scholarly journals CORRECTION OF ALBENDAZOLE DOSAGE AFTER LIVER ECHINOCOCCTOMY

2020 ◽  
Vol 24 (1) ◽  
pp. 16-20
Author(s):  
Azamat M. Shamsiev ◽  
J. A. Shamsiev ◽  
K. E. Rakhmanov
Keyword(s):  
Adverse Reactions ◽  
Liver Enzymes ◽  
Postoperative Chemotherapy ◽  
Medical Institute ◽  
Control Group ◽  
Liver Insufficiency ◽  
Surgical Department ◽  
Experimental Group

Purpose. To improve the quality of treatment of patients with liver echinococcosis by optimizing postoperative chemotherapy. Material and methods. 226 patients with liver echinococcosis were admitted to the surgical department of the 2nd Clinic of the Samarkand State Medical Institute in 2009-2017. Patients were divided into two groups. In 2009-2012, 112 (49.5%) patients were operated on and were included into a control group. In 2013-2017, 114 (50.5%) patients were followed -up and were included into a study group. In the control group, postoperative chemotherapy was made by the standard protocol. In the studied group, Albendazole dosage was corrected according to the initial functional state of the liver. Due to positive findings in the experimental group, Albendazole was used at the dosage 5 mg / kg / day in patients with verified chronic liver disease and if liver enzymes were elevated before surgery. Results. Adverse reactions of Albendazole chemotherapy, by clinical and laboratory parameters, could develop in 52.7% - due to the preparation toxic effect and concomitant chronic diffuse liver pathology- while under dose correction, this figure is reduced to 18.3%. Conclusion. The proposed dose correction in patients with signs of liver insufficiency normalizes biochemical parameters and reduces toxic manifestations during chemotherapy. Of these 144 patients, long-term observations revealed echinococcosis relapse in 6 (4.2%) patients.

scholarly journals Effectiveness of a Sexuality Workshop for Nurse Aides in Long-Term Care Facilities

2021 ◽  
Vol 18 (23) ◽  
pp. 12372
Author(s):  
Man-Hua Yang ◽  
Shu-Ting Yang ◽  
Tze-Fang Wang ◽  
Li-Chun Chang
Keyword(s):  
Long Term Care ◽  
Sexual Life ◽  
Control Group ◽  
Term Care ◽  
Attitudes Toward Elderly ◽  
Care Facilities ◽  
Nurse Aides ◽  
Experimental Group

Background: In long-term care facilities, there are frequent conflicts related to elderly residents’ sexual expression. Nurse aides usually handle such conflicts with negative or negligent attitudes; therefore, elderly sexuality is considered “problem behavior” and is stigmatized. Objectives: This study aimed to improve elderly residents’ quality of sexual life by enhancing nurse aides’ knowledge and attitudes toward elderly sexuality through sexuality workshops. Methods: A quasi-experimental study was conducted with 64 nurse aides and 58 residents, who were divided into two groups, i.e., an experimental group and a control group, according to the floor where the residents resided. The nurse aides in the experimental group participated in sexuality workshops and were compared with those in the control group with respect to their knowledge of and attitudes toward sexuality; the residents’ quality of sexual life was also compared between groups. Results: Compared with the control group, in the experimental group, the nurse aides’ knowledge of and attitudes toward elderly sexuality as well as the residents’ quality of sexual life significantly and continually improved after the sexuality workshops. Conclusion: The four-week sexuality workshop is effective and may be used as an example in developing occupational education programs regarding elderly sexuality in long-term care facilities.

scholarly journals Clinical application effect evaluation of Kanglaite combined with DCF chemotherapy program in patients with gastric cancer

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
Haibin Ding
Keyword(s):  
Quality Of Life ◽  
Gastric Cancer ◽  
Clinical Application ◽  
Adverse Reactions ◽  
Life Quality ◽  
Effective Rate ◽  
Control Group ◽  
Therapeutic Effects ◽  
Experimental Group

Objective: To evaluate the clinical application effect of Kanglaite combined with DCF chemotherapy program in the patients with gastric cancer. Methods: 86 cases who were all the gastric cancer patients admitted to our hospital from February 2014 to June 2016 were selected, according to randomly divided into two groups, control group and experimental group. The control group was treated with DCF treatment, and the experimental group were treated with Kanglaite combined DCF chemotherapy program, and the therapeutic effects, the quality of life of patients and incidence rate of adverse reactions in two groups were observed and compared. Result: Compared with the control group, the total effective rate and the quality of life score of the experimental group were significantly higher, and the incidence of adverse reactions was less (P < 0.05). Conclusion: In clinic, Kanglaitecombined with DCF chemotherapy program on patients with gastric cancer, can improve the treatment effect and life quality of patients, with less adverse reaction and high application value.

scholarly journals Clinical Study for Safety Evaluation of GXN Tablets Combined with Aspirin in Long-Term Treatment of Coronary Heart Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Mingjie Zi ◽  
Ruiqi Li ◽  
Fang Lu ◽  
Qingna Li ◽  
Yang Zhao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Adverse Reactions ◽  
Blood Stasis ◽  
Gastrointestinal Symptoms ◽  
Control Group ◽  
Bleeding Events ◽  
The Difference ◽  
Group 5 ◽  
Experimental Group

Background. GXN tablets are composed of Danshen and Chuanxiong, with the functions of activating blood circulation, removing blood stasis, invigorating the pulse, and nourishing the heart, which are used for CHD patients with stable exertional angina Grade I or II (according to traditional Chinese medicine, it is a syndrome of heart and blood stasis with chest pain and dark purple lips and tongue). Clinical trials have shown satisfactory effects on coronary heart disease (CHD). 90.6% of Chinese patients with CHD use both Western medicine and Chinese medicine with the latter being thought to promote blood circulation and remove blood stasis. Some researchers doubt that the combination of Chinese medicine increases the risk of bleeding. The main objective of this study is to observe the safety of long-term use of Guanxinning (hereafter referred to as GXN) tablets combined with aspirin. Methods. The study population is patients with CHD after percutaneous coronary intervention (PCI). Randomization was performed for patients with stable CHD who received dual antiplatelet therapy (DAPT) with aspirin plus clopidogrel or ticagrelor for more than 12 months and then switched to the treatment with aspirin alone for 1 month. This study includes a total of 3,595 subjects in 63 hospitals. The experimental group took aspirin orally (100 mg, 1 time/day) + GXN tablets (0–6 months: 4 tablets/time, 3 times/day; 7–12 months, 4 tablets/time, 2 times/day), and the control group received oral aspirin (100 mg, 1 time/day). Major observation indicators are the incidence of bleeding events, adverse events (AEs), and adverse reactions. The primary endpoint indicators are the incidence of major adverse cardiovascular and cerebrovascular events (MACCE) and the MACCE composite endpoint. Results. A total of 31 cases of symptomatic bleeding were found in the two groups, including 21 cases (0.98%) in the experimental group and 10 cases (0.86%) in the control group; the difference between the two groups was not statistically significant. There were 29 cases (1.35%) of bleeding not reaching BARC type 1 in the experimental group. No attention was paid to the laboratory indicators in the control group during the trial process, so the bleeding as a laboratory indicator between the two groups was not comparable. For BARC type 3–5 bleeding events, there were 3 cases in the experimental group (0.139%) and 2 cases in the control group (0.172%); the difference between the two groups was not statistically significant and not clinically significant. During the trial period, there were a total of 255 cases of adverse reactions in 208 subjects with an incidence of 6.57% (141/2146) in the experimental group and 5.77% (67/1161) in the control group, and the P value was 0.5021; the difference between the two groups was not statistically significant. According to the analysis, the adverse reactions with a statistically significant difference between the two groups were gastrointestinal diseases, with the incidence in the experimental group being higher than that in the control group, and the main manifestations were gastrointestinal symptoms. There was no statistical difference in other types of adverse reactions between the two groups. In the trial period, there were 10 cases of serious adverse reactions, including 5 cases in the experimental group (5/2146, 0.23%) and 5 cases in the control group (5/ 1161, 0.43%), the P value was 0.3351; the difference in the incidence between the two groups was not statistically significant. Conclusion. For CHD patients with heart-blood stasis syndrome, the combination of aspirin and GXN tablets in the experimental group did not increase the incidence of bleeding events, nor did it increase the risk of bleeding of types 3–5 defined by BARC. Except for the increase in gastrointestinal symptoms, there was no increase in other adverse reactions in the experimental group. This trial is registered with Registration no. ChiCTR-IIR-17010688.

scholarly journals Éber, tudatos figyelemre épülő, a rákbetegséggel való megküzdést segítő program (MBCR) hatásvizsgálata magyar rákbetegek körében

2017 ◽  
Vol 158 (33) ◽  
pp. 1293-1301 ◽  
Author(s):  
Magda Rohánszky ◽  
Károly Berényi ◽  
Dóra Fridrik ◽  
Henriette Pusztafalvi
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Life Quality ◽  
Two Dimensions ◽  
Control Group ◽  
Psychological Variables ◽  
Stress Symptoms ◽  
Experimental Group

Abstract: Introduction and aim: Employment of mindfulness-based programs and techniques in the treatment of cancer patients have spread exponentially in the past decade. A large number of studies have proved the effectiveness of the program in the reduction of stress symptoms, depression and anxiety, and the improvement of sleep and mood patterns. The present study was done at Firebird Foundation and examines the effectiveness of the complex, MBCR (mindfulness-based cancer recovery)-based psycho-social intervention in the treatment of cancer patients. Method: The experimental group consisted of 101 people with various types and states of cancer. The control group consisted of 72 adjusted people. We did measurements (PPS, HADS, FACT-G, POMS-SF, Freiburg Adaptation Questionnaire) before the intervention (T1), right after the 8-week intervention (T2), and 6 months after the intervention (T3). Results: The experimental group showed significant improvement in the measured psychological variables, and in few aspects of life quality between T1 and T2. There was a decrease in levels of observed stress and depression, and an escalation in optimism and vitality. We found a decrease in depressive and minimizing coping scores as well. There was a significant improvement in two dimensions of quality of life, and all these positive changes remained present by the end of the follow-up period (T3). In the control group, we only found a significant increase in minimizing coping scores at the time of T3 measurements. This is the first impact assessment study done on cancer patients using MBCR techniques in Hungary. Conclusions: The MBCR program is a very effective psychosocial intervention among cancer patients; it has a long term significant impact on mood and quality of life. Orv Hetil. 2017; 158(33): 1293–1301.

scholarly journals Influence of Standardized Nursing Management of Hospital Based on Smart Electronic Medical Blockchain on Nursing Quality of Digestive Endoscopy Room

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Yufen Niu
Keyword(s):  
Nursing Staff ◽  
Adverse Reactions ◽  
Management Mode ◽  
Control Group ◽  
Digestive Endoscopy ◽  
Nursing Management ◽  
Nursing Satisfaction ◽  
Nursing Quality ◽  
Experimental Group

With the increase of the incidence rate of digestive system diseases, digestive endoscopy has become an essential measure. The nursing quality of digestive endoscopy room will have a direct impact on the examination results and treatment effect, so improving the nursing quality of digestive endoscopy room has always been the focus of attention. In this paper, the smart electronic medical blockchain technology and hospital standardized nursing management mode are combined to develop the smart medical standardized nursing management mode. Firstly, 88 patients with digestive endoscopy in a hospital from October 2018 to October 2019 were selected as the experimental subjects: 44 cases in the control group and 44 cases in the experimental group. The control group implemented the traditional management mode of digestive endoscopy room, and the experimental group implemented the standardized nursing management mode of smart medicine. The blood pressure level before and after nursing and the probability of adverse reactions in the process of nursing were counted. After nursing, the patients were asked to fill in the nursing satisfaction questionnaire, evaluate the nursing quality of nursing staff, and make statistics and comparison on the occurrence of safety events in digestive endoscopy room. After nursing, the systolic pressure drop of the experimental group was 125.36 ± 7.27 mmhg, diastolic pressure drop was 73.24 ± 4.21 mmhg, and the incidence of adverse reactions was 11.36%. The satisfaction rate of the experimental group was 15%, 29.55%, and 22.73% higher than that of the control group. The average scores of nursing skills, operation level, and examination results of nursing staff in the experimental group were 94.49, 95.12, and 95.89, respectively; the qualified rate of disinfection of digestive endoscopy room in the experimental group was 100%, the degree of cooperation between doctors and nurses was 100%, the timely rate of emergency measures was 95.45%, and the incidence of accidents was 0%. This shows that, under the standardized nursing of smart medicine, the blood pressure of patients is more stable, the incidence of adverse reactions is lower, the nursing satisfaction is higher, and the nursing quality of nursing staff and the safety of digestive endoscopy room are also improved.

scholarly journals Effect of Cinepazide Maleate Combined with Promethazine Hydrochloride in the Treatment of Emergency Vertigo

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Jun Yi ◽  
Yincai Zhou ◽  
Xinghao Cheng
Keyword(s):  
Quality Of Life ◽  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Symptom Relief ◽  
Effective Rate ◽  
Control Group ◽  
Combined Application ◽  
Promethazine Hydrochloride ◽  
Experimental Group

Objective: To explore the effect of cinepazide maleate combined with promethazine hydrochloride in the treatment of emergency vertigo. Methods: 48 cases of emergency vertigo patients in our hospital from November 2017 to November 2019 were divided into experimental group (24 cases, treated with cinepazide maleate combined with promethazine hydrochloride) and control group (24 cases, treated with cinepazide maleate). The clinical efficacy, symptom relief time, adverse reactions and quality of life were compared. Results: The total effective rate of the experimental group (95.83%, 23 / 24) was higher than that of the control group (75.00%), The remission time of nausea and vomiting (1.75 ± 0.22) d, vertigo (3.54 ± 0.63) d, deafness and tinnitus (3.47 ± 0.58) d, night sweats (3.05 ± 0.33) d in the experimental group were shorter than those in the control group, P < 0.05; the incidence of adverse reactions in the experimental group (8.33%, 2 / 24) was lower than that in the control group (33.33%, The scores of social function, material life attitude, physical health and psychological function in the experimental group were 59.14 ± 7.23, 54.05 ± 8.04, 53.58 ± 8.86 and 60.11 ± 8.44 respectively, P < 0.05. Conclusion: In the process of clinical treatment of emergency vertigo patients, the combined application of cinepazide maleate and promethazine hydrochloride has definite curative effect, can relieve clinical symptoms in a short time, has less adverse reactions, and improves the quality of life of patients to a certain extent, which is worthy of promotion.

The Implementation of Learning Materials Based on Local Wisdom of Agricultural in Binjai to Improve the Students Problem Solving Abilities

2019 ◽  
Author(s):  
Nur Tsalits Fahman Mughni
Keyword(s):  
Problem Solving ◽  
Control Group ◽  
School Grade ◽  
Teaching Materials ◽  
Quasi Experimental ◽  
Equivalent Control ◽  
The Subject ◽  
And Control ◽  
Experimental Group

Teaching materials by integrating local culture makes easier for students to understand the subject matter in the learning process. The aims of the study is to measure the effectiveness of teaching materials based on local wisdom of agriculture in Binjai in improving the students problem solving abilities. The research method was a quasi experimental which use non equivalent control group in the pretest posttest design. The sample of study were students of Senior High School grade X in Binjai that consisted of experiment group which used teaching materials based on local wisdom of agriculture in Binjai and control group that used student handbooks. Teaching materials are tested by material experts and technology experts to ensure the quality of teaching materials. Data collection was conducted through test. The results showed that the teaching materials based on local wisdom of agriculture in Binjai effective in improving students problem solving abilities in the experimental group students based on the results of N gain value was 0.67 which has medium criteria. It means teaching materials based on agricultural local wisdom of agriculture in Binjai can be used as one of the teaching materials in learning activities.

The use of poly additive Nabicat in the feeding of laying hens

2020 ◽  
pp. 44-55
Author(s):  
S. Nikolaev ◽  
L. Andreenko
Keyword(s):  
Laying Hens ◽  
Optimal Dose ◽  
Control Group ◽  
Nutrient Metabolism ◽  
Volgograd Region ◽  
Mineral Components ◽  
Environmentally Safe ◽  
Experimental Group ◽  
Poultry Farming

In modern poultry farming the most urgent tasks are to search for and test new environmentally safe feed and economically justifi ed additives that stimulate productivity, positively aff ect the health of poultry, and consequently increase the livability of livestock and other important zootechnical traits. In order to maintain physiologically normal processes of life, metabolism and increase the level of productivity of poultry it needs mineral components and their chelated compounds. The purpose of this work was to increase the egg productivity of poultry by using the silicon-containing poly additive Nabicat in feeding young hens and laying hens. The researches have been carried out on the poultry cross Highsex Brown under the environments in CJSC “Poultry Farm “Volzhskaya” in the Sredneakhtubinsky area in the Volgograd region. In this paper, The optimal dose of the introduction of the silicon-containing poly additive Nabicat in the diets of young and laying hens of the cross Highsex Brown has been scientifi cally justifi ed and the biological value of using an organic form of silicon has been determined. The positive infl uence of the optimal dose of poly additive on growth, consumption, and digestibility, nutrient metabolism in the poultry body, as well as egg productivity and quality of the resulting egg has been revealed. Thus, the average egg productivity per 1 hen in the control group during the experiment period was 321,3 pcs., and in the 1st, 2nd and 3rd experimental groups it was 322,6 pcs., 325,8 and 325,7 pcs., which was higher than in the control group by 0,40 %, 1,40 and 1,37 %, respectively. The average egg weight in the 1st experimental group exceeded the control by 0,43 g or 0,68 %, in the 2nd experimental group by 1,16 g or 1,84 %, in the 3rd experimental group by 0,81 g or 1,28 %. The economic eff ectiveness of using the organic silicon additive in the composition of Nabicat poly additive in the feeding of laying hens has been proved. The economic eff ect due to the use of diff erent doses of the introduction of silicon-containing poly additive Nabicat in compound feed for laying hens of the 1st experimental group was 141,66 rubles, the 2nd experimental group 962,76 rubles, and the 3rd experimental group 821,89 rubles.

Effectiveness of mobile applications on healthy lifestyles aimed at diabetic patients: review of systematic reviews. (Preprint)

2019 ◽  
Author(s):  
Francisco Jesús Represas Carrera Sr ◽  
Ángel Alfredo Martínez Ques Sr ◽  
Ana Clavería Fontán Sr
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Systematic Reviews ◽  
Mobile Applications ◽  
Control Group ◽  
Diabetic Patients ◽  
Healthy Lifestyles ◽  
Major Public Health Problem

BACKGROUND Diabetes mellitus is currently a major public health problem worldwide. It is traditionally approached in a clinical inpatient relationship between the patient and the healthcare professional. However, the rise of new technologies, particularly mobile applications, is revolutionizing the traditional healthcare model through the introduction of telehealthcare. OBJECTIVE (1) To assess the effects of mobile applications for improving healthy lifestyles on the quality of life and metabolic control of diabetes mellitus in adult patients. (2) To describe the characteristics of the mobile applications used, identify the healthy lifestyles they target, and describe any adverse effects their use may have. METHODS Review of systematic reviews and meta-analysis, following the guidelines of the Cochrane Collaboration and the Joanna Briggs Institute. We included studies that used any mobile application aimed at helping patients improve self-management of diabetes mellitus by focusing on healthy lifestyles. Studies needed to include a control group receiving regular care without the use of mobile devices. In May 2018, a search was conducted in Medline, Embase, Cochrane, LILACS, PsychINFO, Cinahl and Science Direct, updated in May 2019. The methodological quality of the studies was assessed using the Amstar-2 tool. RESULTS Seven systematic reviews of 798 articles were initially selected for analysis. The interventions had a duration of between 1 and 12 months. Mobile applications focused singly or simultaneously on different lifestyles aspects (diet, physical exercise, motivation, blood glucose levels, etc.). There are significant changes in HbA1c values, body weight and BMI, although in others, such as lipid profile, quality of life, or blood pressure, there is no clear improvement. CONCLUSIONS There is clear evidence that the use of mobile applications improves glycemic control in diabetic patients in the short term. There is a lack of evidence in its long-term benefits. It is thus necessary to carry out further studies to learn about the long-term effectiveness of mobile applications aimed at promoting the healthy lifestyles of diabetic patients. CLINICALTRIAL PROSPERO Register: CRD42019133685

scholarly journals Effects of a positive thinking program on hope and sleep quality in Iranian patients with thalassemia: a randomized clinical trial

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Somayeh Makaremnia ◽  
Marieh Dehghan Manshadi ◽  
Zahra Khademian
Keyword(s):  
Clinical Trial ◽  
Sleep Quality ◽  
Training Program ◽  
Randomized Clinical Trial ◽  
Thalassemia Major ◽  
Trial Registration ◽  
Control Group ◽  
Positive Thinking ◽  
Experimental Group

Abstract Background Thalassemia have a negative impact on the patients' psychological health and sleep quality. This study aimed to determine the effects of a positive thinking training program on hope and sleep quality of patients with thalassemia major. Methods This randomized clinical trial was conducted on 78 patients with thalassemia major including 36 males (46.2%) and 42 females (53.8%) with a mean age of 25.56 ± 29.6 in Iran. Subjects were randomly assigned into experimental and control groups. Experimental group received 16 h training based on positive thinking materials published by Martin Seligman. Control group received only usual programs. Data were collected at baseline, as well as immediately and one month after the intervention, using Snyder’s Hope Scale and the Pittsburgh Sleep Quality Index. Data analysis was performed using SPSS Software 18.0; statistical tests included the independent T-test, the Chi-square, Mann Whitney, and Friedman test. Significance level was set at 0.05 in this study. Results The experimental group had a significantly higher mean hope score compared to the control group immediately (45.38 ± 7.82 vs. 35.32 ± 5.54, P < 0.001) and one month following intervention (44.67 ± 3.47 vs. 35 ± .54, P < 0.001). Moreover, the mean sleep quality scores of the experimental group was significantly greater than that for control group immediately (5.35 ± 2.02 vs. 7 ± 2.4, P = 0.004) and one month after the intervention (4.23 ± 2.2 vs.7.02 ± 3.03, P < 0.001). Conclusion Since our training program on positive thinking improved hope and quality of sleep in patients with thalassemia major, we recommend the use of such courses as an important step toward promotion of hope and sleep quality among these patients. Trial registration The name of the registry: Iranian Registry of Clinical Trials. Trial Registration Number: IRCT2017010431774N1. URL of the trial registry record: https://en.irct.ir/trial/24923. Registration Date: 07/03/2017.

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