scholarly journals Effect of Puguntano Extract (Curanga Fel-Terrae Merr.) on hs-CRP Level in Newly Diagnosed Type 2 Diabetes Mellitus Patient

2018 ◽  
Vol 10 (1) ◽  
pp. 79
Author(s):  
Hartono Apriliasta Purba ◽  
Santi Syafril ◽  
Dharma Lindarto
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Maximum Dose ◽  
Newly Diagnosed ◽  
Hs Crp ◽  
Level Monitoring

BACKGROUND: Inflammation is one of the factors that associated with insulin resistance which causes type 2 diabetes mellitus (T2DM). Inflammation can be measured by using high sensitivity C-reactive protein (hs-CRP), a quantitative measurement of CRP concentration. Puguntano is a plant that traditionally used for antidiabetic treatment found in North Sumatera. The objective of this study is to know the effect of Puguntano extract on hs-CRP level in newly diagnosed T2DM patient.METHODS: The study was a randomized controlled clinical trial on 24 newly diagnosed T2DM patients. Subjects were divided into 2 groups. The first group was given Puguntano extract with starting doses at 100 mg daily, then the dose was increased in titration up to a maximum dose of 2x100 mg daily depending on blood sugar level monitoring. Meanwhile, the other group (which serves as a control group) was given metformin with starting doses at 500 mg daily, then the dose was increased in titration up to a maximum dose of 3x500 mg per day depending on blood sugar level monitoring. The hs-CRP and HbA1c are assessed at the baseline and after 12 weeks of treatment.RESULTS: The hs-CRP level was decreased in Puguntano group by 1.41 (-7.54-0.52) (p=0.06) and decrease by 0.58 (-7.86-33.41) (p=0.695) in metformin group. There was no difference in hs-CRP level between the two groups (p=0.630).CONCLUSION: Puguntano extract showed the effect of lowering HbA1C and hs-CRP level in T2DM patients, although it was not statistically significant.KEYWORDS: type 2 diabetes mellitus, hs-CRP, puguntano

scholarly journals Plasma Neuregulin 4 Levels Are Associated with Metabolic Syndrome in Patients Newly Diagnosed with Type 2 Diabetes Mellitus

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Pijun Yan ◽  
Yong Xu ◽  
Qin Wan ◽  
Jian Feng ◽  
Hua Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Multiple Logistic Regression Analysis ◽  
Newly Diagnosed ◽  
Hs Crp ◽  
Wbc Count ◽  
Neuregulin 4

Neuregulin 4 (Nrg4) has been proposed to play a role in the pathogeneses of obesity, insulin resistance, and dyslipidemia. However, information about the link between Nrg4 and metabolic syndrome (MetS) is scarce, especially in patients with newly diagnosed type 2 diabetes mellitus (nT2DM). This study aimed at investigating whether Nrg4 is associated with MetS in nT2DM patients. A total of 311 patients with nT2DM were recruited. Plasma Nrg4 concentration was determined by ELISA. Plasma Nrg4 concentration was lower in nT2DM patients with MetS than in nT2DM patients without MetS (P=0.001). Nrg4 concentration showed negative correlations with most of the analyzed indicators of MetS. MetS was less prevalent among subjects in the highest quartile of plasma Nrg4 concentration than among those in the lowest quartile (P<0.01). Age- and sex-adjusted plasma Nrg4 concentrations were positively correlated with concentrations of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A (both P<0.05) and negatively correlated with triglyceride, high-sensitivity C-reactive protein (hs-CRP), and gamma-glutamyltransferase concentrations, neutrophil count, and white blood cell (WBC) count (all P<0.05). In multivariate analysis, Nrg4 was independently associated with hs-CRP level, WBC count, and HDL-C level (P=0.001 or P<0.05). Multiple logistic regression analysis of MetS prediction by Nrg4 revealed an odds ratio of 0.560 (95% CI: 0.374–0.837; P<0.01). Decreased plasma Nrg4 levels, which may be associated with augmented oxidative stress, inflammation, and dyslipidemia, might be involved in the development of MetS in nT2DM patients.

Improvement in fasting blood sugar, anthropometric measurement and hs-CRP after consumption of epigallocatechin-3-gallate (EGCG) in patients with type 2 diabetes mellitus

2019 ◽  
Vol 50 (2) ◽  
pp. 348-359 ◽  
Author(s):  
Said Hadi ◽  
Meysam Alipour ◽  
Vahideh Aghamohammadi ◽  
Sahar Shahemi ◽  
Fatemeh Ghafouri-Taleghani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Anthropometric Measurement ◽  
Model Assessment ◽  
Content Type ◽  
Hs Crp

Purpose The epigallocatechin gallate (EGCG) effect in diabetes has been investigated in animal studies, but results of clinical trials are inconsistent. Thus, this study aims to evaluate the effects of EGCG supplementation in patients with type 2 diabetes mellitus (T2DM). Design/methodology/approach A total of 50 patients with T2DM were recruited in a double-blind, randomized, placebo-controlled trial. The eligible participants were randomly allocated to EGCG (n = 25) and placebo (n = 25) groups. The EGCG group received two capsules of EGCG (each capsule contained 150 mg; Shari Made®, Iran) and placebo group was administered two capsules of placebo (starch) for eight weeks. A three-day 24-h dietary recall and anthropometric and laboratory measurements were carried out at the beginning and the end of the study. Findings At the end of the trial, weight and body mass index (BMI) were decreased significantly in both groups, but the reduction was not statistically significant between the two groups. Fasting blood sugar decreased significantly in EGCG group. No significant between-group and within-group differences were found in insulin, homeostatic model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index values. The high-sensitive C-reactive protein (hs-CRP) was significantly reduced in the EGCG group (4.13 ± 0.48-3.93 ± 0.50, p = 0.003) compared to baseline. Originality/value This study showed that consuming 300 mg/day of EGCG for eight weeks in patients with T2DM caused a significant decrease in fasting blood glucose, body weight, BMI and hs-CRP compared to baseline. Therefore, the EGCG supplementation may improve glycemic control, anthropometric and inflammation status in T2DM.

scholarly journals Prevalence of Type 2 Diabetes Mellitus among People Attending Medical Camp in a Community Hospital

2020 ◽  
Vol 58 (225) ◽  
Author(s):  
Anu Kushwaha ◽  
Anuj Raj Kadel
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Diabetes Mellitus Type 2 ◽  
Blood Sugar Level ◽  
Community Hospital ◽  
Diabetes Mellitus Type ◽  
Random Blood Sugar

Introduction: Diabetes is a health problem on the rise in developing countries like Nepal. Oftenin the suburban and rural areas, patients are diagnosed in the late stages with complications. Theaim of this study is to find out the prevalence of diabetes type 2 in a community hospital of Nepal. Methods: This is a descriptive cross-sectional study done in a community hospital from January toMarch of 2019 after ethical clearance (Registration number: 150320192) from the institutional reviewcommittee of Kathmandu Medical College. Convenient sampling technique was used. Glucometerusing glucose sticks is used to measure random blood sugar level and relevant questions were askedin a short interview. The data were analyzed using the Statistical Package for the Social Sciences 20version. Results: Out of a total of 114 people, the prevalence of type 2 diabetes mellitus was 5 (4.38%). Amongthose 5 (4.385%) people with type 2 diabetes mellitus, 2 (1.75%) were female and 3 (2.63%) were male.The minimum age of the patient was 17 years and the maximum age was 92 years. Five out of 95patients with mild physical activity had random blood sugar more than 200 mg/dl and five out of46 alcoholic patients had random blood sugar levels more than 200 mg/dl. Only 1 out of 26 smokershad a random blood sugar level of more than 200 mg/dl. Conclusions: Prevalence of diabetes mellitus type 2 in our study population is quite high. Earlydetection of diabetes mellitus type 2 can be a good screening tool for early treatment and preventionof complications.  

scholarly journals Association of serum amylase and lipase levels in newly diagnosed type 2 diabetes mellitus

2021 ◽  
Vol 8 (2) ◽  
pp. 254
Author(s):  
Hareesh R. ◽  
Harish K. V. ◽  
Akshatha Savith
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Serum Amylase ◽  
Healthy Controls ◽  
Newly Diagnosed ◽  
Function Test

Background: Type 2 diabetes mellitus is a chronic metabolic disorder due to insulin resistance caused by destruction of beta cells of pancreas. Insulin resistance in newly diagnosed type 2 diabetes mellitus patients leads to hyperglycemia. Serum amylase and lipase levels is an exocrine enzyme produced by acinar cells of pancreas. Altered levels of serum amylase and lipase leads to endocrine disorders, metabolic syndrome and diabetes mellitus.Methods: This is a case-control study conducted in Akash Institute of Medical Sciences, A total 100 subjects (50 cases and 50 controls). All the subjects included after informed consent, blood samples are collected from the all the subjects. The serum amylase and was estimated by using enzymatic commercial available kits and fasting blood sugar (FBS), post-parandial blood sugar (PPBS), renal function test (RFT) and liver function test (LFT) was also estimated by laboratory standard methods.Results: This study evaluated the FBS, PPBS, RFT, LFT, Amylase and Lipase levels in patients with newly diagnosed type 2 diabetes mellitus patients and compare them with healthy controls. The serum amylase and lipase levels more significantly elevated in newly diagnosed type 2 diabetes mellitus patients and compared with the healthy controls. The study also found that significantly elevated levels of FBS, PPBS, RFT and LFT in newly diagnosed type 2 diabetes mellitus patients and compared with the healthy controls, The statistically significant levels of serum amylase and lipase levels in patients with newly diagnosed type 2 diabetes mellitus when compared with the controls (p=0.0001).Conclusions: The study suggesting that to estimation of serum amylase and lipase levels in newly diagnosed type 2 diabetes mellitus patients useful for early detection of diabetes mellitus and its complications. Because elevated levels of serum amylase and lipase in patients with newly diagnosed type 2 diabetes mellitus, these levels are positively correlated with the FBS and PPBS.  

scholarly journals Levels of β2-Microglobulin and Association of ACE Gene I/D Polymorphism with Type 2 Diabetes Mellitus patients

2013 ◽  
Vol 3 (3) ◽  
pp. 248-255
Author(s):  
Nageen Hussain ◽  
Mahwish Mahwish
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Body Mass ◽  
Blood Sugar Level ◽  
Ace Gene ◽  
Beta 2

BackgroundDiabetes mellitus is a metabolic ailment which is an outcome of defect in insulin secretion, insulin action, or both. The ACEgene systematizes Angiotensin Converting Enzyme (ACE) and is the most profoundly studied gene because of its crucial role in the renin-angiotensin system (RAS). The insertion/ deletion (I/D) of a 287bp long Alu repetitive sequence in intron 16 is responsible for three genotypes, DD and II homozygotes and ID heterozygotes.ACE levels differ in carriers with respect to their genotype; DD carriers have twice the levels of ACE than that found in II genotype individuals. The main purpose of this study is to investigate the association ofACE gene I/Dpolymorphism in Pakistani Type 2 Diabetes Mellitus (T2DM) patients primarily from Lahore.Methods:Hundred patients (T2DM) and fifty healthy controls were enrolled in this study. The ACE I/D polymorphism, located in intron 16, was analyzed by a triple primer method called nested-PCR and subsequently the results were analyzed by gel electrophoresis.Urine samples were also collected from patients suffering from diabetic nephropathy for the determination of beta-2 microglobulin.Results: The frequency of ACE genotypes DD, ID and II among the patients with type 2 diabetes mellitus was found to be 76%, 10%, 14% whereas in control subjects, 38% , 4% , 8% respectively. Other clinical parameters like blood sugar level and body mass index were also evaluated to find an association with genotype. The findings showed a non-significant association of ACE genotype with Blood Sugar Level (BSL) and Body Mass Index (BMI).Of the hundred T2DM patients enrolled in the study ten (10%) were of diabetic nephropathy. Beta-2-microglobulin was measured in the urine of these patients as well as healthy controls. A significant association between β2-microglobulin and T2DM was found by Fischer’s exact test. Serum creatinine values were noted and correlation was found. The results showed a positive correlation but non-significant between creatinine and beta-2-microglobulin.Conclusion:In the present study, no significant association was found between ACE gene I/D polymorphism and T2DM. Gender of the T2DM patients showed null effect on genotype.  Other clinical parameters like blood sugar level and body mass index also revealed a non-significant association with the ACE gene genotype.

scholarly journals Beneficial Effects of Soygurt Intake in Type 2 Diabetes Mellitus in Animal Model Rat (Rattus Norvegitus)

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Ni Wayan Desi Bintari ◽  
Putu Ayu Parwati
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Diabetic Rats ◽  
Male Rats ◽  
Probiotic Food

Type 2 Diabetes Mellitus (T2DM) is the more common type of diabetes results from the ineffective use of insulin. Improvement of the metabolic system in T2DM patients can be done through the regulation of gut microbiota balance. Gut microbial improvement can be modulated directly by probiotic food consumption. Soygurt is probiotic food with a low glycemic index (GI) and glycemic load (GL) value and rich in isoflavones, which has a potential effect in reducing diabetes risk. The aim of this study is to determine the effect of soygurt consumption in blood glucose levels and body weight of albino wistar rats (Rattus norvegitus). Reseach using a completely randomized design for experimental study. Subjects of this research are 30 male rats (R. norvegistus) aged 2-3 months with average body weight 150-200 gr. Diabetic rats were induced by using single intraperitoneal injection (175 mg/kg BW) alloxan monohydrate. Soygurt feeding given once daily using oral gavage feeding. The result showed that soygurt feeding in diabetic rats with three variations of treatment could significantly (p<0,05), lowering blood sugar level and improve body weight after 28 days of treatment. Treatment of 4ml/day soygurt has the highest effect in lowering blood sugar level and improving body weight, followed by treatment of 3ml/day and 2ml/day soygurt.

Association between Glycemic Indices, hs-CRP and Anthropometrical Parameters of Patients with Type 2 Diabetes Mellitus

2018 ◽  
Vol 55 (2) ◽  
pp. 187
Author(s):  
Hetal N. Parekh ◽  
Subhadra Mandalika ◽  
Suresh Mehtalia
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Composition ◽  
Glycemic Control ◽  
Blood Sugar ◽  
Poor Glycemic Control ◽  
Dietary Practices ◽  
Hs Crp

Risk of obesity, inflammatory conditions and poor glycemic control have been reported to be lower among vegetarian T2DM patients due to their lower intake of fat, high intake of dietary fiber and micronutrients. However, several factors influence dietary practices and thereby glycemic control among patients which demands in depth observation. A cross-sectional observational study to examine the association between body composition, glycemic control and hs-CRP of Type 2 Diabetes Mellitus (T2DM) patients was conducted on 160 uncontrolled T2DM patients including 81 (50.6%) vegetarians and 79 (49.4%) non-vegetarians with mean age of 49.8±7.2 years. They were assessed for body composition using anthropometry. Biochemical parameters [(Fasting Blood Sugar (FBS), Post Prandial Blood Sugar (PPBS), Glycosylated Hemoglobin (HbA1c) and high sensitive C Reactive Protein (hs-CRP)] were obtained from their case files. Data were analysed using SPSS software for Windows (Version 16.0, 2007, SPSS Inc, Chicago IL). Anthropometric indices (weight, BMI, WC, hip circumference, WHR, BMR, visceral fat) and hs-CRP levels were significantly higher in vegetarians than non-vegetarians (p&lt;0.05). However, there was no significant difference in FBS, PPBS and HbA1C between the two groups (p&gt;0.05). Vegetarian participants had higher hs-CRP (≤3.0 mg/dl) and poor glycemic control. A positive correlation of anthropometry indices with hs-CRP was also observed among the participants (p&lt;0.05). Dietary practices of vegetarians might vary across the populations and communities and hence there is a strong need to strictly consider these differences in the development of dietary strategies for T2DM.

scholarly journals Hubungan Aktifitas Fisik dengan Kadar Gula Darah Puasa Penderita Diabetes Melitus Tipe 2

2017 ◽  
Vol 1 (2) ◽  
pp. 80
Author(s):  
Laila Nurayati ◽  
Merryana Adriani
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Diabetes Mellitus Patient ◽  
Fasting Blood Sugar ◽  
Diabetes Melitus

 Background: Diabetes Mellitus is one of the degenerative diseases which is the highest morbidity by increasing 30,2 % from 2012 to 2013 in Surabaya. Low physical activity is suspected to be one factor of uncontrolled fasting blood sugar level of Diabetes Melitus patients. Objectives: Based on the problem, this study was conducted to analyze the relationship of physical activity with fasting blood sugar level of type 2 Diabetes Mellitus patient in MulyorejoPublic Health Center Surabaya. Methods: This research used cross sectional design with a sample of 62 people. Data were collected using structured interview guide and IPAQ. Blood sampling using spectrophotometer method performed by medical analyst of laboratory of Mulyorejo Public Health Center. Analysis used was Spearman's Rho statistical test. Results: The results showed as many as 62.9% of respondents had low physical activity and as much as 58.0% of respondents had fasting blood sugar levels in the high category. The results showed there was a correlation between physical activity with fasting blood sugar level of type 2 Diabetes Mellitus patient. Conclusion: Theconclusion of this research there was relationship between physical activity with fasting blood glucose level of type 2 Diabetes Mellitus patient. We recommend that people with type 2 Diabetes Mellitus apply good physical activity such as cycling  or walking routinely 3-4 days a week for 20 minutes each day and reduce sitting activity so that fasting blood sugar levels can be controlled.ABSTRAK Latar belakang: Diabetes Mellitus merupakan salah satu penyakit degeneratif yang masih tinggi di kota Surabaya dengan peningkatan kasus dari tahun 2012 ke tahun 2013 sebesar 30,2 %. Aktivitas fisik rendah merupakan salah satu faktor resiko tidak terkontrolnya kadar gula darah penderita Diabetes Melitus. Tujuan: Berdasarkan masalah tersebut, dilakukan penelitian untuk menganalisis ada tidaknya hubungan antara aktivitas fisik dengan kadar gula darah puasa penderita Diabetes Melitus tipe 2 di Puskesmas Mulyorejo Surabaya. Metode: Penelitian ini menggunakan desain cross sectional dengan sampel penelitian sebanyak 62 orang. Pengumpulan data dengan panduan wawancara terstruktur dan IPAQ. Pengambilan sampel darah dengan metode spektrofotometer yang dilakukan oleh analis medis laboratorium Puskesmas Mulyorejo. Analisis dilakukan dengan uji statistik Spearman’s Rho. Hasil: Hasil penelitian menunjukkan sebanyak 62,9 % responden memiliki aktivitas fisik rendah dan sebanyak 58,0 % responden memiliki kadar gula darah puasa dalam kategori tinggi. Hasil penelitian menunjukkan ada hubungan antara aktivitas fisik dengan kadar gula darah puasa penderita Diabetes Melitus tipe 2 (p=0,000). Kesimpulan: Kesimpulan dari penelitian ini adalah ada hubungan antara aktivitas fisik dengan kadar gula darah puasa penderita Diabetes Melitus tipe 2. Sebaiknya bagi penderita Diabetes Melitus tipe 2 dapat menerapkan aktivitas fisik yang baik seperti rutin bersepeda atau jalan kaki 3-4 hari dalam seminggu selama 20 menit setiap harinya dan mengurangi aktivitas duduk supaya kadar gula darah puasa terkontrol.

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