scholarly journals COMPARATIVE EVALUATION OF AUTOANTIBODIES LEVELS, REFLECTING THE CONDITION OF THE CARDIOVASCULAR SYSTEM IN PATIENTS WITH VIBRATION DISEASE DUE TO LOCAL AND COMBINED VIBRATION

2019 ◽  
Vol 98 (10) ◽  
pp. 1102-1107
Author(s):  
Liudmila B. Masnavieva ◽  
I. V. Kudaeva ◽  
Y. A. Kuznetsova ◽  
O. V. Naumova
Keyword(s):  
Cardiovascular System ◽  
Comparative Evaluation ◽  
The State ◽  
The Body ◽  
Myocardial Cells ◽  
Membrane Structures ◽  
Local Vibration ◽  
Distinctive Features ◽  
Vibration Disease ◽  
Vascular Bed

Introduction. Vibration disease occupies one of the leading places in the structure of occupational pathology and is caused by exposure to both local and general vibration. Since the mechanism of local and general vibration effects on the body differs, it can be assumed that their effect on the cardiovascular system will have distinctive features. The aim of the work was to study the content of specific autoantibodies, which characterize the state of the cardiovascular system, in patients with vibration disease caused by exposure to local and combined vibration. Material and methods. The relative levels of specific autoantibodies to antigens, reflecting the state of the heart and the vascular bed, were determined in the blood of persons with vibration disease caused by exposure to local and combined vibration (29 and 36 cases, respectively). Results. 18 to 26% of persons with the vibratory disease caused by the effect of combined vibration were found to have elevated levels of autoantibodies to components of the membrane and cytoplasm of myocardial cells, components of the cytoplasm of neutrophils and endothelial cells, β1-adrenoreceptors, PAPP-A, and cardiomyosin protein. In the group of individuals exposed to local vibration, the frequency of occurrence of elevated levels of antibodies by more than 20% was detected only for β1-adrenoreceptors and PAPP-A protein. Elevated levels of other indices were observed in 10-14% of individuals in this group. The levels of antibodies to components of the membrane of myocardial cells and platelets were higher in patients with the vibratory disease caused by exposure to a combined vibration than in individuals with vibratory syndrome caused by the action of local vibration. conclusion. Elevated levels of auto-AT to platelet membrane structures may be due to changes in their membranes caused by the accumulation of highly toxic lipid peroxidation metabolites.

scholarly journals DETERMINATION OF THE FUNCTIONAL STATE OF THE PERIPHERAL NERVOUS SYSTEM IN PATIENTS WITH VIBRATION DISEASE BY ELECTRONEUROMIOGRAPHY INDICES

2019 ◽  
Vol 98 (10) ◽  
pp. 1119-1123
Author(s):  
D. V. Rusanova ◽  
Larisa S. Vasileva ◽  
N. V. Slivnitsyna ◽  
O. L. Lakhman
Keyword(s):  
Functional State ◽  
Lower Extremities ◽  
The State ◽  
The Body ◽  
Local Vibration ◽  
Spinal Cord Neurons ◽  
Vibration Disease ◽  
Prolonged Contact ◽  
Upper And Lower Extremities ◽  
F Wave

Introduction. Vibration disease (VD) is a chronic occupational disease caused by the long-term influence of industrial vibration on the body, with prolonged contact with which a polyneuropathic syndrome is formed. Material and methods. 150 males were examined in the clinic. The first group consisted of 50 patients with VD associated with combined exposure to local and General vibration (48.7±3.1 years); the second - 50 patients with VB associated with exposure to local vibration (48.9±2.8 years); the third - 50 relatively healthy individuals without contact with vibration (49.1±2.5 years). Stimulation electroneuromyography (ENMG) was carried out according to the generally accepted method. The results of ENMG show demyelinating lesions of motor and sensory components to be registered in the examined VD patients, changes in the speed indices of axons of nerves of the upper and lower extremities are observed. Analysis of F-wave indices revealed the lesion of both the fastest and the slowest conductive fibers of the tibial and peroneal nerves in patients of both groups. There is an increase in the maximum amplitude of the F-wave and the F/M ratio, more pronounced in patients of the first examined group. In patients of the first and second examined groups, there is an increase in the blocks of the pulse, more pronounced with the combined effect of general and local vibration. Conclusion. Changes in the state of the peripheral nerves of the upper extremities are similar in patients of the first and second groups and consist in the presence of processes of demyelination of motor and sensory axons. In patients of the first group, there are more pronounced disorders in the state of the motor component of the nerves of the upper and lower extremities, while in persons of the second group there are sub-threshold changes in the lower extremities. Changes at the level of roots and in the functional state of the spinal cord neurons are more pronounced in patients of the second group.

scholarly journals Autoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus

2020 ◽  
Vol 22 (2) ◽  
pp. 311-318
Author(s):  
L. B. Masnavieva ◽  
I. V. Kudaeva ◽  
Yu. A. Kuznetsova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Thrombus Formation ◽  
The State ◽  
Myocardial Cells ◽  
Diabetes Group ◽  
Vibration Disease ◽  
Group I ◽  
Group Ii

Physical and chemical factors, obesity, lipid metabolism disorder, diabetes affect the state of the vascular endothelium, the processes of thrombus formation, fibrinolysis and increase the risk of developing cardiovascular diseases. It can be assumed that the development and course of pathological processes in the cardiovascular system, caused by vibration disease with the onset of diabetes, will undergo changes. The purpose of the study was to assess the state of heart condition according to the level of specific autoantibodies with the combined effect of vibration disease and type 2 diabetes mellitus. Patients with vibration disease (group I), patients with type 2 diabetes (group II) and persons with vibration disease in combination with type 2 diabetes (group III) were examined. Individuals do not have a history of coronary heart disease, stroke, and myocardial infarction have been included in obsledrovanie. Serum levels of specific autoantibodies characterizing the state of the heart have been studied. It was revealed that the content of autoantibodies to 1-adrenoreceptors in patients of group I was higher than in individuals of group II. The relative content of autoantibodies to the components of the membrane and cytoplasm of myocardial cells in patients of groups I-III did not differ. It was found that elevated levels of autoantibodies to components of the membrane and cytoplasm of myocardial cells, cardiomyosin, 1-adrenoreceptors were observed more often in patients with vibration disease combined with diabetes and in persons with vibration disease than in people with diabetes. Persons with a reduced content of autoantibodies to 1-adrenergic receptors were not detected among patients of groups I and III. Changes in the levels of specific autoantibodies in persons with vibration disease may indicate the development of functional metabolic and structural changes in the heart, disorders of its electrical activity that have not yet been manifested in the form of a pathological process. Lower levels of 1-adrenoceptor autoantibodies in patients with type 2 diabetes without vibration disease can be caused by increased levels of catecholamines, which is characteristic of diabetics. Further research, including clinical data and indicators of functional diagnostics is necessary to confirm our assumptions.

scholarly journals A system for monitoring the state of human cardiovascular system based on the most complete mathematical model of vascular bed

2019 ◽  
Keyword(s):  
Cardiovascular System ◽  
Biomechanical Model ◽  
The State ◽  
Individual Tree ◽  
Biomechanical Models ◽  
Vascular Bed ◽  
Human Cardiovascular System ◽  
A New Technique ◽  
Blood Flow Velocities

The structure of a new system for monitoring the state of the human cardiovascular system based on geometric and biomechanical models of the vascular bed as a branching tree of arteries is presented. The tree geometry was obtained by averaging the data of postmortem measurements on five bodies, a statistical analysis of the patterns of the structure of vascular trees, and a new technique for generating an individual tree for a particular patient by performing several in vivo measurements. The developed biomechanical model allows numerical calculations of pressures and blood flow velocities in each artery, storing information in a database, analyzing the distribution of blood volumes, calculating important diagnostic indices, identifying pathologies and planning surgical operations in silico.

scholarly journals The State of the Cardiovascular System of Qualified Table Tennis Athletes at the Stage of Competitive Activity

2021 ◽  
Vol 6 (4) ◽  
pp. 231-236
Author(s):  
Ulizko V. M. ◽  
◽  
V. R. Kryzhanivsky ◽  
T. M. Zakharkevich ◽  
I. L. Belyavsky
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Cardiovascular System ◽  
High Frequency ◽  
Heart Rhythm ◽  
Frequency Component ◽  
The State ◽  
Autonomic Regulation ◽  
The Body ◽  
High Frequency Component

The condition of the cardiovascular system is one of the important criteria for assessing the impact of sports training on the human body. According to the indicators characterizing the state of the cardiovascular system, it is possible to trace the changes associated with fluctuations in the level of training, as well as to identify signs of overload as early as possible. The study of adaptive reactions of the cardiovascular system in athletes under physical activity is an important indicator for sports practice. The purpose of the study was to investigate the quantitative criteria for assessing the state of the cardiovascular system and approaches to correct the functional state of qualified athletes specializing in table tennis. Materials and methods. Studies of heart rate variability, quantitative and qualitative indicators that sufficiently reflect the autonomic functions of the body were used in order to assess the state of autonomic regulation in highly qualified athletes. Systematic physical activity causes a significant restructuring of the cardiovascular system and leads to morphofunctional changes in the mechanisms of the heart. Depending on the autonomic regulation of heart rhythm, there are different ways of myocardial adaptation processes. The balance of sympathetic and parasympathetic links of autonomic rhythm regulation is reflected in the activation of the left ventricle. Results and discussion. Adaptive changes of the cardiovascular system to competitive and training loads in the competitive period in qualified athletes are characterized by a significant decrease in heart rate (from 84.75±1.74 beats / min to 74.8±0.38 beats / min). In addition, a significantly faster process of restoring heart rate was established after exercise in the group of qualified athletes, compared with athletes of the category 1 at 4 (p >0.05) and 5 (p >0.05) minutes, respectively. According to the indicators of autonomic regulation of heart rhythm, activation of the parasympathetic link prevails in athletes of the category 1 in comparison with qualified athletes activation (according to high-frequency component, p <0.05). Significantly higher rates of individual parts of the body compared to low-skilled athletes were found out: the hormonal system (the indicator responsible for the hormonal part of the body – very low-frequency component) and the nervous system (indicators of the sympathetic nervous system – low frequency component). There are significantly higher values of the magnitude of the heart rate spectrum and high-frequency component at p <0.05, which indicates a higher power of all units of the parasympathetic regulation in the category 1 in relation to masters of sports and candidates masters of sports. Conclusion. Systematic physical activity causes a significant restructuring of the cardiovascular system and leads to morphofunctional changes in the mechanisms of the heart. Depending on the autonomic regulation of heart rhythm, there are different ways of myocardial adaptation processes. The balance of sympathetic and parasympathetic links of autonomic rhythm regulation is reflected in the activation of the left ventricle. The analysis showed that the spectral characteristics of heart rate variability significantly differ between groups of athletes with different dominance that are observed only in terms of high-frequency component, which in turn led to a change in the sympathetic-vagal balance

Formation of pathology of internal organs in miners with vibration disease

2020 ◽  
pp. 399-403
Author(s):  
O. Yu. Korotenko ◽  
N. I. Panev ◽  
Yu. S. Korchagina ◽  
R. N. Panev ◽  
I. P. Danilov
Keyword(s):  
Cardiovascular System ◽  
Kidney Diseases ◽  
Coal Industry ◽  
Control Group ◽  
Internal Organs ◽  
Local Vibration ◽  
Vibration Disease ◽  
Long Time ◽  
Somatic Diseases ◽  
Medical Examinations

Introduction. Adverse working conditions can contribute to the development of not only occupational pathology, but also diseases with complex multifactorial etiology, such as hypertension, coronary heart disease, disorders of the musculoskeletal system, chronic non-specifi c respiratory diseases, as well as the formation of combined pathology, which worsens the course of these diseases and leads to the development of complications.The aim of the study is to study the manifestations of somatic pathology in coal industry workers with vibration disease.Materials and methods. We examined 144 coal mine workers with vibration disease caused by local vibration, and 161 control group miners who have been working in contact with local vibration for a long time (15 years or more) and do not have professional pathology.It was found that employees of coal mines with vibration disease more often (70,8%) than workers of the control group (27,3%) (p<0,001), there is a pathology of internal organs: diseases of the cardiovascular system (mainly arterial hypertension), diseases of the digestive system (functional disorders of the biliary tract and non-alcoholic fatt y liver disease), kidney diseases (mainly chronic pyelonephritis), as well as a combination of these diseases. With a more severe course of vibration disease (II degree), pathology of internal organs is more common (81.2%) than in patients with vibration disease of I degree (46.5%) (p<0.001). Conclusions. In miners with vibration disease, more oft en than in the control group, there is a pathology of internal organs: the cardiovascular system, digestive organs, kidneys, as well as a combination of several somatic diseases. In individuals with grade II vibration disease, internal organ pathology is more common than in patients with grade I vibration disease. Th e results obtained should be considered when developing treatment and rehabilitation measures for medical examinations and conducting preventive medical examinations of coal industry workers. 

Vibration disease: quality of life

2020 ◽  
pp. 24-31
Author(s):  
Sergey Babanov ◽  
Nataliya Tatarovskaya
Keyword(s):  
Quality Of Life ◽  
Physical Functioning ◽  
The Body ◽  
Systemic Effects ◽  
Local Vibration ◽  
Vibration Disease ◽  
Sf 36 ◽  
The Impact

The article presents data on the impact of vibration disease on the quality of life of patients. The main changes in the quality of life parameters of patients based on the results of the study using the SF-36 questionnaire are described. The quality of life of patients with various types of vibration disease is compared. It is established that industrial vibration (both General and local) in addition to the classical changes characteristic of vibration disease from exposure to local vibration (WBL), vibration disease from exposure to vibration (VBOW) first and second degrees (vascular, neurological) substantially violates the quality of life of patients, with the most pronounced changes are characteristic for WBOW, which confirms the systemic effects of vibration and its effects on the body working. The quality of life of sick WIDOWS is significantly reduced, although significant differences are observed only on the scales of «physical functioning» and «physical component of health».

scholarly journals Effect suppresive therapy with levothyroxine on the state of the cardiovascular and sympathoadrenal systems

2019 ◽  
Vol 63 (2) ◽  
pp. 207-215
Author(s):  
T. A. Mityukova ◽  
T. A. Leonova ◽  
S. B. Kohan ◽  
A. A. Sivakov ◽  
O. E. Polulyach
Keyword(s):  
Heart Rate ◽  
Thyroid Cancer ◽  
Cardiovascular System ◽  
Young Patients ◽  
Sharp Decrease ◽  
The State ◽  
The Body ◽  
Suppressive Therapy ◽  
Subclinical Hyperthyroidism ◽  
Sympathoadrenal System

Thyroid hormones can affect the cardiovascular system directly by binding to nuclear thyroid receptors, as well as indirectly by changing the neuro – humoral status of the body as a whole. The aim of the work was to assess the effect of levothyroxine suppressive therapy on the regulation of the heart rate and activity of the sympathoadrenal system, as well as the level of cortisol in the blood of young patients with thyroid cancer. It is shown that the effect of suppressive therapy with levothyroxine on the state of the cardiovascular system is manifested in an increase in the risk of tachycardia and changes in heart rate variability associated with the body mass index. Patients with thyroid cancer had a sharp decrease in normetanephrine (norepinephrine metabolite) in the urine. The levels of metanephrine (metabolite of adrenaline) and dopamine in the urine was dependent on the tonus of the autonomic nervous system and blood pressure. The revealed shifts indicate that against the background of subclinical hyperthyroidism, the mechanisms aimed at stabilizing the heart rate and preventing the effects of hyperstimulation of thyroid and beta-adrenoreceptors of the myocardium are included.

scholarly journals Vibration disease: hygienic and medical aspects

2019 ◽  
Vol 95 (12) ◽  
pp. 1180-1183 ◽  
Author(s):  
Dina V. Rusanova ◽  
M. V. Kuleshova ◽  
E. V. Katamanova ◽  
N. V. Kartapoltseva ◽  
V. A. Pankov ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Working Conditions ◽  
Magnetic Stimulation ◽  
Auditory Evoked Potentials ◽  
The State ◽  
Morbidity Rate ◽  
Conduction Time ◽  
Subcortical Structures ◽  
Local Vibration ◽  
Vibration Disease

The hygienic assessment of working conditions of employees exposed to local vibration established that working conditions for employees ofvibration dangerous occupations at the aircraft plant according to the degree from a health standpoint and hazard are referred to the fourth (dangerous) class of the degree of danger that stipulates stable high levels of the morbidity rate. The leading factor is a local vibration that results in the consistently high levels of occupational morbidity rate. There was shown the efficiency of the use of the pulsed magnetic stimulation in the treatment ofpatients with vibration disease associated with the exposure to local vibration. For the evaluation of the effectiveness of treatment in patients the condition of the central nervous system was determined with the use of computer electroencephalography with the registration of visual and auditory evoked potentials and somatosensory evoked potentials; there was studied the state of the peripheral nerves in arms and legs relying upom electromyographic data; there was performed psychological study. After the performance of pulse magnetic stimulation in patients diagnosed to have the vibration diseases there were observed the improvement in the interaction of cortical-subcortical structures and associative areas of the frontal and temporal lobes of the brain. After treatment there was noted the shortening of the time of the conduction of the afferent wave of the excitation at the level of the cervical spinal cord, subcortical structures and the central conduction time. There was restored previously reduced the speed of the conduction of the impulse via the distal parts of the tibial and median nerve, through the ulnar nerve in the area of the elbow joint. There was noted the rise in the average temperature on the hands; the decline of thresholds of vibration and pain sensitivity; the improvement of indices characterizing of the state of mnestic- attentional and psycho-emotional scope of activity.

Physiological and hygienic assessment of work of nurses of children’s resuscitation

2020 ◽  
pp. 794-795 ◽  
Author(s):  
A. Yu. Forverts ◽  
K. T. Oniani ◽  
A. V. Zaitseva
Keyword(s):  
Cardiovascular System ◽  
Working Conditions ◽  
The State ◽  
The Body ◽  
Work Shift ◽  
Dynamic Work ◽  
Shift Analysis

Investigated the working conditions of nursesn children’s resuscitationon the basis of professiographic the results of timekeeping observations. An assessment of the state of the cardiovascular system of nurses in a dynamic work shift. Analysis of indicators of the cardiovascular system revealed high values of dBP and sBP exceeding the physiological norms of the working voltage of the body by the end of the work shift.

Characteristics of the level of somatic health and biological age of persons with neuro-stressful professional activity

2019 ◽  
pp. 297-302
Author(s):  
Michail P. Bush ◽  
Marina P. Diakovich
Keyword(s):  
Cardiovascular System ◽  
Police Officers ◽  
Blood Circulation ◽  
Cardiac Activity ◽  
The State ◽  
The Body ◽  
Biological Age ◽  
Static Balancing ◽  
Somatic Health ◽  
The Impact

Introduction. Unfavorable tendencies in the health of the working population, especially those with high neuro-emotional stress in professional activities, the scarcity of information about the impact of professional factors on the health and performance of police officers, which is characterized by nervous and hard work, determine the relevance of this study.The aim of the study is to study the biological age with an assessment of the rate of aging of individual body systems and the level of somatic health of police officers.Materials and methods. We examined 110 men — police officers. Biological age was determined by an automated expert system of diagnostics of aging by the method of A.A. Podkolzin, V.N. Crutko. To quantify the level of somatic health the method of G.L. Apanasenko was used. We used clinical, physiological and computational methods to study the state of the cardiovascular and respiratory systems, static balancing, interviewing methods and mathematical statistics.Results. The accelerated rate of aging was revealed in 65.4% of the examined patients. Accelerated aging of the neuropsychic, respiratory and cardiovascular systems was the most common (97.3%, 94.6% and 75.5%, respectively). A decrease in functional activity of blood circulation was revealed in 70.9%. The coefficients of endurance of cardiac activity and efficiency of blood circulation exceeded the norm, which indicates a possible weakening of the activity and the state of fatigue of the cardiovascular system, myocardial weakness. The ratio of pulse wave velocity in the vessels of muscular and elastic types below the norm was determined in 40.9% of the surveyed, which may indicate the presence of transitional and late-stage hypertension, 62.2% of such persons have an accelerated type of aging of the cardiovascular system. The proportion of persons with accelerated type of aging of the respiratory system significantly (p<0.05) exceeded the proportion of persons with normal and delayed type of aging. The proportion of persons with an accelerated rate of aging was significantly higher in persons with a duration of static balancing below the standard (79.1% [71.5–86.7] versus 20.9% [13.3–28.5], p=0.009).Conclusions. Accelerated rates of aging of cardiovascular, respiratory and neuropsychic systems, low functionality of the body can be regarded as a manifestation of occupational stress. The discrepancy between the subjective assessment of their health and objective indicators of the rate of aging, the level of somatic health can be caused by the socio-psychological characteristics of the service and the tightening of medical requirements for police officers.

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