scholarly journals Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder

2021 ◽  
Author(s):  
İlkay BAHÇECİ ◽  
Umut Serkan SÖZTANACI ◽  
Meltem PUŞUROĞLU ◽  
Nuray ARSLAN ◽  
Ömer Faruk DURAN ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Anxiety Disorder ◽  
General Anxiety Disorder ◽  
General Anxiety ◽  
The Relationship ◽  
And Oxidative Stress

scholarly journals Mental Disorder in Obesity

2021 ◽  
Vol 15 (7) ◽  
pp. 2029-2032
Author(s):  
Mahesa Permana Kardis ◽  
Alifiati Fitrikasari
Keyword(s):  
Anxiety Disorder ◽  
Mental Disorders ◽  
Mental Disorder ◽  
Nuclear Family ◽  
Demographic Characteristics ◽  
Asia Pacific ◽  
Cross Sectional ◽  
General Anxiety Disorder ◽  
General Anxiety ◽  
The Relationship

Background: Obesity is a condition of incompatibility between body weight and height that shows a value above the normal range of body mass index. Obesity has an impact on the individual's psychological developmental processes. Limitations of Research on the relationship between obesity and mental disorders lead researchers to be interested in knowing whether there are incidents and types of mental disorders in obese individuals. Objective: To investigate mental disorders in individual with obesity. Methods: This was an observational and cross-sectional study. A total of 45 respondents who met the inclusion criteria according to WHO Asia Pacific obesity criteria (BMI ≥ 25 Kg/m2) were screened using MINI ICD 10. Statistical analysis using Mann-Whitney Test and Fisher’s Exact Test to determine the relationship of mental disorders incident with the demographic characteristics of respondents. Gamma and Mann-Whitney tests were used to determine the relationship between mental disorders types with the demographic characteristics of respondents. Results: There were eight of 45 respondents experiencing mental disorders. The study found that three respondents were diagnosed with general anxiety disorder, three with depression, one with distimia, and one with mania at past. There was no significant relationship between mental disorders incidents and demographic characteristics. The relationship between types of mental disorders with a history of mental disorders in the nuclear family showed significant results. Conclusion: There were mental disorders in obese individuals. Most mental disorders diagnosis were depression and general anxiety disorder. Keywords: Obesity, Mental disorder

scholarly journals Assessing the Level of Awareness of COVID-19 and Prevalence of General Anxiety Disorder among the Hail Community, Kingdom of Saudi Arabia

2021 ◽  
Vol 18 (13) ◽  
pp. 7035
Author(s):  
Bandar Alsaif ◽  
Najm Eldinn Elsser Elhassan ◽  
Ramaiah Itumalla ◽  
Kamal Elbassir Ali ◽  
Mohamed Ali Alzain
Keyword(s):  
Saudi Arabia ◽  
Anxiety Disorder ◽  
Positive Attitude ◽  
Major Public Health Problem ◽  
Kingdom Of Saudi Arabia ◽  
General Anxiety Disorder ◽  
General Anxiety ◽  
Attitudes And Practices ◽  
Awareness Campaigns ◽  
Positive Attitudes

Background: The COVID-19 pandemic has caused a major public health problem around the world. Therefore, the aim of the study was to assess the awareness and prevalence of General Anxiety Disorder (GAD) with regard to COVID-19 among the Hail community, in the Kingdom of Saudi Arabia, in order to help health authorities to effectively control the pandemic. Methods: A cross-sectional online survey was completed by 412 participants living in Hail, Saudi Arabia. The questionnaire assessed demographic characteristics, knowledge, attitudes, and practices for the prevention of COVID-19, as well as psychological feelings in terms of GAD as an impact of the COVID-19 pandemic. Results: The study found that most of the respondents demonstrated good knowledge, attitudes, and practice for COVID-19 prevention. The elderly and employed demonstrated significant positive attitudes and practices (p < 0.05). Participants with a positive attitude were almost two and a half times (OR = 2.4; 95% CI: 1.54–3.99) more likely to have good practices. Additionally, the rural respondents were less likely (OR = 0.45; 95% CI: 0.21–0.96) to have a positive attitude. Married participants were more than one and a half (OR = 1.60; 95% CI: 1.04–2.44) times more likely to have a positive attitude. The prevalence of GAD was 21.8% and was significantly increased among participants with inadequate knowledge (OR = 2.01; 95% CI: 1.25–3.22), females (OR = 1.92; 95% CI: 1.19–3.09), individuals with chronic diseases (OR = 1.71; 95% CI: 1.02–2.86), and non-Saudi participants (OR = 2.44; 95% CI: 1.02–5.85). Conclusions: Ensuring a sufficient combination of relatively good levels of knowledge, positive attitudes, and desired practices serves as a good approach to preventing the spread of COVID-19. However, the increased prevalence of GAD requires the attention of policymakers. Therefore, a great emphasis should be placed on health awareness campaigns, with a focus on misconceptions and the provision of counseling.

The Association between Oxidative Stress and Cardiac Functions in Infants Born to Preeclamptic Mothers

2018 ◽  
Vol 36 (11) ◽  
pp. 1205-1210
Author(s):  
Didem Arman ◽  
Secil Ercin ◽  
Sevilay Topcuoğlu ◽  
Ayşem Kaya ◽  
Taner Yavuz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Premature Infants ◽  
Stress Index ◽  
Control Group ◽  
Cardiac Functions ◽  
Total Antioxidant ◽  
Echocardiographic Parameters ◽  
Oxidant Status ◽  
The Relationship ◽  
And Oxidative Stress

Objective The present study aimed to assess the global oxidant and antioxidant status in infants born to preeclamptic mothers and their correlation with cardiac functions. Study Design We compared 40 infants born to preeclamptic mothers with 40 premature infants born to normotensive mothers. We assessed the relationship between echocardiographic measurements and total antioxidant capacity (TAC) and total oxidant status (TOS) values. Results In the study group, TAC, TOS, and oxidative stress index (OSI) levels were significantly higher in the cord blood (p = 0.03, 0.04, and 0.039, respectively) than in the control group. We did not observe any correlation between echocardiographic measurements and TAC, TOS, and OSI levels in infants born to preeclamptic mothers. Conclusion Compared with the control group, despite higher TAC levels in infants born to preeclamptic mothers, concurrent elevated OSI levels reveal that the oxidant–antioxidant balance is disturbed in favor of oxidants. Furthermore, the findings of this study suggest that echocardiographic parameters are unaffected by the oxidant status.

Relationship between aldose reductase enzyme and the signaling pathway of protein kinase C in an in vitro diabetic retinopathy model

2020 ◽  
Vol 98 (4) ◽  
pp. 243-251
Author(s):  
Mutlu Sarikaya ◽  
Nuray Yazihan ◽  
Net Daş Evcimen
Keyword(s):  
Oxidative Stress ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Molecular Mechanisms ◽  
Signaling Molecules ◽  
Protein Levels ◽  
Kinase C ◽  
The Relationship ◽  
And Oxidative Stress ◽  
Expression And Activity

Protein kinase C (PKC) and aldose reductase (AR) enzyme activities are increased in diabetes and complications are include retinopathy, nephropathy, and neuropathy. However, the relationship between PKC and AR and the underlying molecular mechanisms is still unclear. We aimed to evaluate the relationship between these two enzymes and clarify the underlying molecular mechanisms by the related signaling molecules. The effects of hyperglycemia and oxidative stress on AR and PKC enzymes and the signaling molecules such as nuclear factor-kappa B (NF-κB), inhibitor kappa B-alpha (IkB-α), total c-Jun, phospho c-Jun, and stress-activated protein kinases (SAPK)/Jun amino-terminal kinases (JNK) were evaluated in human retinal pigment epithelial cells (ARPE-19). AR, PKC protein levels, and related signaling molecules increased with hyperglycemia and oxidative stress. The AR inhibitor sorbinil decreased PKC expression and activity and all signaling molecule protein levels. Increased AR expression during hyperglycemia and oxidative stress was found to be correlated with the increase in PKC expression and activity in both conditions. Decreased expression and activity of PKC and the protein levels of related signaling molecules with the AR inhibitor sorbinil showed that AR enzyme may play a key role in the expression of PKC enzyme and oxidative stress during diabetes.

scholarly journals Relationship Between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

2019 ◽  
Vol 8 (9) ◽  
pp. 1385 ◽  
Author(s):  
Burgos-Morón ◽  
Abad-Jiménez ◽  
Marañón ◽  
Iannantuoni ◽  
Escribano-López ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Er Stress ◽  
Mitochondrial Dysfunction ◽  
Current Knowledge ◽  
Β Cells ◽  
The Relationship ◽  
And Oxidative Stress

Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin resistance in which oxidative stress is thought to be a primary cause. Considering that mitochondria are the main source of ROS, we have set out to provide a general overview on how oxidative stress is generated and related to T2D. Enhanced generation of reactive oxygen species (ROS) and oxidative stress occurs in mitochondria as a consequence of an overload of glucose and oxidative phosphorylation. Endoplasmic reticulum (ER) stress plays an important role in oxidative stress, as it is also a source of ROS. The tight interconnection between both organelles through mitochondrial-associated membranes (MAMs) means that the ROS generated in mitochondria promote ER stress. Therefore, a state of stress and mitochondrial dysfunction are consequences of this vicious cycle. The implication of mitochondria in insulin release and the exposure of pancreatic β-cells to hyperglycemia make them especially susceptible to oxidative stress and mitochondrial dysfunction. In fact, crosstalk between both mechanisms is related with alterations in glucose homeostasis and can lead to the diabetes-associated insulin-resistance status. In the present review, we discuss the current knowledge of the relationship between oxidative stress, mitochondria, ER stress, inflammation, and lipotoxicity in T2D.

scholarly journals Susceptibility to weathering damage and oxidative stress on soybean seeds with different lignin contents in the seed coat

2016 ◽  
Vol 38 (4) ◽  
pp. 296-304 ◽  
Author(s):  
Caroline Huth ◽  
Liliane Marcia Mertz-Henning ◽  
Sidnei Jose Lopes ◽  
Luciane Almeri Tabaldi ◽  
Liana Veronica Rossato ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Seed Coat ◽  
Lignin Content ◽  
Accelerated Aging ◽  
Guaiacol Peroxidase ◽  
Soybean Seeds ◽  
Soybean Cultivars ◽  
Activity Of Enzymes ◽  
The Relationship ◽  
And Oxidative Stress

Abstract: This study aimed at evaluating the relationship among lignin content in the seed coat of soybean seeds with tolerance to weathering damage and oxidative stress. Four soybean cultivars (CD 208, CD 215, CD 202 and BRS 184), with lignin contents in the seed coat of 4.2, 2.6, 2.0 and 1.7%, respectively, were used. Seeds were subjected to deterioration by moisture, through artificially simulated rains. Pods of all cultivars were subjected to irrigation by constant sprinkling during 4 hours, and then dried in oven, set at 35 °C, for 37 hours; repeating twice such procedure. After these treatments seeds were subjected to tests and then compared to the control. Tests performed were: germination, accelerated aging and tetrazolium test; thereby quantifying the occurrence of damages by weathering damage. The activity of enzymes superoxide dismutase and guaiacol peroxidase was measured; and the lipid peroxidation was assessed. Soybean cultivars CD 208 and CD 215, with higher lignin content in the seed coat, were less susceptible to weathering damage. Seeds of cultivar CD 208 have also presented lower oxidative stress, when subjected to weathering damage stress.

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