scholarly journals ASSESSMENT OF THE EFFECTIVENESS OF PREVENTION PROGRAMS FOR COUNTERMEASURE OF SPREAD OF SOCIALLY IMPORTANT INFECTIONS

2019 ◽  
Vol 96 (4) ◽  
pp. 392-396
Author(s):  
A. N. Barinova ◽  
O. G. Khurtsilava ◽  
S. L. Plavinskii
Keyword(s):  
Hiv Infection ◽  
Russian Federation ◽  
Panel Study ◽  
Prevention Programs ◽  
Health Technology ◽  
Relative Reduction ◽  
Life Years ◽  
Prevention And Treatment ◽  
The Russian Federation ◽  
Quality Adjusted Life

Purpose of the study. To evaluate the effectiveness of the prevention programs aimed at the prevention of the spread of socially important infections on example of HIV infection, as well to express it in units permitting the comparison with other fields of health care and to compare with to expenses for the prevention and treatment of sequelae of infection. Materials and methods. Results of the panel study, executed in 2006-2013 in 10 regions of the Russian Federation in HIV infection risk groups (4 waves). The total number of participants is 9891. Study protocol included detailed survey of risk behavior, involvement in prevention programs and HIV testing. Obtained data were used for the assessment of the change of the morbidity rate as a result of prevention and calibration of the dynamic (Markov) model of the effect of the prevention on the length of quality-adjusted life and treatment cost. Expenses for the prevention were estimated from field reports of prevention projects. Results. Programs for the comprehensive prevention of socially important infections, first of all HIV-infections, among injecting drug users result in the significant decrease in HIV incidence. The assessment of the effect of the prevention within framework of the multivariable model shows odds ratio to be of 0.56 (95% CI=0.40-0.78). This relative reduction corresponds to the decline of the absolute incidence from 3.98 per 100 person per year in the group of persons who was not involved in prevention programs (95% CI=3.37-4.69) to 2.22 per 100 person per year (95% CI=1.89-2.62) among participants. Such effect of the prevention leads to the increase in quality-adjusted life-years per each person (QALY=0.23, 95% CI=0.10-0.37), and the saving of budget cost by 226 thousand rubles (95% CI=209,6 - 822,2 thousand rubles). With the use of more pessimistic assumptions in relation to expenses for the prevention and treatment, the cost per quality-adjusted life per year failed to surpass the threshold of society’s willingness to pay for health technology, with demonstrating high cost-effectiveness of investing in the prevention. Conclusion. Programs of the comprehensive prevention of socially important infections in the Russian Federation have significant effectiveness and under most plausible assumptions are cost-saving. For the solution the problem of financing preventive measures it is necessary to apply the same principles of health technology assessment as it is done is the area of drug coverage.

scholarly journals ASSESSMENT OF EFFICIENCY OF PROGRAMS OF COMPREHENSIVE PREVENTION OF HIV-INFECTION FROM THE POINT OF VIEW OF THE PREVENTION OF LOSS OF YEARS, CUSTOMIZED FOR DISABILITY

2017 ◽  
Vol 20 (2) ◽  
pp. 95-99
Author(s):  
Anna N. Barinova
Keyword(s):  
Cost Saving ◽  
Hiv Infection ◽  
Russian Federation ◽  
Drug Users ◽  
Panel Study ◽  
Prevention Programs ◽  
Risk Groups ◽  
Relative Reduction ◽  
Life Years ◽  
Prevention Of Hiv

Purpose of the study. To evaluate the efficiency of the prevention programs aimed at the prevention of the spread of HIV infection, represent the it in disabled adjusted life years (DALY) and compare the efficiency with the prevention and treatment costs. Material and methods. Results of the panel study executed in 2006-2013 in 10 regions of Russian Federation in HIV infection risk groups (4 waves). The total number of include participants accounted of 9891. The study protocol included the detailed survey for the risk behavior and HIV testing. The obtained results of the study were used to calibrate the dynamic (Markov) model of the effect of the prevention on the length of the quality-adjusted life and treatment cost. The cost of the prevention was estimated on the base of reporting documents of prevention programs. Results. Programs of the comprehensive prevention of HIV-infection, among injecting drug users give rise in the significant decrease in the HIV incidence. The evaluation of the effect of prevention in frameworks of a multidimensional model shows odds ratio to be of 0.56 (95% CI = 0.40-0.78). This relative reduction of the incidence corresponds to the absolute incidence decrease from 3.98 per 100 person-years, among those not participating in prevention programs (95% CI: 3.37-4.69) to 2.22 per 100 person-years (95% CI: 1.89-2.62) among participants. This effect of the prevention leads to averting losses of 0.75-1.1 DALY per person, with most savings from the diminishing of the disability. In most plausible scenario this results in cost saving with return on the investment of 40 kopeks per rouble invested in prevention. Conclusion. Comprehensive programs of HIV prevention in Russian Federation possess of the significant effectiveness and under plausible assumptions are cost-saving. When discussing financing preventive measures they should be evaluated on real effectiveness and cost.

Secondary Syringe Exchange as a Model for HIV Prevention Programs in the Russian Federation

2006 ◽  
Vol 41 (6-7) ◽  
pp. 979-999 ◽  
Author(s):  
Kevin Irwin ◽  
Evgeni Karchevsky ◽  
Robert Heimer ◽  
Larissa Badrieva
Keyword(s):  
Hiv Prevention ◽  
Russian Federation ◽  
Prevention Programs ◽  
Syringe Exchange ◽  
The Russian Federation

The current state of the pharmaceutical market for anthelmintic drugs for veterinary use

2021 ◽  
Vol 1 (9) ◽  
pp. 37-44
Author(s):  
A. K. Klyueva ◽  
◽  
A. A. Deltsov ◽  
K. O. Belova ◽  
◽  
...  
Keyword(s):  
Russian Federation ◽  
Wide Spectrum ◽  
Pharmaceutical Market ◽  
The Past ◽  
Veterinary Medicines ◽  
Current State ◽  
Prevention And Treatment ◽  
The Russian Federation ◽  
State Registration ◽  
Anthelmintic Drugs

This paper presents an analysis of the range of veterinary medicines registered in the territory of the Russian Federation and used for the prevention and treatment of helminthiasis. The Russian Federation is a leader in the development and production of anthelmintic medicines registered on its territory. Antiparasitic medicines used for the prevention and treatment of helminthiasis are divided according to the spectrum of action depending on the class of helminths. It was revealed that the majority of medicines (89 medicines – 58,17%) have a wide spectrum of action. Of these, 62 medicines (40,52% of the total amount of anthelmintic medicines) are intended for the treatment of nematodes and cestodoses. When distributing anthelmintic medicines among target animals, it was found that 75 medicines (49.02%) are intended for the treatment of productive animals, and 78 medicines (50,98%) are intended for the treatment of unproductive animals. When assessing the dynamics of state registration of anthelmintic medicines for veterinary use, it can be noted that over the past 4 years there has been a tendency towards an increase in the average annual registration.

PRS4 HEALTH TECHNOLOGY ASSESSMENT OF DUPILUMAB IN SEVERE BRONCHIAL ASTHMA IN THE RUSSIAN FEDERATION

2019 ◽  
Vol 19 ◽  
pp. S77
Author(s):  
S.V. Nedogoda ◽  
M.Y. Frolov ◽  
A.S. Salasyuk ◽  
I.N. Barikina ◽  
V.O. Smirnova ◽  
...  
Keyword(s):  
Health Technology Assessment ◽  
Bronchial Asthma ◽  
Russian Federation ◽  
Technology Assessment ◽  
Health Technology ◽  
The Russian Federation

scholarly journals THE DYNAMICS AND STRUCTURE OF THE DETECTION OF HIV INFECTION AT THE STAGE OF RECRUITMENT OF CITIZENS FOR MILITARY SERVICE AND DURING THEIR MILITARY SERVICE IN THE ARMED FORCES OF THE RUSSIAN FEDERATION

2012 ◽  
Vol 17 (3) ◽  
pp. 23-27
Author(s):  
V. G. Akimkin ◽  
M. Zh. Parshin ◽  
C. V. Zemlyakov
Keyword(s):  
Hiv Infection ◽  
Russian Federation ◽  
Military Service ◽  
Armed Forces ◽  
Hiv Disease ◽  
Major Threat ◽  
High Prevalence ◽  
The Russian Federation ◽  
Structural Indices ◽  
Epidemiological Situation

HIV infection is a major threat to national security of the Russian Federation. Unfavorable epidemiological situation of HIV infection and drug addiction in Russia leads to a significant increase in the number of conscripts, recognized unfitfor military service on health grounds in connection with this disease. The quantitative and structural indices of detection of HIV infection in people at the stage of recruitment and during the period of their service in the Armed Forces of the Russian Federation in the dynamics have been analyzed. The most detection rate of HIV infection in soldiers in the regions of the Russian Federation with high prevalence of HIV = disease has been established. With aim to prevent the carrying and further spread of HIV infection in the Armed Forces of the Russian Federation the performance of the mandatory medical examination ofpersons qualifying for induction has been suggested.

scholarly journals Personolized treatment of patients with HIV-infection

2020 ◽  
Vol 12 (3) ◽  
pp. 7-34
Author(s):  
N. A. Belyakov ◽  
V. V. Rassokhin ◽  
E. V. Stepanova ◽  
N. V. Sizova ◽  
A. V. Samarina ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Medical Care ◽  
Russian Federation ◽  
Diagnosis And Treatment ◽  
The Russian Federation ◽  
Personalized Diagnosis

The paper studies key epidemiological, medical, social and economic, and demographic prerequisites determining the necessity of personalized diagnosis and treatment of patients with HIV-infection and comorbid states. Some regularities and sequence of creation of personalized medical care for patients of the Russian Federation were investigated, common characteristics and aspects of each component of personalized check-up and treatment of patients with HIV-infection were presented, separate groups and cohorts of people for whom such approach is essential and acceptable were selected.

scholarly journals CRITERIA OF RATIONAL PHARMACOTHERAPY: EVIDENCE FROM HIV TREATMENT

2018 ◽  
Vol 63 (1) ◽  
pp. 41-47
Author(s):  
N. B. Rostova ◽  
N. A. Gudilina
Keyword(s):  
Hiv Infection ◽  
Russian Federation ◽  
Clinical Laboratory ◽  
Antiretroviral Drugs ◽  
Hiv Treatment ◽  
Laboratory Diagnostics ◽  
Minimum Potential ◽  
The Russian Federation ◽  
Potential Impact ◽  
The Impact

Results of evaluation of the impact of drugs on indicators of clinical laboratory diagnostics as a criterion of safety of therapy are presented. Antiretroviral therapy for HIV infection was chosen as an example. Information from official sources (summary of product characteristics and medicinal product labels) on the potential impact of antiretroviral drugs registered in the Russian Federation on indicators of clinical laboratory diagnostics was analyzed and systematized. Individual INN and antiretroviral regimens recommended by WHO documents and protocols of follow-up and treatment of patients with HIV infection in the Russian Federation with the maximum and minimum potential impact on indicators of clinical laboratory diagnostics were revealed. The research results can be used to develop recommendations for the rational choice, prescription and use of medicines.

scholarly journals Comparative Characteristics of the Incidence of Healthcare-Associated Infections in the Chelyabinsk region and in the Russian Federation in Total

2015 ◽  
Vol 14 (5) ◽  
pp. 56-61 ◽  
Author(s):  
O. A. Orlova
Keyword(s):  
Health Care ◽  
Russian Federation ◽  
Healthcare Associated Infections ◽  
Prevention And Treatment ◽  
Hospital Acquired Pneumonia ◽  
The Russian Federation ◽  
General Demand ◽  
Chelyabinsk Region ◽  
Healthcare Associated ◽  
Hospital Acquired

Currently, the problem of prevention and treatment of healthcare-associated infections (HAI), only in hospitals from 5 to 20% of patients HAI get sick. In Chelyabinsk region, in comparison with the Russian Federation, the quantity of the infections connected with delivery of health care tends to growth. The greatest number of HAI is registered in hospitals of a surgical profile 70.3 ± 5.7% (in the Russian Federation - 31.4 ± 0.2%). In area hospital-acquired pneumonia steadily holds the first - second place in structure of HAI (38.2 ± 10.3%) in the country - the fourth - fifth (10.1 ± 5.1%). Detection of distinctions in structure of HAI in Chelyabinsk region and in the country in general demand further studying for the purpose of identification and introduction of the most effective preventive and antiepidemic actions.

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