Comparing the Clinical Effects of Amiodarone and Propafenone in the Arrhythmia’s Treatment

Objective: To compare the clinical effects of Amiodarone and Propafenone in the treatment of arrhythmia. Methods: Choose our hospital 100 cases of patients with cardiac arrhythmias. We shall divided into control group (50 cases, Propafenone treatment) and treatment group (50 cases, Amiodarone therapy), to collect the curative effect of two groups of patients, adverse reactions, nausea and vomiting, dizziness, headache, low blood pressure, heart rate slow down) in accordance with the drug treatment and electrocardiogram (ecg) changes before and after the treatment (PR interphase, QT interphase, QRS duration). Results: Control group and the clinical curative effect of treatment group total effectiveness 98%, 86% respectively, the treatment group is significantly higher than the control group. Control group and treatment group the incidence of adverse reactions were 4%, 12%, treatment group was significantly lower than the control group, and two groups of patients duration are improved after treatmentstage PRinterval and QT, QRS.But the treatment group patients with stage PRinterval and QT,such as electrocardiogram QRS duration change was better than control group, which difference hasstatisticalsignificance (P < 0.05). Conclusion: Compared with propafenone, amiodarone in the treatment of arrhythmia patients has better therapeutic effect and higher safety, and improve the clinical symptoms of patients effectively. It is suggested to promote clinical practice.

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Clinical Study of Azithromycin in Treatment of Respiratory Tract Infections in Children

Advanced Emergency Medicine ◽

10.18686/aem.v4i2.2 ◽

2015 ◽

Vol 4 (2) ◽

pp. 4

Author(s):

Fei Qian ◽

Ershang Yang ◽

Haoyuan Zheng

Keyword(s):

Treatment Group ◽

Respiratory Tract ◽

Respiratory Tract Infections ◽

Adverse Reactions ◽

Clinical Symptoms ◽

Control Group ◽

Before And After ◽

Chest X Ray ◽

Grouping Method ◽

Tract Infections

Objective: To observe the clinical efficacy and safety of azithromycin in the treatment of respiratory tract infections in children. Method: This study was select 110 cases of respiratory tract infection in our hospital from April 2013 to December 2014 as the research object. According to the random grouping method, the children were divided into two groups, 55 cases in the control group and 55 cases in the treatment group. On the basis of conventional treatment, the control group was treated with erythromycin 15 to 30 mg/kg per day for 1 week while for the treatment group was treated with Azithromycin 10 mg/kg per day by intravenous drip, and 8 mg/kg per day was administered orally for 4 days. To observe the clinical symptoms, signs, chest X-ray and adverse reactions of two groups before and after treatment. Results: The treatment group cure rate was significantly higher than that of the control group (p < 0.05), cough and fever disappearance time is shorter than that of the control group (p < 0.05), adverse reactions occurred rate of treatment group was lower than that of the control group (p < 0.05). Conclusion: The efficacy of azithromycin in the treatment of respiratory tract infections in children is reliable, less adverse reactions and it is worthy of promotion.

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The Efficacy of Tripterygium Glycosides Combined with LMWH in Treatment of HSPN in Children

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/7223613 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Yan Jin ◽

Yanzheng Wang ◽

Sai Wang ◽

Qiongqiong Zhao ◽

Donghua Zhang ◽

...

Keyword(s):

Clinical Efficacy ◽

Clinical Symptoms ◽

Effective Rate ◽

Control Group ◽

Clinical Effects ◽

Observation Group ◽

Significant Difference ◽

Before And After ◽

Qilu Hospital ◽

Tripterygium Glycosides

Objective. This study aimed to explore the clinical efficacy and relevant mechanism of Tripterygium glycosides combined with low molecular weight heparin calcium (LMWH) in the treatment of Henoch–Schönlein purpura nephritis (HSPN) in children. Methods. 64 cases of children patients with HSPN treated at Qilu Hospital (Qingdao) from January 2015 to May 2020 were selected and randomly divided into the control group and the observation group and 32 cases in each group. Conventional medical treatment was applied in the two groups, besides which the control group was given LMWH while the observation group was given Tripterygium glycosides based on the control group. The clinical efficacy and the indexes of clinical symptoms of the two groups were compared. Immune globulin level, fibrinogen content (FIB), prothrombin time (PT), platelet level (PLT), and activated partial thromboplastin time (APTT) level of the two groups were compared before and after the treatment. Results. The total effective rate in the observation group was significantly higher than that of the control group, and the recurrence rate in the observation group was lower than that in the control group. After treatment, urine red blood cell count and 24 h urine protein were obviously better than those of the control group. There was no statistically significant difference in PT between the two groups of children before and after treatment. The levels of PLT and FIB in the two groups of patients after treatment were significantly lower than before treatment, and the PLT levels in the observation group were lower than those in the control group. Conclusion. The combination of Tripterygium glycosides and LMWH had good clinical effects in the treatment of children with HSPN, and it could improve the clinical symptoms, the mechanism of which might be related to the increase of PT, a decrease of PLT, and the improvement of coagulation function.

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Curative effect of Omeprazole under different treatment courses in treatment of children with PU and HP infection and its influence on inflammatory factors

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.7.3048 ◽

2020 ◽

Vol 36 (7) ◽

Author(s):

Shaohui Zhang ◽

Yuan-da Zhang ◽

Qing-wei Dong ◽

Fang Gu

Keyword(s):

Adverse Reactions ◽

Eradication Rate ◽

Clinical Symptoms ◽

Statistical Significance ◽

Symptom Relief ◽

Inflammatory Factors ◽

Controlled Study ◽

Control Group ◽

Observation Group ◽

Curative Effect

Objective: To compare curative effect and safety of omeprazole under different treatment courses in treatment of children with peptic ulcer (PU, diameter ≤1.0cm) and helicobacter pylori (HP) infection and its influence on inflammatory cytokines. Methods: The study was a randomized controlled study and conducted at Baoding children’s hospital from June 2015 to June 2018. In this study 100 PU children with positive HP were chosen and classified into two groups at random. The 58 cases in the observation group were given omeprazole + amoxicillin + clarithromycin, and the antibiotics were not used two weeks later. Then, omeprazole was used to treat for two weeks. 42 cases in the control group were given omeprazole + amoxicillin + clarithromycin for two weeks. Curative effect, HP eradication rate, clinical symptoms, incidence of adverse reactions, level of serum inflammatory cytokine interleukin-6 (IL-6) and level of tumor necrosis factor-a (TNF-a) in two groups were compared. Results: Total effective rate, HP eradication rate and clinical symptom relief of observation group were better than those of control group, and the differences showed statistical significance (P<0.05). The differences of two groups in the incidence of adverse reactions had no statistical significance (P<0.05). Serum IL-6 level and TNF-a level of observation group were significantly lower than those of control group and before the treatment, and the differences had statistical significance (P<0.05). Conclusion: The application of omeprazole in treatment of PU patients with positive HP for four weeks can significantly improve PU cure rate and HP eradication rate, relieve clinical symptoms and reduce inflammatory response, so it deserves to be promoted clinically. doi: https://doi.org/10.12669/pjms.36.7.3048 How to cite this:Zhang S, Zhang Y, Dong Q, Gu F. Curative effect of Omeprazole under different treatment courses in treatment of children with PU and HP infection and its influence on inflammatory factors. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.3048 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Treatment of Non-erosive Effect of Clinical Study of Gastroesophageal Reflux Disease

Advanced Emergency Medicine ◽

10.18686/aem.v6.89 ◽

2018 ◽

Vol 6 (3) ◽

Author(s):

Qian Liu

Keyword(s):

Treatment Group ◽

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Reflux Disease ◽

Clinical Symptoms ◽

Effective Rate ◽

Control Group ◽

Significant Difference ◽

Before And After ◽

And Control

Abstract: Objective: To observe the clinical effect of “Chaihu Shugan Powder Zuojin Pill” in the treatment of non-erosive gastroesophageal reflux disease. Methods: Sixty patients with non-erosive gastroesophageal reflux disease were randomly divided into treatment group and control group (30 cases in each group). The patients were treated with “Zaohu Shugan Powder” and “Zangjin Pills” and omeprazole respectively. For 8 weeks, the clinical efficacy and changes in clinical symptoms were observed. Results: The total effective rate was 93.3% in the treatment group and 80.0% in the control group. There was significant difference between the two groups before and after treatment (P <0.05). Conclusion: “Chaihu Shugan Powder Zuojin Pill” can effectively improve the clinical symptoms of non-erosive gastroesophageal reflux disease.

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Clinical Study of Urinary Kallidinogenase in the Treatment of Progressive Cerebral Infarction

Advanced Emergency Medicine ◽

10.18686/aem.v2i1.5 ◽

2013 ◽

Vol 2 ◽

pp. 13

Author(s):

Binghui Fan ◽

Weidong Li

Keyword(s):

Treatment Group ◽

Cerebral Infarction ◽

Adverse Reactions ◽

Total Effective Rate ◽

Neurological Impairment ◽

Effective Rate ◽

Control Group ◽

Before And After ◽

And Control ◽

Better Than

Objective: To evaluate the efficacy and safety of Urinary kallidinogenase in the treatment of progressive cerebral infarction. Method: 104 cases of patients with acute cerebral infarction were randomly divided into treatment group and control group; where control group (52 cases) patients on with only basic medicine, while treatment group (52 cases), besides the basic medicine, patients will on urinary kallidinogenase 0.15 PNAU + 0.9% normal saline 100 mL intravenous injection, 1 times per day, and continuous for 14 days. The degree of neurological impairment (NIHSS) was assessed before and after treatment, and the changes of blood pressure were monitored. The liver, renal function, fibrinogen, platelet, and the adverse reactions were recorded and followed up in three month. Results: After treatment, NIHSS scores of the both groups were decreased (p < 0.05), however, total effective rate for treatment group were better than control group (p < 0.05). Conclusion: Urinary kallidinogenase is safe and effective in the treatment of progressive cerebral infarction.

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Effect of Moxibustion on HIF-1α and VEGF Levels in Patients with Rheumatoid Arthritis

Pain Research and Management ◽

10.1155/2019/4705247 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Yuanyuan Gong ◽

Zeyun Yu ◽

Yingni Wang ◽

Yan Xiong ◽

Yumei Zhou ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Treatment Group ◽

Clinical Symptoms ◽

Conventional Medicine ◽

Hypoxia Inducible Factor ◽

Serum Levels ◽

Serum Markers ◽

Control Group ◽

Analgesic Effects ◽

Before And After

Background. Moxibustion has a therapeutic effect of reducing swelling and relieving pain in patients with rheumatoid arthritis (RA) but its mechanism is uncertain. Objective. To evaluate the effect of moxibustion on serum levels of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in patients with RA and to explore the possible mechanism of moxibustion. Methods. This study involved 46 RA patients who had fulfilled the inclusion criteria and were randomly assigned to a treatment group and a control group in an equal ratio. The control group was treated with methotrexate or leflunomide, while the treatment group received methotrexate or leflunomide and moxibustion at ST 36 (Zusanli), BL 23 (Shenshu), and Ashi points. Patients’ clinical symptoms, RA-associated serum markers, and serum levels of TNF-α, IL-1β, HIF-1α, and VEGF were compared in the two groups before and after intervention. Statistical analysis was performed using SPSS 21.0 statistical software. Results. 37 of 46 RA patients eventually completed the whole treatment course. Compared with the control group, the treatment group significantly improved the clinical symptoms (P<0.05) but with no significant differences in RA-associated serum markers (P>0.05). There were significant differences in TNF-α and IL-1β among the groups after 8 weeks of treatment (P<0.05). HIF-1α and VEGF were decreased in the treatment group after therapy (P<0.05). VEGF was reduced in the control group (P<0.05), while HIF-1α was not significantly improved (P>0.05). The reductions of HIF-1α and VEGF in the treatment group were superior to the control group (P<0.05). Conclusions. Moxibustion enhanced the anti-inflammatory and analgesic effects of conventional medicine and can enhance the effect of conventional medicine, downregulating HIF-1α/VEGF contents to inhibit angiogenesis.

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Efficacy of pyonex in the treatment of functional dyspepsia with mild to moderate depression

Traditional Medicine and Modern Medicine ◽

10.1142/s257590002050007x ◽

2021 ◽

pp. 1-7

Author(s):

Qing Ye ◽

Xiqun Chen ◽

Hui Li ◽

Yuqing Hu ◽

Jie Zhou ◽

...

Keyword(s):

Functional Dyspepsia ◽

Adverse Reactions ◽

Clinical Symptoms ◽

Safety Evaluation ◽

Test Group ◽

Control Group ◽

Moderate Depression ◽

Symptom Scores ◽

Before And After ◽

Better Than

Objective: To observe efficacy of pyonex in the treatment of functional dyspepsia (FD) with mild to moderate depression. Methods: 64 FD patients with mild to moderate depression were randomly divided into control group ([Formula: see text]) and test group ([Formula: see text]). The test group was given mosapride combined with pyonex, acupuncture at Neiguan, Shenmen, Zusanli and Taichong, and the control group was given mosapride combined with sertraline. The course of treatment was 4 weeks in both groups. The changes of LDQ and HAMD scores were compared between the two groups before and after treatment, and the safety and efficacy were evaluated. Results: ① LDQ scores: The total efficacy of the test group was 87.5%, and that of the control group was 81.3% after treatment. The curative effect of the test group was similar to that of the control group ([Formula: see text]). The total LDQ scores and single symptom scores of the test group were significantly better than those of the control group ([Formula: see text]). ② HAMD scores: The both groups were significantly improved as compared with those before treatment ([Formula: see text]). ③ Safety evaluation: There were no obvious adverse reactions in the two groups during the treatment. Conclusions: Pyonex combined with mosapride can be safe and may improve the clinical symptoms of dyspepsia and depression.

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Effects of Modified Wenjing Decoction Combined with Online Publicity and Education on the Treatment of Primary Dysmenorrhea of Cold Coagulation and Blood Stasis

Journal of Healthcare Engineering ◽

10.1155/2022/1899356 ◽

2022 ◽

Vol 2022 ◽

pp. 1-5

Author(s):

Na Li ◽

Jie Li ◽

Pengpeng Gai

Keyword(s):

Treatment Group ◽

Clinical Symptoms ◽

Blood Stasis ◽

Control Group ◽

Primary Dysmenorrhea ◽

Menstrual Cycles ◽

Associated Symptoms ◽

Before And After ◽

And Control ◽

Cold Coagulation

Objective. To explore the effects of modified Wenjing decoction combined with online publicity and education on the treatment of primary dysmenorrhea of cold coagulation and blood stasis. Methods. The materials of 111 patients with primary dysmenorrhea of cold coagulation and blood stasis in the outpatient department (January 2019–June 2021) were collected to conduct the retrospective study. The 111 patients were randomized into treatment group (n = 59) and control group (n = 52). The control group received online publicity and education and conventional treatment, and the treatment group received online publicity and education and modified Wenjing decoction. The patients in the two groups were continuously treated for three menstrual cycles. The treatment effects, the dosage of analgesics, the scores of associated symptoms before and after treatment, and other indexes were compared between the two groups. Results. The differences in the efficacy on abdominal pain were statistically significant between the two groups P < 0.05 . Compared with the control group, the treatment group had lower scores of associated symptoms after treatment p < 0.5 . After the treatment of three menstrual cycles, 54 patients in the treatment group stopped taking ibuprofen, and the average ibuprofen dosage of the other 5 patients was (0.24 ± 0.16)g. The 52 patients in the control group still needed to take ibuprofen, and the mean dosage was (0.51 ± 0.05)g. The differences in the ibuprofen dosage between the two groups had remarkable difference P < 0.001 . Conclusion. Modified Wenjing decoction combined with online publicity and education can obviously improve the clinical symptoms of the patients with primary dysmenorrhea of cold coagulation and blood stasis and reduce the dosage of analgesics. It is worth promoting and applying in practice.

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Comparison of azithromycin and erythromycin in the treatment of mycoplasma pneumonia in children

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.2.1441 ◽

2019 ◽

Vol 36 (2) ◽

Author(s):

Rui Han ◽

Qianqian Yu ◽

Guohui Zhang ◽

Baoqiang Li ◽

Shuzhen Han ◽

...

Keyword(s):

Adverse Reactions ◽

Clinical Symptoms ◽

Control Group ◽

Clinical Effects ◽

Observation Group ◽

Research Subjects ◽

Creative Commons ◽

Significant Difference ◽

Mycoplasma Pneumonia ◽

The Difference

Objective: To study and compare the clinical effects of azithromycin and erythromycin on children with mycoplasma pneumonia. Methods: Total 132 children with mycoplasma pneumonia who were admitted to our hospital between November 2017 and September 2018 were selected as the research subjects. All the children were divided into an observation group and a control group according to random number table, 66 each. The observation group was treated with azithromycin, while the control group was treated with erythromycin. The therapeutic effect, incidence of adverse reactions and disappearance time of clinical symptoms were compared between the two groups. Results: The total efficacy of the observation group was 98.04%, and that of the control group was 74.51%; there was a significant difference (X2=7.184, P=0.007). The incidence of adverse reactions in the observation group was 15.69%, significantly lower than that in the control group (41.18%) (X2=6.376, P=0.002). The disappearance of fever, cough, rale and X ray shadow of the observation group was significantly earlier than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Compared with erythromycin, azithromycin is more effective in the treatment of mycoplasma pneumonia in children. Azithromycin can further shorten the improvement time of clinical symptoms and signs and has few adverse reactions and high safety. It is worth clinical application. doi: https://doi.org/10.12669/pjms.36.2.1441 How to cite this:Han R, Yu Q, Zhang G, Li B, Han S, Li G. Comparison of azithromycin and erythromycin in the treatment of mycoplasma pneumonia in children. Pak J Med Sci. 2020;36(2):---------. doi: https://doi.org/10.12669/pjms.36.2.1441 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The Effects of Information and Support on Individuals Awaiting Cadaveric Kidney Transplantation

Progress in Transplantation ◽

10.1177/152692480201200308 ◽

2002 ◽

Vol 12 (3) ◽

pp. 201-207 ◽

Cited By ~ 2

Author(s):

Cynthia L. Russell ◽

Kristi Brown

Keyword(s):

Kidney Transplantation ◽

Treatment Group ◽

Nursing Intervention ◽

Control Group ◽

Body Of Knowledge ◽

Phone Calls ◽

Growing Body ◽

Before And After ◽

Cadaveric Kidney ◽

Cadaveric Kidney Transplantation

Context No empirical studies exist to direct nursing interventions for individuals during the long period of waiting for a transplant. Objective To measure the effect of information and support on hope and uncertainty for individuals awaiting cadaveric kidney transplantation. Design Randomized, controlled study. Setting A university-affiliated hospital in the Midwest from 1997 to 1999. Patients Fifty participants awaiting cadaveric kidney transplantation. Interventions The control group received no intervention phone calls or mailings, which was the current standard of care. The treatment group received phone calls and mailings once every month for 6 months. Main Outcome Measures Hope, measured by the Herth Hope Index, and uncertainty, measured by the Mishel's Uncertainty in Illness Scale for Adults, were evaluated at the beginning of the study and 6 months later. Results No statistically significant effect of the nursing intervention was found on hope and uncertainty in this sample (F = 0.5322, P = .81). Hope was found to be negatively related to uncertainty both before ( r = $0.53, P = .0001) and after ( r = $0.59, P = .0001) intervention. No significant change was found between hope before and after intervention, and uncertainty before and after intervention in the treatment group (F = 1.10, P = .40) or the control group. Conclusion The individuals indicated that definite needs were met by the information and support intervention even though the results did not statistically support the effect of the nursing intervention. Conclusions Several conclusions can be drawn from the findings of this study. First, even though the nursing intervention of providing information and support did not have a statistically significant effect on levels of hope and uncertainty in individuals awaiting kidney transplantation, anecdotal reports from the respondents indicated that the phone calls and mailed information were helpful and appreciated. Valuable information, potentially impacting the outcomes of kidney transplantation, was gathered by the researchers and shared with the transplant team. Secondly, levels of hope were relatively high, whereas levels of uncertainty were moderate in this sample of individuals waiting for cadaveric kidney transplantation. Furthermore, in this sample, the average time since diagnosis of ESRD was more than 4 years and the average waiting time was more than 1 year. There may have been a change over time from viewing the waiting experience as a negative experience to a positive opportunity. Thirdly, the finding of a negative relationship between hope and uncertainty provided support to the growing body of knowledge of this association. Finally, time on the waiting list, gender, and marital status were not associated with levels of hope or uncertainty. Generally, the findings of this study are consistent with existing literature and add to the growing body of knowledge related to the midrange theories of hope and uncertainty.

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