scholarly journals Collagen role in the mechanisms of chronic wounds healing diabetic foot syndrome.

2018 ◽  
Vol 96 (2) ◽  
pp. 106-115 ◽  
Author(s):  
Ekaterina V. Silina ◽  
V. A. Stupin ◽  
R. B. Gabitov
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
World Literature ◽  
Chronic Wounds ◽  
Diabetic Foot Syndrome ◽  
Medical Products ◽  
The World ◽  
Native Collagen ◽  
Different Types

The review of the world literature, is devoted to the role of collagen in the process of wound healing. The problems of epidemiology of chronic wounds and ulcers of various genesis, physiology and pathophysiology of wound healing phases are considered. The pathogeneticrole of different types of collagen, as well as the mechanisms of collagen, macrophage, fibroblasts, matrix metalloproteinases and other cytokines in healing ulcers are discussed. The prospects of development and use of medical products and preparations based on collagen in the treatment of patients with chronic wounds and ulcers are shown. The results of clinical studies on the effectiveness of collagen with preserved (native) and unsaved (fractionated) structure are presented. The advantages of using native collagen in the treatment of diabetic foot syndrome are demonstrated.

scholarly journals Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

2018 ◽  
Vol 19 (4) ◽  
pp. 373-382 ◽  
Author(s):  
Victor Alexandrovich Stupin ◽  
Ruslan Borisovich Gabitov ◽  
Tatiana Georgievna Sinelnikova ◽  
Ekaterina Vladimirovna Silina
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
World Literature ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Treatment Algorithm ◽  
Diabetic Foot Syndrome ◽  
Results Of Treatment ◽  
Native Collagen ◽  
Chronic Ulcers

Abstract The treatment of chronic wounds is a continuously developing research focus. The problems of excessive mechanical forces, infection, inflammation, reduced production of growth factors, and lack of collagen will affect the results of treatment. The purpose of this study was to analysse the elements that lead to long-term non-healing of chronic wounds and trophic ulcers, including diabetic foot syndrome, by determining the optimal treatment algorithm. The paper presents an analysis of the world literature on the etiopathogenesis and principles of chronic wound treatment in diabetic foot syndrome. The epidemiology of chronic wounds of different genesis is presented. The issues of physiological and metabolic disorders in chronic ulcers affecting the process of wound healing are discussed. Particular attention is paid to collagen, which is a protein that forms the basis of connective tissue; collagen ensures the strength and elasticity of the skin, which confirms the importance of its role not only in aesthetics but also in the process of wound healing. Different types of collagen and their roles in the mechanisms of chronic wound healing in diabetic foot syndrome are described. The results of clinical studies evaluating the effectiveness of medical products and preparations, consisting of collagen with preserved (native collagen) and fractionated structures, in treating chronic wounds of diabetic foot syndrome are analysed. It has been shown that the use of native collagen preparations is a promising treatment for chronic ulcers and wounds, including diabetic foot syndrome, which makes it possible to increase the effectiveness of treatment and reduce the economic costs of managing these patients.

scholarly journals Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers

Medicina ◽  
2021 ◽  
Vol 57 (9) ◽  
pp. 917
Author(s):  
Robert G. Frykberg
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Clinical Studies ◽  
Oxygen Therapy ◽  
Chronic Wounds ◽  
Supplemental Oxygen ◽  
Foot Ulcers ◽  
Critical Threshold ◽  
Diabetic Foot Ulcers

Oxygen is a critical component of many biological processes and is essential for wound healing. Chronic wounds are typically characterized as being hypoxic in that the partial pressure of oxygen (pO2) in the center of the wound is often below a critical threshold necessary to fully support those enzymatic processes necessary for tissue repair. Providing supplemental oxygen can effectively raise pO2 levels to better optimize functioning of these essential enzymes. While hyperbaric oxygen therapy has been well studied in this regard, comparative clinical studies have fallen short of providing clear evidence in support of this modality for healing chronic diabetic foot ulcers (DFU). Topical oxygen therapy (TOT) has been in clinical use for over 50 years with encouraging pre-clinical and clinical studies that have shown improved healing rates when compared to standard care. Nonetheless, TOT has heretofore been discounted as an unproven wound healing modality without theoretical or clinical evidence to support its use. This review shall provide a brief summary of the role of oxygen in wound healing and, specifically, discuss the different types of topical oxygen devices and associated studies that have convincingly shown their efficacy in healing chronic DFUs. The time has come for topical oxygen therapy to be embraced as a proven adjunctive modality in this regard.

scholarly journals THE EFFICACY OF HONEY AS AN ALTERNATIVE TO STANDARD ANTISEPTIC CARE IN THE TREATMENT OF CHRONIC PRESSURE ULCERS AND DIABETIC FOOT ULCERS IN ADULTS

2021 ◽  
pp. 37-47
Author(s):  
GF PEREIRA ◽  
M BALMITH ◽  
M NELL
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Bacterial Infections ◽  
Chronic Wounds ◽  
Pressure Ulcers ◽  
Keyword Search ◽  
Selection Process ◽  
Foot Ulcers ◽  
Published Data ◽  
Diabetic Foot Ulcers

Objective: A chronic wound fails to progress through the phases of wound healing in an orderly and appropriate process, and poses a major challenge to wound care professionals. Pressure ulcers (PUs) and diabetic foot ulcers (DFUs) are classified as chronic wounds. Antiseptics, such as povidone-iodine (PVP-I), are often used to treat bacterial infections in chronic wounds; however, their efficacy and ability to accelerate wound healing has come into question. As a result, current medical research is now focusing on alternative and natural antiseptic agents, such as honey, for the treatment of chronic wounds. The aim of this study was to analyze the wound healing effects of honey in PU and DFU treatment in comparison to standard antiseptic care. Methods: A systematic literature search of PubMed, ScienceDirect, and ClinicalKey was conducted to identify all published data of clinical trials and narrative reviews that investigated or reported the use of honey and standard antiseptics in the treatment of PUs and DFUs in adults. A keyword search was then performed using the following keywords: “PUs”, “DFUs”, “antiseptics”, “PVP-I”, “honey”, “Manuka honey (MH)”, and “wound healing”. Database restrictions were implemented based on the inclusion and exclusion criteria, notably the report’s availability, completion status and language, the sample populations’ age, as well as, the date of publication. A preferred reporting item for systematic review and meta-analysis (preferred reporting items for systematic reviews and meta-analyzes) diagram was constructed illustrating the study selection process. The eligibility of articles was assessed by the screening of titles, abstracts and full texts. A total of 12 articles were included in this study comprising of 775 patients with PUs, DFUs or a combination of PUs and DFUs. Results: Results indicated that honey reduced bacterial infection, reduced pain and edema experienced by patients, reduced the odor of the wound and promoted wound healing in the treatment of chronic ulcers. Honey was also found to be effective in the process of debridement and exudate removal. Conclusion: Honey was found to be highly effective in the treatment of PUs and DFUs and should be considered as an alternative to standard antiseptic care in the treatment of chronic wounds. However, the literature in this study is limited and so further research into honey and its antiseptic-promoting activity in wound healing is recommended.

scholarly journals The Regenerative Potential of Substance P

2022 ◽  
Vol 23 (2) ◽  
pp. 750
Author(s):  
Patrycja Redkiewicz
Keyword(s):  
Wound Healing ◽  
Substance P ◽  
Autoimmune Diseases ◽  
Chronic Wounds ◽  
Different Types ◽  
Healing Wounds ◽  
Active Substances

Wound healing is a highly coordinated process which leads to the repair and regeneration of damaged tissue. Still, numerous diseases such as diabetes, venous insufficiencies or autoimmune diseases could disturb proper wound healing and lead to chronic and non-healing wounds, which are still a great challenge for medicine. For many years, research has been carried out on finding new therapeutics which improve the healing of chronic wounds. One of the most extensively studied active substances that has been widely tested in the treatment of different types of wounds was Substance P (SP). SP is one of the main neuropeptides released by nervous fibers in responses to injury. This review provides a thorough overview of the application of SP in different types of wound models and assesses its efficacy in wound healing.

scholarly journals The use of the VersaJet hydrosurgical system in patients with diabetic foot syndrome

2010 ◽  
Vol 13 (3) ◽  
pp. 121-126
Author(s):  
Lyudmila Petrovna Doronina ◽  
Valeriy Afanas'evich Mitish ◽  
Gagik Radikovich Galstyan
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Treatment Duration ◽  
Diabetic Foot Syndrome ◽  
Adequate Treatment ◽  
Technical Problems ◽  
Medical Aid ◽  
Foot Lesions ◽  
Multifactor Approach

The management of chronic lesions in DM patients implies a multifactor approach, its important component being the adequate treatment of thewound bed. The new hydrosurgical technology for the purpose based on the VersaJet system poses a number of technical problems and requires assessmentof its applicability and efficiency in patients with different forms of diabetic foot syndrome. Results of the work with this system (62 patients)revealed its advantages, such as reduction of treatment duration and the number of repeat treatments, higher probability of wound healing at sitesdifficult to access (heel, tendon projection regions, etc.). It is concluded that the VersaJet system may be recommended for the use in surgical departmentsproviding specialized medical aid to patients with DM and pyonecrotic foot lesions.

Between Isolation and Assimilation

2021 ◽  
pp. 1-15
Author(s):  
Nick Williams
Keyword(s):  
Economic Activity ◽  
Institutional Environment ◽  
Home Country ◽  
Negative Impact ◽  
Policy Actors ◽  
The World ◽  
Different Types ◽  
Negative Perceptions ◽  
At Home

The chapter introduces key debates related to the role of the diaspora in their home economies, particularly the role that they can play as returnee entrepreneurs. With increased movements of people around the world, the role of transnational economic activity is becoming ever more significant. The chapter shows that the diaspora can be caught between isolation and assimilation. They can be isolated because of their years living abroad, as well as their negative perceptions of the institutional environment at home. Yet many of them also wish to become more assimilated and have an emotional desire to help their home country. Many stay away and do not invest. Those who return later can seek to avoid the negative impact of barriers to entrepreneurship, and can for example avoid government engagement activities as they mistrust policy actors’ intentions. The chapter sets out the implications of these different types of engagement for homeland economies.

scholarly journals Role of infection in wound healing

2020 ◽  
Vol 19 (4) ◽  
pp. 598-602
Author(s):  
Malik Asif Hussain ◽  
Flavia Huygens
Keyword(s):  
Wound Healing ◽  
Pathogenic Bacteria ◽  
Chronic Wounds ◽  
Medical Science ◽  
Vascular Diseases ◽  
Research Papers ◽  
Patients With Diabetes ◽  
Research Findings ◽  
The Impact

Chronic wounds, particularly infected wounds are clinically very important due to their significant impact on health budgets as well as patients` health worldwide. Patients with diabetes mellitus, vascular diseases especially peripheral vascular disease and pressure ulcers are major categories of patients presenting with chronic wounds. It is known that there are multiple factors determining chronic wound prognosis. The presence of multiple types of pathogenic bacteria, with specific virulence and adherent (biofilm) properties, contribute a significant role to the development of chronic wounds. This review article is based on the research project entitled” An investigation of the impact of bacterial diversity, pathogenic determinants and biofilms on chronic wounds”. The research findings have been published in form of research papers as well as conference posters. The aim of this article is to highlight various important aspects of bacterial impact on wound healing. Bangladesh Journal of Medical Science Vol.19(4) 2020 p.598-602

From state socialism to capitalism: The role of class and the world system

2006 ◽  
Vol 39 (2) ◽  
pp. 135-152 ◽  
Author(s):  
David Lane
Keyword(s):  
World System ◽  
Political Elite ◽  
Modern World ◽  
State Socialism ◽  
Social Actors ◽  
The World ◽  
Different Types ◽  
Transition To Capitalism ◽  
State Socialist

While theories of global capitalism have added a new dimension to our understanding of the dynamics of the modern world, a ‘globalisation’ approach to the transformation of the state socialist societies is relatively underdeveloped. This paper studies the role of international and global factors under state socialism and the world system in the pre-1989 period. The paper considers traditional Marxist approaches to the transition to capitalism and criticises the model of state capitalism as well as the world system approach. In contrast, social actors (the ‘acquisition’ and ‘administrative’ social strata and the global political elite)are identified as playing a major role in the fall of state socialism, and were a nascent capitalist class. The transformation of state socialism, it is contended, had the character of a revolution rather than a shift between different types of capitalism.

scholarly journals Translation Policies in Legal and Institutional Settings

2021 ◽  
Keyword(s):  
State Of The Art ◽  
Minority Rights ◽  
Institutional Settings ◽  
Linguistic Justice ◽  
The Everyday ◽  
The World ◽  
Different Types ◽  
Everyday Interaction ◽  
Multidisciplinary Perspective

Translation Policies in Legal and Institutional Settings documents the state of the art in research on translation policies in legal and institutional settings. Offering case studies of past and present translation policies from several parts of the world, it allows for a compelling comparison of attitudes towards translation in varying contexts. This edited volume highlights the virtues of integrating different types of expertise in the study of translation policy: theoretical and applied, historical and modern, legal, institutional, and political. It effectively illustrates how a multidisciplinary perspective furthers our understanding of translation policies and unveils their intrinsic link with topics such as multilingualism, linguistic justice, minority rights, and citizenship. In this way, each contribution sheds new light on the role of translation in the everyday interaction between governments and multilingual populations.

scholarly journals Sartans and Melanoma: Valsartan Induced Multiple Primary Cutaneous Melanomas: first Description in the Medical Literature!

2020 ◽  
Vol 7 (4) ◽  
pp. 1-3
Author(s):  
Georgi Tchernev ◽  
Gavrail Poterov ◽  
Valeri Malev
Keyword(s):  
Antihypertensive Therapy ◽  
World Literature ◽  
Medical Literature ◽  
Renin Angiotensin System ◽  
Pure Substance ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
The World ◽  
Multiple Primary

The data in the medical literature about the possible development of cutaneous melanoma and dysplastic nevi after therapy with sartans in the world literature are already dozens. The role of the renin angiotensin system in various cancers such as melanoma but breast cancer also seems to be discussed in the past, in the present, but seems to be still the subject of many future discussions, which do not have a definitive solution. We describe the first case of multiple cutaneous melanomas in the world literature, which developed simultaneously after the introduction of systemic antihypertensive therapy with Valsartan. Given the already established role of the renin angiotensin system in melanogenesis, as well as the possibility of promoting carcinogenesis through the practical influence of the “pure substance” of sartans, their widespread use in the treatment of hypertension should be seriously debated. Keywords: Melanoma, Melanogenesis; Antihypertensive Therapy; Valsartan, Sartans; Surgery; Multiple Primary Melanomas

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