relacionados a tecidos moles e duros para uma correta e completa reabilitação dos pacientes. Com isso, os biomateriais enriquecidos com plaquetas ganharam uma maior evidência por estarem proporcionado ótimos resultados no dia a dia da clínica odontológica, em especial na área de implatodontia oral, onde há uma grande necessidade de reabilitar pacientes que sofreram perdas desses tecidos e que se torna imprescindível sua recuperação para um correto posicionamento dos implantes osseointegráveis. A Fibrina Rica em Plaquetas (PRF) é um concentrado, obtido de sangue centrifugado do próprio paciente sem qualquer aditivo, que pode ser considerado um biomaterial de cicatrização autólogo que possui incorporado a ele leucócitos, plaquetas e uma vasta gama de proteínas-chave em uma uma matriz densa de fibrina. As aplicações clínicas deste biomaterial na clínca de implantodontia oral são no prenchimento de alvéolos pós-extração para hemostasia ou associado a enxertos ósseos, levantamento de seio-maxilar ficando em contato direto com a membrana de Schneider, no recobrimento de enxertos instalados sobre alvéolos para que se evite exposição ou traumas externos, dentre outros que auxiliam o dia a dia dos profissionais que trabalham nesta área. Isso com um baixo custo e uma alta taxa de sucesso. O objetivo deste trabalho é realizar uma revisão da literatura demostrando as vantagens e indicações do uso deste biomaterial como auxilio no tratamento de pacientes na clínica de implantodontia oral.Palavras-chave: Fibrina rica em plaquetas; Implantodontia; Biomaterial.Abstract In recent years around the world, several scientific researches carried out in the areas of Medicine and Dentistry have had as their central theme the tissue engineering involving biomaterials. These researches are being conducted to answer some gaps found in the treatment of soft and hard tissue-related injuries for correct and complete rehabilitation of patients. With this, platelet-enriched biomaterials have gained greater evidence because they provide excellent results in daily dental practice, especially in the area of oral implants, where there is a great need to rehabilitate patients who have suffered loss of these tissues. their recovery is essential for the correct positioning of osseointegrated implants. Platelet Rich Fibrin (PRF) is a concentrate obtained from the patient's own centrifuged blood without any additive that can be considered an autologous healing biomaterial that incorporates leukocytes, platelets and a wide range of key proteins into it. a dense matrix of fibrin. The clinical applications of this biomaterial in the oral implant dentistry clinic are in the filling of post-extraction alveoli for hemostasis or associated with bone grafts, sinus-maxillary lift being in direct contact with the Schneider membrane, in the covering of grafts installed over the alveoli so that Avoid exposure or external trauma, among others that help the daily lives of professionals working in this area. This with a low cost and a high success rate. The aim of this paper is to perform a literature review demonstrating the advantages and indications of the use of this biomaterial as an aid in the treatment of patients in the oral implant dentistry clinic. Key-words: Platelet-rich fibrin; Implant dentistry; Biomaterial.


2019 ◽  
Vol 36 (2) ◽  
pp. 109-123 ◽  
Author(s):  
Kristina Feigin ◽  
Bonnie Shope

Platelet concentrates, mostly represented by platelet-rich plasma and platelet-rich fibrin, have gained significant interest in various medical and oral disciplines because of their potential to stimulate and boost regeneration of hard and soft tissues. Prepared from the patient’s own blood, they have been tested and used in various different surgical fields including oral and maxillofacial surgery. The effects of these biomaterials are described to be a result of the large concentration of platelets which contain a wide range of growth factors. The aim of this article is to introduce the principle and function of these platelet concentrates, to review their preparation, and to provide a comprehensive examination of the published oral and maxillofacial literature on this subject.


2018 ◽  
Vol 4 (3) ◽  
pp. 1196-1202
Author(s):  
Felipe Cid

Regeneration is defined as the reproduction or reconstruction of a lost part or injury of the body in such a way that the architecture and function of the lost or injured tissue are completely restored. The goal of regenerative periodontal therapy is to restore the structure and function of the periodontium. The positive effects of Platelet-rich plasma (PRP) are attributed to the angiogenic, mitogenic and proliferative capacities of growth factors such as platelet-derived growth factor, transforming growth factor and vascular endothelial growth factor. Platelet-rich fibrin (PRF) is a second generation platelet concentrate that allows fibrin membranes enriched with platelets and growth factors to be obtained after starting an anticoagulant-free blood collection without any biomechanical artificial modification. The objective of this review is to know the efficacy of platelet-rich plasma and platelet-rich fibrin in the periodontal regeneration of intrabony defects. The clinical implications for this autologous material are promising. Further long term, larger, multicentred randomized controlled clinical trials are required to determine the effects of PRP and PRF on the regeneration of alveolar bone due to periodontal disease.


Author(s):  
Rodrigo Resende

Resumo            Nos últimos anos em todo o mundo, diversas pesquisas científicas realizadas nas áreas de Medicina e Odontologia tem tido como seu tema central à engenharia tecidual envolvendo biomateriais. Essas pesquisas estão sendo realizadas para que possa responder algumas lacunas encontradas no tratamento de lesões relacionados a tecidos moles e duros para uma correta e completa reabilitação dos pacientes. Com isso, os biomateriais enriquecidos com plaquetas ganharam uma maior evidência por estarem proporcionado ótimos resultados no dia a dia da clínica odontológica, em especial na área de implatodontia oral, onde há uma grande necessidade de reabilitar pacientes que sofreram perdas desses tecidos e que se torna imprescindível sua recuperação para um correto posicionamento dos implantes osseointegráveis. A Fibrina Rica em Plaquetas (PRF) é um concentrado, obtido de sangue centrifugado do próprio paciente sem qualquer aditivo, que pode ser considerado um biomaterial de cicatrização autólogo que possui incorporado a ele leucócitos, plaquetas e uma vasta gama de proteínas-chave em uma uma matriz densa de fibrina. As aplicações clínicas deste biomaterial na clínca de implantodontia oral são no prenchimento de alvéolos pós-extração para hemostasia ou associado a enxertos ósseos, levantamento de seio-maxilar ficando em contato direto com a membrana de Schneider, no recobrimento de enxertos instalados sobre alvéolos para que se evite exposição ou traumas externos, dentre outros que auxiliam o dia a dia dos profissionais que trabalham nesta área. Isso com um baixo custo e uma alta taxa de sucesso. O objetivo deste trabalho é realizar uma revisão da literatura demostrando as vantagens e indicações do uso deste biomaterial como auxilio no tratamento de pacientes na clínica de implantodontia oral.Palavras-chave: Fibrina rica em plaquetas; Implantodontia; Biomaterial.Abstract In recent years around the world, several scientific researches carried out in the areas of Medicine and Dentistry have had as their central theme the tissue engineering involving biomaterials. These researches are being conducted to answer some gaps found in the treatment of soft and hard tissue-related injuries for correct and complete rehabilitation of patients. With this, platelet-enriched biomaterials have gained greater evidence because they provide excellent results in daily dental practice, especially in the area of oral implants, where there is a great need to rehabilitate patients who have suffered loss of these tissues. their recovery is essential for the correct positioning of osseointegrated implants. Platelet Rich Fibrin (PRF) is a concentrate obtained from the patient's own centrifuged blood without any additive that can be considered an autologous healing biomaterial that incorporates leukocytes, platelets and a wide range of key proteins into it. a dense matrix of fibrin. The clinical applications of this biomaterial in the oral implant dentistry clinic are in the filling of post-extraction alveoli for hemostasis or associated with bone grafts, sinus-maxillary lift being in direct contact with the Schneider membrane, in the covering of grafts installed over the alveoli so that Avoid exposure or external trauma, among others that help the daily lives of professionals working in this area. This with a low cost and a high success rate. The aim of this paper is to perform a literature review demonstrating the advantages and indications of the use of this biomaterial as an aid in the treatment of patients in the oral implant dentistry clinic. Key-words: Platelet-rich fibrin; Implant dentistry; Biomaterial.


2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Fernando Suárez-López del Amo ◽  
Alberto Monje ◽  
Miguel Padial-Molina ◽  
ZhiHui Tang ◽  
Hom-Lay Wang

The advancement of molecular mediators or biologic agents has increased tremendously during the last decade in periodontology and dental implantology. Implant site development and reconstruction of the lost periodontium represent main fields in which these molecular mediators have been employed and investigated. Different growth factors trigger different reactions in the tissues of the periodontium at various cellular levels. Proliferation, migration, and differentiation constitute the main target areas of these molecular mediators. It was the purpose of this comprehensive review to describe the origin and rationale, evidence, and the most current understanding of the following biologic agents: Recombinant Human Platelet-Derived Growth Factor-BB (rhPDGF-BB), Enamel Matrix Derivate (EMD), Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF), Recombinant Human Fibroblast Growth Factor-2 (rhFGF-2), Bone Morphogenic Proteins (BMPs, BMP-2 and BMP-7), Teriparatide PTH, and Growth Differential Factor-5 (GDF-5).


2019 ◽  
Vol 11 (6) ◽  
pp. 126 ◽  
Author(s):  
SunilParamel Mohan ◽  
Nallusamy Jaishangar ◽  
Sandha Devy ◽  
Anjhana Narayanan ◽  
Deepthi Cherian ◽  
...  

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