Efficacy of pyonex in the treatment of functional dyspepsia with mild to moderate depression

Objective: To observe efficacy of pyonex in the treatment of functional dyspepsia (FD) with mild to moderate depression. Methods: 64 FD patients with mild to moderate depression were randomly divided into control group ([Formula: see text]) and test group ([Formula: see text]). The test group was given mosapride combined with pyonex, acupuncture at Neiguan, Shenmen, Zusanli and Taichong, and the control group was given mosapride combined with sertraline. The course of treatment was 4 weeks in both groups. The changes of LDQ and HAMD scores were compared between the two groups before and after treatment, and the safety and efficacy were evaluated. Results: ① LDQ scores: The total efficacy of the test group was 87.5%, and that of the control group was 81.3% after treatment. The curative effect of the test group was similar to that of the control group ([Formula: see text]). The total LDQ scores and single symptom scores of the test group were significantly better than those of the control group ([Formula: see text]). ② HAMD scores: The both groups were significantly improved as compared with those before treatment ([Formula: see text]). ③ Safety evaluation: There were no obvious adverse reactions in the two groups during the treatment. Conclusions: Pyonex combined with mosapride can be safe and may improve the clinical symptoms of dyspepsia and depression.

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Comparing the Clinical Effects of Amiodarone and Propafenone in the Arrhythmia’s Treatment

Learning & Education ◽

10.18282/l-e.v9i3.1562 ◽

2020 ◽

Vol 9 (3) ◽

pp. 17

Author(s):

Charmarke Ibrahim ◽

Sakarie Hidig ◽

Xiang Ma

Keyword(s):

Treatment Group ◽

Adverse Reactions ◽

Clinical Symptoms ◽

Control Group ◽

Amiodarone Therapy ◽

Clinical Effects ◽

Curative Effect ◽

Before And After ◽

Qrs Duration ◽

Group Control Group

Objective: To compare the clinical effects of Amiodarone and Propafenone in the treatment of arrhythmia. Methods: Choose our hospital 100 cases of patients with cardiac arrhythmias. We shall divided into control group (50 cases, Propafenone treatment) and treatment group (50 cases, Amiodarone therapy), to collect the curative effect of two groups of patients, adverse reactions, nausea and vomiting, dizziness, headache, low blood pressure, heart rate slow down) in accordance with the drug treatment and electrocardiogram (ecg) changes before and after the treatment (PR interphase, QT interphase, QRS duration). Results: Control group and the clinical curative effect of treatment group total effectiveness 98%, 86% respectively, the treatment group is significantly higher than the control group. Control group and treatment group the incidence of adverse reactions were 4%, 12%, treatment group was significantly lower than the control group, and two groups of patients duration are improved after treatmentstage PRinterval and QT, QRS.But the treatment group patients with stage PRinterval and QT,such as electrocardiogram QRS duration change was better than control group, which difference hasstatisticalsignificance (P < 0.05). Conclusion: Compared with propafenone, amiodarone in the treatment of arrhythmia patients has better therapeutic effect and higher safety, and improve the clinical symptoms of patients effectively. It is suggested to promote clinical practice.

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Clinical Study of Azithromycin in Treatment of Respiratory Tract Infections in Children

Advanced Emergency Medicine ◽

10.18686/aem.v4i2.2 ◽

2015 ◽

Vol 4 (2) ◽

pp. 4

Author(s):

Fei Qian ◽

Ershang Yang ◽

Haoyuan Zheng

Keyword(s):

Treatment Group ◽

Respiratory Tract ◽

Respiratory Tract Infections ◽

Adverse Reactions ◽

Clinical Symptoms ◽

Control Group ◽

Before And After ◽

Chest X Ray ◽

Grouping Method ◽

Tract Infections

Objective: To observe the clinical efficacy and safety of azithromycin in the treatment of respiratory tract infections in children. Method: This study was select 110 cases of respiratory tract infection in our hospital from April 2013 to December 2014 as the research object. According to the random grouping method, the children were divided into two groups, 55 cases in the control group and 55 cases in the treatment group. On the basis of conventional treatment, the control group was treated with erythromycin 15 to 30 mg/kg per day for 1 week while for the treatment group was treated with Azithromycin 10 mg/kg per day by intravenous drip, and 8 mg/kg per day was administered orally for 4 days. To observe the clinical symptoms, signs, chest X-ray and adverse reactions of two groups before and after treatment. Results: The treatment group cure rate was significantly higher than that of the control group (p < 0.05), cough and fever disappearance time is shorter than that of the control group (p < 0.05), adverse reactions occurred rate of treatment group was lower than that of the control group (p < 0.05). Conclusion: The efficacy of azithromycin in the treatment of respiratory tract infections in children is reliable, less adverse reactions and it is worthy of promotion.

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Clinical Study of Urinary Kallidinogenase in the Treatment of Progressive Cerebral Infarction

Advanced Emergency Medicine ◽

10.18686/aem.v2i1.5 ◽

2013 ◽

Vol 2 ◽

pp. 13

Author(s):

Binghui Fan ◽

Weidong Li

Keyword(s):

Treatment Group ◽

Cerebral Infarction ◽

Adverse Reactions ◽

Total Effective Rate ◽

Neurological Impairment ◽

Effective Rate ◽

Control Group ◽

Before And After ◽

And Control ◽

Better Than

Objective: To evaluate the efficacy and safety of Urinary kallidinogenase in the treatment of progressive cerebral infarction. Method: 104 cases of patients with acute cerebral infarction were randomly divided into treatment group and control group; where control group (52 cases) patients on with only basic medicine, while treatment group (52 cases), besides the basic medicine, patients will on urinary kallidinogenase 0.15 PNAU + 0.9% normal saline 100 mL intravenous injection, 1 times per day, and continuous for 14 days. The degree of neurological impairment (NIHSS) was assessed before and after treatment, and the changes of blood pressure were monitored. The liver, renal function, fibrinogen, platelet, and the adverse reactions were recorded and followed up in three month. Results: After treatment, NIHSS scores of the both groups were decreased (p < 0.05), however, total effective rate for treatment group were better than control group (p < 0.05). Conclusion: Urinary kallidinogenase is safe and effective in the treatment of progressive cerebral infarction.

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The effectiveness of emotional freedom techniques (EFT) on depression of postmenopausal women: a randomized controlled trial

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2020-0245 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Asieh Mehdipour ◽

Parvin Abedi ◽

Somayeh Ansari ◽

Maryam Dastoorpoor

Keyword(s):

Randomized Controlled Trial ◽

Postmenopausal Women ◽

Controlled Trial ◽

Intervention Group ◽

Control Group ◽

Randomized Controlled ◽

Moderate Depression ◽

Before And After ◽

The Mean ◽

And Control

Abstract Objectives Postmenopausal women are at greater risk of depression. Depression may negatively affect the quality of life of women. An emotional freedom technique (EFT) is an evidence-based therapy combining cognitive and exposure components with acupressure. This study aimed to evaluate the effect of EFT on depression in postmenopausal women. Methods This was a randomized controlled trial in which 88 women with mild to moderate depression recruited from a menopausal clinic in Ahvaz, Iran, and randomly assigned into two groups of EFT (n=44) and control for sham therapy (n=44). Women in the EFT group received two sessions of training and asked to continue EFT for 8 weeks, one time per day. The Beck Depression Inventory (BDI2) completed by women before and after the intervention. The control group received training on sham acupressure points similar to the intervention group. Data collected using a demographic and BDI2. Women requested to complete the BDI2 before and after the intervention. The independent t-test, chi-square, and ANCOVA were used to analyze data. Results The mean depression score in the intervention group reduced from 20.93 ± 4.6 to 10.96 ± 4.38 in comparison to the control group that reduced from 19.18 ± 2.79 to 17.01 ± 6.05 after intervention (p=0.001). After the 8 week intervention, the frequency of moderate depression decreased from 56.8 to 9.35% in the intervention and from 50 to 29.5% in the control group. In total, 63.4 and 34.15% in the intervention and control groups were free of depression respectively after the intervention (p<0.001). Conclusions The results of this study showed that using EFT for 8 weeks could significantly reduce the mean score of depression in postmenopausal women. Using this method in public health centers for postmenopausal women is recommended.

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Effects of Passive Immunization by Anti-Gingipain IgY on the Oral Health of Cats Fed Kibble Diets

Journal of Veterinary Dentistry ◽

10.1177/0898756418814010 ◽

2018 ◽

Vol 35 (4) ◽

pp. 275-280 ◽

Cited By ~ 1

Author(s):

Patrícia Massae Oba ◽

Fernanda Corrêa Devito ◽

João Paulo Fernandes Santos ◽

Rafael Nóbrega Stipp ◽

Márcia de Oliveira Sampaio Gomes ◽

...

Keyword(s):

Oral Health ◽

Adverse Reactions ◽

Passive Immunization ◽

Test Group ◽

Control Group ◽

Promising Alternative ◽

Mixed Breed ◽

Prevalent Disease ◽

Adult Cats ◽

Key Microorganisms

Porphyromonas gulae is one of the key microorganisms in biofilm dysbiosis that leads to periodontal disease, a prevalent disease in cats. Gingipains are proteases secreted that promote the disruption of cell adhesion and the differentiation of osteoclasts. The use of anti-gingipain immunoglobulin Y (IgY-GP) has emerged as a promising alternative to conventional prevention and treatment methods. The aim of this study was to evaluate the efficacy of IgY-GP on different parameters related to oral health in cats. Twenty adult mixed-breed cats were divided into 2 groups of 10 cats fed with 2 extruded diets differing only by coating. The control group received a coating of 4 g/kg of powdered egg and the test group received a coating of 4 g/kg of IgY-GP. The experiment followed a crossover design with 2 periods, each lasting 40 days with a washout period of 30 days. The evaluated parameters were plaque, calculus, gingivitis index, and percentage of Porphyromonas gingivalis of the oral cavity (%PG-OC) at baseline and after 40 days of diet consumption. All cats remained healthy throughout the study and no adverse reactions or side effects were observed. After 40 days of IgY-GP consumption, the plaque index was significantly lower compared to the baseline ( P = .0133). There were no significant changes in calculus index, gingivitis index, and %PG-OC between groups after 40 days ( P > .05). The consumption of IgY-GP reduces plaque accumulation, which may lead to an improvement in the oral health of adult cats.

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Meta-Analysis of Clinical Efficacy and Safety of Ligustrazine in the Treatment of Idiopathic Pulmonary Fibrosis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/2416132 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Xiaozheng Wu ◽

Wen Li ◽

Zhenliang Luo ◽

Yunzhi Chen

Keyword(s):

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Clinical Efficacy ◽

Adverse Reactions ◽

Clinical Symptoms ◽

Gas Analysis ◽

Control Group ◽

Efficacy And Safety ◽

Arterial Blood Gas ◽

Arterial Blood

Objective. To systematically review the efficacy and safety of Ligustrazine in the treatment of idiopathic pulmonary fibrosis (IPF). Methods. The electronic literature databases (PubMed, EMbase, CNKI, WanFang database, and VIP) were retrieved through a computer to find out the randomized controlled trials (RCT) of Ligustrazine in the treatment of IPF according to the inclusion/exclusion criteria screening test. Cochrane’s bias risk table was also used to evaluate the quality of the study and to extract effective data. RevMan 5.3 was used for statistical analysis. Results. A total of 7 RCTs (a total of 366 patients, including 196 in experimental and 170 in control group). Compared with the control group, Ligustrazine could improve the clinical symptoms ([OR] = 2.20, 95% CI [1.40, 3.46], P = 0.0006 ), lung function (VC % [MD] = 3.92, 95% CI [0.68, 7.17], P = 0.02 ), (TLC% [MD] = 4.94, 95% CI [0.37, 9.52], P = 0.03 ), the pulmonary diffusion function (DLCO % [MD] = 9.12, 95% CI [5.70, 12.55], P < 0.00001 ), and arterial blood gas analysis (PaO2 [MD] = 7.11, 95% CI [1.96, 12.25], P = 0.007 ) (PaCO2 [MD] = −2.42, 95% CI [−4.36, −0.49], P = 0.01 ) of IPF patients, respectively. However, FEV1/FVC % ([MD] = 9.37, 95% CI [−1.23, 19.97], P = 0.08 ) and adverse reactions ([MD] = 0.35, 95% CI [0.02, 5.36], P = 0.45 ) were not significantly improved. Conclusion. Ligustrazine has certain clinical efficacy in the treatment of IPF, but the safety of applying it and the adverse reactions need to be further analyzed and determined. It can be considered as a new alternative and complementary medicine to be promoted and recommended for use in medical units in various countries in the world and it solved the difficult problem of conventional drug treatment of IPF; therefore, more research strength can be put in the treatment of the pathological mechanism of IPF for further exploration. The study was registered under registration number CRD42020193626.

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Sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of acute cerebral infarction

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.4.1831 ◽

2020 ◽

Vol 36 (4) ◽

Author(s):

Xuewen Wo ◽

Jinyan Han ◽

Jiajia Wang ◽

Xinmin Wang ◽

Xiaoying Liu ◽

...

Keyword(s):

Plasma Level ◽

Cerebral Infarction ◽

Antiplatelet Therapy ◽

Adverse Reactions ◽

Dual Antiplatelet Therapy ◽

Acute Cerebral Infarction ◽

Control Group ◽

Observation Group ◽

Significant Difference ◽

Better Than

Objective: To observe the clinical efficacy of sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of elderly patients with acute cerebral infarction (ACI). Methods: One hundred and twenty-two elderly patients with ACI who were admitted to the department of neurology of our hospital at May 2016-August 2018 were selected grouped into a control group and an observation group by random number table method, 61 in each group. On the basis of conventional treatment, the patients in the control group were given dual antiplatelet therapy (aspirin enteric-coated tablets + clopidogrel bisulfate tablets), while the patients in the observation group were given sequential butylphthalide therapy on the basis of the control group. The clinical effects of the two groups were compared after four weeks of treatment, and the changes of National Institutes of Health Stroke Scale (NIHSS), ADL score, plasma 3-mercaptopyruvate sulphurtransferase (3-MST) and Amyloid β42 (Aβ42) levels and the occurrence of adverse reactions during treatment were recorded. Results: The clinical efficacy of the observation group was better than that of the control group (P<0.05). There was no significant difference in NIHSS and ADL scores between the two groups before treatment (P>0.05). After treatment, the NIHSS and ADL scores of the observation group were better than those of the control group (P<0.05). There was no significant difference in plasma levels of 3-MST and AB42 between the two groups before treatment (P>0.05). The level of plasma 3-MST in the observation group was higher than that in the control group, and the level of plasma Aβ42 was lower than that in the control group (P<0.05). No serious adverse reactions occurred during the treatment period in both groups. Conclusion: Butylphthalide sequential therapy combined with dual antiplatelet therapy is effective in the treatment of elderly ACI. It can effectively improve the plasma level of 3-MST and decrease the plasma level of Aβ42, which is conducive to improving the living ability and neurological function of patients and has high safety. doi: https://doi.org/10.12669/pjms.36.4.1831 How to cite this:Wo X, Han J, Wang J, Wang X, Liu X, Wang Z. Sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of acute cerebral infarction. Pak J Med Sci. 2020;36(4):---------. doi: https://doi.org/10.12669/pjms.36.4.1831 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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USING MANIPULATIVES TO IMPROVE LEARNING IN THE UNDERGRADUATE NEUROPHYSIOLOGY CURRICULUM

AJP Advances in Physiology Education ◽

10.1152/advan.00042.2002 ◽

2003 ◽

Vol 27 (3) ◽

pp. 109-119 ◽

Cited By ~ 26

Author(s):

Johanna Krontiris-Litowitz

Keyword(s):

Membrane Properties ◽

Control Group ◽

Problem Solving Skills ◽

Student Comprehension ◽

Concrete Objects ◽

Before And After ◽

Experimental Group ◽

Modeling Clay ◽

Passive Membrane Properties ◽

Better Than

Educational research has demonstrated that the use of concrete objects or manipulatives in the classroom enhances problem-solving skills and conceptual learning. This project examines the use of manipulatives in a neurophysiology curriculum and assesses their effectiveness on student comprehension. Three activities, building an ion channel, building a nerve cell, and passive membrane properties, were developed using modeling clay and beads as manipulatives. Their effect on learning was assessed in a neurobiology class that had been divided into an experimental group that worked with manipulative-based activities and a control group that did not. After the experimental group had completed the manipulative activity, both groups were given a quiz. Students who had used manipulatives scored significantly better than those who had not. In a second study, students were given a quiz before and after completing a manipulative activity. Students who had used manipulatives showed the greatest grade improvement. These studies suggest that manipulative activities can be used to enhance learning in the neurophysiology curriculum.

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Efficacy of a herbal toothpaste on patients with established gingivitis: a randomized controlled trial

Brazilian Oral Research ◽

10.1590/s1806-83242006000200015 ◽

2006 ◽

Vol 20 (2) ◽

pp. 172-177 ◽

Cited By ~ 26

Author(s):

Fabiana Ozaki ◽

Claudio Mendes Pannuti ◽

Ana Vitória Imbronito ◽

Wellington Pessotti ◽

Luciana Saraiva ◽

...

Keyword(s):

Adverse Reactions ◽

Controlled Trial ◽

Test Group ◽

Experimental Period ◽

Positive Control ◽

Control Group ◽

Control Groups ◽

Double Blind ◽

Significant Difference ◽

And Control

The aim of this randomised, double blind controlled trial was to verify the efficacy of a herbal dentifrice on the reduction of plaque and gingivitis. Forty eight volunteers with established gingivitis were randomly assigned to either a test group (herbal dentifrice) or positive control group (dentifrice with triclosan and fluoride). The dentifrices were distributed in plain white tubes by an independent pharmacy, which revealed the contents of each tube only after the experimental period. Plaque and gingivitis assessments were carried out on baseline and after 28 days of product use. All examinations were conducted by the same calibrated investigator. Subjects were instructed to brush their teeth three times daily using their assigned dentifrice for 28 days. There was a significant reduction in plaque levels in both the test and control groups. However, there was no significant difference between the groups. A significant reduction in gingivitis was observed in both groups, although there was no significant difference between them. No adverse reactions were reported. The authors concluded that both dentifrices were effective in reducing plaque and gingivitis in subjects with established gingivitis.

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Nurses’ perspectives about communication with patients in an intensive care setting using a communication board: A pilot study

Health SA Gesondheid ◽

10.4102/hsag.v24i0.1162 ◽

2019 ◽

Vol 24 ◽

Author(s):

Martelize Gropp ◽

Ensa Johnson ◽

Juan Bornman ◽

Rajinder Koul

Keyword(s):

Intensive Care ◽

Care Setting ◽

Test Group ◽

Control Group ◽

Intensive Care Setting ◽

Before And After ◽

Post Test ◽

Quasi Experimental ◽

Communication Needs ◽

Communication Board

Background: Communication in the intensive care setting (ICS) is critical for both the patient and the medical staff to provide efficient care and thus alleviate possible patient adverse effects. Persons with complex communication needs are particularly vulnerable in ICSs and therefore require additional communication support.Aim: This study focused on the perspectives of nurses about communication with patients with communication needs in ICSs using paper-based communication boards, namely the translated Vidatak EZ Board, before and after a training session.Setting: A 1650-bed public hospital with a 26-bed ICS in a semi-urban, low socio-economic area in South Africa served as the research setting.Methods: A quasi-experimental pre-test post-test group design with withdrawal and a control group was used. Data were gathered using a custom-designed questionnaire completed by ICS nurse participants recruited from a public hospital.Results: Responses of some nurses did not change in post-test 1, but their responses did change in post-test 2. Some of the nurses’ perspectives changed, as expected from the pre-test to post-test 1. Nurses recommended specific adaptations to the communication board.Conclusions: Most nurses agreed that communication is crucial in ICSs and that a communication board can be implemented; however, limited success was observed implementing the board following a short training. The inter-professional collaboration between nurses and speech-language therapists to provide optimal health care to patients in ICS is emphasised.

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