scholarly journals Serum Levels of Growth Differentiation Factor-15 as an Inflammatory Marker in Patients with Unstable Angina Pectoris

2021 ◽  
Author(s):  
Fariba Raygan ◽  
Aniseh Etminan ◽  
Hanieh Mohammadi ◽  
Hossein Akbari ◽  
Hassan Nikoueinejad
Keyword(s):  
Angina Pectoris ◽  
Serum Level ◽  
Unstable Angina ◽  
Serum Levels ◽  
Unstable Angina Pectoris ◽  
Risk Scores ◽  
Growth Differentiation Factor 15 ◽  
Differentiation Factor ◽  
The Mean ◽  
And Control

Background: Growth differentiation factor-15 (GDF-15), a member of transforming growth factors, is a stress-responsive marker whose levels may significantly increase in response to pathological stresses associated with inflammatory tissue injuries such as unstable angina pectoris (USAP). This study evaluated the diagnostic value of GDF-15 in patients with USAP. Methods: The present cross-sectional study recruited 39 patients with USAP criteria and 30 patients with stable angina pectoris (SAP), referred to Shahid Beheshti Hospital, Kashan, Iran. All the patients with USAP had at least 1 coronary artery stenosis (>50%) in angiography. The control group comprised 42 healthy individuals. The serum levels of GDF-15 were measured in all the participants by ELISA. Also analyzed were the relationship between GDF-15 levels and thrombolysis in myocardial infarction (TIMI) and the Global Registry of Acute Coronary Events (GRACE) risk scores in the patients with USAP to determine the severity of the disease. Result: The study population consisted of 111 subjects, 62 women and 49 men, divided into 3 groups of USAP (n=39, mean age=60.07±14.10 y), SAP (n=30, mean age=67.56±9.88 y), and control (n=42, mean age=61.21±7.76 y). The mean serum level of GDF-15 in the USAP group was significantly different from the other 2 groups (P<0.001), while no significant difference was observed in this regard between the SAP and control groups (P=0.797). No correlation was found between the mean GDF-15 serum level and the GRACE (P=0.816) and TIMI (P=0.359) risk scores in the USAP group. Conclusion:  The mean serum level of GDF-15 exhibited a rise in our patients with USAP. GDF-15 may be a diagnostic biomarker of USAP and its severity.

scholarly journals Serum levels of homocysteine and circulating antioxidants associated with heart rate variability in patients with unstable angina pectoris

2019 ◽  
Vol 132 (1) ◽  
pp. 96-99
Author(s):  
Yong-Cheng Wang ◽  
Du-Fang Ma ◽  
Ping Jiang ◽  
Jin-Long Yang ◽  
Yi-Mei Zhang ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Angina Pectoris ◽  
Unstable Angina ◽  
Serum Levels ◽  
Unstable Angina Pectoris

scholarly journals THE ASSOCIATION OF MCP-1 -2518 G/A POLYMORPHISM, ITS SERUM LEVELS WITH UNSTABLE ANGINA PECTORIS

Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E187.3-E187
Author(s):  
He Guo-ping ◽  
Jiang Jiu ◽  
He Guo-ping
Keyword(s):  
Angina Pectoris ◽  
Unstable Angina ◽  
Serum Levels ◽  
Unstable Angina Pectoris

The Relationship Between Serum Orexin A, TGF-β, and Leptin Levels with Body Mass Index in Multiple Sclerosis Patients

2021 ◽  
Author(s):  
Sepideh Moharami ◽  
Alireza Nourazarian ◽  
Masoud Nikanfar ◽  
Delara Laghousi ◽  
behrouz shademan ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Serum Level ◽  
Serum Levels ◽  
Healthy Controls ◽  
Control Groups ◽  
Orexin A ◽  
The Mean ◽  
Multiple Sclerosis Patients ◽  
And Control ◽  
The Relationship

Abstract Backgrounds: Multiple Sclerosis (MS) is a chronic inflammatory and autoimmune disease linked to several inflammatory and dietary parameters. This study was carried out to determine the relationship between serum leptin, orexin-A, and TGF-β levels with BMI in MS patients.Methods and results: In this cross-sectional study, 25 relapsing-remitting multiple sclerosis (RRMS) patients and 40 healthy controls were enrolled. The serum level of Leptin, Orexin-A, and TGF- were measured by the Enzyme-linked immunosorbent assay (ELISA). The data was analyzed using descriptive statistics, t-test, Chi-square test, and Linear regression test. A total of 65 volunteers, including 25 MS patients and 40 healthy, were enrolled in the study. The mean age of individuals in the case and control groups was 38.04 ± 7.53 and 40.23 ± 5.88. There were no statistically significant differences between the case and control groups regarding gender, age, alcohol, and cigarette use (P>0.05). The mean serum levels of Orexin-A and TGF-ß were lower among multiple sclerosis patients than in healthy controls, but leptin was higher (42.8 vs. 18.9 ng/ml, P<0.001). The relationship between BMI and serum levels of Orexin-A, TGF-ß, and Leptin among Multiple Sclerosis patients was not statistically significant (P > 0.05).Conclusion: Our results showed that the serum levels of Orexin-A and TGF-β were significantly lower. The serum level of leptin was higher among multiple sclerosis patients than among healthy controls. Also, there was no statistically significant relationship between BMI and serum levels of Orexin-A, TGF-ß, and Leptin among multiple sclerosis patients.

scholarly journals A Novel Index for Prompt Prediction of Severity in Patients with Unstable Angina Pectoris

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Mustafa Bolatkale ◽  
Ahmet Cagdas Acara
Keyword(s):  
High Risk ◽  
Angina Pectoris ◽  
Unstable Angina ◽  
Stress Testing ◽  
Treatment Decision ◽  
Unstable Angina Pectoris ◽  
Control Group ◽  
Heart Score ◽  
Risk Patients ◽  
The Mean

Objectives. Rapid risk stratification by emergency department (ED) physicians to evaluate patients with chest pain for predicting the short-term occurrence of major adverse cardiac event (MACE) is crucial. The aim of this study was to investigate the predictive value of platelet-lymphocyte ratio (PLR) levels and compare with the modified heart score (m-HS) and stress testing to predict the severity of high-risk patients with unstable angina pectoris (UAP) in the ED. Methods. This study is prospective which included 316 patients with UAP and 316 control healthy subjects. The study took place from 01 April 2016, until 01 April 2017, in Medipol University. Result. The mean PLR levels in the UAP group were higher than those in the control group (p<0.001). The mean PLR of the m-HS ≥4 group was higher than that in the m-HS ≤3 group (p<0.001). The mean levels of PLR in the subgroups based on the stress testing positivity were higher than those in the stress testing negative subgroup (p<0.001). PLR levels were positively correlated with the m-HS, stress testing, and treatment decision in this study (r = 0.559; p<0.001; r = 0.582; p<0.001; r = 0.789; p<0.001, respectively). Conclusion. A positive correlation was determined with an increase in m-HS, treatment decision, and positive exercise testing as the PLR levels increased, indicating the severity of high risk of UAP in the ED.

Relation of Heart Rate Variability to Serum Levels of C-Reactive Protein in Patients With Unstable Angina Pectoris

2006 ◽  
Vol 97 (12) ◽  
pp. 1702-1706 ◽  
Author(s):  
Gaetano A. Lanza ◽  
Gregory Angelo Sgueglia ◽  
Domenico Cianflone ◽  
Antonio G. Rebuzzi ◽  
Giulia Angeloni ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Angina Pectoris ◽  
Unstable Angina ◽  
Serum Levels ◽  
Unstable Angina Pectoris ◽  
C Reactive Protein ◽  
Reactive Protein

Serum levels of anti heat shock protein 70 antibodies in patients with stable and unstable angina pectoris

2006 ◽  
Vol 8 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Itzhak Herz ◽  
Raphael Rosso ◽  
Arie Roth ◽  
Gad Keren ◽  
Jacob George
Keyword(s):  
Heat Shock ◽  
Angina Pectoris ◽  
Heat Shock Protein ◽  
Unstable Angina ◽  
Heat Shock Protein 70 ◽  
Serum Levels ◽  
Unstable Angina Pectoris

Serum levels of interleukin-18 in patients with stable and unstable angina pectoris

2005 ◽  
Vol 98 (1) ◽  
pp. 45-48 ◽  
Author(s):  
Rafael Rosso ◽  
Arie Roth ◽  
Itzhak Herz ◽  
Hylton Miller ◽  
Gad Keren ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Unstable Angina ◽  
Serum Levels ◽  
Unstable Angina Pectoris ◽  
Interleukin 18

scholarly journals Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Wei Yao ◽  
Yuxia Gao ◽  
Zheng Wan
Keyword(s):  
Angina Pectoris ◽  
Unstable Angina ◽  
Unstable Angina Pectoris ◽  
Control Groups ◽  
Serum Samples ◽  
Mortality And Morbidity ◽  
H Nmr ◽  
And Control ◽  
Insight Into ◽  
Serum Metabolomics

Although statistical evidence is clear regarding the dangerousness of unstable angina (UA), a form of coronary heart disease (CHD) characterised by high mortality and morbidity globally, it is important to recognise that diagnostic precision for the condition is unfavourable. In the present research, to gain insight into candidate biomarkers, the author draws on1H NMR-based serum metabolic profiling to analyze the unstable angina pectoris (UAP) metabolic signatures; this constitutes an effective way to produce medical diagnosis. 101 unstable angina pectoris patients and 132 healthy controls were enrolled and 22 serum samples from each group were analyzed. Effective separation was noted regarding the UAP and control groups, and, for the former group considered in relation to their counterpart, the serum concentrations of Lac, m-I, lipid, VLDL, 3-HB, and LDL were higher whereas the concentrations of Thr, Cr, Cho, PC/GPC, Glu, Gln, Lys, HDL, Ile, Leu, and Val were lower. The conclusion drawn in view of the results is that the plasma metabolomics examined by1H NMR displayed promise for biomarker identification for UA. In addition to this, the analysis illuminated the metabolic processes of UA.

scholarly journals Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Jing Cheng ◽  
Xing Su ◽  
Lei Qiao ◽  
Chungang Zhai ◽  
Wenqiang Chen
Keyword(s):  
Risk Factors ◽  
Growth Factor ◽  
Angina Pectoris ◽  
Unstable Angina ◽  
Fibroblast Growth Factor ◽  
Unstable Angina Pectoris ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Fgf21 Level ◽  
And Control

There is increasing evidence that serum adipokine levels are associated with higher risks of cardiovascular diseases. As an important adipokine, fibroblast growth factor 21 (FGF21) has been demonstrated to be associated with atherosclerosis and coronary artery disease (CAD). However, circulating level of FGF21 in patients with angina pectoris has not yet been investigated. Circulating FGF21 level was examined in 197 patients with stable angina pectoris (SAP, n=66), unstable angina pectoris (UAP, n=76), and control subjects (n=55) along with clinical variables of cardiovascular risk factors. Serum FGF21 concentrations on admission were significantly increased more in patients with UAP than those with SAP (Ln-FGF21: 5.26 ± 0.87 compared with 4.85 ± 0.77, P<0.05) and control subjects (natural logarithm (Ln)-FGF21: 5.26 ± 0.87 compared with 4.54 ± 0.72, P<0.01). The correlation analysis revealed that serum FGF21 concentration was positively correlated with the levels of cardiac troponin I (cTnI) (r2  =  0.026, P=0.027) and creatine kinase-MB (CK-MB) (r2  =  0.023, P= 0.04). Furthermore, FGF21 level was identified as an independent factor associated with the risks of UAP (odds ratio (OR): 2.781; 95% CI: 1.476–5.239; P=0.002), after adjusting for gender, age, and body mass index (BMI). However, there were no correlations between serum FGF21 levels and the presence of SAP (OR: 1.248; 95% CI: 0.703–2.215; P=0.448). The present study indicates that FGF21 has a strong correlation and precise predictability for increased risks of UAP, that is independent of traditional risk factors of angina pectoris.

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