scholarly journals Potential Drug–Drug Interactions among Hospitalized COVID-19 Patients Admitted to Medical Wards of a Referral Hospital, North-East of Iran: A Cross Sectional Study

2021 ◽  
Author(s):  
Niloofar Saber-Moghaddam ◽  
Sepideh Hejazi ◽  
Sepideh Elyasi
Keyword(s):  
Drug Interaction ◽  
Virus Disease ◽  
Median Number ◽  
Cross Sectional Study ◽  
Referral Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
North East ◽  
East Of Iran ◽  
Drug Drug Interaction

Background: Hospitalized corona virus disease 2019 (COVID-19) patients are special population in term of drug-drug interaction (DDI), as they receive various experimental novel medications and also most of them are elderly with various comorbidities and consequently numerous medications. The aim of present study was to assess the prevalence and determinants of potential DDIs in hospitalized COVID-19 patients admitted to the medical ward of a Referral Hospital in North-East of Iran. Methods: A cross-sectional study was conducted among COVID-19 inpatients between March 2020 and April 2020. Prescribed medication being taken concurrently for at least 24 h were included and checked for DDI using Lexicomp® online drug reference. Data were analyzed using SPSS19. Results: A total of 88 patients were evaluated. The cardiovascular disease was the most common comorbidity (30.68%). The median number of medications prescribed for each patient was 5. Hydroxychloroquine was the most common prescribed medication for COVID-19 management (92.05%). About two-third (62.5 %) of patients were exposed to at least one potential C (84.09 %) or D (52.27%) DDI and no X DDIs were found. Patients with at least five prescribed medications were at higher risk of having DDI (P = 0.001). Conclusion: Drug–drug interaction in COVID-19 inpatients was common. Considering these DDIs, clinical pharmacist involvement can be helpful in minimizing the risk of these potentially harmful drug combinations.

scholarly journals Drug Use Evaluation of Crystalline Penicillin in Pediatrics Ward of Dessie Referral Hospital, North East Ethiopia: A Hospital Based Cross Sectional Study

2020 ◽  
Author(s):  
Taklo Simeneh Yazie ◽  
Ayalneh Gedif Tessema
Keyword(s):  
Drug Interaction ◽  
Cross Sectional Study ◽  
Referral Hospital ◽  
Antibiotic Prescribing ◽  
Sectional Study ◽  
Prescribing Practices ◽  
Cross Sectional ◽  
North East ◽  
Significant Difference ◽  
Dessie Referral Hospital

Background: Antibiotic resistance is a worldwide issue due to rise of antibiotic consumption and wide variation in antibiotic prescribing practices. Crystalline penicillin is the most highly consumed antibiotics by hospitalized pediatrics patients in Dessie Referral Hospital and its utilization pattern is not known in the study area. The objective is to assess the appropriateness of crystalline penicillin use in pediatrics ward of Dessie Referral Hospital, Northeast Ethiopia. Methods: A hospital based cross-sectional study was used for evaluating medication records of hospitalized pediatric patients who received crystalline penicillin from October to December 2018. Results: A total of 262 hospitalized pediatrics patient records were included in the study. All the 262 (100%) cases were consistent with guidelines for contraindication and drug interaction to use the drug. Crystalline penicillin use was consistent with guideline recommendations in 93.8%, 92.8%, 89.6%, 66.7% and 39.4% of the cases with regard to, indication, outcome, frequency, dose and duration of treatment, respectively. The observed value of all drug utilization evaluation parameters except drug interaction and contraindication showed statistically significant difference from the set threshold in nonparametric binomial test. Conclusion: The result of the current study especially with regard to dose and duration is much below the recommended threshold and needs scheduled trainings and necessary interventions to tackle the problem.

scholarly journals Medication Self-efficacy and Its Related Factors: A Cross-sectional Study on Patients with Coronary Artery Disease in North East of Iran Medication Self-efficacy and its Related Factors

2021 ◽  
Vol 17 (4) ◽  
Author(s):  
Fahimeh Nikraftar ◽  
Seyed Reza Mazloum ◽  
Mostafa Dastani ◽  
Fatemeh Heshmati Nabavi
Keyword(s):  
Coronary Artery ◽  
Self Efficacy ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Related Factors ◽  
Cross Sectional ◽  
North East ◽  
The North ◽  
East Of Iran ◽  
The Mean

Background: Patients with coronary artery diseases (CAD) use a wide spectrum of medications; hence, strategies are needed to increase their adherence. In this line, identifying factors associated with medication self-efficacy can be useful. Objectives: The current study aimed to investigate medication self-efficacy and its related factors in patients with CAD in the north-east of Iran. Methods: In this cross-sectional study, 104 patients with CAD hospitalized in one of the largest teaching hospitals in the north-east of Iran are studied. Participants were selected by convenience sampling method. Data were collected using Demographic and clinical information form, Information Satisfaction questionnaire (ISQ), and Self-Efficacy for Appropriate Medication Use scales (SEAMS). Data were analyzed by SPSS version 22 using descriptive statistics and multiple regression test. Results: The mean age of patients was 52.3 ± 8.8 years. The mean medication self-efficacy score was 24.9 ± 9.5 (out of 39). Multiple regression showed a linear and significant association between information satisfaction, income, medications used in the last month, information about the nature of the disease, doctors as a preferred source of information, nurses, family members, internet and social networks as the most information sources used by patients, with medication self-efficacy (R = 0.907, P < 0.001). These variables could explain 82.2% of the self-efficacy variance. Conclusions: Based on the result, it can be argued that in designing and implementing educational interventions aimed to promote medication self-efficacy in patients with CAD, individuals with lower income and under long-term medication treatment should receive more support. Educational programs should emphasize more on explaining the nature of the disease to the patients, and physicians should be more involved in educating patients.

scholarly journals Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (243) ◽  
pp. 1125-1130
Author(s):  
Lujaw Ratna Tuladhar ◽  
Shirish Lal Shrestha ◽  
Sneha Bimali ◽  
Srijana Bhusal ◽  
Pingala Khadka
Keyword(s):  
Drug Interaction ◽  
Confidence Interval ◽  
Drug Interactions ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Outpatient Department ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
Drug Drug Interaction

Introduction: Drug-drug interaction is one of the causes of adverse drug reactions. Generally, drug-drug interaction is common in multidrug therapy. Diabetic patients, particularly due to associated comorbidities tend to have various drug-drug interactions due to the effect of multiple drugs. The objective of this study was to find out the prevalence of drug-drug interactions in diabetic patients. Methods: It was a descriptive cross-sectional study that was conducted among previously diagnosed diabetic patients visiting the outpatient department of medicine at a tertiary care hospital between March 2021 and August 2021. Ethical approval was taken from the institutional review committee (Ref no: 030-076/077). Data was collected from diabetic patients presenting to the outpatient department of medicine using a preformed self-constructed questionnaire. Convenient sampling was done. Statistical Package for Social Sciences version 21 and Microsoft Excel were used for data analysis. Point estimate at 95% confidence interval was calculated along with frequency and proportion for binary data. Results: The prevalence of drug-drug interaction between hypoglycemic and non-hypoglycemic medication was 56 (44.1%) (35.5-52.7 at 95% Confidence Interval) of the patients out of which at least one drug-drug interaction was seen in 48 (37.8%) of the patients. Conclusions: Our study showed the prevalence of drug-drug interactions in diabetic patients to be higher than other studies done in similar settings. Based on the severity, we observed two types of drug-drug interactions; close monitoring drug-drug interactions and minor drug-drug interactions.

A Cross-Sectional Study to Evaluate Adherence to the Ten Steps to Successful Breastfeeding at a Referral Hospital in Rwanda

2018 ◽  
Author(s):  
Janvier Hitayezu ◽  
David Ntirushwa ◽  
Jean Claude Ntiyamira ◽  
Jeannette Kayitesi ◽  
Rose Mary Murungi ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Referral Hospital ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Practice of spinal anesthesia among anesthetists in the operation room of referral hospital: Cross-sectional study

2020 ◽  
Vol 27 ◽  
pp. 145-148
Author(s):  
Yonas Admasu Ferede ◽  
Yonas Addisu Nigatu ◽  
Abatneh Feleke Agegnehu ◽  
Salh Yalew Mustofa
Keyword(s):  
Spinal Anesthesia ◽  
Cross Sectional Study ◽  
Referral Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Operation Room

scholarly journals Knowledge about self-care and associated factors among heart-failure patients in Ayder Referral Hospital, Ethiopia, 2018: A cross-sectional study

2020 ◽  
pp. 201010582096214
Author(s):  
Tsegu Hailu Gebru ◽  
Haftea Hagos Mekonen ◽  
Kbrom Gemechu Kiros
Keyword(s):  
Heart Failure ◽  
New York ◽  
Logistic Regression ◽  
Self Care ◽  
Heart Association ◽  
Cross Sectional Study ◽  
Referral Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Knowledge Age

Background: Good knowledge of self-care related to heart failure (HF) is key to improve patient outcomes. However, information regarding how much patients know about self-care is lacking in developing countries, particularly in the study setting. Objective: The objectives of this study were to assess HF patients’ knowledge about self-care and to explore predictors among HF patients in Ayder comprehensive specialised referral hospital, Tigray, Ethiopia. Methods: This hospital-based cross-sectional study design was undertaken in Ayder comprehensive specialised referral hospital, Tigray, Ethiopia. A total of 408 HF patients participated, and the study was done between February and April 2018. An interviewer-assisted structured questionnaire was used to collect data. Bivariate logistic regression and multivariable logistic regression were conducted to identify the predictors associated with knowledge about self-care. Results: The mean age of the participants was 45.4 years (standard deviation=19 years). Around 255 (62.5%) of the participants had poor self-care knowledge. Age, New York Heart Association classes, duration of the disease and previous hospitalisation were the factors associated with knowledge about self-care. Conclusion: More than half of all participants had poor knowledge about self-care. Improving existing prevention strategies and strengthening patients’ knowledge are recommended to address this knowledge deficit.

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