scholarly journals Cognitive Function Differences based on Hemispheric Lesions of First-Ever Ischemic Stroke Patients

2018 ◽  
Vol 5 (3) ◽  
pp. 3616-3618
Author(s):  
Irina Kemala Nasution ◽  
Nenni Dwi Aprianti Lubis ◽  
Iswandi Erwin ◽  
Muhammad Iqbal Nusa
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Function ◽  
Right Hemisphere ◽  
Hemispheric Lateralization ◽  
Stroke Patients ◽  
Stroke Subtype ◽  
Cognitive Differences ◽  
Cross Sectional ◽  
Hemispheric Stroke ◽  
Mean Differences

Ischemic stroke is one of stroke subtype often correlated with disturbance of cognitive function. We conduct an observational study with cross-sectional design of 70 ischemic stroke patients. Objective of this study is to evaluate cognitive differences based on hemispheric lateralization lesions. We used Montreal Cognitive Assessment – Indonesian version (MoCA-Ina) to assess cognitive function resulting on 70 patients, consist of 48 subjects (68.57 %) of left hemispheric stroke and 22 subjects (31.43%) of right hemispheric stroke. As much as 68 subjects (97.14 %) are categorized as having cognitive disturbance. Mean differences of MoCA-Ina was assessed using Mann-Whitney test resulting no significant differences between left vs right hemisphere groups (18.94 + 3.26 vs 19.82 + 3.13; p= 0.320). Further study would warrant lesions lateralizations could affects cognitive performance of ischemic stroke patients.

scholarly journals HUBUNGAN ANTARA PERUBAHAN KADAR HS-CRP DENGAN FUNGSI KOGNITIF PADA STROKE ISKEMIK

2018 ◽  
Vol 35 (2) ◽  
Author(s):  
Betsi Sumanti ◽  
Hexanto Hexanto ◽  
Widiastuti Widiastuti
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Function ◽  
Acute Ischemic Stroke ◽  
Inflammatory Marker ◽  
Cross Sectional Study ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Hs Crp ◽  
Relationship Of

   ASSOCIATION BETWEEN ALTERED HS-CRP LEVELS AND  COGNITIVE FUNCTION OF ISCHEMIC STROKE PATIENTSABSTRACTIntroduction: The incidence of cognitive impairment in acute ischemic stroke patients is increasing. The mechanism of the inflammatory effect, such as  elevated hs-CRP level, a  non-specific inflammatory marker  sensitive to chronic inflammation due to hypoperfusion as well other vascular risk, is thought to have an effect on cognitive function.Aims: To determine the relationship of cognitive function changes in acute phase of ischemic stroke with hs-CRP level changes on day 3 and day 7 after onset.Methods: This was a cross sectional study of 31 first-timer ischemic stroke patients who met inclusion and exclusion criteria. The level of hs-CRP was checked on the 3rd day and 7th day after onset, while MoCA-Ina was assessed on the 7th day after onset. Cognitive disturbance was considered if MoCA <26. Analyses was done using SPSS 2.0Results: The average onset of day 3 Hs-CRP concentration was 0.66 (0.12-16.67)mg/dl and the onset of day 7 was 5.455 (0.14-17.34)mg/dl. The mean change of hs-CRP level between 3 day and 7 day after onset was -0,16 (-3.32-4.95). There was a significant correlation between elevated hs-CRP levels on day 3 and day 7 after onset with cognitive function of acute ischemic stroke patients.Discussion: There was a significant correlation between elevated hs-CRP levels on day 3 and day 7 after onset with cognitive function of acute ischemic stroke patients.Keyword: Acute ischemic stroke, hs-CRP, MoCA-Ina scoresABSTRAKPendahuluan: Insidens penurunan fungsi kognitif pada pasien stroke iskemik akut semakin meningkat. Hal ini diduga dipengaruhi oleh mekanisme efek inflamasi, meliputi peningkatan kadar high sensitive-C reactive protein (hs-CRP), salah satu penanda inflamasi non-spesifik yang sangat sensitif pada inflamasi kronis, akibat hipoperfusi maupun karena risiko vaskuler lainnya.Tujuan: Mengetahui hubungan perubahan fungsi kognitif pasien stroke iskemik fase akut dengan perubahan kadar hs-CRP hari ke-3 dan hari ke-7 setelah awitan.Metode: Studi potong lintang terhadap penderita stroke iskemik pertama kali yang memenuhi kriteria inklusi dan eksklusi. Dilakukan pemeriksaan kadar hs-CRP hari ke-3 dan hari ke-7 setelah awitan dan MoCA-Ina pada hari ke-7 setelah awitan. Fungsi kognitif dinyatakan terganggu jika MoCA-Ina <26. Analisis data menggunakan program SPSS 22.0.Hasil: Didapatkan rerata kadar Hs-CRP hari ke-3 setelah awitan adalah 0,66 (0,12-16,67)mg/dl dan hari ke-7 setelah awitan adalah 5,455 (0,14-17,34)mg/dl. Dengan rerata perubahan kadar hs-CRP awitan hari ke-3 dan awitan hari ke-7 adalah -0,16 (-3,32-4,95). Didapatkan hubungan yang bermakna antara perubahan kadar hs-CRP hari ke-3 setelah awitan dan hari ke-7 setelah awitan dengan fungsi kognitif pasien stroke iskemik akut.Kesimpulan: Didapatkan hubungan yang bermakna antara peningkatan kadar hs-CRP pada hari ke-7 dan kadar hari ke-3 dengan fungsi kognitif pasien stroke iskemik akut.Kata kunci: hs-CRP, MoCA-Ina, stroke iskemik akut 

scholarly journals COMPARISON OF COGNITIVE FUNCTION BETWEEN FIRST ISCHEMIC STROKE AND RECURRENT ISCHEMIC STROKE PATIENTS

2022 ◽  
Vol 8 (1) ◽  
pp. 30-34
Author(s):  
Fildza Intan Rizkia ◽  
Chandra Calista ◽  
Suryani Gunadharma ◽  
Asep Nugraha Hermawan ◽  
Lisda Amalia ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Recurrent Stroke ◽  
Demographic Data ◽  
P Value ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Significant Difference ◽  
Stroke Group

Background: Cognitive impairment is a common condition that may affect up to 50% of stroke patients. Post stroke cognitive impairment is associated with reduced quality of life, which may increase the number of dependency. Recurrent stroke may happen in approximately 25% patients and they have higher rates of cognitive impairment. Objective: The aim of this study is to examine the comparison of cognitive function between first ischemic stroke and recurrent ischemic stroke patients in Hasan Sadikin Hospital, Bandung. Methods: This study is a retrospective, cross-sectional study using the data recruited between the year 2012 - 2016 at the Department of Neurology at the Hasan Sadikin Hospital Bandung. The data collected in this study were demographic data, including age, level of education, and residence, and the clinical data as well. Cognitive function was assessed using Mini-Mental State Examination (MMSE). The comparison between the cognitive function between both groups were analyzed using the Mann-Whitney U test. Results: There were 428 subjects eligible for this study, with 207 subjects categorized as first ischemic stroke group and 221 subjects categorized as recurrent ischemic stroke group. There was a statistically significant difference in MMSE scores between the first ischemic stroke patients (24.90 ± 4.64) and recurrent ischemic stroke patients (22.85 ± 4.64 ) with a p value of 0.002. Conclusion: Recurrent ischemic stroke patients had lower MMSE scores than the first ischemic stroke patients. Clinicians should be more aware in detecting early cognitive impairment in stroke patients and in preventing the incidence of recurrent stroke.

scholarly journals Accuracy of Siriraj stroke scale in the diagnosis of stroke subtypes among stroke patients

2017 ◽  
Vol 5 (3) ◽  
pp. 1084
Author(s):  
Abhilash Somasundaran ◽  
Hashik Mohammed ◽  
Jayaraj Kezhukatt ◽  
Alvin Treasa George ◽  
S. Narayanan Potty
Keyword(s):  
Ischemic Stroke ◽  
Ct Scan ◽  
Rural Areas ◽  
Hemorrhagic Stroke ◽  
Cross Sectional Study ◽  
Stroke Patients ◽  
Stroke Subtype ◽  
Cross Sectional ◽  
Tertiary Centre ◽  
Low Sensitivity

Background: Early detection of intracranial blood is essential for the rational use of anti hemostatic drugs in stroke patients. CT scan is quite expensive as well as it is not easily available especially in the rural areas. Clinical stroke scores were developed to overcome these limitations. Aim of present study is to identify the stroke subtype using Siriraj stroke scoring and thus asses its accuracy by comparing with CT scan reports.Methods: A cross sectional study was conducted in a tertiary centre that evaluated 464 patients admitted with a diagnosis of stroke. Siriraj Stroke score was calculated for each patient and a CT scan of brain was also taken. The results of diagnosis made by Siriraj stroke scoring were compiled and compared with the diagnosis obtained by CT Scan.Results: Of the total 464 patients, the incidence of hemorrhagic stroke was 27.8% and ischemic stroke was 72.2%, as per the CT scan reports, while the Siriraj stroke score diagnosed 16.8% patients to have hemorrhagic stroke and 74.6% to have ischemic stroke and no definite diagnosis was made in rest of the patients (8.6%). The sensitivity of the scoring was found to be 59.2% in diagnosing hemorrhagic stroke and 95.5% in ischemic stroke.Conclusions: Our study has shown that siriraj stroke scoring has a high degree of accuracy in detecting both types of strokes, with roughly 80% of both hemorrhagic and ischemic strokes being correctly identified. However there is a low sensitivity in diagnosing hemorrhagic strokes and higher sensitivity in diagnosing ischemic strokes.

scholarly journals PERBEDAAN GANGGUAN KOGNITIF SUBJEK STROKE ISKEMIK BERDASARKAN SISI HEMIPARESIS

2020 ◽  
Vol 37 (2) ◽  
Author(s):  
Gabriella Gabriella ◽  
Budi Riyanto Wreksoatmodjo ◽  
Andre Andre
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Mental State ◽  
Significant Relationship ◽  
Mini Mental State Examination ◽  
P Value ◽  
Stroke Patients ◽  
Cross Sectional ◽  
State Examination

DIFFERENCE OF COGNITIVE IMPAIRMENT IN ISCHEMIC STROKE PATIENTS BASED ON HEMIPARESIS SIDEABSTRACTIntroduction: Cognitive impairment in stroke has a significant impact on the quality of life and is different from the location of the lesion. Patients with a lesion in the left cerebral hemisphere tend to have cognitive impairment and dementia.Aim: This study investigates the relationship between the location of the lesion, which is manifested by hemiparesis side, and the occurrence of cognitive impairment in ischemic stroke patients.Method: A cross-sectional study was conducted in the population of ischemic stroke patients at Atma Jaya Hospital, who were registered from January 2014 to December 2018. Cognitive function was measured by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Indonesian Version (MoCA-Ina). Data were analyzed univariate and bivariate with the software program, statistical package for the social sciences (SPSS) version 25.0.Result: There were 125 patients included in this study, which predominantly was 55 years old and older (62.4%) and had a low education level (58.4%). The proportion of patients with right-sided hemiparesis (54.4%) was slightly higher than the left-side one (45.6%). No significant relationship was observed between the hemiparesis side and every cognitive function domain measured by MMSE and MoCA-Ina (p-value >0.05).Discussion Hemiparesis side indicating hemisphere lateralization in ischemic stroke patients showed no significant relationship with the occurrence of cognitive impairment based on MMSE and MoCA-Ina score.   Keywords: Cognitive impairment, hemisphere lateralization, ischemic stroke, MMSE score, MoCA-Ina scoreABSTRAKPendahuluan: Gangguan kognitif pada stroke menyebabkan penurunan kualitas hidup dan berbeda berdasarkan letak lesi. Berdasarkan letak lesi, lesi di hemisfer serebri kiri lebih sering menyebabkan gangguan kognitif dan demensia.Tujuan: Tujuan penelitian untuk mengetahui pengaruh perbedaan letak lesi dilihat dari sisi hemiparesis terhadap gangguan kognitif pada subjek stroke iskemik.Metode: Studi potong lintang dilakukan pada pasien stroke iskemik di RS Atma Jaya periode tahun 2014- 2018. Fungsi kognitif dinilai dengan menggunakan Mini Mental State Examination(MMSE) danMontreal Cognitive Assesment Indonesian Version(MoCA-Ina). Analisis data dilakukan secara univariat dan bivariat menggunakan menggunakan program sStatistical pPackage for the sSocial sSciences (SPSS) versi 25.0.Hasil: Sebanyak 125 pasien tergabung dalam penelitian ini, yang sebagian besar berusia ≥55 tahun (62,4%) dan memiliki tingkat pendidikan <9 tahun (58,4%). Proporsi pasien dengan hemiparesis kanan (54,4%) lebih besar daripada kiri (45,6%). Tidak terdapat hubungan antara sisi hemiparesis dengan skor MMSE dan MoCA-Ina pada semua ranah (nilai p >0,05).Diskusi: Sisi hemiparesis pasien stroke iskemik yang menunjukkan lateralisasi hemisfer serebri tidak berhubungan dengan gangguan kognitif berdasarkan skor MMSE dan MoCA-Ina.Kata kunci: Gangguan kognitif, lateralisasi hemisfer, skor MMSE, skor MoCA-Ina, stroke iskemik

scholarly journals Hubungan Stroke Iskemik dengan Gangguan Fungsi Kognitif di RS Universitas Sumatera Utara

2020 ◽  
Vol 2 (1) ◽  
pp. 20-7
Author(s):  
Salsa Shafira Ramadhani ◽  
Haflin Soraya Hutagalung
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Health Problem ◽  
Stroke Patients ◽  
Chi Square ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Social Burden ◽  
Consecutive Sampling

Background: Stroke is a major health problem worldwide, especially in Asia, which has more than 60% of the world’s population. Besides causing a health problem, stroke is also an economic and social burden in low and middle-income countries. Stroke may cause cognitive impairment, thus cognitive assessment in stroke survivors is important in addition to determine the treatment aimed at improving cognitive function following a stroke. Objectives: This study aims to determine the association between gender, age, and duration of education and cognitive impairment of post-stroke patients at Rumah Sakit Universitas Sumatera Utara. Methods: This study is an analytical research study using a cross-sectional design with a total of 24 respondents selected by consecutive sampling. Data collection was done by using medical records and interviewing the MoCA-Ina questionnaire to respondents. Results: On the analysis of chi-square obtained, gender value p = 0.673 indicating there is no association between gender and cognitive impairment, age (p = 0.035) and duration of education (p = 0.013) indicating there is an association between age as well as the duration of education and cognitive impairment of post-ischemic stroke patients. Conclusion: There is an association between age as well as the duration of education and cognitive impairment, whereas gender does not show association with cognitive impairment in post-ischemic stroke patients. Keywords: cognitive function, ischemic stroke, MoCA-Ina, post ischemic stroke     Latar Belakang: Stroke merupakan masalah kesehatan utama di dunia terutama di Benua Asia dengan penduduk lebih dari 60% populasi dunia. Selain menimbulkan masalah kesehatan stroke juga menjadi beban ekonomi dan sosial di negara yang berpendapatan rendah dan menengah. Stroke dapat menyebabkan gangguan fungsi kognitif sehingga pemeriksaan fungsi kognitif pada pasien stroke merupakan hal yang penting untuk dapat menentukan penanganan selanjutnya yang bertujuan memperbaiki fungsi kognitif. Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan jenis kelamin, usia dan lama pendidikan dengan gangguan fungsi kognitif pada pasien pasca stroke iskemik di Rumah Sakit Universitas Sumatera Utara. Metode: Penelitian ini merupakan penelitian analitik menggunakan desain penelitian potong lintang dengan sampel penelitian pasien pasca stroke iskemik di poliklinik saraf di Rumah Sakit Universitas Sumatera Utara dipilih dengan metode consecutive sampling sebanyak 24 responden. Pengambilan data dilakukan dengan menggunakan rekam medik serta wawancara menggunakan kuisioner MoCA-Ina kepada responden. Hasil: Pada analisis uji chi square didapatkan jenis kelamin (p = 0,673) tidak berhubungan dengan gangguan fungsi kognitif pada pasien pasca stroke, sedangkan usia (p = 0,035) dan lama pendidikan (p = 0,013) menunjukkan hubungan dengan gangguan fungsi kognitif pada pasien pasca stroke iskemik. Kesimpulan: Terdapat hubungan antara usia dan lama pendidikan dengan gangguan fungsi kognitif, sedangkan jenis kelamin tidak menunjukkan adanya hubungan dengan gangguan fungsi kognitif pada pasien pasca stroke iskemik. Kata kunci: fungsi kognitif, MoCA-Ina, pasca stroke iskemik, stroke iskemik

Abstract WP226: Short Lasting Runs (<30 sec) of Atrial Fibrillation are More Commonly Observed in Ischemic Stroke Patients in Comparison to Controls

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Ethem Murat Arsava ◽  
Ezgi Yetim ◽  
Ugur Canpolat ◽  
Necla Ozer ◽  
Kudret Aytemir ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Multivariate Analyses ◽  
Holter Monitoring ◽  
Female Gender ◽  
Prior History ◽  
Consecutive Series ◽  
Stroke Patients ◽  
Cross Sectional ◽  
History Of

Background: The role of short-lasting (<30 sec) runs of atrial fibrillation (AF) in ischemic stroke pathophysiology is currently unknown. Although these non-sustained attacks are considered as a risk factor for future development of longer lasting, classical AF episodes, prior research has highlighted that associated clinical stroke features are not entirely similar between these two types of arrhythmias. In this study we determined the prevalence of short-lasting AF in stroke-free controls and compared it to a consecutive series of ischemic stroke patients. Methods: A total 235 controls, without any prior history stroke or AF, were evaluated with ECG and 24-hour Holter monitoring for the presence of <30-sec or ≥30-sec lasting AF episodes. The results were compared to a consecutive series of ischemic stroke patients without prior history of AF (n=456). Univariate and multivariate analyses were performed to determine demographic and cardiovascular factors related to <30-sec lasting AF and its association with ischemic stroke. Results: Expectedly, the frequency of newly diagnosed ≥30-sec lasting AF, detected either on ECG or Holter monitoring, was significantly higher in patients with ischemic stroke (18% vs. 2%; p<0.01). Non-sustained AF was positively related to old age (p<0.01), female gender (p=0.01) and hypertension (p<0.01) in univariate analyses. In multivariate analyses, after adjustment for demographic and cardiovascular risk factors, presence of non-sustained AF was significantly higher among both cryptogenic (OR 1.78; 95% CI 1.02-3.10) and non-cryptogenic (OR 1.84; 95% CI 1.15-2.94) stroke patients with respect to controls. Conclusion: Our study shows a higher prevalence of non-sustained AF episodes in ischemic stroke patients in comparison to controls. Whether this cross-sectional association translates into causality in terms of stroke pathophysiology will be the subject of future studies.

Abstract WP190: Clinical Features of Sarcoid Patients With Ischemic Stroke

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Ahmed Z Obeidat ◽  
Heidi Sucharew ◽  
Charles J Moomaw ◽  
Dawn O Kleindorfer ◽  
Brett M Kissela ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Current Knowledge ◽  
Case Reports ◽  
Brain Mri ◽  
Sporadic Case ◽  
Prior History ◽  
Stroke Patients ◽  
Stroke Subtype ◽  
Stroke Event ◽  
History Of

Background: Current knowledge on ischemic stroke in sarcoid patients stems from sporadic case reports. The mechanism is thought to be related to granulomatous involvement of brain vasculature. However, clinical, demographic, and radiographic features of sarcoid patients with ischemic stroke are lacking. If sarcoid patients are at higher risk for ischemic stroke event, we hypothesized that the risk factors for ischemic stroke and stroke subtype distribution would differ between sarcoid and non-sarcoid ischemic stroke patients. Methods: Cases of ischemic stroke were identified for the years 2005 and 2010 from the population-based Greater Cincinnati/Northern Kentucky Stroke Study (population 1.3 million). Ischemic stroke cases were physician study confirmed and patients with a history of sarcoid were identified through medical chart review. Clinical variables were compared between stroke patients with history of sarcoid and those with no prior sarcoid history. Results: A total of 4258 cases of ischemic stroke were identified; of them, only 18 had prior diagnosis of sarcoid (0.04%). Brain MRI showed diffusion restriction in 14 out of 15 (93%) MRIs performed in sarcoid patients. The table presents risk factor and subtype data on sarcoid patients compared with non-sarcoid patients. Conclusions: We identified only a few cases of prior sarcoid history in our two-year ascertainment of ischemic stroke patients in our population. In comparison with stroke patients with no prior history of sarcoid, the sarcoid patients tended to be of younger age at presentation, female, have a history of diabetes and hyperlipidemia, and more likely of African descent, perhaps related to the diagnosis of sarcoid itself. We were unable to detect differences in stroke subtype distributions between sarcoid and non-sarcoid ischemic stroke patients.

scholarly journals Correlation of neutrophil-to-lymphocyte ratio and clinical outcome of acute thrombotic stroke in patients with COVID-19

Narra J ◽  
2021 ◽  
Vol 1 (3) ◽  
Author(s):  
Rizky Sarengat ◽  
Mohammad S. Islam ◽  
Mohammad S. Ardhi
Keyword(s):  
Ischemic Stroke ◽  
Clinical Outcome ◽  
Acute Ischemic Stroke ◽  
National Institutes Of Health ◽  
Neutrophil To Lymphocyte Ratio ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Lymphocyte Ratio ◽  
Life Threatening ◽  
The Mean

The coronavirus disease 2019 (COVID-19) pandemic has caused millions of deaths worldwide. Acute ischemic stroke is a life-threatening risk factor for COVID-19 infection. Neutrophil-to-lymphocyte ratio (NLR) is one of the predictors of poor prognosis in acute ischemic stroke. The aim of this study was to assess the correlation between NLR values and the clinical outcome of acute thrombotic stroke patients with COVID-19 that was measured using the National Institutes of Health Stroke Scale (NIHSS). A cross-sectional hospital-based study was conducted in Dr. Soetomo General Hospital Surabaya, Indonesia. Patients with acute thrombotic stroke and COVID-19 admitted between 1 March 2020 and 31 May 2021 were recruited. The NLR values and the NIHSS scores were assessed during the admission and the correlation between NLR and NIHSS scores was calculated. This study included 21 patients with acute thrombotic stroke and COVID-19, consisting of 12 males and 9 females. The mean age was 57.6 years old. The mean NLR values was 8.33±6.7 and the NIHSS scores ranging from 1 to 33. Our data suggested a positive correlation between NLR values and NIHSS scores, r=0.45 with p=0.041. In conclusion, the NLR value is potentially to be used as a predictor of the clinical outcome in acute thrombotic stroke patients with COVID-19. However, further study is warranted to validate this finding.

scholarly journals The Difference of Barthel Index Score Based on Stroke Severity, Weakness Side, and Onset of Physiotherapy in Ischemic Stroke Patients at Atma Jaya Hospital

2017 ◽  
Vol 6 (02) ◽  
pp. 15
Author(s):  
Agustina Novita Putri Soegiarto ◽  
Linda Suryakusuma ◽  
Jane Pelealu
Keyword(s):  
Ischemic Stroke ◽  
Barthel Index ◽  
Daily Living ◽  
Index Score ◽  
Stroke Severity ◽  
Activity Of Daily Living ◽  
Stroke Patients ◽  
Barthel Index Score ◽  
Cross Sectional ◽  
Stroke Registry

Background: Stroke is the third cause of disability that can affect the Activity of Daily Living (ADL). Ischemicstroke had higher incidence compared to hemorrhagic strokes. Rehabilitation in the form of physiotherapy canreduce the level of ADL dependencies, that is be measured by Barthel Index Score. Stroke severity, weaknessside, and physiotherapy onset can be factors that influence the success of physiotherapy to reducing the levelof ADL dependencies.Methods:A descriptive analytic study with a cross-sectional design in ischemic stroke patients using secondarydata from the Stroke Registry and medical records at Atma Jaya Hospital for the period of January 2016 toDecember 2017. The data were analyzed using Chi-Square.Results: Study on 110 subjects, consisted of 62 men(56.4%), aged divided by under of 58 years, and above of 58years were 52(47.3%) and 58 (52.7%). While subjects divided by stroke severity, i.e. minor, moderate, moderateto severe, and severe; 44 (40%), 58 (52.7%), 5 (4.5%), and 3 (2.7%) respectively. There were 77 participants(70%) had right side weakness and 33 participants (30%) were left side weakness. The changes of Barthel Indexof ADL score, were 73 (66.4%) improvement, 6 (5.5%) deterioration, and 31 (28.2%) remained. The study hasshown relationship between severity of stroke (p=0.008), weakness side (p=0.000), and physiotherapy onset(p=0.039) with the changes of Barthel Indexscore after treatment.Conclusion: There was a relationship between stroke severity, the weakness side of stroke, and physiotherapyonset with the better result of Barthel Index of ADL score after the physiotherapy.Keywords: Activity of Daily Living (ADL), Barthel Index, ischemic stroke, physiotherapy onset, stroke severity,Weakness side

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