scholarly journals Effects of Vitamin B12 and E on Lipid Profile of Male Wistar Albino Rats Infected with Trypanosomabrucei Infection

2021 ◽  
Vol 10 (1) ◽  
pp. 23-30
Author(s):  
Adebayo Olugbenga Adegoke ◽  
Ibitoroko Maureen George Opuda ◽  
Ifunaya B. Ekweozoh
Keyword(s):  
Vitamin B12 ◽  
Lipid Profile ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Effect of resveratrol on diabetic neuropathy in wistar albino rats

2019 ◽  
Vol 9 (1) ◽  
pp. 16
Author(s):  
Smita Das ◽  
Jayanti Prava Behera ◽  
Y. Rojaramani ◽  
Rashmi Ranjan Mohanty
Keyword(s):  
Diabetic Neuropathy ◽  
Lipid Profile ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
High Fat Diet ◽  
Albino Rats ◽  
High Fat ◽  
Multiple Comparison Test ◽  
Wistar Albino Rats

Background: Type 2 diabetes mellitus (DM) is a common chronic disease with increasing prevalence worldwide. Prolonged uncontrolled hyperglycemia, dyslipidemia are major risk factor for its complication like neuropathy. Since there is no definite treatment for diabetic neuropathy, this study aims to evaluate the effect of resveratrol on diabetic neuropathy in high fat diet with low dose streptozotocin induced type-2 DM model in wistar albino rats.Methods: First type 2 diabetic rat model was established. Wistar albino rats, fed with high-fat diet (HFD) rendered diabetic with streptozotocin, were divided into 6 groups, disease control (DC) treated with vehicle, standard control (SC) which received metformin, test groups treated with 5, 10, and 20 mg/kg b.w. of resveratrol and combination of half dose of metformin and resveratrol (10 mg/kg) (TC). A group of six normal animals served as normal control (NC), another six as HFD control. Fasting plasma glucose, lipid profile were measured one week after induction of diabetes. The animals were then treated orally for 2 weeks after which the same parameters were repeated. Behavioral biomarkers for neuropathy are measured in 4 weeks and 6 weeks of treatment. The in-vivo results were analyzed by one way ANOVA followed by Tukey’s multiple comparison test for biochemical parameters and Kruskal Wallis test followed by Dun’s multiple comparison test for behavioral biomarkers.Results: Increase in fasting plasma glucose (FPG), deranged lipid profile, increased neuropathy in DC compared to NC, HFD control while a significant decrease in FBG, improved pain behavior with SC, test groups (p<0.05) as compared to the DC group.Conclusions: Resveratrol prevents diabetic neuropathy.

Cadmium acts as a silent killer of liver by inducing oxidative stress and hepatocellular injury and a possible amelioration by vitamin B12 and folic acid in rat model

2019 ◽  
Vol 1 ◽  
pp. 105-117
Author(s):  
A. Banerjee ◽  
P. Nandi ◽  
C. Bhattacharya ◽  
Z. Kabir ◽  
S. Mukherjee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Rat Model ◽  
Male Rats ◽  
Albino Rats ◽  
Therapeutic Effects ◽  
Hepatocellular Injury ◽  
Male Adult ◽  
Wistar Albino Rats

<br/><b>Purpose:</b> To investigate the involvement of oxidative stress in Cadmium (Cd) induced alteration in the functional status of the liver. And to assess the efficacy of folic acid and vitamin B12 in preventing Cd-induced damage in the same. <br/><b>Materials and methods:</b> The experiment was carried out for four weeks. For the experiment, 25 healthy male adult Wistar albino rats were randomly selected and were divided into five equal groups and treated as control, treated with Cd, supplemented with vitamin B12 and folic acid and in the combination of these two. After 28 days the liver function enzymes and oxidative stress parameters were measured. <br/><b>Results:</b> Cd is the silent killer of the hepatic system through the induction of oxidative stress in male rats. From this investigation, it is evident that the folic acid+vitamin B12 possess significant hepatoprotective and antioxidant activity against Cd-induced hepatotoxicity in the rat model. In addition, results revealed that the folic acid alone and or in combination with vitamin B12 blunted the hepatotoxic effect significantly. <br/><b>Conclusions:</b> Based on results obtained, it can be concluded that folic acid and vitamin B12 offer a protective effect in Cd-induced oxidative stress associated with hepatocellular injury. Folic acid and vitamin B12 can be considered as a potent natural antioxidant which has the capacity to provide protection against Cd-induced oxidative stress in the liver in rats. However, to elucidate the exact mechanism of this modulatory effect and to examine its potential therapeutic effects further studies are essential.

scholarly journals Efficacy of Zanthoxylum armatum fruit on isoproterenol induced myocardial infarction in rats

2019 ◽  
Vol 8 (1) ◽  
pp. 4-11 ◽  
Author(s):  
Malathi Mangalanathan ◽  
Tamiloli Devendhiran ◽  
Saraswathi Uthamaramasamy ◽  
Keerthika Kumarasamy ◽  
K Mohanraj ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Body Weight ◽  
Lipid Profile ◽  
Troponin T ◽  
Serum Markers ◽  
Albino Rats ◽  
Zanthoxylum Armatum ◽  
Creatine Kinase Mb ◽  
Enzymic Antioxidants ◽  
Wistar Albino Rats

The present study was elucidating the cardioprotective activity of hydroethanoic extract of Zanthoxylum armatum (Z. armatum) fruit on serum cardiac markers, lipid profile and the level of antioxidants in experimentally induced myocardial infarction (MI). The hydroethanolic extract of Z. armatum fruit was administered at a dose of 200 and 400 mg/kg body weight for 30 days to male Wistar albino rats. On 28th and 29th day, isoproterenol (ISO) (8.5mg/100g body weight) wasadministered to induce MI. Animals were sacrificed; blood and heart tissues were removed and the biochemical parameters were carried out. Serum markers such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB) and troponin –T were significantly (p<0.05) increased after ISO treatment. Altered lipid profile and significant changes in enzymic and non- enzymic antioxidants were also observed in MI. The altered levels were brought back to near normal by the administration of hydroethanoic extract of Z. armatum fruit which might be due to the active phytoconstituents present in it.

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