scholarly journals HYPOTENSIVE DRUGS EFFECT AND LIVER MONOOXIGENASE FUNCTION IN ARTERIAL HYPERTENSION PATIENTS AFTER ADRENAL HYPERFUNCTION CORRECTION

2007 ◽  
Vol 13 (4) ◽  
pp. 262-265
Author(s):  
A. S. Kogan ◽  
V. V. Lomivorotov ◽  
M. N. Deryagin ◽  
M. A. Novikov ◽  
V. A. Nepomnyashchikh
Keyword(s):  
Arterial Hypertension ◽  
Adrenal Glands ◽  
Drug Tolerance ◽  
Hypotensive Drug ◽  
Monooxygenase Activity ◽  
Microsomal Liver ◽  
Before And After ◽  
Liver Monooxygenase ◽  
Liver Monooxygenases ◽  
Adrenal Hyperfunction

Hypotensive drug tolerance and liver monooxygenase activity were investigated in 24 refractory arterial hypertension patients before and after surgical suppression of adrenal hyperfunction. Liver monooxygenase activity was studied using antipyrine test. It was found that hypotensive drug tolerance was decreased after one and two side operations on adrenal glands. In parallels halftime of antipyrine elimination was shown to be prolonged by 88.5% in 3 months - 3 years after suppression of adrenal hyperfunction. Our findings suggest that the hypotensive drug tolerance diminution may be the consequence of liver monooxygenase activity reduction. This assumption is in accordance with well known the hypotensive drug metabolism by microsomal liver monooxygenases

scholarly journals PRIMARY ALDOSTERONISM: THE RESULTS OF THE TREATMENT ACCORDING TO THE DATA OF RENAL ARTERIES DUPLEX SCANNING

World Science ◽  
2019 ◽  
Vol 2 (4(44)) ◽  
pp. 16-21
Author(s):  
Zubryk I. V.
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Renal Artery ◽  
Primary Aldosteronism ◽  
Reference Range ◽  
Renal Arteries ◽  
Duplex Scanning ◽  
Aldosterone Level ◽  
Before And After ◽  
Segmental Arteries

In the structure of arterial hypertension, primary aldosteronism (РА) ranges from 5 to 15%. Changes in intrarenal hemodynamics are due to both high blood pressure and direct aldosterone level. The purpose of the study was to analyze the results of PA treatment according to ultrasound doppler scanning of renal arteries. In general, 55 patients with PA were treated. Renal arteries duplex scanning before and after the treatment was performed in 20 patients. During treatment, the normalization of Vps, Ved, S/D, PI, PI, AT, TAMX indices was recorded in patients. The RI of the interlobar arteries slightly increased, however, it remained within the reference range. The reduction of aldosterone levels led to increase of TAMX index at the level of the renal artery trunk, S/D, RI and decrease in AT at the level of the segmental arteries, as well as increase of Ved and S/D at the level of the interlobar arteries.

A problem with the interpretation of before-and-after experiments of drug tolerance.

1996 ◽  
Vol 4 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Tod E. Kippin ◽  
John P. J. Pinel ◽  
Lisa E. Kalynchuk
Keyword(s):  
Drug Tolerance ◽  
Before And After

scholarly journals ELECTROLYTE BALANCE STUDIES IN ADRENALECTOMIZED DOGS WITH PARTICULAR REFERENCE TO THE EXCRETION OF SODIUM

1933 ◽  
Vol 57 (5) ◽  
pp. 775-792 ◽  
Author(s):  
Robert F. Loeb ◽  
Dana W. Atchley ◽  
Ethel M. Benedict ◽  
Jessica Leland
Keyword(s):  
Adrenal Glands ◽  
Urine Volume ◽  
Chloride Ion ◽  
Sodium Concentration ◽  
The Body ◽  
Electrolyte Balance ◽  
Protein Nitrogen ◽  
Water Excretion ◽  
Before And After ◽  
Sodium Metabolism

1. Balance studies have been made on three dogs before and after adrenalectomy, performed in two stages. 2. It has been shown that the sodium concentration of the blood decreases in adrenalectomized dogs, as is true in patients suffering from Addison's disease and in cats experimentally adrenalectomized. 3. There are also decreases in the chloride and bicarbonate concentrations which together are approximately equivalent to the decrease in sodium. 4. An increase in the potassium concentration of the blood occurs after adrenalectomy, as reported in other studies. There is no obvious correlation of this change with changes in potassium balances. 5. The balance studies show a striking loss of sodium from the body during the development of adrenal insufficiency. This loss of Na results from an increased excretion of sodium in the urine and is not complicated by loss of base as a result of vomiting or diarrhea. 6. Following adrenalectomy, both the total amount of sodium and its concentration in the urine are markedly increased. This increase in concentration of sodium occurs in spite of an augmented urine volume. 7. The behavior of the chloride ion following adrenalectomy parallels that of the sodium ion, but the loss is not equivalent. 8. During the period of accumulation of non-protein nitrogen in the blood, the rate of water excretion by the kidney is even greater than before removal of the adrenal glands. 9. The possibility of a regulatory effect of the adrenal glands upon sodium metabolism and renal function has been discussed.

scholarly journals Directing Therapy in Pulmonary Arterial Hypertension Using a Target 6 Min Walk Distance

2013 ◽  
Vol 20 (2) ◽  
pp. 111-115
Author(s):  
Nancy Rose Porhownik ◽  
Renelle Myers ◽  
Zoheir Bshouty
Keyword(s):  
Survival Rate ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Survival Rates ◽  
Registry Data ◽  
Walk Distance ◽  
Treatment Groups ◽  
Advanced Therapies ◽  
Before And After ◽  
Pulmonary Arterial

BACKGROUND: The most effective approaches to escalating advanced therapies in pulmonary arterial hypertension (PAH) are controversial.OBJECTIVE: To compare outcomes before and after introducing a target 6 min walk distance (6MWD) treatment strategy in PAH using registry data.METHODS: From 2001 to 2005, WHO class II to IV patients were treated with bosentan or prostanoids. In July 2005, a target 6MWD strategy was adopted. Monotherapy continued if 6MWD remained >350 m. For patients in whom 6MWD was ≤350 m, sildenafil was added. If 6MWD remained <350 m, prostanoids were considered. Changes in 6MWD, WHO class and survival rate were compared between periods.RESULTS: Before using the 6MWD strategy, there was a statistically significant improvement in mean WHO class at six, nine and 12 months (2.5±0.8 [P<0.015]; 2.5±0.8 [P<0.005]; and 2.5±0.9 [P<0.03], respectively) compared with baseline (2.9±0.9). There was a statistically significant increase in mean 6MWD at three, six, nine and 12 months (383±113 m [P<0.005]; 401±102 m [P<0.006]; 400±109 m [P<0.001]; and 399±110 m [P<0.004], respectively) compared with baseline (321±119 m). The survival rate was 95% at one and two years. From 2005 to 2009, there was a statistically significant improvement in mean WHO class at three, six, nine and 12 months (2.6±0.8 [P<0.05]; 2.3±0.9 [P<0.0001]; 2.3±0.9 [P<0.0001]; and 2.3±1.0 [P<0.0005], respectively) compared with baseline (2.8±0.7). There was statistically significant improvement in 6MWD at six months (381±126 m [P<0.05]), followed by a decline toward baseline (354±117 m). One- and two-year survival rates in the 6MWD target era were 95% and 80%, respectively.CONCLUSION: Based on registry data, adoption of this strategy did not affect survival rates, nor cause a sustained improvement in 6MWD by 12 months. WHO class improved similarly in both treatment groups.

Prevalence of Arterial Hypertension in Diabetic Patients Before and After the JNC-V

Diabetes Care ◽  
1994 ◽  
Vol 17 (11) ◽  
pp. 1247-1251 ◽  
Author(s):  
L. Tarnow ◽  
P. Rossing ◽  
M.-A. Gall ◽  
F. S. Nielsen ◽  
H.-H. Parving
Keyword(s):  
Arterial Hypertension ◽  
Diabetic Patients ◽  
Before And After

scholarly journals The Influence Of Therapy Playing Cut And Stick Paper On An Anxiety In Pre-School Children Hospitalization in Blambangan Room, RSUD Prof. Dr. Soekandar Mojosari

2017 ◽  
Vol 1 (1) ◽  
pp. 99-103
Author(s):  
Indra Yulianti
Keyword(s):  
Blood Pressure ◽  
Preschool Children ◽  
Blood Vessels ◽  
School Children ◽  
Adrenal Glands ◽  
Anxiety Scale ◽  
Anxiety Score ◽  
Consecutive Sampling ◽  
Before And After

Hospitalization is a new experience that can make the child be afraid, it can take effect for his physical and psychology because of a new environment and the officer. Afraid feels and uncertain feeling is a danger warning that can make the children take an action for the threat. As a result the child is not cooperative. Then the nurse can give the child distraction therapy with playing therapy. Playing therapy is to change the children problematic are playing with a situation. This research is to prove the influence of therapy playing cut and stick paper on an anxiety in preschool children hospitalization in Blambangan Room, RSUD Prof. Dr. Soekandar. The population is all of the preschool children, with design pre-experiment with one group pretest-posttest approach. The Sample 15 children are taken with consecutive sampling. 15 child is given playing therapy playing cut and stick paper. Collection of data taking with Spence Children’s Anxiety Scale. Then data is processed and tested by modus analysis.  The anxiety score of the child before is given playing therapy is 9 (60%) normal anxiety, 5 (33,3%) slight anxiety, 1 (6,7%) medium anxiety. The anxiety score of the child after given playing therapy is 15 (100%) decreased anxiety. There was a change from before and after therapy to play cutting and sticking paper. Decreased anxiety from this stressors is delivered on the hypothalamus that will stimulate the adrenal glands to perform vasodilatation of blood vessels so that blood pressure decreases.

scholarly journals Efficacy of "Kardiovitin" in integrated treatment in arterial hypertension patients

2020 ◽  
Vol 210 ◽  
pp. 17001
Author(s):  
Elena Katamanova ◽  
Elena Beygel ◽  
Oxana Ushakova ◽  
Irina Kudaeva ◽  
Nataliya Pavlenko
Keyword(s):  
Arterial Hypertension ◽  
Urine Analysis ◽  
Statistical Processing ◽  
Vascular Wall ◽  
Integrated Treatment ◽  
Blood Analysis ◽  
World Health ◽  
Average Weight ◽  
Before And After ◽  
Health Organization

Arterial hypertension is one of the most spread chronic non-specific human diseases and according to World Health Organization, is due to 30% of all-death outcomes in general. The aim of this study was to investigate the efficacy of Kardiovitin in the integrated treatment of arterial hypertension. Methods. A total of twenty patients took part in the study - seventeen women (average age – 64.5±8.7 years, average weight – 77.8±11.4 kg) and three men (average age – 54.6±12.4 years, average weight – 114±402 kg). A questionnaire, anamnesis, study of risk factors for hypertension, ECG, general blood analysis, general urine analysis, biochemical blood tests, were included in the examination program before and after treatment. Statistical processing was carried out with the program “Statistica 6.0”. Differences at p<0.05 were considered statistically significant. Results. It was observed a statistically significant decrease in systolic blood pressure - 120.0 (120.0-130.0) at p<0.05, in total cholesterol – 5.6 (4.6-6.4), LDL cholesterol – 3.2 (3.1-3.5) at p<0.05 after 2 months Kardiovitin therapy in addition to the standard hypotensive therapy. Conclusion. The results of the study indicate the efficacy of including Kardiovitin in the scheme for basic antihypertensive therapy as a source of bioflavonoids involved in the stabilization of the vascular wall.

scholarly journals Hemodynamic effects of fluoxetine in pulmonary arterial hypertension: an open label pilot study

2020 ◽  
Vol 10 (4) ◽  
pp. 204589402097195
Author(s):  
Adetoun Sodimu ◽  
Sonja Bartolome ◽  
Oluwatosin P. Igenoza ◽  
Kelly M. Chin
Keyword(s):  
Pilot Study ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Therapeutic Potential ◽  
Hemodynamic Effects ◽  
Open Label ◽  
Before And After ◽  
Secondary Endpoints ◽  
Pulmonary Arterial ◽  
Fluoxetine Therapy

In order to evaluate the therapeutic potential of fluoxetine in pulmonary arterial hypertension, 13 patients with pulmonary arterial hypertension underwent catheterization before and after 12 (N = 5) or 24 (N = 8) weeks fluoxetine therapy. No change was seen in the primary endpoint of pulmonary vascular resistance, other hemodynamic values, or any secondary endpoints.

Adrenal gland denervation and diving in ducks

1987 ◽  
Vol 252 (6) ◽  
pp. R1143-R1151
Author(s):  
H. J. Mangalam ◽  
D. R. Jones ◽  
A. M. Lacombe
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Adrenal Gland ◽  
Plasma Glucose ◽  
Adrenal Glands ◽  
Blood Gas ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
O2 Partial Pressure ◽  
Before And After

The extreme elevation in plasma levels of free norepinephrine (NE) and free epinephrine (EP), which occurs during forced diving of ducks (Anas platyrhynchos), was studied before and after denervation of the adrenal glands. In intact animals both NE and EP concentration increased by up to two orders of magnitude in a 4-min dive but by a significantly lesser amount if the duck breathed O2 before the dive. Denervating the adrenal glands reduced the amounts of both catecholamines (CA) released during dives, plasma EP decreased to 10%, and NE to 50% of values obtained before denervation. Breathing O2 before a dive virtually eliminated CA release in denervates, indicating that hypoxia was the important non-neural releasing agent. Hypoxia was also the most important neural releasing agent compared with hypercapnia, acidosis, or hypoglycemia. Adrenal denervation did not cause significant changes in heart rate, blood pressure, arterial blood gas tensions, pH, or plasma glucose during dives, although denervation caused increased variation in some of these variables. In ducks CA release in dives is largely due to decreasing arterial O2 partial pressure, and full expression of the response is dependent on intact innervation of the adrenal gland.

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