scholarly journals The Sensitivity Pattern of Bacteria Against Antibiotics in Urinary Tract Infection Patients at RSD DR. Soebandi Jember

2018 ◽  
Vol 4 (3) ◽  
pp. 171
Author(s):  
Ryan Ravi Is Syahputra ◽  
Dini Agustina ◽  
Septa Surya Wahyudi
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bacterial Resistance ◽  
Supportive Therapy ◽  
Secondary Data ◽  
Gram Positive Bacteria ◽  
Descriptive Research ◽  
Sensitivity Pattern ◽  
Bacterial Sensitivity

Urinary tract infection (UTI) was infection by microorganisms in the urinary tract. Treatment of UTI required supportive therapy and adequate antibiotics. Antibiotic resistance was the solution in the treatment of UTI, so it is important to assess the factors of bacterial resistance and strategies to control the incidence of resistance by choosing antibiotics in accordance with the pattern of sensitivity of germs obtained. This study aimed to determine the pattern of bacterial susceptibility to antibiotics in patients with UTI in RSD dr. Soebandi Jember. This research used descriptive research design by taking secondary data that was medical record data of urine culture examination and sensitivity test to antibiotics in UTI patients who have been diagnosed in inpatient and outpatient room RSD dr. Soebandi Jember between the period January 1, 2014 until November 30, 2017. The results of this study obtained 57 samples of urine positive bacteria, which found 18 types of bacteria that caused UTI. Of the 18 types of bacteria, there were 16 Gram negative bacteria and 2 Gram positive bacteria. Five bacteria divided among others E. coli on 24 samples, K. ornithinolytica on 5 samples, K. pneumoniae on 4 samples, B. cepacia on 4 samples, and E. cloacae on 3 samples. The results of bacterial sensitivity to antibiotic pattern showed the highest sensitivity level ie amikacin, fosfomicin, netilmicin, gentamicin, and nitrofurantoin. While the results of patterns of bacterial resistance to antibiotics based on hormonal levels of cephalotin, cephazolin, ampicillin, sulphametoxazole, and trimetoprim. Keywords: Urinary Tract Infection (UTI), Bacterial sensitivity, Antibiotics

scholarly journals Isolation of Organism and its Drug Sensitivity Pattern in Patients with Urinary Tract Infection at Kathmandu Model Hospital

2018 ◽  
Vol 13 (1) ◽  
pp. 46-50
Author(s):  
Rajesh Dhoj Joshi ◽  
Sachin Khadka ◽  
Deepak Man Joshi ◽  
Basudha Shrestha ◽  
Ganesh Dangal ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bacterial Resistance ◽  
Demographic Data ◽  
Empirical Therapy ◽  
Polymyxin B ◽  
Drug Resistant ◽  
Sensitivity Pattern ◽  
Culture Positive

Introduction: Lack of compliance and unjustified antibiotic prescriptions has resulted in increasing bacterial resistance and is proving as a major challenge in the management of infections. Knowing the commonly isolated uropathogens and their antimicrobial susceptibility is beneficial in planning treatment protocols.Methods: A retrospective review of records of patients with urinary tract infection from January 2012 to December 2016 was conducted at Kathmandu Model Hospital. All patients who were diagnosed as having culture positive urinary tract infection in medical ward of Kathmandu Model Hospital during 5 years period were analyzed for demographic data, prevalence of organism and antibiotic susceptibility patterns.Results: A total of 315 samples were culture positive. The majority of bugs were gram negative E.coli (48.57%) followed  by multi-drug resistant E.coli (28.89%).  The other major pathogens were E. faecalis (6.03%), S. epidermidis (4.44%), K. pneumoniae (4.13%), respectively. The highest level of sensitivity in first line antibiotics was seen in nitrofurantoin (84.9%), whereas least sensitivity was shown by amoxicillin/clavulanic acid (21%). Similarly, in second line antibiotics, highest sensitivity was seen in tetracycline (100%), imipenem (91.9%) and least to meropenem (49.2%). Ceftazidime is mostly (93.3%) resistant antibiotics among uropathogens. All the third line antibiotics such as polymyxin B, tigecycline and colistin were 100% sensitive to all our isolates.Conclusions: Nitrofurantoin may be an appropriate choice for initial empirical therapy of urinary tract infection. Similarly, the multi-drug resistant E.coli is increasing but it can be tailored if antibiotics are used appropriately on the basis of susceptibility data.

scholarly journals The Pattern of Organism Causing Urinary Tract Infection in Diabetic and Non Diabetic Patients in Bangladesh

1970 ◽  
Vol 4 (1) ◽  
pp. 6-8 ◽  
Author(s):  
Md Hamza Saber ◽  
Lovely Barai ◽  
J Ashraful Haq ◽  
Md Shariful Alam Jilani ◽  
Jaheda Begum
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Diabetic Patient ◽  
Bacterial Resistance ◽  
Diabetic Patients ◽  
Beta Lactamase ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum ◽  
Sensitivity Pattern

Urinary tract infection (UTI) is common both in the diabetic and non-diabetic patients. The widespread use of antimicrobial agents leads to emergence of resistant microorganisms. Since the pattern of bacterial resistance is constantly changing, the monitoring of the antimicrobial susceptibilities of the predominantly isolated organisms becomes more important. Aim of this study was to determine the etiologic agents and their antibiotic sensitivity pattern in both diabetic and non-diabetic patients with urinary tract infection (UTI). A total of 288 diabetics (196 female and 92 males) and 63 non diabetic patients (43 female and 20 males) with symptomatic UTI were included in this study. Among the study cases, 43.8% diabetic patients and 42.9% non-diabetic patients had positive growth from urine. Rate of isolation of Escherichia coli in diabetic was less (61.8%) compared to non diabetic (77.8%). Rate of other organisms isolated in diabetic and non diabetic patients were respectively: Klebsiella sp 6.9% vs 3.7%, Enterococcus 12.2% vs3.7%, Pseudomonas species 3.8% vs 0%, Candida species 4.6% versus 3.7%, Staphylococcus aureus 4.6% versus 7.4% etc. E coli isolated from diabetic patient was significantly (p<0.05) less sensitive to ceftriaxone, ceftazidime, cefuroxime, netilmicin, gentamicin, ciprofloxacin and nitrofurantoin than that of non diabetic patients. In addition, isolation rate of the Extended Spectrum Beta Lactamase producing gram negative bacilli was found higher among diabetic population (47.8%) compared to the non-diabetics (9.1%). Key words: Urinary tract infection (UTI), Diabetic and non diabetic patient, Extended Spectrum Beta Lactamase. DOI: http://dx.doi.org/10.3329/bjmm.v4i1.8461 BJMM 2011; 4(1): 6-8

scholarly journals Urinary Tract Infection in Pregnancy and its Correlation with Nitrite Test

1970 ◽  
Vol 7 (2) ◽  
pp. 80-83
Author(s):  
M Subedi ◽  
SR Basnyat ◽  
SD Acharya
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pregnant Women ◽  
Rapid Test ◽  
Culture Method ◽  
Predictive Values ◽  
Gram Positive Bacteria ◽  
Sensitivity Pattern ◽  
Sensitivity Specificity

Background: Urinary Tract Infection is one of the most frequently seen medical complications of pregnant women. The value of screening for bacteriuria by rapid test has to be readdressed considering methods, significance and costs. The study was done to assess the sensitivity and specificity of rapid test (nitrite test) for the confirmation of UTI and etiology of infection during pregnancy and antibiotics sensitivity pattern of the isolates. Methods: In this observational based study, mid stream urine samples from 100 pregnant women clinically suspected of urine infection were evaluated by urine dipstick analysis, microscopic and by culture method. The isolates were identified and antibiotic sensitivity pattern was determined by standard protocol. At the end, Sensitivity, Specificities, Positive and Negative predictive values of isolates were determined from nitrite test. Results: Out of 100 clinically suspected UTI cases, 45% were culture positive of which (55.5%) were Gramnegative bacteria of them Escherichia coli (n=14) was the most common pathogens and Staphyococcus aureus (n=11) was found to be predominant in Gram positive bacteria. Among total 45 positive cases, 17 samples were nitrite positive and also culture positive. The Sensitivity, Specificity, Positive and Negative predictive values of nitrite test in relation to Enterobacteriaceae were 70.8%, 100%, 100% and 91.5% respectively where as Sensitivity, Specificity, Positive and Negative predictive value of nitrite test in relation to Escherichia coli were 100%, 96.6%, 82.3%, and 100%, respectively. Amikacin as well as Gentamycin was found the most effective antibiotics against Gram negative and Gram positive bacteria. Conclusions: Although, confirmatory diagnosis can be achieved by urine culture method, the combination of Nitrite test with pyuria appears to be rapid test and very useful markers for bacterial UTI in district laboratories where culture facilities are rare. On the basis of in vitro tests Amikacin and Ciprofloxacin are comparatively effective drugs for UTI. Key words: antibiotics; nitrite test; pregnant women; urinary tract infection. DOI: 10.3126/jnhrc.v7i2.3011 Journal of Nepal Health Research Council Vol.7(2) Apr 2009 80-83

scholarly journals Prevalence of SUL(1,2), GYR(A, B) and OXA genes among multidrug resistance Klebsiella pneumoniae isolates recovered from women suffering urinary tract infection

2020 ◽  
Vol 11 (2) ◽  
pp. 2424-2432
Author(s):  
Nabil Salim Saaid Tuwaij ◽  
Huda Jameel Baker Al-khilkhali ◽  
Haneen Mohamed Mohsen
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Klebsiella Pneumoniae ◽  
Multidrug Resistant ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Vitek 2 ◽  
Resistant Microorganism ◽  
Urine Specimens

Klebsiella pneumoniae is a significant concern multidrug-resistant microorganism and a one common gram negative bacteria associated with infections of women urinary tract. Therefore, this work aimed to the molecular screening of Sul(1and 2), Gyr(A and B) and OXA genes among K. pneumoniae isolates in Najaf City, Iraq. Out of 250 urine specimens were collected from women showing symptoms of urinary tract infection during five months January to of May 2019, bacterial growth was157 isolates, included 133 gram negative compared with  24 gram positive bacteria while 98 specimens were no growth. According to the Vitek-2 system, 30 K. pneumoniae isolates were obtained.Data on current work revealed that the 26-35 age group was the highest 14 K. pneumoniae isolates. Results of antimicrobial susceptible recorded all isolates were multi-drug resistant (MDR) and they have a different range of resistance. However, all 30 isolates(100%) resistant to ampicillin drugs, while the lowest rate was 1(3.33%) forImipenemdrug. PCR assay revealed exist of oxa, sul-1, sul-2, gyr-A and gyr-B genes among K. pneumoniae isolates with rates 20(66.66%), 11(36.66%), 22(73.33%), 3(10%) and 17(56.66%) respectively.

scholarly journals Prevalence of Urinary Tract Infection and Antibiotic Susceptibility Pattern to Urinary Pathogens in Kathmandu Medical College and Teaching Hospital , Duwakot

2017 ◽  
Vol 2 (1) ◽  
pp. 134-137 ◽  
Author(s):  
Binita Pradhan ◽  
SB Pradhan
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Teaching Hospital ◽  
Urine Culture ◽  
College Teaching ◽  
Pathogenic Microorganism ◽  
Medical College ◽  
Sensitivity Pattern ◽  
Tract Infections

IntroductionIn developing countries, urinary tract infections (UTIs) are one of the most commonly diagnosed diseases among the patient seeking medical service and being treated with empirical antibiotics which causes resistance.ObjectiveTo find out the prevalence of urinary tract infection and sensitivity pattern of antibiotics among bacterial pathogens isolated in patients attending Kathmandu Medical College Teaching Hospital, Duwakot.MethodologyAll the patients with the clinical suspicion of UTI were sent for urine culture. Prevalence of UTI and urinary pathogens isolated with antimicrobial profile was correlated.ResultA total number of 1735 clinically suspected as UTI cases were sent for urine culture sensitivity. Total culture positive were 239 (13.8%). The majority of isolates were from female patients comprising 180 (75%). The most common pathogenic microorganism isolated was E.coli (79.1%). Second most common organism was Klebsiella (11.7%) followed by Citrobacter (3.34%) and Proteus (2.92%). The isolated microorganism showed maximum number of sensitivity with the antibiotics Ofloxacin and Ciprofloxacin. The isolated microorganism demonstrated resistance with Nalidixic Acid and Co-Trimoxazole. ConclusionUrinary tract infection is a commonly encountered case in general practice. Females are commonly affected than men. The microbiological profile and the antibiotic sensitivity pattern while initiating empirical treatment must be taken into account while planning for the management. Regular supervision of the sensitivity pattern of pathogenic microorganism is mandatory for effective treatment.Birat Journal of Health Sciences Vol.2/No.1/Issue 2/ Jan - April 2017, Page: 134-137

scholarly journals Antibiotic Sensitivity of Pathogens Causing Urinary Tract Infection

2013 ◽  
Vol 16 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Taslima Akter ◽  
Zakaria Mia ◽  
Masum Shahriar
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Age Groups ◽  
Antibiotic Sensitivity ◽  
Pharmaceutical Journal ◽  
Reproductive Age ◽  
Mueller Hinton ◽  
Sensitivity Pattern ◽  
Mueller Hinton Agar

Diagnosis of urinary tract infection (UTI) causing pathogens with their sensitivity to different antibiotics was performed with a total of 96 samples from both male (n=31; 32.3%) and female (n=65; 67.7%) of different age groups. Out of 96 urine samples, 55 (57.3%) were found positive after culturing in MacConkey agar plates. The percent distribution of positive cases against collected samples was higher for female (67%) than male (32%). However, female and male at the reproductive age of 16-30 years were more susceptible to UTI. A total of 55 bacterial isolates were identified by conventional methods and their antibiotic sensitivity was tested using Mueller- Hinton agar plates. The predominant isolates were Escherichia coli (34.5%), Klebsiella sp. (18.2%) and Staphylococci (20.0%). The sensitivity pattern for most of the isolated organisms showed 50% and/or higher sensitivity to imipenem, azithromycin and cephalexin, except Staphylococci (only 9.09% to azithromycin). DOI: http://dx.doi.org/10.3329/bpj.v16i1.14491 Bangladesh Pharmaceutical Journal 16(1): 53-58, 2013

scholarly journals Urinary Tract Infection among Patients Visiting Ganesh Man Singh Memorial Hospital and Research Center, Lalitpur, Nepal

2019 ◽  
Vol 6 ◽  
pp. 108-112
Author(s):  
Janak Raj Dhungana ◽  
Aruna Budhathoki ◽  
Goma Poudel ◽  
Jyotika Basnet ◽  
Ravi Shah
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antibiotic Sensitivity ◽  
Memorial Hospital ◽  
Diffusion Method ◽  
Gram Negative ◽  
Microbiological Methods ◽  
Sensitivity Pattern ◽  
Antibiotic Susceptibility Test

Objectives: The objective of this study was to determine the prevalence of urinary tract infection (UTI) and antibiotic sensitivity pattern among the suspected UTI cases visiting at Ganeshman Singh Memorial Hospital Lalitpur, Nepal. Methods: A total of 300 mid-stream urine, catheter and suprapubic aspirate from UTI suspected patients were included and processed for routine microscopy and culture and then identified by standard microbiological methods. Antibiotic susceptibility test was performed by Kirby- Bauer disc diffusion method. Results: Out of 300 samples, 55(84.6%) mid-stream urine and 10(15.4%) catheter sample had significant bacterial growth. E. coli (32,49.2%) was the most common isolate followed by Staphylococcus aureus (10,15.3%), Enterobacter spp. (8,12.3%), Klebsiella spp. (7,10.7%), Pseudomonas aeruginosa (3,4.6%), Proteus spp.  (3,4.6%), Acinetobacter spp. (1,1.5%) and Enterococcus spp. (1,1.5%). Most of the Gram-negative bacterial isolates were sensitive to Ceftriaxone (88.8%) followed by Gentamicin (72.2%), and Nitrofurantoin (64.8%) and resistant to Amoxicilin (68.5%) followed by Nalidixic Acid (53.7%). Gram positive isolates were sensitive to Amikacin (72.7%) followed by Imipenem (63.6%) and Gentamicin (63.6%) whereas resistant to Amoxycilin (72.7%) and Ciprofloxacin (63.63%). Conclusion: The main cause of the UTIs was found as Gram negative bacteria. Prescription of antibiotics based on susceptibility tests would help in reduction of antibiotic resistance.

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